公开(公告)号：US5609819A

公开(公告)日：1997-03-11

申请号：US499658

申请日：1995-07-07

申请人： Katsumi Shimizu ,  Washiro Honda

发明人： Katsumi Shimizu ,  Washiro Honda

IPC分类号： B65B55/14 ,  A61L2/06 ,  A61L2/08 ,  A61L2/12 ,  A61L2/24 ,  B65B55/02

CPC分类号： A61L2/085 ,  A61L2/06 ,  A61L2/12

摘要： While a sealed vessel such as a vial having an inside plug such as a rubber stopper is conveyed, the sealed vessel is slanted by a slanting device until liquid medicine in the sealed vessel touches the inside plug. The sealed vessel is moved and simultaneously rotated by a rotating device while the vial is slanted. The liquid medicine in the sealed vessel is heated at a heating portion by heat energy such as infrared, fuel gas and microwave, so that the heated liquid medicine causes heat sterilization of the whole sealed vessel including the inside plug. Sterilization can be completely carried out by providing a heat-retaining portion, cooling portion and drying portion next to the heating portion. An infrared radiation thermometer is provided at the end of the heating portion to measure the temperature of the liquid medicine, so that the temperature of the liquid medicine in each sealed vessel may be controlled to a desired temperature.

摘要翻译： 虽然输送了诸如具有内塞（例如橡胶塞）的小瓶的密封容器，但是密封容器通过倾斜装置倾斜，直到密封容器中的液体药物接触内塞。 当小瓶倾斜时，密封容器通过旋转装置移动并同时旋转。 密封容器中的液体药物通过红外线，燃料气体和微波等热能在加热部分加热，使得加热的液体药物对包括内塞的整个密封容器进行加热灭菌。 通过在加热部分附近设置保温部，冷却部和干燥部，能够完全灭菌。 在加热部分的末端设置红外线辐射温度计，以测量液体药物的温度，从而将每个密封容器中的液体药物的温度控制在所需温度。

公开(公告)号：US5366989A

公开(公告)日：1994-11-22

申请号：US986800

申请日：1992-12-08

申请人： Hiroyuki Imaizumi ,  Tetsuya Kajita ,  Kenichi Takashima ,  Minako Yotsuji ,  Keiko Takakura ,  Akira Yotsuji ,  Junichi Mitsuyama ,  Katsumi Shimizu ,  Hiroshi Sakai ,  Hirokazu Narita

发明人： Hiroyuki Imaizumi ,  Tetsuya Kajita ,  Kenichi Takashima ,  Minako Yotsuji ,  Keiko Takakura ,  Akira Yotsuji ,  Junichi Mitsuyama ,  Katsumi Shimizu ,  Hiroshi Sakai ,  Hirokazu Narita

IPC分类号： A61K31/41 ,  A61P31/04 ,  A61P31/10 ,  C07D249/08 ,  C07D401/12 ,  C07D417/06 ,  C07D521/00 ,  A01N43/653

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

摘要： The present invention relates to a compound represented by the general formula (1) or its salt, a process for producing the same, and an antifungal agent comprising the same as an effective component: ##STR1## wherein R.sup.1 represents a substituted or unsubstituted aryl group or a substituted or unsubstituted heterocyclic group bonded through a carbon atom in the ring to the main chain; R.sup.2 presents a hydrogen atom, a fluorine atom or a substituted or unsubstituted alkyl group; and R.sup.3 represents a cyano group, a thioamido group or a group represented by the formula ##STR2## in which R.sup.4 is a hydroxyl group or a group of the formula ##STR3## (R.sup.7 and R.sup.8, which may be the same or different, are hydrogen atoms or substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, amino, alkoxy, hydroxyl or heterocyclic groups, and may form a substituted or unsubstituted heterocyclic group together with the nitrogen atom to which R.sup.7 and R.sup.8 attach), R.sup.5 is a substituted or unsubstituted alkoxy group or a group of the formula ##STR4## (R.sup.7 and R.sup.8 are as defined above), and R.sup.6 is a hydrogen atom or a substituted or unsubstituted alkyl group.

