公开(公告)号：US09354241B2

公开(公告)日：2016-05-31

申请号：US13878235

申请日：2011-10-08

Applicant: Yue Zhang ,  Jun Bao ,  Hua Mao ,  Fei Xiang ,  Hongbin Sun ,  Jie Qian ,  Yongjun Han ,  Weina Situ

Inventor： Yue Zhang ,  Jun Bao ,  Hua Mao ,  Fei Xiang ,  Hongbin Sun ,  Jie Qian ,  Yongjun Han ,  Weina Situ

IPC: G01N33/68 ,  A61K38/19 ,  C07K14/52 ,  G01N33/564

CPC classification number: G01N33/6893 ,  A61K38/19 ,  C07K14/52 ,  G01N33/564 ,  G01N2800/22

Abstract: The present application provides compositions and methods useful for detecting and monitoring acquired aplastic anemia.

Abstract translation: 本申请提供了用于检测和监测获得性再生障碍性贫血的组合物和方法。

公开(公告)号：US09347950B2

公开(公告)日：2016-05-24

申请号：US13878237

申请日：2011-10-08

Applicant: Yue Zhang ,  Jun Bao

Inventor： Yue Zhang ,  Jun Bao

IPC: G01N33/68 ,  C07K14/52 ,  G01N33/564

CPC classification number: G01N33/6854 ,  C07K14/52 ,  C07K2319/02 ,  C07K2319/50 ,  G01N33/564 ,  G01N2800/222 ,  G01N2800/52

Abstract: The present application provides compositions and methods useful for detecting and monitoring immune thrombocytopenia.

Abstract translation: 本申请提供了用于检测和监测免疫血小板减少症的组合物和方法。

公开(公告)号：US09148710B2

公开(公告)日：2015-09-29

申请号：US13622481

申请日：2012-09-19

Applicant: Jean-Luc Archambault ,  Jun Bao ,  Balakrishnan Sridhar

Inventor： Jean-Luc Archambault ,  Jun Bao ,  Balakrishnan Sridhar

IPC: H04B10/291 ,  H04Q9/00 ,  H04B10/071 ,  G01M11/00 ,  H01S3/094 ,  H01S3/30

CPC classification number: H04B10/0797 ,  G01M11/3109 ,  G01M11/3136 ,  G01M11/319 ,  H01S3/094042 ,  H01S3/094046 ,  H01S3/1312 ,  H01S3/302 ,  H04B10/071 ,  H04B10/0731 ,  H04B10/2916 ,  H04J14/0227 ,  H04Q9/00

Abstract: Raman amplifier systems and methods with an integrated Optical Time Domain Reflectometer (OTDR) for integrated testing functionality include an amplifier system, an OTDR and telemetry subsystem, and a method of operation. The OTDR and telemetry subsystem is configured to operate in an OTDR mode when coupled to a line in port and to operate in a telemetry mode when coupled to a line out port. The OTDR and telemetry subsystem enables on-demand fiber testing while also operating as a telemetry channel that is both a redundant optical service channel (OSC) and provides a mechanism to monitor Raman gain over time. The OTDR and telemetry subsystem minimizes cost and space by sharing major optical and electrical components between the integrated OTDR and other functions on the Raman amplifier.

Abstract translation: 具有用于集成测试功能的集成光时域反射计（OTDR）的拉曼放大器系统和方法包括放大器系统，OTDR和遥测子系统以及操作方法。 OTDR和遥测子系统配置为在耦合到端口线路时以OTDR模式运行，并且在耦合到线路输出端口时以遥测模式运行。 OTDR和遥测子系统实现了按需光纤测试，同时也作为冗余光学服务通道（OSC）的遥测通道运行，并提供了一种随时间监测拉曼增益的机制。 OTDR和遥测系统通过在集成OTDR和拉曼放大器上的其他功能之间共享主要的光学和电气部件，最大限度地降低成本和空间。

公开(公告)号：US20140077971A1

公开(公告)日：2014-03-20

申请号：US13622481

申请日：2012-09-19

Applicant: Jean-Luc Archambault ,  Jun Bao ,  Balakrishnan Sridhar

Inventor： Jean-Luc Archambault ,  Jun Bao ,  Balakrishnan Sridhar

IPC: G08C23/04

CPC classification number: H04B10/0797 ,  G01M11/3109 ,  G01M11/3136 ,  G01M11/319 ,  H01S3/094042 ,  H01S3/094046 ,  H01S3/1312 ,  H01S3/302 ,  H04B10/071 ,  H04B10/0731 ,  H04B10/2916 ,  H04J14/0227 ,  H04Q9/00

Abstract: Raman amplifier systems and methods with an integrated Optical Time Domain Reflectometer (OTDR) for integrated testing functionality include an amplifier system, an OTDR and telemetry subsystem, and a method of operation. The OTDR and telemetry subsystem is configured to operate in an OTDR mode when coupled to a line in port and to operate in a telemetry mode when coupled to a line out port. The OTDR and telemetry subsystem enables on-demand fiber testing while also operating as a telemetry channel that is both a redundant optical service channel (OSC) and provides a mechanism to monitor Raman gain over time. The OTDR and telemetry subsystem minimizes cost and space by sharing major optical and electrical components between the integrated OTDR and other functions on the Raman amplifier.

