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公开(公告)号：US08491132B2
公开(公告)日：2013-07-23
申请号：US12930741
申请日：2011-01-14
申请人： Keigo Inoue , Kazuhiro Fukuta
发明人： Keigo Inoue , Kazuhiro Fukuta
IPC分类号： G03B21/26
CPC分类号： G03B21/28 , H04N9/3105 , H04N9/3144 , H04N9/3164
摘要： Provided is a projector which includes a first lamp, a second lamp in an identical direction to the first lamp, a projection optical system that emits image light to an outside, a first mirror that reflects the light from the first lamp or the second lamp to cause the light to enter the lighting optical system, a movable mirror that, when the first lamp is turned on, causes the light to directly enter the first mirror by deviating from an optical path connecting the first lamp and the first mirror and, when the second lamp is turned on, reflects the light by being set up on the optical path to cause the light to enter the first mirror, and a second mirror that reflects the light from the second lamp to cause the light to enter the movable mirror.
摘要翻译： 提供一种投影仪，其包括第一灯，与第一灯相同方向的第二灯，向外部发射图像光的投影光学系统，将来自第一灯或第二灯的光反射到第一灯 使光进入照明光学系统;可动反射镜，当第一灯被接通时，通过偏离连接第一灯和第一反射镜的光路而使光直接进入第一反射镜，并且当 第二灯被接通，通过在光路上设置以使光进入第一反射镜而反射光;以及第二反射镜，其反射来自第二灯的光以使光进入可动镜。
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公开(公告)号：US08003607B2
公开(公告)日：2011-08-23
申请号：US12226448
申请日：2007-03-30
CPC分类号： C07K14/4753 , A61K38/00
摘要： An HGF precursor protein variant, in which a peptide structure comprises a sequence including a peptide chain X inserted between an α chain of HGF or a polypeptide where 1 to 20 amino-acid residues from the C-terminus of the α chain are deleted, and a β chain of HGF or a polypeptide where 1 to 20 amino-acid residues from the N-terminus of the β chain are deleted; wherein (i) the peptide chain X has an amino-acid sequence of at least two residues, (ii) the peptide chain X can be cleaved by a protease reaction or a chemical reaction, and (iii) a protein obtained by cleaving at least one site of the peptide chain X has HGF action.
摘要翻译： 一种HGF前体蛋白质变体，其中肽结构包含插入在H链α链或多肽之间的肽链X的序列，其中缺失来自α链C末端的1-20个氨基酸残基， 一个 的HGF链或多肽，其中从＆lt; bgr的N末端1至20个氨基酸残基; 链被删除; 其中（i）肽链X具有至少两个残基的氨基酸序列，（ii）肽链X可以通过蛋白酶反应或化学反应来切割，和（iii）通过至少裂解获得的蛋白质 肽链X的一个位点具有HGF作用。
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公开(公告)号：US20090209463A1
公开(公告)日：2009-08-20
申请号：US12226448
申请日：2007-03-30
IPC分类号： A61K38/18 , C07K14/475 , C12P21/06
CPC分类号： C07K14/4753 , A61K38/00
摘要： An HGF precursor protein variant, in which a peptide structure comprises a sequence including a peptide chain X inserted between an α chain of HGF or a polypeptide where 1 to 20 amino-acid residues from the C-terminus of the α chain are deleted, and a β chain of HGF or a polypeptide where 1 to 20 amino-acid residues from the N-terminus of the β chain are deleted; wherein (i) the peptide chain X has an amino-acid sequence of at least two residues, (ii) the peptide chain X can be cleaved by a protease reaction or a chemical reaction, and (iii) a protein obtained by cleaving at least one site of the peptide chain X has HGF action.
摘要翻译： 一种HGF前体蛋白质变体，其中肽结构包含插入在HGF的α链或多肽之间的肽链X的序列，其中缺失来自α链的C末端的1至20个氨基酸残基，以及 HGF的β链或多肽，其中β链的N末端有1至20个氨基酸残基被缺失; 其中（i）肽链X具有至少两个残基的氨基酸序列，（ii）肽链X可以通过蛋白酶反应或化学反应来切割，和（iii）通过至少裂解获得的蛋白质 肽链X的一个位点具有HGF作用。
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公开(公告)号：US20070161549A1
公开(公告)日：2007-07-12
申请号：US10582973
申请日：2004-12-15
IPC分类号： A61K38/18 , A61K48/00 , C07K14/475 , C07H21/04 , C12P21/06
CPC分类号： C07K14/4753 , A61K48/00
摘要： The invention provides a modified glycosylation-deficient HGF and a production method thereof. The glycosylation-deficient HGF is produced by introducing amino acid mutation(s) so that no glycosylation take place at at least one glycosylation site of hepatocyte growth factor.
