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公开(公告)号：US20070231374A1
公开(公告)日：2007-10-04
申请号：US10572306
申请日：2004-09-17
Applicant: Fredrik Tiberg , Justas Barauskas , Kare Larsson
Inventor： Fredrik Tiberg , Justas Barauskas , Kare Larsson
CPC classification number: A61K9/1274 , A61K9/1075
Abstract: The invention provides a composition suitable for administration to a mammalian, particularly human, subject wherein the composition comprises an active agent and an amphilic component (containing at least one amphiphile) wherein at least a portion of the amphiphilic component is an ether-linked lipid and wherein the composition includes a non-lamellar phase, preferably in the form of particles, or forms a non-lamellar phase on contact with an aqueous liquid. The aqueous liquid may be a body fluid. The invention also provides pharmaceutical and cosmetic formulations comprising the compositions and methods for their formation.
Abstract translation: 本发明提供适用于给予哺乳动物，特别是人的受试者的组合物，其中所述组合物包含活性剂和两亲性组分（含有至少一个两亲物），其中至少一部分两亲性组分是醚连接的脂质， 其中所述组合物包括非层状相，优选为颗粒形式，或在与水性液体接触时形成非层状相。 水性液体可以是体液。 本发明还提供了包含组合物和其形成方法的药物和化妆品制剂。
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2.发明授权Implant material composition, preparation thereof as well as uses thereof and implant product obtainable therefrom 失效植入材料组合物，其制备方法及其用途以及由其获得的植入物产品
公开(公告)号：US5196201A
公开(公告)日：1993-03-23
申请号：US600335
申请日：1990-10-19
Applicant: Kare Larsson , Hakan Hakansson
Inventor： Kare Larsson , Hakan Hakansson
CPC classification number: A61L27/10 , A61K9/1274 , A61L27/04 , A61L27/105 , A61L27/12 , A61F2310/00203 , A61F2310/00293
Abstract: The invention relates to an implant material composition, its preparation, and its use for restoring bone tissue in a human or animal body. The composition comprises a particulate biocompatible bone tissue substitute material distributed in a bioacceptable mixture of (a) a water-based liquid, (b) a monoglyceride, and optionally (c) a triglyceride. The ingredients (a), (b) and (c) form an L2-phase or a lamellary liquid crystalline phase, and are present in such proportions within said phases that they are capable of being transformed into a cubic liquid crystalline phase or a reversed hexagonal liquid crystalline phase when contacted with an aqueous liquid. The phase conversion imparts to the composition such a high viscosity that it functions as an implant material as defined.
Abstract translation: 本发明涉及一种植入材料组合物，其制备方法及其在人或动物体内恢复骨组织的用途。 组合物包含分布在（a）水基液体，（b）甘油单酯和任选的（c）甘油三酯）的生物可接受混合物中的颗粒生物相容性骨组织替代材料。 成分（a），（b）和（c）形成L2相或层状液晶相，并且在所述相中以这样的比例存在，使得它们能够转化为立方晶体相或反相 当与水性液体接触时为六方晶系。 相转化赋予组合物如此高的粘度，其用作如所定义的植入材料。
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公开(公告)号：US4296095A
公开(公告)日：1981-10-20
申请号：US944195
申请日：1978-09-20
Applicant: Udo Hoppe , Gerhard Sauermann , Julius Curts , Per-Olof Glantz , Bo Krasse , Kare Larsson , Borje Noren , Goran Odham , Jan Olsson
Inventor： Udo Hoppe , Gerhard Sauermann , Julius Curts , Per-Olof Glantz , Bo Krasse , Kare Larsson , Borje Noren , Goran Odham , Jan Olsson
Abstract: A composition is disclosed which is useful in preventing dental plaque and tartar from forming on the teeth. The composition includes compounds which are esters or their mono or double salts derived from lysine in combination with straight chain or branched, saturated or unsaturated, monovalent aliphatic alcohols having 4 to 20 carbon atoms.
Abstract translation: 公开了一种组合物，其可用于防止在牙齿上形成牙菌斑和牙垢。 该组合物包括作为衍生自赖氨酸的酯或其单或双盐与具有4至20个碳原子的直链或支链，饱和或不饱和的一价脂族醇组合的化合物。
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公开(公告)号：US20070264365A1
公开(公告)日：2007-11-15
申请号：US10588037
申请日：2005-02-07
Applicant: Thomas Arnebrant , Ulla Elofsson , Kare Larsson
Inventor： Thomas Arnebrant , Ulla Elofsson , Kare Larsson
CPC classification number: A61K36/55
Abstract: The present invention provides a water-soluble or water-dispersible linseed extract for the treatment of xerostomia characterised in that the extract has an absorption of at least 1.2 g/m2, wherein the adsorption is measured by contacting an aqueous solution or dispersion of the extract with a silica substrate, rinsing the silica substrate and then measuring the adsorption by ellipsometry.
