公开(公告)号：US4871772A

公开(公告)日：1989-10-03

申请号：US253902

申请日：1988-10-06

Applicant: Kohtaro Miwa ,  Kazuo Igusa ,  Toshichika Ogasawara

Inventor： Kohtaro Miwa ,  Kazuo Igusa ,  Toshichika Ogasawara

IPC: A61K9/48 ,  A61K31/557 ,  A61K31/5575 ,  A61P1/04 ,  A61P7/02 ,  A61P25/02 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00

CPC classification number: A61K31/557 ,  A61K9/4858 ,  Y10S514/97

Abstract: A process for making a stable pharmaceutical preparation of prostaglandin E compounds and/or 15R forms thereof is diclosed.Prostagladin E compounds and 15R forms thereof are know to have useful pharmacological actions even if they are used in a vary small amounts. However, they are extremely unstable and, therefore, considerably difficult in application for routine clinical purposes.In order to remove this difficulty, prostagladin E compounds and 15R forms thereof are formulated into a stable preparation by filling a hard capsule with a solution or a suspension thereof.

Abstract translation: 制备前列腺素E化合物和/或其15R形式的稳定药物制剂的方法被包围。 已知前列腺素E化合物及其15R形式即使以不同的量使用也具有有用的药理作用。 然而，它们非常不稳定，因此在常规临床目的的应用中相当困难。 为了消除这个困难，通过用其溶液或悬浮液填充硬胶囊将前列腺素E化合物及其15R形式配制成稳定的制剂。

公开(公告)号：US4668665A

公开(公告)日：1987-05-26

申请号：US775935

申请日：1985-09-10

Applicant: Kouji Ishihara ,  Kazuo Igusa ,  Toshichika Ogasawara

Inventor： Kouji Ishihara ,  Kazuo Igusa ,  Toshichika Ogasawara

IPC: A61K31/255 ,  A61K31/70 ,  A61K47/18 ,  A61K47/36 ,  A61P1/04 ,  A61P35/00 ,  C07H11/00 ,  A61K31/195

CPC classification number: A61K31/70 ,  Y10S514/97

Abstract: A storage-stable sucralfate-containing preparation which maintains its ability, even after extended periods of time, to form a viscous, sticky, paste-like material in the presence of gastric secretions is disclosed as well as the method of making same.

Abstract translation: 公开了一种储存稳定的含硫糖铝的制剂，其在胃分泌物存在下保持其能力，即使在长时间之后形成粘稠的，粘稠的糊状物质，以及其制备方法。

公开(公告)号：US4221814A

公开(公告)日：1980-09-09

申请号：US44687

申请日：1979-06-01

Applicant: Sakae Takaku ,  Takashi Mori ,  Yasushi Murakami ,  Yoshiyuki Ohsugi ,  Shigeyuki Kataoka ,  Yasuhisa Takeda ,  Takashi Matsuno ,  Yoshimitsu Iida ,  Akiko Ariga ,  Akira Okazaki ,  Kazuo Igusa ,  Toshichika Ogasawara ,  Minoru Shindo

Inventor： Sakae Takaku ,  Takashi Mori ,  Yasushi Murakami ,  Yoshiyuki Ohsugi ,  Shigeyuki Kataoka ,  Yasuhisa Takeda ,  Takashi Matsuno ,  Yoshimitsu Iida ,  Akiko Ariga ,  Akira Okazaki ,  Kazuo Igusa ,  Toshichika Ogasawara ,  Minoru Shindo

IPC: A61K20060101 ,  A61K31/16 ,  A61K31/165 ,  A61K31/235 ,  A61K31/245 ,  C07C20060101 ,  C07C101/44

Abstract: A terephthalic acid monoamide derivative of the formula: ##STR1## (wherein R is a straight- or branched-chain lower alkyl group; R' and R" may be the same or different, and represent a hydrogen atom, or a straight- or branched-chain lower alkyl group) or pharmaceutically acceptable salts thereof are disclosed. A process for preparing such terephthalic acid monoamide derivative or its salts, as well as an anti-allergic agent containing such derivative or its salts as an effective ingredient are also disclosed.

