公开(公告)号：US10311171B2

公开(公告)日：2019-06-04

申请号：US14636134

申请日：2015-03-02

申请人： Steven L. Greenspan ,  Debra J. Danielson ,  James D. Reno ,  John P. Kane ,  Prashant Parikh

发明人： Steven L. Greenspan ,  Debra J. Danielson ,  James D. Reno ,  John P. Kane ,  Prashant Parikh

IPC分类号： H04W4/70 ,  G06F17/50

摘要： Systems and methods may include receiving real-time data about a real component operating in a real-world environment. The systems and methods may further include generating a virtual representation of the real component based on the real-time data about the real component and historical data associated with the real component. In addition, the systems and methods may include receiving injected data from a lab. The injected data may provide data about a lab component operating in the lab. The systems and methods may also include simulating, in a virtual environment, a real-time interaction in the real-world environment between the real component and the lab component using the virtual representation of the real component and the injected data. Moreover, the systems and methods may include determining a real-time performance characteristic of at least one of the lab component and the real component based on the simulated real-time interaction in the real-world environment.

公开(公告)号：US09221986B2

公开(公告)日：2015-12-29

申请号：US12756175

申请日：2010-04-07

申请人： Puthalath K. Sujeeth ,  John P. Kane ,  Daniel A. Ouellette ,  Mark Ulrich

发明人： Puthalath K. Sujeeth ,  John P. Kane ,  Daniel A. Ouellette ,  Mark Ulrich

IPC分类号： C09D11/00 ,  C09D11/037 ,  A61K8/44 ,  A61Q1/02 ,  C07D251/54 ,  C09B67/04 ,  C09B67/08 ,  C09B67/46 ,  C09C1/24 ,  C09C1/36 ,  C09C3/12 ,  C09D7/00 ,  C09D11/326 ,  C09D11/328 ,  C09D15/00 ,  G02B5/22

CPC分类号： C09D11/037 ,  A61K8/445 ,  A61K2800/412 ,  A61K2800/622 ,  A61Q1/02 ,  C01P2002/85 ,  C01P2004/62 ,  C01P2006/22 ,  C01P2006/62 ,  C01P2006/63 ,  C01P2006/64 ,  C07D251/54 ,  C09B67/0002 ,  C09B67/0009 ,  C09B67/0086 ,  C09C1/24 ,  C09C1/3684 ,  C09C3/12 ,  C09D7/41 ,  C09D11/326 ,  C09D11/328 ,  C09D15/00 ,  G02B5/223

摘要： A method of modifying a particle that includes reacting a reactive compound having an X—[Y]n reactive group with a secondary compound N—S-ZM to form a substituted reactive intermediate [Y]a—X—(N—S-ZM)b, and reacting the particle with the substituted reactive intermediate [Y]a—X—(N—S-ZM)b to attach the substituted reactive intermediate to the surface of the particle to form a surface modified particle. The particle may comprise at least one of a dye particle, an inorganic pigment particle, an additive, or a combination thereof. X may be a sulfonyl, phosphoryl, or 1,3,5-triazinyl group. Y may be a halogen leaving group. N may be a nucleophilic group. S may be an organic group. ZM may be an ionizable end group. Also, n is an integer between 1 and 3, b is an integer between 1 and 3, and a=n−b. When n is equal to or greater than b, and wherein if b is 2 or 3, each N—S-ZM can be the same or different.

摘要翻译： 一种改性颗粒的方法，包括使具有X- [Y] n反应性基团的反应性化合物与次级化合物N-S-ZM反应以形成取代的反应性中间体[Y] a-X-（N-S-ZM ）b，并使该颗粒与取代的反应性中间体[Y] a-X-（N-S-ZM）b反应以将取代的反应性中间体连接到颗粒的表面以形成表面改性颗粒。 颗粒可以包括染料颗粒，无机颜料颗粒，添加剂或其组合中的至少一种。 X可以是磺酰基，磷酰基或1,3,5-三嗪基。 Y可以是卤素离去基团。 N可以是亲核基团。 S可能是一个有机组。 ZM可以是可离子化的端基。 此外，n是1和3之间的整数，b是1和3之间的整数，a = n-b。 当n等于或大于b时，并且其中如果b是2或3，则每个N-S-ZM可以相同或不同。