Abstract translation: 具有用于集成测试功能的集成光时域反射计（OTDR）的拉曼放大器系统和方法包括放大器系统，OTDR和遥测子系统以及操作方法。 OTDR和遥测子系统配置为在耦合到端口线路时以OTDR模式运行，并且在耦合到线路输出端口时以遥测模式运行。 OTDR和遥测子系统实现了按需光纤测试，同时也作为冗余光学服务通道（OSC）的遥测通道运行，并提供了一种随时间监测拉曼增益的机制。 OTDR和遥测系统通过在集成OTDR和拉曼放大器上的其他功能之间共享主要的光学和电气部件，最大限度地降低成本和空间。

公开(公告)号：US20130211051A1

公开(公告)日：2013-08-15

申请号：US13878495

申请日：2010-12-27

Applicant: Xiangming Sun ,  Ling Zhou ,  Jiannan Hong ,  Yun Wu ,  Jun Bao

Inventor： Xiangming Sun ,  Ling Zhou ,  Jiannan Hong ,  Yun Wu ,  Jun Bao

IPC: C07K14/435 ,  C07K16/18

CPC classification number: C07K14/435 ,  A61K38/00 ,  C07K14/70575 ,  C07K16/18 ,  C07K2319/00 ,  C07K2319/30

Abstract: Provided is an anti-angiogenic fusion protein, which comprises a vascular endothelial cell growth inhibitor (VEGI) or variant thereof, and other polypeptide such as IgG Fc. The fusion protein optionally comprises a linker. The fusion protein can induce the apoptosis of endothelial cells and inhibit the growtth of endothelial cells, so as to be used for treating tumor. Also provided are a pharmaceutical composition and use of the fusion protein.

Abstract translation: 提供了抗血管生成融合蛋白，其包含血管内皮细胞生长抑制剂（VEGI）或其变体，以及其它多肽如IgG Fc。 融合蛋白任选地包含接头。 融合蛋白可诱导内皮细胞凋亡，抑制内皮细胞生长，用于治疗肿瘤。 还提供了药物组合物和融合蛋白的用途。

公开(公告)号：US20130203091A1

公开(公告)日：2013-08-08

申请号：US13878235

申请日：2011-10-08

Applicant: Yue Zhang ,  Jun Bao ,  Hua Mao ,  Fei Xiang ,  Hongbin Sun ,  Jie Qian ,  Yongjun Han ,  Weina Situ

Inventor： Yue Zhang ,  Jun Bao ,  Hua Mao ,  Fei Xiang ,  Hongbin Sun ,  Jie Qian ,  Yongjun Han ,  Weina Situ

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  A61K38/19 ,  C07K14/52 ,  G01N33/564 ,  G01N2800/22

Abstract: The present application provides compositions and methods useful for detecting and monitoring acquired aplastic anemia.

Abstract translation: 本申请提供了用于检测和监测获得性再生障碍性贫血的组合物和方法。

公开(公告)号：US20130097717A1

公开(公告)日：2013-04-18

申请号：US13806781

申请日：2011-06-23

Applicant: Yong Zhu ,  Shili Wu ,  Jun Bao

Inventor： Yong Zhu ,  Shili Wu ,  Jun Bao

IPC: A61K38/16

CPC classification number: A61K38/16 ,  A61K38/00 ,  B82Y5/00 ,  C12N5/0637 ,  C12N5/0696 ,  C12N2501/60 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/606 ,  Y10S977/773

Abstract: The present inventions are directed to compositions and methods regarding the reprogramming of other cells (such as fibroblast cells) into cardiomyocytes without introducing exogenous genes to the samples. In particular, the present inventions are directed to transducible materials that are capable of transducing into the biological samples but are not genes or causing genetic modifications. The present inventions also are directed to methods of reprogramming the path of biological samples or treating diseases using the tranducible compositions thereof.