Abstract translation: 下式的对苯二甲酸单酰胺衍生物：其中R是直链或支链的低级烷基; R'和R“可以相同或不同，表示氢原子， 或支链低级烷基）或其药学上可接受的盐。 还公开了制备这种对苯二甲酸单酰胺衍生物或其盐的方法，以及含有该衍生物或其盐作为有效成分的抗过敏剂。

公开(公告)号：US20060233917A1

公开(公告)日：2006-10-19

申请号：US11429295

申请日：2006-05-05

Applicant: Tomoyuki Shobu ,  Kazuo Igusa ,  Toshichika Ogasawara ,  Keizou Mochizuki ,  Hidejiro Hara ,  Kazumi Yamada

Inventor： Tomoyuki Shobu ,  Kazuo Igusa ,  Toshichika Ogasawara ,  Keizou Mochizuki ,  Hidejiro Hara ,  Kazumi Yamada

IPC: A23L1/00

CPC classification number: A61K9/205 ,  A23P20/11 ,  A61K9/2009 ,  A61K9/2013

Abstract: There are provided an aqueous shellac coating agent comprising shellac, a basic amino acid and/or a basic phosphate as well as a production process therefor; a coated food and a coated drug that have been coated with such a coating agent; a glazing composition for oil-based confectionary which is in a liquid form and comprises an aqueous shellac solution (A) containing shellac, a basic amino acid and/or a basic based confectionary in which this glazing composition is applied, to oil-based confectionary to be glazed, thereby generating a glaze; and glazed oil-based confectionary produced using this process for glazing oil-based confectionary.

Abstract translation: 提供包含虫胶，碱性氨基酸和/或碱式磷酸盐的水性虫胶涂层剂及其制备方法; 已经涂覆有这种涂层剂的涂覆食品和涂覆的药物; 用于油性糖果的油漆组合物，其为液体形式，并且包含含有紫胶的水性紫胶溶液（A），其上涂有该玻璃组合物的碱性氨基酸和/或碱性糖果糖基油，以油性糖果 釉面，从而产生釉料; 并使用这种用于上光油基糖果的方法生产的含油基糖果。

公开(公告)号：US20060075927A1

公开(公告)日：2006-04-13

申请号：US11289165

申请日：2005-11-29

Applicant: Tomoyuki Shobu ,  Kazuo Igusa ,  Toshichika Ogasawara ,  Keizou Mochizuki ,  Hidejiro Hara ,  Kazumi Yamada

Inventor： Tomoyuki Shobu ,  Kazuo Igusa ,  Toshichika Ogasawara ,  Keizou Mochizuki ,  Hidejiro Hara ,  Kazumi Yamada

IPC: A23B4/10 ,  A23L1/00 ,  C08J3/02

CPC classification number: C09D193/02 ,  A23G1/305 ,  A23G1/54 ,  A23G3/343 ,  A23G3/54 ,  A23G2200/00 ,  A23G2200/06 ,  A23L7/122 ,  A23L25/25 ,  A23L29/05 ,  A23P20/11 ,  A23V2002/00 ,  A61K9/2813 ,  A61K9/282 ,  A61K9/2833 ,  C08J3/02 ,  A23V2200/22 ,  A23V2250/50 ,  A23V2250/0606 ,  A23V2250/5118 ,  A23V2250/628

Abstract: There are provided an aqueous-shellac coating agent comprising shellac, a basic amino acid and/or a basic phosphate, as well as a production process therefor; a coated food and a coated drug that have been coated with such a coating agent; a glazing. composition for oil-based confectionary which is in a liquid form and comprises an aqueous shellac solution (A) containing shellac, a basic amino acid and/or a basic phosphate dissolved in water, a thickener (B), and/or a sugar (C); a process for glazing oil-based confectionary in which this glazing composition is applied to oil-based confectionary to be glazed, thereby generating a glaze; and glazed oil-based confectionary produced using this process for glazing oil based confectionary;

Abstract translation: 提供了包含虫胶，碱性氨基酸和/或碱式磷酸盐的水性紫外线包衣剂及其制备方法; 已经涂覆有这种涂层剂的涂覆食品和涂覆的药物; 玻璃窗 油性糖果组合物，其为液体形式，并且包含含有虫胶的水性紫胶溶液（A），溶于水的碱性氨基酸和/或碱式磷酸盐，增稠剂（B）和/或糖（ C）; 这种用于上油的油性糖果的方法，其中该玻璃组合物应用于油性糖果面漆，从而产生釉料; 并使用该方法生产的上釉油基糖果制成的油基糖果;

公开(公告)号：US5985843A

公开(公告)日：1999-11-16

申请号：US930263

申请日：1997-09-26

Applicant: Shoichi Higo ,  Kazuo Igusa

Inventor： Shoichi Higo ,  Kazuo Igusa

IPC: A61K9/22 ,  A61K9/24 ,  A61K9/50 ,  A61K9/52 ,  A61K45/06 ,  A61K31/715

CPC classification number: A61K31/7024 ,  A61K45/06 ,  A61K9/209 ,  A61K9/5078 ,  A61K9/5084

Abstract: Disclosed is a pharmaceutical preparation that contains sucralfate is the presence of another drug and which consists of a delayed release fraction of sucralfate and an immediate release fraction of the another drug. The preparation exhibits an outstanding feature such that when administered, the drug coexistent with the sucralfate can maintain its inherent absorption characteristics without being adsorbed, trapped or otherwise affected by the sucralfate.

