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    6-(1-fluoroethyl)-5-iodo-4-aminopyrimidine compounds process for preparation of the same and pest controllers for agricultural and horticultural use
    3.
    发明授权
    6-(1-fluoroethyl)-5-iodo-4-aminopyrimidine compounds process for preparation of the same and pest controllers for agricultural and horticultural use 失效
    6-（1-氟乙基）-5-碘-4-氨基嘧啶化合物的制备方法和用于农业和园艺用途的害虫控制剂

    公开(公告)号：US06867212B2

    公开(公告)日：2005-03-15

    申请号：US10250971

    申请日：2002-01-10

    申请人： Katsutoshi Fujii ,  Shoji Shikita

    发明人： Katsutoshi Fujii ,  Shoji Shikita

    IPC分类号： A01N43/54 ,  C07D239/42 ,  C07D405/12

    CPC分类号： C07D239/42 ,  A01N43/54

    摘要： The present invention relates to a 6-(1-fluoroethyl)-5-iodo-4-aminopyrimidine compound represented by the following formula (1): wherein Ar represents a phenyl group, a naphthyl group, a thienyl group, an indanyl group or a 1,4-benzodioxan-6-yl group, which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a halogen atom, an alkyl group having 1 to 4 carbon atoms, a haloalkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, a haloalkoxy group having 1 to 4 carbon atoms and a phenoxy group; R represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; *1 represents an asymmetric carbon atom; *2 represents an asymmetric carbon atom when R represents an alkyl group having 1 to 4 carbon atoms, a process for preparing the same, and agricultural and horticultural chemicals for controlling noxious organisms.

    摘要翻译： 本发明涉及由下式（1）表示的6-（1-氟乙基）-5-碘-4-氨基嘧啶化合物：其中Ar表示苯基，萘基，噻吩基，茚满基或 1,4-苯并二恶烷-6-基，其是未取代的或被1至3个选自卤素原子，具有1至4个碳原子的烷基，具有1至4个碳的卤代烷基的取代基取代 原子，碳原子数1〜4的烷氧基，碳原子数1〜4的卤代烷氧基和苯氧基; R表示氢原子或碳原子数1〜4的烷基。 * 1表示不对称碳原子; * 2表示当R表示碳原子数为1〜4的烷基时的不对称碳原子，其制备方法，以及用于控制有害生物的农业和园艺化学品。

    Oxazoline derivative, process for preparing the same and agricultural and horticultural chemical for controlling noxious organisms containing the same
    4.
    发明授权
    Oxazoline derivative, process for preparing the same and agricultural and horticultural chemical for controlling noxious organisms containing the same 失效
    恶唑啉衍生物，其制备方法以及用于控制含有它们的有害生物的农业和园艺化学品

    公开(公告)号：US5639771A

    公开(公告)日：1997-06-17

    申请号：US348921

    申请日：1994-11-25

    申请人： Tokio Obata ,  Katsutoshi Fujii ,  Shoji Shikita ,  Kouichi Goka

    发明人： Tokio Obata ,  Katsutoshi Fujii ,  Shoji Shikita ,  Kouichi Goka

    IPC分类号： A01N43/80 ,  A01N47/02 ,  C07C233/69 ,  C07D263/14 ,  C07D413/12 ,  A01N43/76

    CPC分类号： C07D413/12 ,  A01N43/80 ,  A01N47/02 ,  C07C233/69 ,  C07D263/14

    摘要： Disclosed are an oxazoline compound represented by the formula (I): ##STR1## wherein R.sup.1 represents halogen, hydrogen, alkyl, alkoxy, haloalkyl, haloalkoxy, phenyl, phenoxy, benzyl, benzyloxy, pyridyloxy, pyridylmethyloxy, alkoxy-substituted alkyl, nitro, cyanomethyloxy, haloalkylsulfonyloxy, alkylsulfonyloxy, or alkylthio; R.sup.2 represents hydrogen, halogen, alkyl, haloalkyl, alkoxy, alkylthio, or haloalkoxy; R.sup.1 and R.sup.2 may be combined to form a saturated or unsaturated 6-membered ring with oxygen; R.sup.3 represents hydrogen, halogen or alkoxy; R.sup.4 represents hydrogen, alkyl, or halogen; R.sup.5 represents hydrogen, halogen, or alkyl; X.sup.1 represents halogen, alkyl, haloalkyl, or alkoxy; X.sup.2 represents halogen, hydrogen, or alkoxy; X.sup.3 represents hydrogen or halogen; and n represents an integer of 2 to 5;an amidoethyl halide derivative used for synthesis of the same, a process for preparing the same, and an agricultural and horticultural chemical for controlling noxious organisms comprising the same as an active ingredient.