公开(公告)号：US20140308683A1

公开(公告)日：2014-10-16

申请号：US14002311

申请日：2012-03-07

申请人： John P. Kane ,  Brian Ishida ,  Mary Malloy

发明人： John P. Kane ,  Brian Ishida ,  Mary Malloy

IPC分类号： G01N33/53

CPC分类号： G01N33/53 ,  G01N33/6893 ,  G01N33/92 ,  G01N2800/324

摘要： The present disclosure provides methods for assessing risk of a cardiovascular occlusive event in an individual. The methods find use in diagnostic and prognostic applications. The present disclosure provides a method for measuring the level of pre?-1 high density lipoprotein in a biological sample; and also provides kits for use in carrying out the method.

摘要翻译： 本公开提供了评估个体心血管闭塞事件的风险的方法。 该方法可用于诊断和预后应用。 本公开提供了一种用于测量生物样品中前α-1高密度脂蛋白水平的方法; 并提供用于实施该方法的试剂盒。

公开(公告)号：US08118924B2

公开(公告)日：2012-02-21

申请号：US13109865

申请日：2011-05-17

申请人： Puthalath K. Sujeeth ,  John P. Kane ,  Daniel A. Ouellette ,  Mark Ulrich ,  Vincent Shing ,  Michael Bogomolny

发明人： Puthalath K. Sujeeth ,  John P. Kane ,  Daniel A. Ouellette ,  Mark Ulrich ,  Vincent Shing ,  Michael Bogomolny

IPC分类号： C09B67/10 ,  C09B67/00 ,  C09B67/20 ,  C08K3/28 ,  C08K5/3492 ,  C09C1/48

CPC分类号： C09D17/003 ,  B82Y30/00 ,  C01P2002/52 ,  C01P2002/85 ,  C01P2004/64 ,  C01P2006/12 ,  C01P2006/22 ,  C01P2006/40 ,  C01P2006/60 ,  C09B68/24 ,  C09B68/443 ,  C09B68/446 ,  C09B68/46775 ,  C09C1/56 ,  C09C3/08 ,  C09C3/10 ,  C09D11/322

摘要： A method of modifying a pigment that includes reacting a reactive compound having an X—[Y]n reactive group with a secondary compound N—S—ZM to form a substituted reactive intermediate [Y]a—X—(N—S—ZM)b. A pigment is reacted with the substituted reactive intermediate [Y]a—X—(N—S—ZM)b to attach the substituted reactive intermediate to the surface of the pigment to form a surface modified pigment. X may be a sulfonyl, phosphoryl, or 1,3,5-triazinyl group, Y may be a halogen leaving group, N may be a basic nucleophilic group, S may be an organic group, and ZM may be an ionizable end group. Also, n is an integer between 1 and 3, b is an integer between 1 and 3, and a=n−b. When n is equal to or greater than b, and if b is 2 or 3, each. N—S—ZM can be the same or different.

摘要翻译： 一种改性颜料的方法，其包括使具有X- [Y] n反应性基团的反应性化合物与次级化合物N-S-ZM反应以形成取代的反应性中间体[Y] a-X-（N-S-ZM ）b。 将颜料与取代的反应性中间体[Y] a-X-（N-S-ZM）b反应以将取代的反应性中间体连接到颜料的表面以形成表面改性的颜料。 X可以是磺酰基，磷酰基或1,3,5-三嗪基，Y可以是卤素离去基团，N可以是碱性亲核基团，S可以是有机基团，ZM可以是可离子化端基。 此外，n是1和3之间的整数，b是1和3之间的整数，a = n-b。 当n等于或大于b时，如果b为2或3，则各自。 N-S-ZM可以相同或不同。

公开(公告)号：US07964033B2

公开(公告)日：2011-06-21

申请号：US12197087

申请日：2008-08-22

申请人： Puthalath K. Sujeeth ,  John P. Kane ,  Daniel A. Ouellette ,  Mark Ulrich ,  Vincent Shing ,  Michael Bogomolny

发明人： Puthalath K. Sujeeth ,  John P. Kane ,  Daniel A. Ouellette ,  Mark Ulrich ,  Vincent Shing ,  Michael Bogomolny