Abstract translation: PCT No.PCT / JP96 / 00891 Sec。 371日期：1997年9月26日 102（e）1997年9月26日PCT PCT 1996年4月2日PCT公布。 WO96 / 31218 PCT出版物 日期1996年10月10日公开是含有硫糖铝的药物制剂，是另一种药物的存在，其由硫糖铝的延迟释放部分和另一种药物的立即释放部分组成。 该制剂表现出突出的特征，使得当施用时，与硫糖铝共存的药物可以保持其固有的吸收特征，而不被硫糖铝吸附，捕获或以其它方式影响。

公开(公告)号：US4836957A

公开(公告)日：1989-06-06

申请号：US828596

申请日：1986-02-11

Applicant: Kaoru Nemoto ,  Kazuo Igusa ,  Toshichika Ogasawara

Inventor： Kaoru Nemoto ,  Kazuo Igusa ,  Toshichika Ogasawara

IPC: A61K31/195 ,  A61K31/59 ,  A61K47/18

CPC classification number: A61K31/59 ,  A61K47/183 ,  A61K9/0014 ,  A61K9/0019

Abstract: A preparation containing an active form of vitamin D.sub.3 which is stabilized by incorporation of an amino acid that is neither one containing a sulfur atom or an acid amino group in its structure, nor an acidic amino acid, nor a salt of a basic amino acid is disclosed. Examples of said amino acids that may be used as stabilizers of the active form of vitamin D.sub.3 include neutral amino acids such as alanine, valine, proline, phenylalanine, tryptophan, leucine, isoleucine, glycine and serine, and basic amino acids such as lysine, arginine and histidine.

Abstract translation: 含有活性形式的维生素D3的制剂，其结构中并不含有硫原子或酸性氨基的氨基酸，也不含酸性氨基酸，也不含碱性氨基酸的盐， 披露 可用作活性形式的维生素D3的稳定剂的所述氨基酸的实例包括中性氨基酸，例如丙氨酸，缬氨酸，脯氨酸，苯丙氨酸，色氨酸，亮氨酸，异亮氨酸，甘氨酸和丝氨酸，以及碱性氨基酸如赖氨酸， 精氨酸和组氨酸。

公开(公告)号：US4164569A

公开(公告)日：1979-08-14

申请号：US786483

申请日：1977-04-08

Applicant: Heizi Ikushima ,  Hiroto Nakano ,  Kazuo Igusa ,  Sadao Bessho

Inventor： Heizi Ikushima ,  Hiroto Nakano ,  Kazuo Igusa ,  Sadao Bessho

IPC: A61K9/48 ,  A61K31/59 ,  A61K47/12 ,  A61K47/44 ,  A61P3/02 ,  A61K31/00 ,  A61K31/195

CPC classification number: A61K31/59 ,  A61K47/12 ,  A61K47/44 ,  A61K9/4858 ,  Y10S514/972

Abstract: A soft gelatin capsule preparation of a 1.alpha.-hydroxy-vitamin D which contains sorbic acid or its salt and a process for preparing the preparation are disclosed. Sorbic acid or its salt which is incorporated in a soft gelatin capsule and/or an oily diluent acts as a preservative for gelatin and as a stabilizer for the vitamin D.

Abstract translation: 公开了含有山梨酸或其盐的1α-羟基 - 维生素D的软明胶胶囊制剂及其制备方法。 掺入软明胶胶囊和/或油性稀释剂中的山梨酸或其盐起到明胶的防腐剂和维生素D的稳定剂的作用。

公开(公告)号：US4248867A

公开(公告)日：1981-02-03

申请号：US915987

申请日：1978-06-14

Applicant: Heizi Ikushima ,  Kazuo Igusa ,  Sadao Bessho

Inventor： Heizi Ikushima ,  Kazuo Igusa ,  Sadao Bessho

IPC: A61K9/08 ,  A61K47/14 ,  A61K31/59

CPC classification number: A61K47/14

Abstract: A stabilized oily preparation of a 1.alpha.-hydroxy-vitamin D for oral administration comprising a 1.alpha.-hydroxy-vitamin D and, as oily diluent, a triglyceride of saturated middle chain fatty acid which has been treated under certain conditions, and a method for manufacturing the same are disclosed.

Abstract translation: 用于口服给药的1α-羟基 - 维生素D的稳定油性制剂，其包含1α-羟基维生素D和作为油性稀释剂的在一定条件下处理的饱和中链脂肪酸的甘油三酯，以及方法 公开了制造相同的装置。