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公开(公告)号：US08637642B2
公开(公告)日：2014-01-28
申请号：US13249111
申请日：2011-09-29
申请人： Daulet Satpayev , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Jean Gudas , Aya Jakobovits , Michael Torgov , Zili An
发明人： Daulet Satpayev , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Jean Gudas , Aya Jakobovits , Michael Torgov , Zili An
CPC分类号： A61K47/6851 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6889 , A61K2039/505 , A61N5/1001 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K2317/14 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/92
摘要： Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
摘要翻译： 本文描述了结合191P4D12蛋白及其变体的抗体药物偶联物（ADC）。 191P4D12在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，本发明的ADC提供了用于治疗癌症的治疗组合物。
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2.发明授权Nucleic acid and corresponding protein entitled 162P1E6 useful in treatment and detection of cancer 失效核酸和相应的蛋白质162P1E6可用于治疗和检测癌症公开(公告)号：US08497351B2
公开(公告)日：2013-07-30
申请号：US13043221
申请日：2011-03-08
申请人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
发明人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
IPC分类号： C07K5/00
CPC分类号： C07K14/4748 , A61K39/00 , Y02A50/466 , Y10T436/143333
摘要： A novel gene (designated 162P1E6) and its encoded protein, and variants thereof, are described wherein 162P1E6 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 162P1E6 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 162P1E6 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 162P1E6 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（命名为162P1E6）及其编码的蛋白质及其变体，其中162P1E6在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，162P1E6提供诊断，预后， 癌症的预防和/或治疗靶标。 162P1E6基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与162P1E6反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US08350009B2
公开(公告)日：2013-01-08
申请号：US12757935
申请日：2010-04-09
申请人： Aya Jakobovits , Steven B. Kanner , Pia M. Challita-Eid , Juan J. Perez-Villar , Daulet Satpaev , Arthur B. Raitano , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Xiao-chi Jia , Jean Gudas
发明人： Aya Jakobovits , Steven B. Kanner , Pia M. Challita-Eid , Juan J. Perez-Villar , Daulet Satpaev , Arthur B. Raitano , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Xiao-chi Jia , Jean Gudas
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/24 , C07K2317/73 , C07K2317/732
摘要： Antibodies and molecules derived therefrom that bind to 161P2F10B protein and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.
摘要翻译： 其中161P2F10B在正常成人组织中表现出组织特异性表达，并且在表I所示的癌症中异常表达。因此，161P2F10B提供诊断，预后，预防和 /或癌症治疗靶标。 161P2F10B基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与161P2F10B反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US08236310B2
公开(公告)日：2012-08-07
申请号：US12881461
申请日：2010-09-14
申请人： Aya Jakobovits , Steven B. Kanner , Pia M. Challita-Eid , Juan J. Perez-Villar , Daulet Satpaev , Arthur B. Raitano , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Xiao-chi Jia , Jean Gudas
发明人： Aya Jakobovits , Steven B. Kanner , Pia M. Challita-Eid , Juan J. Perez-Villar , Daulet Satpaev , Arthur B. Raitano , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Xiao-chi Jia , Jean Gudas
IPC分类号： A61K39/395 , G01N33/574 , C07K16/30
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/24 , C07K2317/73
摘要： Antibodies and molecules derived therefrom that bind to 161P2F10B protein and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.
摘要翻译： 其中161P2F10B在正常成人组织中表现出组织特异性表达，并且在表I所示的癌症中异常表达。因此，161P2F10B提供诊断，预后，预防和 /或癌症治疗靶标。 161P2F10B基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与161P2F10B反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US08013128B2
公开(公告)日：2011-09-06
申请号：US12397992
申请日：2009-03-04
申请人： Jean Gudas , Aya Jakobovits , Xiao-chi Jia , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Hui Shao , Pia M. Challita-Eid , Arthur B. Raitano
发明人： Jean Gudas , Aya Jakobovits , Xiao-chi Jia , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Hui Shao , Pia M. Challita-Eid , Arthur B. Raitano
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/00
CPC分类号： A61K39/0011 , A61K51/1051 , A61K51/1054 , A61K51/1057 , A61K51/106 , A61K51/1072 , A61K2039/505 , A61K2039/53 , A61K2039/545 , C07K14/4748 , C07K14/705 , C07K16/30 , C07K16/3069 , C07K2317/34 , C07K2317/73 , C07K2317/734 , C07K2317/77 , G01N33/566 , G01N33/57415 , G01N33/57434 , G01N33/57492 , G01N2500/04
摘要： Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization.
