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1.发明授权公开(公告)号：US08435749B2
公开(公告)日：2013-05-07
申请号：US13001869
申请日：2009-06-30
Applicant: Akira Togashi , Masakazu Katsu , Megumi Takayanagi , Hiroki Yoshioka , Pohsing Ng , Yasuhiro Shiba , Yusuke Nakamura , Keigo Endo
Inventor： Akira Togashi , Masakazu Katsu , Megumi Takayanagi , Hiroki Yoshioka , Pohsing Ng , Yasuhiro Shiba , Yusuke Nakamura , Keigo Endo
IPC: G01N33/53 , A61K39/395 , C07K16/00 , C07K16/28
CPC classification number: G01N33/57407 , A61K51/1027 , A61K2039/505 , C07K16/28 , C07K2317/56 , C07K2317/565 , G01N2333/705
Abstract: The present invention relates to anti-CDH3 antibodies, which can be labeled with a radioisotope. Moreover, the present invention provides methods and pharmaceutical compositions that comprise an anti-CDH3 antibody as an active ingredient. Since CDH3 is strongly expressed in pancreatic, lung, colon, prostate, breast, gastric or liver cancer cells, the present invention is useful in pancreatic, lung, colon, prostate, breast, gastric or liver cancer therapies.
Abstract translation: 本发明涉及可用放射性同位素标记的抗CDH3抗体。 此外，本发明提供包含抗CDH3抗体作为活性成分的方法和药物组合物。 由于CDH3在胰腺，肺癌，结肠癌，前列腺癌，乳腺癌，胃癌或肝癌细胞中强烈表达，本发明可用于胰腺，肺癌，结肠癌，前列腺癌，乳腺癌，胃癌或肝癌的治疗。
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公开(公告)号：US09139655B2
公开(公告)日：2015-09-22
申请号：US13494822
申请日：2012-06-12
Applicant: Yusuke Nakamura , Toyomasa Katagiri , Shuichi Nakatsuru , Keigo Endo
Inventor： Yusuke Nakamura , Toyomasa Katagiri , Shuichi Nakatsuru , Keigo Endo
CPC classification number: C07K16/30 , A61K49/0002 , A61K49/0021 , A61K49/0041 , A61K49/0058 , A61K51/1027 , A61K2039/505 , C07K16/2896 , C07K2317/24 , G01N33/57407 , G01N33/57419 , G01N33/57426 , G01N33/57446
Abstract: The present invention relates to an antibody or a fragment thereof which is capable of binding to a Frizzled homologue 10 (FZD10) protein, such as a mouse monoclonal antibody, a chimeric antibody and a humanized antibody. Also, the present invention relates to a method for treating and/or preventing FZD10-associated disease; a method for diagnosis or prognosis of FZD10-associated disease; and a method for in vivo imaging of FZD10 in a subject.
Abstract translation: 本发明涉及能够结合卷曲同源物10（FZD10）蛋白，例如小鼠单克隆抗体，嵌合抗体和人源化抗体的抗体或其片段。 此外，本发明涉及治疗和/或预防FZD10相关疾病的方法; 一种FZD10相关疾病的诊断或预后的方法; 以及受试者中FZD10的体内成像的方法。
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Patent Agency Ranking
公开(公告)号：US08221751B2
公开(公告)日：2012-07-17
申请号：US12308095
申请日：2006-08-24
Applicant: Yusuke Nakamura , Toyomasa Katagiri , Shuichi Nakatsuru , Keigo Endo , Motoki Kuhara , Kasumi Yagi
Inventor： Yusuke Nakamura , Toyomasa Katagiri , Shuichi Nakatsuru , Keigo Endo , Motoki Kuhara , Kasumi Yagi
CPC classification number: C07K16/30 , A61K49/0002 , A61K49/0021 , A61K49/0041 , A61K49/0058 , A61K51/1027 , A61K2039/505 , C07K16/2896 , C07K2317/24 , G01N33/57407 , G01N33/57419 , G01N33/57426 , G01N33/57446
Abstract: The present invention relates to an antibody or a fragment thereof which is capable of binding to a Frizzled homologue 10 (FZD10) protein, such as a mouse monoclonal antibody, a chimeric antibody and a humanized antibody. Also, the present invention relates to a method for treating and/or preventing FZD10-associated disease; a method for diagnosis or prognosis of FZD10-associated disease; and a method for in vivo imaging of FZD10 in a subject.