    摘要翻译： 公开了由式（I）表示的恶唑啉化合物：其中R1表示卤素，氢，烷基，烷氧基，卤代烷基，卤代烷氧基，苯基，苯氧基，苄基，苄氧基，吡啶氧基，吡啶基甲氧基，烷氧基取代的烷基 ，硝基，氰基甲氧基，卤代烷基磺酰氧基，烷基磺酰氧基或烷硫基; R 2表示氢，卤素，烷基，卤代烷基，烷氧基，烷硫基或卤代烷氧基; R1和R2可以结合形成饱和或不饱和的6元环与氧; R3表示氢，卤素或烷氧基; R4表示氢，烷基或卤素; R5表示氢，卤素或烷基; X 1表示卤素，烷基，卤代烷基或烷氧基; X2表示卤素，氢或烷氧基; X3表示氢或卤素; n表示2〜5的整数， 用于其合成的酰胺基卤化物衍生物，其制备方法，以及用于控制含有活性成分的有害生物的农业和园艺化学品。

    Aralkylaminopyrimidine derivative, and chemical for controlling noxious organisms containing the same
    6.
    发明授权
    Aralkylaminopyrimidine derivative, and chemical for controlling noxious organisms containing the same 失效
    芳烷基氨基嘧啶衍生物和用于控制含有它们的有害生物的化学物质

    公开(公告)号：US5280025A

    公开(公告)日：1994-01-18

    申请号：US977753

    申请日：1992-11-17

    申请人： Tokio Obata ,  Katsutoshi Fujii ,  Kiyoshi Tsutsumiuchi ,  Yasushi Nakamoto

    发明人： Tokio Obata ,  Katsutoshi Fujii ,  Kiyoshi Tsutsumiuchi ,  Yasushi Nakamoto

    IPC分类号： A01N43/54 ,  C07D239/42

    CPC分类号： C07D239/42 ,  A01N43/54

    摘要： Disclosed are an aralkylaminopyrimidine compound represented by the following formula: ##STR1## wherein R.sup.1 represents a halogen atom, a lower acyloxy group, a hydroxyl group, a lower alkoxy group or a lower alkylthio group; R.sup.2 represents a lower alkyl group, a hydrogen atom or a cycloalkyl group; R.sup.3 may be the same or different and represents a lower haloalkoxy group, a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a lower alkylthio group, a nitro group, a lower haloalkyl group, a lower alkylsulfinyl group, a lower alkylsulfonyl group, a lower haloalkylthio group or a hydroxyl group; a carbon atom to which * is attached represents an asymmetric carbon atom provided that the case where R.sup.2 is a hydrogen atom is excluded; and n represents an integer of 1 to 5.a method for preparing the same and a chemical for controlling noxious organisms which contains the same as an active ingredient.

    摘要翻译： 公开了由下式表示的芳烷基氨基嘧啶化合物：（*化学结构*）（I）其中R1表示卤素原子，低级酰氧基，羟基，低级烷氧基或低级烷硫基; R2表示低级烷基，氢原子或环烷基; R3可以相同或不同，表示低级卤代烷氧基，氢原子，低级烷基，低级烷氧基，卤素原子，低级烷硫基，硝基，低级卤代烷基，低级烷基亚磺酰基 ，低级烷基磺酰基，低级卤代烷硫基或羟基; 只要不排除R2为氢原子的情况，则与其相连的碳原子表示不对称碳原子; n表示1〜5的整数。其制备方法和用于控制含有活性成分的有害生物的化学物质。

    Pyrimidine derivatives and a pharmaceutical composition containing them
    8.
    发明授权
    Pyrimidine derivatives and a pharmaceutical composition containing them 失效
    嘧啶衍生物和含有它们的药物组合物

    公开(公告)号：US4450162A

    公开(公告)日：1984-05-22

    申请号：US384416

    申请日：1982-06-02

    申请人： Toshiharu Kamioka ,  Isao Nakayama ,  Takeo Honda ,  Takashi Kobayashi ,  Tokio Obata ,  Katsutoshi Fujii ,  Mikio Kojima ,  Yuji Akiyoshi

    发明人： Toshiharu Kamioka ,  Isao Nakayama ,  Takeo Honda ,  Takashi Kobayashi ,  Tokio Obata ,  Katsutoshi Fujii ,  Mikio Kojima ,  Yuji Akiyoshi

    IPC分类号： A61K31/505 ,  A61K31/517 ,  A61P25/24 ,  A61P25/26 ,  C07D239/42 ,  C07D239/70 ,  C07D239/94

    CPC分类号： C07D239/42 ,  C07D239/70

    摘要： New 4-anilinopyrimidine derivatives of formula (I): ##STR1## (wherein: R.sup.1 and R.sup.2 are the same or different and each represents a C.sub.1 -C.sub.6 alkyl group or R.sup.1 and R.sup.2 together represent a C.sub.3 -C.sub.5 alkylene group;R.sup.3 represents a hydrogen atom or a C.sub.1 -C.sub.6 alkyl group;n is 0, 1 or 2; andR.sup.4 represents a C.sub.1 -C.sub.6 alkyl group, a C.sub.1 -C.sub.6 alkoxy group, a C.sub.1 -C.sub.6 haloalkyl group, a halogen atom, a nitro group, a C.sub.1 -C.sub.6 alkanesulphonyl group, a cyano group, a carboxy group or a C.sub.2 -C.sub.7 alkoxycarbonyl group and, when n is 2, the two groups represented by R.sup.4 may be the same or different or they may together represent a methylenedioxy group)and pharmaceutically acceptable acid addition salts thereof have been found to have strong antidepressant activity, with low toxicity and very few side-effects. The compounds may be formulated in conventional pharmaceutical compositions for administration by various routes and may be prepared by reacting a 4-halopyrimidine with aniline or an aniline derivative.