摘要翻译： 其中PSCA在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，PSCA提供诊断，预后， 癌症的预防和/或治疗靶标。 PSCA基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与PSCA反应的抗体或T细胞可用于主动或被动免疫。
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6.发明授权Nucleic acid and corresponding protein entitled 161P5C5 useful in treatment and detection of cancer 失效核酸和相应的标题为161P5C5的蛋白质可用于治疗和检测癌症公开(公告)号：US07982004B2
公开(公告)日：2011-07-19
申请号：US12646863
申请日：2009-12-23
申请人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
发明人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
IPC分类号： C07K1/00
CPC分类号： C07K14/4748 , A61K39/00 , Y02A50/466 , Y10T436/143333
摘要： A novel gene (designated 161P5C5) and its encoded protein, and variants thereof, are described wherein 161P5C5 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P5C5 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P5C5 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P5C5 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为161P5C5）及其编码的蛋白及其变体，其中161P5C5在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，161P5C5提供诊断，预后， 癌症的预防和/或治疗靶标。 161P5C5基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与161P5C5反应的抗体或T细胞可用于主动或被动免疫。
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7.发明申请NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 151P3D4 USEFUL IN TREATMENT AND DETECTION OF CANCER 审中-公开核酸和相关蛋白151P3D4用于治疗和检测癌症公开(公告)号：US20110123539A1
公开(公告)日：2011-05-26
申请号：US13016639
申请日：2011-01-28
申请人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
发明人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
IPC分类号： A61K39/395 , C07K16/18 , C12N5/071 , C12P21/02
CPC分类号： C07K14/47 , A61K38/00 , C12N9/78 , Y10T436/25
摘要： A novel gene (designated 151P3D4) and its encoded protein, and variants thereof, are described wherein 151P3D4 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 151P3D4 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 151P3D4 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 151P3D4 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为151P3D4）及其编码的蛋白及其变体，其中151P3D4在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，151P3D4提供诊断，预后， 癌症的预防和/或治疗靶标。 151P3D4基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与151P3D4反应的抗体或T细胞可用于主动或被动免疫。
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8.发明授权Nucleic acid and corresponding protein entitled 24P4C12 useful in treatment and detection of cancer 有权核酸和相应的标题为24P4C12的蛋白质可用于治疗和检测癌症公开(公告)号：US07935491B2
公开(公告)日：2011-05-03
申请号：US11518610
申请日：2006-09-08
申请人： Arthur B. Raitano , Karen Jane Meyrick Morrison , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
发明人： Arthur B. Raitano , Karen Jane Meyrick Morrison , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
IPC分类号： G01N33/53
CPC分类号： C07K16/18 , A01K2217/05 , A01K2267/03 , A61K38/1709 , A61K48/00 , C07K14/705 , C12N2799/026 , C12N2799/027 , G01N33/57492
摘要： A novel gene 024P4C12 (also designated 24P4C12) and its encoded protein, and variants thereof, are described wherein 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 24P4C12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 24P4C12 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 24P4C12 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因024P4C12（也称为24P4C12）及其编码蛋白及其变体，其中24P4C12在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，24P4C12提供诊断， 癌症的预后，预防和/或治疗靶标。 24P4C12基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与24P4C12反应的抗体或T细胞可用于主动或被动免疫。
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9.发明授权Nucleic acid and corresponding protein entitled 125P5C8 useful in treatment and detection of cancer 失效核酸和相应的蛋白质125P5C8可用于治疗和检测癌症公开(公告)号：US07928196B2
公开(公告)日：2011-04-19
申请号：US12820083
申请日：2010-06-21
申请人： Mary Faris , Pia M. Challita-Eid , Rene S. Hubert , Daniel E. H. Afar , Arthur B. Raitano , Wangmao Ge , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Aya Jakobovits
发明人： Mary Faris , Pia M. Challita-Eid , Rene S. Hubert , Daniel E. H. Afar , Arthur B. Raitano , Wangmao Ge , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Aya Jakobovits
IPC分类号： C07K14/00
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , Y02A50/466
摘要： A novel gene (designated 125P5C8) and its encoded protein, and variants thereof, are described wherein 125P5C8 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 125P5C8 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 125P5C8 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 125P5C8 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为125P5C8）及其编码的蛋白及其变体，其中125P5C8在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，125P5C8提供诊断，预后， 癌症的预防和/或治疗靶标。 125P5C8基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与125P5C8反应的抗体或T细胞可用于主动或被动免疫。
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10.发明授权Nucleic acid and corresponding protein entitled 162P1E6 useful in treatment and detection of cancer 失效核酸和相应的蛋白质162P1E6可用于治疗和检测癌症公开(公告)号：US07923543B1
公开(公告)日：2011-04-12
申请号：US11841126
申请日：2007-08-20
申请人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
发明人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
CPC分类号： C07K14/4748 , A61K39/00 , Y02A50/466 , Y10T436/143333
摘要： A novel gene (designated 162P1E6) and its encoded protein, and variants thereof, are described wherein 162P1E6 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 162P1E6 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 162P1E6 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 162P1E6 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（命名为162P1E6）及其编码的蛋白质及其变体，其中162P1E6在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，162P1E6提供诊断，预后， 癌症的预防和/或治疗靶标。 162P1E6基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与162P1E6反应的抗体或T细胞可用于主动或被动免疫。
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