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公开(公告)号：US20160355462A1
公开(公告)日：2016-12-08
申请号：US15239446
申请日：2016-08-17
发明人： Kevin Duane Bunker
IPC分类号： C07C233/06 , A61K31/16 , A61K31/221 , A61K9/00 , A61K31/24 , A61K31/216 , A61K45/06 , C07C233/23 , C07C217/52
CPC分类号： A61K31/16 , A61K9/0014 , A61K9/0019 , A61K31/13 , A61K31/133 , A61K31/14 , A61K31/215 , A61K31/216 , A61K31/22 , A61K31/221 , A61K31/235 , A61K31/24 , A61K45/06 , C07C211/62 , C07C217/52 , C07C233/06 , C07C233/23 , C07C233/41 , C07C233/52 , C07C233/63 , C07C235/74 , C07C2602/38
摘要： Analgesic compounds for treatment of pain or fever, comprising a bicyclopentane moiety linked to an amine, combinations of the compounds with opioid analgesic drugs, and methods for treating pain or fever by administering the compounds.
摘要翻译： 用于治疗疼痛或发热的止痛化合物，其包含与胺连接的双环戊烷部分，化合物与阿片样镇痛药物的组合，以及通过施用化合物治疗疼痛或发热的方法。
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公开(公告)号：US09447025B2
公开(公告)日：2016-09-20
申请号：US14199567
申请日：2014-03-06
发明人： Kevin Duane Bunker
IPC分类号： C07C235/74 , C07C235/26 , C07C233/10 , C07C217/52 , A61K31/235 , A61K31/16 , A61K31/215 , C07C233/52 , A61K45/06 , C07C233/06 , C07C233/23 , A61K31/13 , A61K31/14 , A61K31/216 , A61K31/22 , C07C211/62 , C07C233/41
CPC分类号： A61K31/16 , A61K9/0014 , A61K9/0019 , A61K31/13 , A61K31/133 , A61K31/14 , A61K31/215 , A61K31/216 , A61K31/22 , A61K31/221 , A61K31/235 , A61K31/24 , A61K45/06 , C07C211/62 , C07C217/52 , C07C233/06 , C07C233/23 , C07C233/41 , C07C233/52 , C07C233/63 , C07C235/74 , C07C2602/38
摘要： Analgesic compounds for treatment of pain or fever, comprising a bicyclopentane moiety linked to an amine, combinations of the compounds with opioid analgesic drugs, and methods for treating pain or fever by administering the compounds.
摘要翻译： 用于治疗疼痛或发热的止痛化合物，其包含与胺连接的双环戊烷部分，化合物与阿片样镇痛药物的组合，以及通过施用化合物治疗疼痛或发热的方法。
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公开(公告)号：US10308609B2
公开(公告)日：2019-06-04
申请号：US14855102
申请日：2015-09-15
发明人： Kevin Duane Bunker , Chuangxing Guo , Mark Charles Grier , Chad Daniel Hopkins , Joseph Robert Pinchman , Deborah Helen Slee , Qinhua Huang , Mehmet Kahraman
IPC分类号： C07D213/89 , A61K31/164 , C07C233/14 , A61K31/27 , C07C233/05 , C07C271/14 , A61K31/13 , C07C211/38 , C07C233/58 , A61K31/444 , A61K45/06 , C07C317/30 , C07C215/42 , C07C233/06 , C07C233/09 , C07C233/13 , C07C233/23 , A61K31/145 , A61K31/16
摘要： Disclosed herein are compounds of Formulae (I) and (II), methods of synthesizing compounds of Formulae (I) and (II), and methods of using compounds of Formulae (I) and (II) as an analgesic.
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公开(公告)号：US20180042871A1
公开(公告)日：2018-02-15
申请号：US15633480
申请日：2017-06-26
发明人： Kevin Duane Bunker
IPC分类号： A61K31/16 , C07C217/52 , A61K45/06 , A61K31/24 , A61K31/221 , A61K9/00 , C07C233/63 , A61K31/133 , A61K31/14 , C07C211/62 , C07C233/41 , C07C233/52 , A61K31/13 , A61K31/215 , A61K31/216 , A61K31/22 , A61K31/235 , C07C233/23 , C07C235/74 , C07C233/06
CPC分类号： A61K31/16 , A61K9/0014 , A61K9/0019 , A61K31/13 , A61K31/133 , A61K31/14 , A61K31/215 , A61K31/216 , A61K31/22 , A61K31/221 , A61K31/235 , A61K31/24 , A61K45/06 , C07C211/62 , C07C217/52 , C07C233/06 , C07C233/23 , C07C233/41 , C07C233/52 , C07C233/63 , C07C235/74 , C07C2602/38
摘要： Analgesic compounds for treatment of pain or fever that include a bicyclopentane moiety linked to an amine, combinations of the compounds with opioid analgesic drugs, and methods for treating pain or fever by administering a compound described herein.
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公开(公告)号：US20180207132A1
公开(公告)日：2018-07-26
申请号：US15563926
申请日：2016-03-31
发明人： Peter Qinhua Huang , Mehmet Kahraman , Deborah Helen Slee , Kevin Duane Bunker , Chad Daniel Hopkins , Joseph Robert Pinchman , Sunny Abraham , Rakesh Kumar Sit , Daniel Lee Severance
IPC分类号： A61K31/4162 , A61K31/416 , A61P35/00
摘要： Disclosed herein are spirocyclic compounds, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein.