Abstract translation: 本发明提供一种用于治疗口干燥症的水溶性或水分散性亚麻子提取物，其特征在于所述提取物具有至少1.2g / m 2的吸收，其中所述吸附通过接触 提取物的水溶液或分散体与二氧化硅底物，漂洗二氧化硅底物，然后通过椭偏仪测量吸附。
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5.发明授权Method of preparing controlled-release preparations for biologically active materials and resulting compositions 失效制备用于生物活性材料和所得组合物的控释制剂的方法
公开(公告)号：US5753259A
公开(公告)日：1998-05-19
申请号：US313543
申请日：1994-09-27
Applicant: Sven Engstrom , Kare Larsson , Bjorn Lindman
Inventor： Sven Engstrom , Kare Larsson , Bjorn Lindman
CPC classification number: A61K9/1274 , Y10S436/829 , Y10S514/963 , Y10S514/965 , Y10S514/966 , Y10S514/974 , Y10T428/2984
Abstract: A method and product for preparing a controlled-release composition are provided. The method comprises formation of a mixture containing at least one amphiphilic substance capable of forming a liquid crystalline phase, in contact with a liquid selected from the group consisting of water, glycerol, ethylene glycol, propylene glycol and mixtures thereof. The method includes a step of providing in such mixture a bioactive material.
Abstract translation: 提供了制备控释组合物的方法和产品。 该方法包括形成含有至少一种能够形成液晶相的两亲物质与选自水，甘油，乙二醇，丙二醇及其混合物的液体接触的混合物。 该方法包括在这种混合物中提供生物活性物质的步骤。
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Patent Agency Ranking
公开(公告)号：US5531925A
公开(公告)日：1996-07-02
申请号：US211293
申请日：1994-04-11
Applicant: Tomas Landh , Kare Larsson
Inventor： Tomas Landh , Kare Larsson
CPC classification number: A61K9/1274 , B01J13/00 , B01J13/02 , C09K19/02 , C09K19/544 , C09K2019/528 , Y10S514/937 , Y10S514/964 , Y10S516/90 , Y10T428/2982
Abstract: Particles, especially colloidal particles, comprising an interior phase of a non-lamellar reversed cubic, intermediate or hexagonal liquid crystalline phase, or a homogeneous L3 phase, and a surface phase of a lamellar crystalline or liquid crystalline phase, or an L3 phase. A method of preparing such particles by creating a local dispersible phase, within the homogeneous phase, preferably by means of a fragmentation agent, and fragmentating the homogeneous phase so as to form said surface phase. Several medical as well as non-medical uses of the particles referred to, e.g. as an antigen-presenting system, as a delivery system for anticancer, antifungal and antimicrobial drugs, and as carriers of nucleic acids or nucleotides.
Abstract translation: PCT No.PCT / SE92 / 00692 Sec。 371日期1994年04月11日 102（e）日期1994年4月11日PCT提交1992年10月2日PCT公布。 公开号WO93 / 06921 日期：1993年04月15日。颗粒，特别是胶体颗粒，其包含非层状反相立方，中间或六方晶液相或均相L3相的内相，以及层状结晶或液晶相的表面相 ，或L3相。 通过在均相中产生局部可分散相，优选通过破碎剂制备此类颗粒并破坏均相以形成所述表面相的方法。 涉及的颗粒的几种医学和非医学用途，例如。 作为抗原呈递系统，作为抗癌，抗真菌和抗微生物药物的递送系统，以及核酸或核苷酸的载体。
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公开(公告)号：US5260282A
公开(公告)日：1993-11-09
申请号：US864395
申请日：1992-04-06
Applicant: Rolf Attstrom , Per O. Glantz , Hakan Hakansson , Kare Larsson
Inventor： Rolf Attstrom , Per O. Glantz , Hakan Hakansson , Kare Larsson
CPC classification number: A61K47/36 , A61K31/715 , A61K33/16 , A61K38/47
Abstract: A saliva substitute, the characteristic feature of which is that it comprises water-soluble linseed polysaccharides. Said substitute is preferably in the form of an aqueous solution having a viscosity within the range of 1-30 mPa.s, most preferably 2-10 mPa.s. The substitute can be prepared by extracting the polysaccharides from linseed by means of water or a water solution containing inorganic salts. In addition to the fact that said substitute is useful as a saliva substitute it can also be utilized as a carrier for pharmaceuticals adapted for oral applications.