摘要翻译： 本发明涉及由通式（1）表示的化合物或其盐，其制备方法和含有该化合物的有效成分的抗真菌剂：有或无取代的芳基或取代或未取代的杂环基 通过环中的碳原子键合到主链上; R2表示氢原子，氟原子或取代或未取代的烷基; 并且R 3表示氰基，硫代酰氨基或由下式表示的基团：其中R 4是羟基或式（R 3和R 8）可以相同或不同， 氢原子或取代或未取代的烷基，烯基，炔基，环烷基，芳基，氨基，烷氧基，羟基或杂环基，并且可以与R7和R8连接的氮原子一起形成取代或未取代的杂环基），R5是 取代或未取代的烷氧基或式6的基团是氢原子或取代或未取代的烷基。

公开(公告)号：US08894981B2

公开(公告)日：2014-11-25

申请号：US13313739

申请日：2011-12-07

申请人： Katsumi Shimizu ,  Yoshiaki Kawasaki ,  Shigeru Kishida ,  LaFrancia S. Weaver ,  Mark George LePage

发明人： Katsumi Shimizu ,  Yoshiaki Kawasaki ,  Shigeru Kishida ,  LaFrancia S. Weaver ,  Mark George LePage

IPC分类号： A61K8/00 ,  A61K8/18 ,  A61K8/25 ,  A61K8/26 ,  A61K8/27 ,  A61K8/28 ,  A61K8/29 ,  A61Q1/10 ,  A61K8/11 ,  A61K8/19 ,  A61Q1/02 ,  A61K8/36

CPC分类号： A61K8/11 ,  A61K8/19 ,  A61K8/361 ,  A61K8/442 ,  A61K2800/43 ,  A61Q1/02 ,  A61Q1/10

摘要： Described are water based slurry compositions of cosmetic and personal care products and methods of making and using water based slurry compositions for cosmetic and personal care products such as foundations, eye shadows, lotions, and creams.

摘要翻译： 描述了化妆品和个人护理产品的水基浆料组合物以及用于化妆品和个人护理产品如地基，眼影，洗剂和霜剂的水基浆料组合物的制备和使用方法。

公开(公告)号：US20140079745A1

公开(公告)日：2014-03-20

申请号：US13622860

申请日：2012-09-19

申请人： Katsumi SHIMIZU ,  Shoji Takekawa

发明人： Katsumi SHIMIZU ,  Shoji Takekawa

IPC分类号： A61K8/02 ,  A61Q1/02 ,  A61Q1/06 ,  A61Q1/04 ,  A61Q1/08 ,  A61K33/08 ,  A61Q1/10 ,  A61Q17/04 ,  A61Q15/00

CPC分类号： A61K8/0241 ,  A61K8/26 ,  A61K8/29 ,  A61K2800/10 ,  A61K2800/412 ,  A61K2800/621 ,  A61Q1/02 ,  A61Q1/12 ,  A61Q19/00 ,  A61Q19/10 ,  C01P2004/03 ,  C01P2004/61 ,  C01P2004/62 ,  C01P2004/80 ,  C01P2006/60 ,  C09C1/407 ,  C09C3/063

摘要： The embodiments relate to cosmetic compositions providing a high coverage to the skin while retaining a natural skin appearance. The compositions of embodiments include a powder-containing aluminum hydroxide particles having an average coated ratio of from about 60% to about 150% powder by weight of aluminum hydroxide, and a cosmetically acceptable carrier. The compositions may be useful as a foundation and/or as a composition to correct skin discoloration.