Abstract translation: 本发明涉及能够结合到卷曲同源物10（FZD10）蛋白如小鼠单克隆抗体，嵌合抗体和人源化抗体的抗体或其片段。 此外，本发明涉及治疗和/或预防FZD10相关疾病的方法; 一种FZD10相关疾病的诊断或预后的方法; 以及受试者中FZD10的体内成像的方法。
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4.发明申请ANTI-CDH3 ANTIBODIES LABELED WITH RADIOISOTOPE LABEL AND USES THEREOF 有权标有RADIOISOTOPE标签的抗CDH3抗体及其用途公开(公告)号：US20120128584A1
公开(公告)日：2012-05-24
申请号：US13001869
申请日：2009-06-30
Applicant: Akira Togashi , Masakazu Katsu , Megumi Takayanagi , Hiroki Yoshioka , Pohsing Ng , Yasuhiro Shiba , Yusuke Nakamura , Keigo Endo
Inventor： Akira Togashi , Masakazu Katsu , Megumi Takayanagi , Hiroki Yoshioka , Pohsing Ng , Yasuhiro Shiba , Yusuke Nakamura , Keigo Endo
IPC: A61K51/10 , A61P35/00 , G01N33/566 , C07K16/18 , A61K39/395
CPC classification number: G01N33/57407 , A61K51/1027 , A61K2039/505 , C07K16/28 , C07K2317/56 , C07K2317/565 , G01N2333/705
Abstract: The present invention relates to anti-CDH3 antibodies, which can be labeled with a radioisotope. Moreover, the present invention provides methods and pharmaceutical compositions that comprise an anti-CDH3 antibody as an active ingredient. Since CDH3 is strongly expressed in pancreatic, lung, colon, prostate, breast, gastric or liver cancer cells, the present invention is useful in pancreatic, lung, colon, prostate, breast, gastric or liver cancer therapies.
Abstract translation: 本发明涉及可用放射性同位素标记的抗CDH3抗体。 此外，本发明提供包含抗CDH3抗体作为活性成分的方法和药物组合物。 由于CDH3在胰腺，肺癌，结肠癌，前列腺癌，乳腺癌，胃癌或肝癌细胞中强烈表达，本发明可用于胰腺，肺癌，结肠癌，前列腺癌，乳腺癌，胃癌或肝癌的治疗。
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公开(公告)号：US09017669B2
公开(公告)日：2015-04-28
申请号：US13519127
申请日：2009-12-28
Applicant: Yasuhiro Shiba , Hiroki Yoshioka , Shinji Yamamoto , Aiko Kudo , Ryuji Ohsawa , Pohsing Ng , Yusuke Nakamura , Keigo Endo
Inventor： Yasuhiro Shiba , Hiroki Yoshioka , Shinji Yamamoto , Aiko Kudo , Ryuji Ohsawa , Pohsing Ng , Yusuke Nakamura , Keigo Endo
IPC: C07K16/00 , C07K16/46 , C07K16/28 , A61K39/395 , G01N33/53 , A61K51/10 , C07K16/06 , G01N33/574 , A61K39/00
CPC classification number: C07K16/28 , A61K51/1027 , A61K2039/505 , C07K16/065 , C07K2317/41 , C07K2317/56 , G01N33/574 , G01N2333/705
Abstract: The present invention relates to anti-CDH3 antibodies, which can be labeled with a radioisotope. Moreover, the present invention provides methods and pharmaceutical compositions that comprise an anti-CDH3 antibody as an active ingredient. Since CDH3 is strongly expressed in pancreatic, lung, colon, prostate, breast, gastric or liver cancer cells, the present invention is useful in pancreatic, lung, colon, prostate, breast, gastric or liver cancer therapies.