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公开(公告)号：US09724316B2
公开(公告)日：2017-08-08
申请号：US15262852
申请日：2016-09-12
发明人： Kevin Duane Bunker
IPC分类号： C07C233/52 , C07C217/52 , C07C233/06 , C07C233/41 , C07C235/74 , A61K31/13 , A61K31/16 , A61K31/216 , A61K31/222 , A61K31/235 , A61K45/06 , C07C233/23 , A61K31/14 , A61K31/215 , A61K31/22 , C07C211/62 , A61K9/00 , A61K31/221 , A61K31/24 , A61K31/133 , C07C233/63
CPC分类号： A61K31/16 , A61K9/0014 , A61K9/0019 , A61K31/13 , A61K31/133 , A61K31/14 , A61K31/215 , A61K31/216 , A61K31/22 , A61K31/221 , A61K31/235 , A61K31/24 , A61K45/06 , C07C211/62 , C07C217/52 , C07C233/06 , C07C233/23 , C07C233/41 , C07C233/52 , C07C233/63 , C07C235/74 , C07C2602/38
摘要： Analgesic compounds for treatment of pain or fever that include a bicyclopentane moiety linked to an amine, combinations of the compounds with opioid analgesic drugs, and methods for treating pain or fever by administering a compound described herein.
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公开(公告)号：US09447026B2
公开(公告)日：2016-09-20
申请号：US14439636
申请日：2014-03-06
发明人： Kevin Duane Bunker
IPC分类号： C07C233/52 , C07C217/52 , C07C233/06 , C07C233/23 , C07C233/41 , C07C235/74 , A61K31/13 , A61K31/16 , A61K31/216 , A61K31/222 , A61K31/235 , A61K45/06 , A61K31/14 , A61K31/215 , A61K31/22 , C07C211/62
CPC分类号： A61K31/16 , A61K9/0014 , A61K9/0019 , A61K31/13 , A61K31/133 , A61K31/14 , A61K31/215 , A61K31/216 , A61K31/22 , A61K31/221 , A61K31/235 , A61K31/24 , A61K45/06 , C07C211/62 , C07C217/52 , C07C233/06 , C07C233/23 , C07C233/41 , C07C233/52 , C07C233/63 , C07C235/74 , C07C2602/38
摘要： Analgesic compounds for treatment of pain or fever that include a bicyclopentane moiety linked to an amine, combinations of the compounds with opioid analgesic drugs, and methods for treating pain or fever by administering a compound described herein.
摘要翻译： 用于治疗疼痛或发热的止痛化合物，其包括与胺连接的双环戊烷部分，化合物与阿片类止痛药的组合，以及通过施用本文所述的化合物治疗疼痛或发热的方法。
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公开(公告)号：US20140275245A1
公开(公告)日：2014-09-18
申请号：US14199567
申请日：2014-03-06
发明人： Kevin Duane Bunker
IPC分类号： A61K31/235 , A61K31/16 , C07C235/74 , A61K45/06 , C07C233/10 , A61K31/131 , C07C217/52 , C07C235/26 , A61K31/215
CPC分类号： A61K31/16 , A61K9/0014 , A61K9/0019 , A61K31/13 , A61K31/133 , A61K31/14 , A61K31/215 , A61K31/216 , A61K31/22 , A61K31/221 , A61K31/235 , A61K31/24 , A61K45/06 , C07C211/62 , C07C217/52 , C07C233/06 , C07C233/23 , C07C233/41 , C07C233/52 , C07C233/63 , C07C235/74 , C07C2602/38
摘要： Analgesic compounds for treatment of pain or fever, comprising a bicyclopentane moiety linked to an amine, combinations of the compounds with opioid analgesic drugs, and methods for treating pain or fever by administering the compounds.
摘要翻译： 用于治疗疼痛或发热的止痛化合物，其包含与胺连接的双环戊烷部分，化合物与阿片样镇痛药物的组合，以及通过施用化合物治疗疼痛或发热的方法。
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公开(公告)号：US10654812B2
公开(公告)日：2020-05-19
申请号：US15123898
申请日：2015-03-05
发明人： Kevin Duane Bunker
IPC分类号： C07C31/137 , C07C211/19 , C07D249/06 , C07C271/22 , C07C229/28 , C07C45/44 , C07C247/14 , C07C255/46 , C07C255/64 , C07C251/42 , C07C211/35 , C07C29/00 , C07C47/347 , C07C209/26 , C07C209/48 , C07C227/04 , C07C249/04 , C07C251/40 , C07C253/00 , C07C255/31 , C07C255/47 , C07C269/00
摘要： Disclosed herein are compounds of the general Formula (I), and methods of synthesizing substituted bicyclo[1.1.1 jpentanes. The synthetic methods described herein use a [1.1.1]propellane, a Group VIII transition metal compound, a hydride source and a reagent that can contribute a substituent to form a substituted bicyclo[1.1.1]pentane, such as a compound of the general Formula (I).
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公开(公告)号：US10251851B2
公开(公告)日：2019-04-09
申请号：US15633480
申请日：2017-06-26
发明人： Kevin Duane Bunker
IPC分类号： C07D233/52 , C07D233/06 , A61K31/13 , A61K31/16 , A61K31/216 , A61K31/222 , A61K31/235 , A61K45/06 , C07C217/52 , C07C235/74 , C07C233/06 , C07C233/23 , A61K31/14 , A61K31/215 , A61K31/22 , C07C211/62 , C07C233/41 , C07C233/52 , A61K9/00 , A61K31/221 , A61K31/24 , A61K31/133 , C07C233/63
摘要： Analgesic compounds for treatment of pain or fever that include a bicyclopentane moiety linked to an amine, combinations of the compounds with opioid analgesic drugs, and methods for treating pain or fever by administering a compound described herein.
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