Abstract translation: 本发明涉及关于将其它细胞（例如成纤维细胞）重编程成心肌细胞而不向样品中引入外源基因的组合物和方法。 特别地，本发明涉及能够转导到生物样品但不是基因或引起遗传修饰的可导纳材料。 本发明还涉及使用其可转导组合物重新编程生物样品的路径或治疗疾病的方法。

公开(公告)号：US20110258713A1

公开(公告)日：2011-10-20

申请号：US13141326

申请日：2009-12-23

Applicant: Yong Zhu ,  Shili Wu ,  Jun Bao

Inventor： Yong Zhu ,  Shili Wu ,  Jun Bao

IPC: A01K67/033 ,  C12N5/04 ,  C12N5/07 ,  C12N5/071 ,  C12N5/0783 ,  C12Q1/02 ,  C07K14/435 ,  A61K38/17 ,  A61P35/00 ,  A61P3/00 ,  A61P29/00 ,  A61P9/00 ,  A61P25/00 ,  A61P37/00 ,  A61P3/10 ,  A61P25/28 ,  A61P25/16 ,  A61P7/06 ,  A61P19/02 ,  A61P17/02 ,  A61P17/00 ,  A61P1/16 ,  A61P27/16 ,  A61P1/04 ,  A61P21/04 ,  A61P25/18 ,  A61K49/00 ,  A61M37/00 ,  C12N1/00 ,  B82Y5/00

CPC classification number: C12N5/0696 ,  A61K2035/122 ,  C12N5/0637 ,  C12N5/0676 ,  C12N2501/60 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/606

Abstract: The present inventions are directed to compositions and methods regarding the reprogramming of biological samples (such as cells) without introducing exogenous genes to the samples. In particular, the present inventions are directed to transducible materials that are capable of transducing into the biological samples but are not genes or causing genetic modifications. The present inventions also are directed to methods of reprogramming the path of biological samples or treating diseases using the tranducible compositions thereof.

Abstract translation: 本发明涉及关于生物样品（例如细胞）的重新编程而不向样品中引入外源基因的组合物和方法。 特别地，本发明涉及能够转导到生物样品但不是基因或引起遗传修饰的可导纳材料。 本发明还涉及使用其可转导组合物重新编程生物样品的路径或治疗疾病的方法。

公开(公告)号：US20110043896A1

公开(公告)日：2011-02-24

申请号：US12542899

申请日：2009-08-18

Applicant: Jun BAO

Inventor： Jun BAO

IPC: H01S3/00

CPC classification number: H01S3/06704

Abstract: The present disclosure relates to streamlining optical module and/or subassembly development, manufacturing, and testing through introducing a memory component within a module and/or subassembly that is utilized with a host module for system calibration and/or configuration. In an exemplary embodiment, the present invention can streamline optical amplifier (EDFA) module and/or subassembly development, manufacturing, and testing. The present invention includes an optical module/sub-assembly without control circuitry, i.e. a “dumb module”, but with a memory that is used to load relevant data from a supplier. This data is utilized to calibrate, test, and configure the optical module/sub-assembly in a host module. The host module includes control circuitry to access this memory in the optical module/sub-assembly and to calibrate, test, configure, and control the optical module/sub-assembly. Advantageously, this additional memory reduces manufacturing time without the disadvantage of adding complexity in the optical module/sub-assembly.

Abstract translation: 本公开涉及通过在与主机模块一起用于系统校准和/或配置的模块和/或子组件内引入存储器组件来简化光学模块和/或子组件开发，制造和测试。 在示例性实施例中，本发明可以简化光放大器（EDFA）模块和/或子组件开发，制造和测试。 本发明包括没有控制电路的光学模块/子组件，即“哑模块”，但是具有用于从供应商加载相关数据的存储器。 该数据用于校准，测试和配置主机模块中的光模块/子组件。 主机模块包括用于访问光学模块/子组件中的该存储器并且校准，测试，配置和控制光学模块/子组件的控制电路。 有利地，该附加存储器减少了制造时间，而没有增加光学模块/子组件的复杂性的缺点。

公开(公告)号：US20100183311A1

公开(公告)日：2010-07-22

申请号：US12356593

申请日：2009-01-21

Applicant: Xiaohui YANG ,  Zhonghua ZHU ,  Jun BAO

Inventor： Xiaohui YANG ,  Zhonghua ZHU ,  Jun BAO

IPC: H04J14/02

CPC classification number: H04Q11/0005 ,  H04J14/0205 ,  H04J14/0206 ,  H04J14/0212 ,  H04J14/0213 ,  H04J14/0217 ,  H04J14/0219 ,  H04J14/0284 ,  H04Q2011/0035 ,  H04Q2011/0052

Abstract: The present disclosure provides high-degree reconfigurable optical add-drop multiplexing (ROADM) systems using bi-directional wavelength selective switches (WSSs) and optical circulators. A single WSS is utilized on each degree of a node in a bi-directional manner, i.e. both ingress and egress share the same WSS. Advantageously, the present invention eliminates conventional splitters/combiners thereby capping intra-node insertion loss to a certain value regardless of the number of degrees. More importantly, the present invention reduces noise penalty associated with high-degree nodes while minimizing cost.

Abstract translation: 本公开提供使用双向波长选择开关（WSS）和光学循环器的高度可重构的光分插复用（ROADM）系统。 以双向方式在每个节点上使用单个WSS，即入口和出口共享相同的WSS。 有利地，本发明消除了传统的分离器/组合器，从而将节点内插入损耗限制到一定值，而不管度数。 更重要的是，本发明降低了与高度节点相关联的噪声，同时最小化了成本。