USE OF RESISTIVE-PULSE SENSING WITH SUBMICROMETER PORES OR NANOPORES FOR THE DETECTION OF THE ASSEMBLY OF SUBMICROMETER OR NANOMETER SIZED OBJECTS
    3.
    发明申请
    USE OF RESISTIVE-PULSE SENSING WITH SUBMICROMETER PORES OR NANOPORES FOR THE DETECTION OF THE ASSEMBLY OF SUBMICROMETER OR NANOMETER SIZED OBJECTS 审中-公开
    使用电磁脉冲传感器与检测器或纳米器件进行检测,以检测分子或纳米尺寸对象的组装

    公开(公告)号:US20070202495A1

    公开(公告)日:2007-08-30

    申请号:US11671171

    申请日:2007-02-05

    CPC分类号: G01N33/48721

    摘要: Methods and compositions for detecting the assembly of complexes include providing a solution where a first portion is separated from a second portion via a submicrometer pore, submicrometer tube or channel, nanopore, or nanotube or channel. One or more submicrometer or nanometer sized object(s) is added to the first portion of the solution. Due to molecular interactions, these objects assemble to form complexes consisting of two or more submicrometer or nanometer sized objects. Passage of a complex from the first portion of the solution through the submicrometer pore, submicrometer tube or channel, nanopore, or nanotube or channel to the second portion of the solution is detected using resistive pulse sensing. This sensing methodology may comprise detecting formation of complexes in real-time and/or may comprise detecting preassembled complexes.

    摘要翻译: 用于检测复合物组装的方法和组合物包括提供溶液,其中第一部分经由亚微米孔,亚微米管或通道,纳米孔或纳米管或通道从第二部分分离。 将一个或多个亚微米或纳米尺寸的物体加入溶液的第一部分。 由于分子相互作用,这些物体组装形成由两个或多个亚微米或纳米尺寸的物体组成的复合物。 使用电阻脉冲感测来检测复合物从溶液的第一部分通过亚微米孔,亚微米管或通道,纳米孔或纳米管或通道到解决方案的第二部分。 该感测方法可以包括实时检测复合物的形成和/或可以包括检测预组装的复合物。