摘要翻译： 实施方案涉及提供对皮肤的高覆盖率同时保持天然皮肤外观的化妆品组合物。 实施方案的组合物包括平均涂覆比例为约60重量％至约150重量％的氢氧化铝粉末的粉末状氢氧化铝颗粒和美容上可接受的载体。 组合物可用作基础和/或作为校正皮肤变色的组合物。

公开(公告)号：US20120107379A1

公开(公告)日：2012-05-03

申请号：US13313739

申请日：2011-12-07

申请人： Katsumi Shimizu ,  Yoshiaki Kawasaki ,  Shigeru Kishida ,  LaFrancia S. Weaver ,  Mark George LePage

发明人： Katsumi Shimizu ,  Yoshiaki Kawasaki ,  Shigeru Kishida ,  LaFrancia S. Weaver ,  Mark George LePage

IPC分类号： A61K8/04 ,  A61K8/44 ,  A61K8/42 ,  A61K8/58 ,  A61K8/65 ,  A61K8/55 ,  A61K8/81 ,  A61K8/36 ,  A61K8/89 ,  A61K8/67 ,  A61K8/29 ,  A61K8/27 ,  A61K8/28 ,  A61K8/19 ,  A61K8/87 ,  A61K8/92

CPC分类号： A61K8/11 ,  A61K8/19 ,  A61K8/361 ,  A61K8/442 ,  A61K2800/43 ,  A61Q1/02 ,  A61Q1/10

摘要： This invention relates to water based slurry compositions of cosmetic and personal care products and methods of making and using water based slurry compositions for cosmetic and personal care products such as foundations, eye shadows, lotions, and creams.

摘要翻译： 本发明涉及化妆品和个人护理产品的水基浆料组合物以及用于化妆品和个人护理产品如地基，眼影，洗剂和霜剂的水基浆料组合物的制备和使用方法。

公开(公告)号：US07257949B2

公开(公告)日：2007-08-21

申请号：US10499706

申请日：2002-12-24

申请人： Katsumi Shimizu ,  Naoki Nishi ,  Haruhiko Murakami ,  Toshiaki Hosono

发明人： Katsumi Shimizu ,  Naoki Nishi ,  Haruhiko Murakami ,  Toshiaki Hosono

IPC分类号： F25B9/14 ,  F25B9/00 ,  F02G1/043 ,  F02G1/04

CPC分类号： F02G1/0435 ,  F02G2275/20 ,  F25B2309/001 ,  F25B2309/1428

摘要： Through stroke control whereby the stroke of a piston is detected and controlled to be equal to a target stroke, the piston is prevented from colliding with a displacer, and the refrigerating performance of a Stirling refrigerator is enhanced. Different target strokes corresponding to different operation conditions of the Stirling refrigerator are stored in a storage portion in a control box, so that a linear motor can be driven with a target stroke that suits the current operation condition. Thus, the piston is prevented from colliding with a displacer, and the refrigerating performance of a Stirling refrigerator is further enhanced.

摘要翻译： 通过行程控制，由此检测并控制活塞的行程等于目标冲程，防止活塞与置换器碰撞，并且提高了斯特林制冷机的制冷性能。 对应于斯特林冰箱的不同操作条件的不同目标行程被存储在控制箱的存储部分中，使得可以以适合当前操作条件的目标行程驱动线性电动机。 因此，防止活塞与置换器碰撞，并且进一步提高了斯特林冰箱的制冷性能。

公开(公告)号：US5605921A

公开(公告)日：1997-02-25

申请号：US261952

申请日：1994-06-17

申请人： Hiroyuki Imaizumi ,  Tetsuya Kajita ,  Kenichi Takashima ,  Minako Yotsuji ,  Keiko Takakura ,  Akira Yotsuji ,  Junichi Mitsuyama ,  Katsumi Shimizu ,  Hiroshi Sakai ,  Hirokazu Narita

发明人： Hiroyuki Imaizumi ,  Tetsuya Kajita ,  Kenichi Takashima ,  Minako Yotsuji ,  Keiko Takakura ,  Akira Yotsuji ,  Junichi Mitsuyama ,  Katsumi Shimizu ,  Hiroshi Sakai ,  Hirokazu Narita