摘要翻译： 本发明提供了修饰的糖基化缺陷型HGF及其制备方法。 通过引入氨基酸突变来产生糖基化缺陷型HGF，使得在肝细胞生长因子的至少一个糖基化位点处不发生糖基化。
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公开(公告)号：US20050164918A1
公开(公告)日：2005-07-28
申请号：US10926088
申请日：2004-08-26
IPC分类号： A61K38/00 , C07K14/475 , A61K38/18
CPC分类号： C07K14/4753
摘要： The present invention provides a segment of glycosylation-deficient HGF having mutation(s) introduced into an amino acid sequence so as to prevent glycosylation at at least one glycosylation site of a hepatocyte growth factor (HGF), and a method of producing the same. The segment of glycosylation-deficient HGF of the present invention has the same activity as that of a segment of glycosylated HGF, therefore, it is useful as an alternate for a segment of glycosylated HGF.
摘要翻译： 本发明提供了具有引入氨基酸序列的突变以防止肝细胞生长因子（HGF）的至少一个糖基化位点处的糖基化的糖基化缺陷型HGF的片段及其制备方法。 本发明的糖基化缺陷型HGF片段具有与糖基化HGF片段相同的活性，因此，作为糖基化HGF片段的替代物是有用的。
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公开(公告)号：US20080022704A1
公开(公告)日：2008-01-31
申请号：US11880842
申请日：2007-07-24
申请人： Kazuhiro Fukuta
发明人： Kazuhiro Fukuta
CPC分类号： B60H1/321 , B60H2001/3261 , B60H2001/3266 , B60H2001/327 , F24F11/30 , F24F2110/10 , F24F2140/20 , F25B2600/02
摘要： An air conditioner comprises: a refrigerating cycle including a compressor and an evaporator; a heater core for heating the air that has passed through the evaporator; a first sensor for acquiring information related to a temperature of the evaporator; a second sensor for acquiring information related to a temperature of a medium to supply heat to the heater core; and a compressor control unit for controlling the compressor. When the temperature of the evaporator is not higher than a predetermined threshold temperature, the compressor control unit reduces a ratio of compression of the refrigerant by the compressor. When the temperature of the medium is not more than a first predetermined value, the compressor control unit sets the threshold temperature at a value higher than a frost limit temperature of the evaporator.
摘要翻译： 空调包括：包括压缩机和蒸发器的制冷循环; 用于加热已经通过蒸发器的空气的加热器芯; 用于获取与蒸发器的温度相关的信息的第一传感器; 第二传感器，用于获取与介质的温度相关的信息以向加热器芯提供热量; 以及用于控制压缩机的压缩机控制单元。 当蒸发器的温度不高于预定阈值温度时，压缩机控制单元降低压缩机对制冷剂的压缩比。 当介质的温度不大于第一预定值时，压缩机控制单元将阈值温度设置为高于蒸发器的霜冻温度的值。
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公开(公告)号：US20060293275A1
公开(公告)日：2006-12-28
申请号：US10565301
申请日：2005-03-28
IPC分类号： A61K31/727
CPC分类号： C08B37/0075 , A61K31/7016 , A61K31/702 , A61K31/715 , C07H11/00 , C08B37/0078 , C08L5/10 , C12P19/04
摘要： The present invention aims to provide an agent for promoting HGF production comprising, as an effective ingredient, a disaccharide comprised of an uronic acid residue (wherein an uronic acid means an iduronic acid or a glucuronic acid, and has the same meaning hereinafter) and a glucosamine residue that are connected by α1,4-glycosidic linkage or β1,4-glycosidic linkage, or an oligosaccharide of tri- to hexadeca-saccharides having a structure in which uronic acid residues and glucosamine residues are alternately and repeatedly connected by α1,4-glycosidic linkage or β1,4-glycosidic linkage, wherein at least one hydroxy group of the uronic acid residues and/or the glucosamine residues may be sulfated, alkylated, acylated or aminated, and/or the amino group at position 2 of at least one of the glucosamine residue(s) may be sulfated, alkylated or acylated, or a salt thereof. The agent of the present invention for promoting HGF production is useful to promote healing of damaged tissues or organs of a living body.