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公开(公告)号：US5190755A
公开(公告)日：1993-03-02
申请号：US571635
申请日：1990-11-09
Applicant: Nils Molin , Carl-Erik Albertsson , Stig Bengmark , Kare Larsson
Inventor： Nils Molin , Carl-Erik Albertsson , Stig Bengmark , Kare Larsson
IPC: A23K1/18 , A23K1/00 , A23L1/30 , A23L1/305 , A23L2/38 , A23L2/52 , A61K36/48 , A61K36/899 , A61P3/00 , A61P3/02
Abstract: A nutrient composition for administration to patients in, for example, feeding by tube, or for use as a health drink is described. The nutrient composition comprises a fermented cereal-based product, enzyme and, optionally, further nutrient components, in combination with lactobacilli. Also described is a method of preparing a nutrient composition for administration to patients, inter alia in feeding by tube, or for use as a health drink, in which method a cereal flour is mixed with water, a-amylase and, optionally, a protease, the mixture is brought to the boil under agitation, allowed to cool and mixed with B-glucanase which is allowed to act until the viscosity of the mixture has decreased to below 0.020 Pas, whereupon the mixture is fermented.
Abstract translation: PCT No.PCT / SE89 / 00114 Sec。 371日期1990年11月9日 102（e）日期1990年11月9日PCT 1989年3月9日PCT公布。 出版物WO89 / 08405 日期：1989年9月21日。描述了用于给予患者例如通过管饲养或用作健康饮料的营养组合物。 营养组合物包含与乳酸杆菌结合的发酵的谷物类产品，酶和任选的其它营养成分。 还描述了一种制备用于给予患者的营养组合物的方法，特别是通过管饲喂或用作健康饮料，其中将谷物粉与水，α-淀粉酶和任选的蛋白酶混合， ，将混合物在搅拌下煮沸，使其冷却并与可以起作用的β-葡聚糖酶混合，直到混合物的粘度降低到低于0.020Pas，随后混合物被发酵。
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9.发明授权Method of preparing controlled-release preparations for biologically active materials and resulting compositions 失效制备生物活性材料和结果组合物的控制释放制剂的方法
公开(公告)号：US5151272A
公开(公告)日：1992-09-29
申请号：US540441
申请日：1990-06-18
Applicant: Sven Engstrom , Bjorn Lindman , Kare Larsson
Inventor： Sven Engstrom , Bjorn Lindman , Kare Larsson
CPC classification number: A61K9/1274 , Y10S436/829 , Y10S514/963 , Y10S514/965 , Y10S514/966 , Y10S514/974 , Y10T428/2984
Abstract: A method and product for preparing a controlled-release composition are provided. The method comprises formation of a mixture containing at least one amphiphilic substance capable of forming a liquid crystalline phase, in contact with a liquid selected from the group consisting of water, glycerol, ethylene glycol, propylene glycol and mixtures thereof. The method includes a step of providing in such mixture a bioactive material. Preferred controlled-release compositions include an alkylbetaine zwitterionic surfactant therein.
Abstract translation: 提供了制备控释组合物的方法和产品。 该方法包括形成含有至少一种能够形成液晶相的两亲物质与选自水，甘油，乙二醇，丙二醇及其混合物的液体接触的混合物。 该方法包括在这种混合物中提供生物活性物质的步骤。 优选的控释组合物包括其中的烷基甜菜碱两性离子表面活性剂。
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公开(公告)号：US5032115A
公开(公告)日：1991-07-16
申请号：US497475
申请日：1990-03-22
Applicant: Hakan Hakansson , Bjorn Klinge , Kare Larsson
Inventor： Hakan Hakansson , Bjorn Klinge , Kare Larsson
IPC: A61F2/02
CPC classification number: A61F2/02 , Y10S128/12
Abstract: An implantable device for supplying liquid to the oral cavity comprises a liquid container having means for keeping the liquid under pressure, a tube, one end of which being connected to the container, said tube consisting of a material which is suitable for subcutaneous location in the human body, and an lead-through bushing connected to the other end of said tube, said bushing consisting of or being coated with a biocompatible material for being implanted into a jaw bone, and comprising a nozzle opening provided with a filter.
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