IPC分类号： A61K31/41 ,  A61P31/04 ,  A61P31/10 ,  C07D249/08 ,  C07D401/12 ,  C07D417/06 ,  C07D521/00 ,  A01N43/653

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

摘要： The present invention relates to a compound represented by the general formula (1) or its salt, a process for producing the same, and an antifungal agent comprising the same as an effective component: ##STR1## wherein R.sup.1 represents a substituted or unsubstituted aryl group or a substituted or unsubstituted heterocyclic group bonded through a carbon atom in the ring to the main chain; R.sup.2 presents a hydrogen atom, a fluorine atom or a substituted or unsubstituted alkyl group; and R.sup.3 represents a cyano group, a thioamido group or a group represented by the formula ##STR2## in which R.sup.4 is a hydroxyl group or a group of the formula ##STR3## (R.sup.7 and R.sup.8, which may be the same or different, are hydrogen atoms or substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, amino, alkoxy, hydroxyl or heterocyclic groups, and may form a substituted or unsubstituted heterocyclic group together with the nitrogen atom to which R.sup.7 and R.sup.8 attach), R.sup.5 is a substituted or unsubstituted alkoxy group or a group of the formula ##STR4## (R.sup.7 and R.sup.8 are as defined above), and R.sup.6 is a hydrogen atom or a substituted or unsubstituted alkyl group.

摘要翻译： 本发明涉及由通式（1）表示的化合物或其盐，其制备方法和含有该化合物的有效成分的抗真菌剂：有或无取代的芳基或取代或未取代的杂环基 通过环中的碳原子键合到主链上; R2表示氢原子，氟原子或取代或未取代的烷基; 并且R 3表示氰基，硫代酰氨基或由下式表示的基团：其中R 4是羟基或式（R 3和R 8）可以相同或不同， 氢原子或取代或未取代的烷基，烯基，炔基，环烷基，芳基，氨基，烷氧基，羟基或杂环基，并且可以与R7和R8连接的氮原子一起形成取代或未取代的杂环基），R5是 取代或未取代的烷氧基或式的基团（R 7和R 8如上定义），R 6为氢原子或取代或未取代的烷基。

公开(公告)号：US5352750A

公开(公告)日：1994-10-04

申请号：US67990

申请日：1993-05-27

申请人： Hisamichi Yanai ,  Takanori Kitamura ,  Fumio Nakahara ,  Katsumi Shimizu ,  Akimasa Aoyama ,  Takeshi Moritani

发明人： Hisamichi Yanai ,  Takanori Kitamura ,  Fumio Nakahara ,  Katsumi Shimizu ,  Akimasa Aoyama ,  Takeshi Moritani

IPC分类号： C08F2/00 ,  C08F8/12 ,  C08F218/04

CPC分类号： C08F218/04 ,  B29C47/00 ,  C08F8/12 ,  C08J5/18 ,  C08F2800/10

摘要： Process for producing ethylene-vinyl ester copolymers using a polymerization solvent of a dialkyl sulfoxide (process X); process for producing ethylene-vinyl alcohol copolymer by liquid phase saponification using a solvent of a dialkyl sulfoxide (process Y); and process for producing shaped articles which comprises contacting the ethylene-vinyl alcohol copolymer obtained by the process Y, or that obtained by saponifying the ethylene-vinyl ester copolymer obtained by process X, to a non-solvent for ethylene-vinyl alcohol copolymer.Ethylene-vinyl ester copolymers having a wide range of ethylene content and higher degree of polymerization than that with solution polymerization using methanol.The rate of saponification is higher than that with single solvent system of lower alcohol.Production cost is low, because production process of polymer is directly connected to that of shaped articles utilizing the polymer.

摘要翻译： 使用二烷基亚砜的聚合溶剂制备乙烯 - 乙烯基酯共聚物的方法（方法X）; 通过使用二烷基亚砜的溶剂进行液相皂化生产乙烯 - 乙烯醇共聚物的方法（方法Y）; 以及制造成型制品的方法，其包括将通过方法Y获得的乙烯 - 乙烯醇共聚物或通过将由方法X获得的乙烯 - 乙烯基酯共聚物皂化而获得的乙烯 - 乙烯醇共聚物与乙烯 - 乙烯醇共聚物的非溶剂接触。 乙烯 - 乙烯基酯共聚物的乙烯含量范围宽，聚合度高于使用甲醇的溶液聚合。 皂化率高于单一溶剂体系的低级醇。 生产成本低，因为聚合物的生产过程直接与使用聚合物的成型制品相连。