摘要翻译： 本发明的目的在于提供一种促进HGF生产的试剂，其包含由糖醛酸残基（其中糖醛酸表示艾杜糖醛酸或葡糖醛酸，并且具有下述相同含义）的二糖作为有效成分，和 通过α1,4-糖苷键或β1,4-糖苷键连接的葡糖胺残基或具有其中糖醛酸残基和葡糖胺残基被α1,44交替并重复连接的结构的三十六碳糖的寡糖 - 糖苷键或β1,4-糖苷键，其中所述糖醛酸残基和/或所述葡糖胺残基的至少一个羟基可以被硫酸化，烷基化，酰化或胺化，和/或至少在第2位的氨基 一种或多种葡糖胺残基可被硫酸化，烷基化或酰化，或其盐。 用于促进HGF产生的本发明的药剂可用于促进活体损伤的组织或器官的愈合。
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公开(公告)号：US20060186224A1
公开(公告)日：2006-08-24
申请号：US11351178
申请日：2006-02-09
申请人： Kenichi Yoshii , Kazuhiro Fukuta , Kazuhisa Makida
发明人： Kenichi Yoshii , Kazuhiro Fukuta , Kazuhisa Makida
CPC分类号： B60H1/00542 , B60H1/00378
摘要： A vehicle air conditioner is disclosed. Internal air paths and external air paths are arranged in parallel to each other, and the internal air and the external air are blown by a blower to the internal and external air paths. Heat exchangers are arranged in at least the internal air paths, and the internal air after passing through the heat exchangers are blown toward the passenger in the cabin from a face air outlet and a foot air outlet on the one hand and toward the wind shield in the cabin from a wind shield defroster air outlet. Also, the external air passed through the external air paths is blown toward the door window glass in the cabin from door defroster air outlets.
摘要翻译： 公开了一种车辆空调。 内部空气路径和外部空气路径彼此平行地布置，并且内部空气和外部空气被鼓风机吹送到内部和外部空气路径。 热交换器至少布置在内部空气路径中，并且在通过热交换器之后的内部空气一方面从面向空气出口和脚部空气出口朝向驾驶室中的风挡被吹向客舱中的乘客 客舱从风屏除霜器出风口。 此外，通过外部空气路径的外部空气从门除霜器出口吹向机舱内的门窗玻璃。
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公开(公告)号：US20050221441A1
公开(公告)日：2005-10-06
申请号：US11041363
申请日：2005-01-25
IPC分类号： A61K38/00 , C07K14/475 , C07H21/04 , C12N15/09
CPC分类号： C07K14/4753
摘要： The present invention provides a segment of glycosylation-deficient HGF having mutation(s) introduced into an amino acid sequence so as to prevent glycosylation at least one glycosylation site of a hepatocyte growth factor (HGF), and a method of producing the same. The segment of glycosylation-deficient HGF of the present invention has the same activity as that of a segment of glycosylated HGF, therefore, it is useful as an alternate for a segment of glycosylated HGF.
摘要翻译： 本发明提供具有引入氨基酸序列的突变的糖基化缺陷型HGF片段，以防止肝细胞生长因子（HGF）的至少一个糖基化位点的糖基化及其制备方法。 本发明的糖基化缺陷型HGF片段具有与糖基化HGF片段相同的活性，因此，作为糖基化HGF片段的替代物是有用的。
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公开(公告)号：US5756319A
公开(公告)日：1998-05-26
申请号：US676666
申请日：1996-07-10
申请人： Kazuhiro Fukuta , Nobuhiro Fukuhara
发明人： Kazuhiro Fukuta , Nobuhiro Fukuhara
CPC分类号： C12P13/12
摘要： S-phenyl-L-cysteine can be produced in a high yield by reacting thiophenol and L-serine under the action of tryptophan synthase at a pH in a range of from 9.0 to 10.5. Purification of S-phenyl-L-cysteine obtained by this enzyme reaction can be effectively achieved by adjusting the pH of a crystal-containing reaction mixture to a strongly acidic level of 1.5 or lower to dissolve crystals of S-phenyl-L-cysteine, adding activated carbon to the pH-adjusted mixture, maintaining the resultant mixture at a temperature of from 20.degree. to 60.degree. C. under aeration with an oxygen-containing gas, subjecting the thus-obtained mixture to filtration, raising the pH of the resulting filtrate back to a range of from 2.5 to 6.0 to precipitate crystals of S-phenyl-L-cysteine and then recovering the thus-precipitated crystals.
摘要翻译： S-苯基-L-半胱氨酸可以通过在色氨酸合成酶的作用下，在9.0至10.5的pH范围内使苯硫酚和L-丝氨酸反应而以高产率制备。 通过将含有结晶的反应混合物的pH调节至1.5以下的强酸性水平，可以有效地实现通过该酶反应得到的S-苯基-L-半胱氨酸的纯化，以溶解S-苯基-L-半胱氨酸的结晶， 将活性炭加入到pH调节的混合物中，在含氧气体通气下将所得混合物保持在20℃至60℃的温度，对由此得到的混合物进行过滤，使所得混合物的pH值升高 滤液回到2.5至6.0的范围，以沉淀S-苯基-L-半胱氨酸的晶体，然后回收如此沉淀的晶体。
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