    摘要翻译： 式（I）的新的4-苯胺基嘧啶衍生物：其中：R 1和R 2相同或不同，各自表示C 1 -C 6烷基或R 1和R 2一起代表C 3 -C 5亚烷基; R3表示氢原子或C1-C6烷基; n为0,1或2; R4表示C1-C6烷基，C1-C6烷氧基，C1-C6卤代烷基，卤素原子， 硝基，C1-C6烷磺酰基，氰基，羧基或C2-C7烷氧基羰基，当n为2时，由R4表示的两个基团可以相同或不同，或者它们可以一起代表亚甲二氧基 组）及其药学上可接受的酸加成盐被发现具有强的抗抑郁活性，毒性低，副作用非常少。 化合物可以配制成用于通过各种途径给药的常规药物组合物，并且可以通过4-卤代嘧啶与苯胺或苯胺衍生物反应来制备。

    4-phenethylaminopyrimidine derivative, and agricultural and horticultural chemical for controlling noxious organisms containing the same
    10.
    发明授权
    4-phenethylaminopyrimidine derivative, and agricultural and horticultural chemical for controlling noxious organisms containing the same 失效
    4-苯乙基氨基嘧啶衍生物，以及用于控制含有其的有害生物的农业和园艺化学品

    公开(公告)号：US5498612A

    公开(公告)日：1996-03-12

    申请号：US380717

    申请日：1995-01-30

    申请人： Tokio Obata ,  Katsutoshi Fujii ,  Akira Ooka ,  Yoshinori Yamanaka

    发明人： Tokio Obata ,  Katsutoshi Fujii ,  Akira Ooka ,  Yoshinori Yamanaka

    IPC分类号： A01N43/54 ,  A01N47/06 ,  A01N55/00 ,  C07D239/42 ,  C07D401/12 ,  C07D405/12 ,  C07F7/18 ,  C07D239/30

    CPC分类号： C07D239/42 ,  A01N43/54 ,  A01N47/06 ,  A01N55/00 ,  C07D401/12 ,  C07D405/12 ,  C07F7/1856

    摘要： Disclosed are a 4-phenethylaminopyrimidine compound represented by the formula (I): ##STR1## wherein R.sup.1 represents halogen, hydroxyl, acyloxy, alkoxy, haloalkoxy, alkylthio, benzyloxycarbonyloxy, alkyloxycarbonyloxy, alkylsulfonyloxy, tri(alkyl)silyloxy or alkyloxycarbonylalkyloxy;R.sup.2 represents hydrogen, alkyl, alkoxy, halogen, haloalkyl, haloalkoxy, unsubstituted or substituted benzoyl, hydroxyl, haloalkylcarbonyl, alkylsulfonyloxy, haloalkylsulfonyloxy, alkylsulfonyl, alkylsulfinyl, haloalkylsulfinyl, tri(alkyl)silylalkoxy, alkylthio, unsubstituted or substituted pyridyloxy, unsubstituted or substituted phenoxy, alkenyloxy, haloalkenyloxy, unsubstituted or substituted benzyl, 2-phenyl-2-1,3-dioxolanyl, alkoxyiminobenzyl, nitro, haloalkylthio or alkynyloxy; n is an integer of 1 to 5 and * represents an asymmetric carbon atom.a process for preparing the same and an agricultural and horticultural chemical for controlling noxious organisms which contains the same as an active ingredient.

    摘要翻译： 公开了由式（I）表示的4-苯乙基氨基嘧啶化合物：其中R 1表示卤素，羟基，酰氧基，烷氧基，卤代烷氧基，烷硫基，苄氧羰基氧基，烷氧基羰氧基，烷基磺酰氧基，三（烷基）甲硅烷氧基或烷氧基羰基烷氧基。 R 2表示氢，烷基，烷氧基，卤素，卤代烷基，卤代烷氧基，未取代或取代的苯甲酰基，羟基，卤代烷基羰基，烷基磺酰氧基，卤代烷基磺酰氧基，烷基磺酰基，烷基亚磺酰基，卤代烷基亚磺酰基，三（烷基）甲硅烷基烷氧基，烷硫基，未取代或取代的吡啶氧基，未取代或取代的苯氧基 ，烯氧基，卤代烯氧基，未取代或取代的苄基，2-苯基-2,3-二氧戊环，烷氧基亚氨基苄基，硝基，卤代烷硫基或炔氧基; n为1〜5的整数，*表示不对称碳原子。 其制备方法以及用于控制含有与活性成分相同的有害生物的农业和园艺化学品。