公开(公告)号：US5316030A

公开(公告)日：1994-05-31

申请号：US947454

申请日：1992-09-21

申请人： Katsumi Shimizu ,  Kazumi Maruoka ,  Kiyoshi Yamagishi

发明人： Katsumi Shimizu ,  Kazumi Maruoka ,  Kiyoshi Yamagishi

IPC分类号： B08B3/12 ,  B08B9/24 ,  B08B9/30 ,  B08B9/42 ,  B65G49/04 ,  B08B3/10

CPC分类号： B08B9/42 ,  B08B3/126 ,  B08B9/24

摘要： A container is held between a conveyor and guide means provided around the conveyor and the guide means come in frictional contact with the container to rotate the container around its own axis as the conveyor runs in its circumferential path. The conveyor is partially water-immersed within a water tank and the container being rotated by cooperation of the conveyor and the guide means within the water tank is applied on its side wall with ultrasonic waves from ultrasonic vibrators serving to flush the container.The conveyor is provided on its outer peripheral surface with fin-like projections vertically extending and circumferentially spaced from one another at regular intervals and there are provided around the conveyor upper rails, sloped rails and lower rails serving to support the bottom of the container. There may be provided guide means associated with the respective rails. Only the lower rails are immersed in water.There may be provided above the conveyor a nozzle serving to fill the container with flushing liquid such as water and there may be provided a heater below the water tank to enhance a flushing effect.

摘要翻译： 容器被保持在输送机和设置在输送机周围的引导装置之间，并且当输送机在其圆周路径中运行时，引导装置与容器摩擦接触以使容器围绕其自身的轴线旋转。 输送机部分地浸在水箱中，并且通过输送机和引导装置在水箱内协同旋转的容器在其侧壁上用来自用于冲洗容器的超声波振动器的超声波施加。 输送机在其外周表面上设有翅片状的突出部，其垂直延伸并以规则的间隔彼此周向间隔开，并且设置在输送机上轨道，倾斜轨道和用于支撑容器底部的下轨道周围。 可以设置与相应轨道相关联的引导装置。 只有下轨才能浸入水中。 可以在输送机上方设置有用于向容器填充诸如水的冲洗液的喷嘴，并且可以在水箱下方设置加热器以增强冲洗效果。

公开(公告)号：US5279788A

公开(公告)日：1994-01-18

申请号：US824003

申请日：1992-01-22

申请人： Minoru Kudo ,  Toshiyasu Ehara ,  Kenichi Iijima ,  Washiro Honda ,  Katsumi Shimizu

发明人： Minoru Kudo ,  Toshiyasu Ehara ,  Kenichi Iijima ,  Washiro Honda ,  Katsumi Shimizu

IPC分类号： A23L3/01 ,  A61L2/12 ,  B65B55/16 ,  H05B6/78 ,  A61L2/00

CPC分类号： A23L3/01 ,  A61L2/12 ,  B65B55/16 ,  H05B6/78 ,  H05B2206/045

摘要： In the microwave oven of square waveguide type or coaxial tube type, the waveguide or inner conductor of the tube type is gradually declined from the inlet toward the outlet of the oven. A top slot is provided so that containers may be moved along the slot with their bottom portions being received in the oven and the contents heat sterilized. There is laid on a bottom surface of the oven a support rail for the bottoms of the containers, and this rail is gradually thickened from the inlet toward the outlet. More preferably, two or more such microwave ovens may be serially connected and the containers may be moved therethrough to heat sterilize medical fluids within each container in a stepwise manner.

摘要翻译： 在方波导型或同轴管型的微波炉中，管型的波导管或内导体从入口朝向炉的出口逐渐下降。 设置顶部狭槽，使得容器可以沿着狭槽移动，其底部容纳在烘箱中并且内容物被热灭菌。 在烤箱的底面上放置有用于容器底部的支撑轨道，并且该轨道从入口朝向出口逐渐变厚。 更优选地，两个或更多个这样的微波炉可以串联连接，并且容器可以通过其移动，以逐步的方式对每个容器内的医用流体进行加热灭菌。