公开(公告)号：US20070066893A1

公开(公告)日：2007-03-22

申请号：US10558597

申请日：2004-12-03

申请人： Morten Eriksen ,  Lars Hoff ,  Henrik Rasmussen ,  Audun Tornes ,  Jonny Ostensen

发明人： Morten Eriksen ,  Lars Hoff ,  Henrik Rasmussen ,  Audun Tornes ,  Jonny Ostensen

IPC分类号： A61B6/00

CPC分类号： A61B5/415 ,  A61B5/1075 ,  A61B5/418 ,  A61B8/481 ,  A61K49/225

摘要： The present invention relates to a method of processing ultrasound images from a subject preadministered with an ultrasound contrast agent wherein quantitative measures of the contrast enhancement pattern of said lymph nodes are generated. The lymphatic system is made of vessels or ducts that begin in tissues and are designed to carry lymph fluid to local lymph nodes where the fluid is filtered and processed and sent to the next lymph node down the line until the fluid reaches the thoracic duct where it enters the blood stream. Lymph fluid which enters the lymph vessels carries with it substances and materials from the tissue, e.g. antigens, particles and cells. The lymph nodes process the lymph fluid by sieving it and macrophages inside the nodes remove particulate and cell material carried by the lymph fluid via phagocytosis.

摘要翻译： 本发明涉及一种处理来自预先给予超声造影剂的受试者的超声图像的方法，其中产生所述淋巴结的对比度增强模式的定量测量。 淋巴系统由在组织中开始并被设计成将淋巴液携带到淋巴结的淋巴管构成，其中流体被过滤和处理，并被送到下一个淋巴结，直到流体到达胸廓管 进入血液流。 进入淋巴管的淋巴液携带来自组织的物质和物质，例如， 抗原，颗粒和细胞。 淋巴结通过筛选淋巴液和淋巴结内的巨噬细胞通过吞噬除去淋巴液携带的颗粒和细胞物质。

公开(公告)号：US20060173339A1

公开(公告)日：2006-08-03

申请号：US10530094

申请日：2003-10-01

申请人： Audun Tornes ,  Jonny Ostensen ,  Henrik Rasmussen

发明人： Audun Tornes ,  Jonny Ostensen ,  Henrik Rasmussen

IPC分类号： A61B8/14

CPC分类号： A61K49/223 ,  A61K9/0009 ,  A61K9/5015

摘要： The present invention relates methods for the identification of a sentinel lymph node and to compounds and preparations used in said methods.

摘要翻译： 本发明涉及用于鉴定前哨淋巴结的方法和用于所述方法的化合物和制剂。

公开(公告)号：US07931595B2

公开(公告)日：2011-04-26

申请号：US10536482

申请日：2003-11-27

申请人： Ragnar Bendiksen ,  Henrik Rasmussen ,  Jonny Ostensen

发明人： Ragnar Bendiksen ,  Henrik Rasmussen ,  Jonny Ostensen

IPC分类号： A61B8/14 ,  A61B8/00

CPC分类号： A61B8/481 ,  A61B8/065 ,  A61B8/0883 ,  A61B8/543

摘要： The invention relates to a triggered ultrasound imaging method for imaging of the myocardium, minimizing the risk of eliciting cardiac arrhythmia. Particularly, the invention is directed to a method of assessing cardiac perfusion. Destruction pulses are triggered such that they fall within the refractory period of the heart, while imaging pulses are triggered at any given time of the ECG cycle, preferably during end-systole.