Abstract translation: 本发明涉及可用放射性同位素标记的抗CDH3抗体。 此外，本发明提供包含抗CDH3抗体作为活性成分的方法和药物组合物。 由于CDH3在胰腺，肺癌，结肠癌，前列腺癌，乳腺癌，胃癌或肝癌细胞中强烈表达，本发明可用于胰腺，肺癌，结肠癌，前列腺癌，乳腺癌，胃癌或肝癌的治疗。
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公开(公告)号：US20130230521A1
公开(公告)日：2013-09-05
申请号：US13494822
申请日：2012-06-12
Applicant: Yusuke Nakamura , Toyomasa Katagiri , Shuichi Nakatsuru , Keigo Endo
Inventor： Yusuke Nakamura , Toyomasa Katagiri , Shuichi Nakatsuru , Keigo Endo
IPC: C07K16/30
CPC classification number: C07K16/30 , A61K49/0002 , A61K49/0021 , A61K49/0041 , A61K49/0058 , A61K51/1027 , A61K2039/505 , C07K16/2896 , C07K2317/24 , G01N33/57407 , G01N33/57419 , G01N33/57426 , G01N33/57446
Abstract: The present invention relates to an antibody or a fragment thereof which is capable of binding to a Frizzled homologue 10 (FZD10) protein, such as a mouse monoclonal antibody, a chimeric antibody and a humanized antibody. Also, the present invention relates to a method for treating and/or preventing FZD10-associated disease; a method for diagnosis or prognosis of FZD10-associated disease; and a method for in vivo imaging of FZD10 in a subject.
Abstract translation: 本发明涉及能够结合卷曲同源物10（FZD10）蛋白，例如小鼠单克隆抗体，嵌合抗体和人源化抗体的抗体或其片段。 此外，本发明涉及治疗和/或预防FZD10相关疾病的方法; 一种FZD10相关疾病的诊断或预后的方法; 以及受试者中FZD10的体内成像的方法。
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公开(公告)号：US20130034566A1
公开(公告)日：2013-02-07
申请号：US13519127
申请日：2009-12-28
Applicant: Yasuhiro Shiba , Hiroki Yoshioka , Shinji Yamamoto , Aiko Kudo , Ryuji Ohsawa , Pohsing Ng , Yusuke Nakamura , Keigo Endo
Inventor： Yasuhiro Shiba , Hiroki Yoshioka , Shinji Yamamoto , Aiko Kudo , Ryuji Ohsawa , Pohsing Ng , Yusuke Nakamura , Keigo Endo
IPC: C07K16/18 , A61P35/00 , G01N33/53 , C07K17/00 , A61K39/395
CPC classification number: C07K16/28 , A61K51/1027 , A61K2039/505 , C07K16/065 , C07K2317/41 , C07K2317/56 , G01N33/574 , G01N2333/705
Abstract: The present invention relates to anti-CDH3 antibodies, which can be labeled with a radioisotope. Moreover, the present invention provides methods and pharmaceutical compositions that comprise an anti-CDH3 antibody as an active ingredient. Since CDH3 is strongly expressed in pancreatic, lung, colon, prostate, breast, gastric or liver cancer cells, the present invention is useful in pancreatic, lung, colon, prostate, breast, gastric or liver cancer therapies.
Abstract translation: 本发明涉及可用放射性同位素标记的抗CDH3抗体。 此外，本发明提供包含抗CDH3抗体作为活性成分的方法和药物组合物。 由于CDH3在胰腺，肺癌，结肠癌，前列腺癌，乳腺癌，胃癌或肝癌细胞中强烈表达，本发明可用于胰腺，肺癌，结肠癌，前列腺癌，乳腺癌，胃癌或肝癌的治疗。
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