摘要翻译： 本发明涉及一种用于心肌成像的触发超声成像方法，使得引起心律失常的风险最小化。 特别地，本发明涉及评估心脏灌注的方法。 触发破坏脉冲使得它们落入心脏的不应期内，而在心电周期的任何给定时间，优选在末期收缩期间触发成像脉冲。

公开(公告)号：US5601085A

公开(公告)日：1997-02-11

申请号：US538286

申请日：1995-10-02

申请人： Jonny Ostensen ,  Morton Eriksen ,  Lars Hoff ,  Sigmund Frigstad ,  Nils Sponheim ,  Knut Dyrstad

发明人： Jonny Ostensen ,  Morton Eriksen ,  Lars Hoff ,  Sigmund Frigstad ,  Nils Sponheim ,  Knut Dyrstad

IPC分类号： A61B8/06 ,  A61B8/00 ,  A61K49/22 ,  G01S7/52 ,  G01S15/52 ,  G06T1/00

CPC分类号： A61B8/481 ,  A61K49/223 ,  G01S15/52 ,  G01S7/52036

摘要： Temporal variations in backscatter from an ultrasound contrast agent located in the vascular system and induced by movement of the scatterers are used to visualise the presence of contrast agent by determining areas where correlation between successive ultrasound images is poor. This low level of correlation arising from intravascular contrast agent movement permits distinction between stationary bulk tissue and moving bulk tissue since movement of the latter solid tissue scatterers is correlated.

摘要翻译： 使用位于血管系统中并由散射体移动引起的超声造影剂的后向散射的时间变化，通过确定连续超声图像之间的相关性较差的区域来显现造影剂的存在。 由于血管内造影剂运动引起的这种低水平的相关性允许区分固定块体组织和运动体块组织，因为后者的固体组织散射体的运动是相关的。

公开(公告)号：US20060155192A1

公开(公告)日：2006-07-13

申请号：US10536482

申请日：2003-11-27

申请人： Ragnar Bendiksen ,  Henrik Rasmussen ,  Jonny Ostensen

发明人： Ragnar Bendiksen ,  Henrik Rasmussen ,  Jonny Ostensen

IPC分类号： A61B8/14

CPC分类号： A61B8/481 ,  A61B8/065 ,  A61B8/0883 ,  A61B8/543

摘要： The invention relates to a triggered ultrasound imaging method for imaging of the myocardium, minimizing the risk of eliciting cardiac arrhythmia. Particularly, the invention is directed to a method of assessing cardiac perfusion. Destruction pulses are triggered such that they fall within the refractory period of the heart, while imaging pulses are triggered at any given time of the ECG cycle, preferably during end-systole.

摘要翻译： 本发明涉及一种用于心肌成像的触发超声成像方法，使得引起心律失常的风险最小化。 特别地，本发明涉及评估心脏灌注的方法。 触发破坏脉冲使得它们落入心脏的不应期内，而在心电周期的任何给定时间，优选在末期收缩期间触发成像脉冲。

公开(公告)号：US20050118104A1

公开(公告)日：2005-06-02

申请号：US10889361

申请日：2004-07-12

申请人： Jonny Ostensen ,  Morten Eriksen ,  Sigmund Frigstad ,  Pal Rongved

发明人： Jonny Ostensen ,  Morten Eriksen ,  Sigmund Frigstad ,  Pal Rongved

IPC分类号： A61K49/00 ,  A61K9/107 ,  A61K9/127 ,  A61K49/22

CPC分类号： A61K49/223 ,  Y10S977/928 ,  Y10S977/929

摘要： Ultrasonic visualisation of a suject, particularly of perfusion in the myocardium and other tissues, is performed using novel gas-containing contrast agent preparations which promote controllable and temporary growth of the gas phase in vivo following administration and can therefore act as deposited perfusion tracers. The preparations include a coadministerable composition comprising a diffusible component capable of inward diffusion into the dispersed gas phase to promote temporary growth thereof. In cardiac perfusion imaging the preparations may advantageously be coadministered with vasodilator drugs such as adenosine in order to enhance the differences in return signal intensity from normal and hypoperfused myocardial tissue respectively.

摘要翻译： 使用新型含气体的造影剂制剂进行超声波可视化，特别是心肌和其他组织中的灌注，其可在给药后在体内促进气相的可控和临时生长，因此可用作沉积灌注示踪剂。 制剂包括可共混组合物，其包含能够向内扩散到分散气相中以促进其暂时生长的可扩散组分。 在心脏灌注成像中，制剂可以有利地与血管扩张剂药物如腺苷共同施用，以分别增强来自正常和低灌注心肌组织的返回信号强度的差异。