IPC分类号： C09B67/20 ,  C08K5/16

CPC分类号： C09D17/003 ,  B82Y30/00 ,  C01P2002/52 ,  C01P2002/85 ,  C01P2004/64 ,  C01P2006/12 ,  C01P2006/22 ,  C01P2006/40 ,  C01P2006/60 ,  C09B68/24 ,  C09B68/443 ,  C09B68/446 ,  C09B68/46775 ,  C09C1/56 ,  C09C3/08 ,  C09C3/10 ,  C09D11/322

摘要： A method of modifying a pigment that includes reacting a reactive compound having an X-[Y]n reactive group with a secondary compound N-S-ZM to form a substituted reactive intermediate [Y]a-X-(N-S-ZM)b. A pigment is reacted with the substituted reactive intermediate [Y]a-X-(N-S-ZM)b to attach the substituted reactive intermediate to the surface of the pigment to form a surface modified pigment. X may be a sulfonyl, phosphoryl, or 1,3,5-triazinyl group, Y may be a halogen leaving group, N may be a basic nucleophilic group, S may be an organic group, and ZM may be an ionizable end group. Also, n is an integer between 1 and 3, b is an integer between 1 and 3, and a=n−b. When n is equal to or greater than b, and if b is 2 or 3, each N-S-ZM can be the same or different.

摘要翻译： 一种改性颜料的方法，包括使具有X- [Y] n反应性基团的反应性化合物与次级化合物N-S-ZM反应以形成取代的反应性中间体[Y] a-X-（N-S-ZM）b。 将颜料与取代的反应性中间体[Y] a-X-（N-S-ZM）b反应以将取代的反应性中间体连接到颜料的表面以形成表面改性的颜料。 X可以是磺酰基，磷酰基或1,3,5-三嗪基，Y可以是卤素离去基团，N可以是碱性亲核基团，S可以是有机基团，ZM可以是可离子化端基。 此外，n是1和3之间的整数，b是1和3之间的整数，a = n-b。 当n等于或大于b时，如果b是2或3，则每个N-S-ZM可以相同或不同。

公开(公告)号：US20100061951A1

公开(公告)日：2010-03-11

申请号：US12545790

申请日：2009-08-21

申请人： Puthalath K. Sujeeth ,  John P. Kane ,  Mark Ulrich ,  Daniel A. Ouellette ,  Vincent Shing ,  Mihaela Madaras ,  Carol D. Landi ,  Alberto Guerrero

发明人： Puthalath K. Sujeeth ,  John P. Kane ,  Mark Ulrich ,  Daniel A. Ouellette ,  Vincent Shing ,  Mihaela Madaras ,  Carol D. Landi ,  Alberto Guerrero

IPC分类号： A61K8/84 ,  C08G73/02 ,  C09D179/02 ,  A61Q1/10

CPC分类号： C09C3/08 ,  B82Y30/00 ,  C01P2002/52 ,  C01P2002/85 ,  C01P2004/64 ,  C01P2006/12 ,  C01P2006/22 ,  C01P2006/60 ,  C01P2006/80 ,  C09C1/56 ,  C09D11/322 ,  C09D17/003

摘要： A modified pigment that may include a polymer. The pigment may be directly attached to a nitrogen atom. The nitrogen atom may be attached directly or indirectly to a group that may include —S-Z. S may be a substituted or unsubstituted alkyl group, substituted or unsubstituted aromatic group, or polymer chain having a molecular weight range from about 300 to about 20000. Z may be a hydrogen, carboxyl, sulfonyl, phenolic, phosphoryl, ammonium, trimethylammonium, or tributylammonium group. Also, a modified pigment that may include a polymer. The pigment may be attached to an organic group through a carbon atom that is part of a N—C═N bond. A cosmetic formulation that may include a pigment covalently bonded to an organic group.

摘要翻译： 可以包括聚合物的改性颜料。 颜料可以直接连接到氮原子上。 氮原子可以直接或间接地连接到可以包括-S-Z的基团。 S可以是取代或未取代的烷基，取代或未取代的芳族基团或分子量范围为约300至约20000的聚合物链.Z可以是氢，羧基，磺酰基，酚类，磷酰基，铵，三甲基铵或 三丁基铵组。 而且，可以包括聚合物的改性颜料。 颜料可以通过作为N-C = N键的一部分的碳原子连接到有机基团上。 可以包括与有机基团共价结合的颜料的化妆品制剂。

公开(公告)号：US4800944A

公开(公告)日：1989-01-31

申请号：US12427

申请日：1987-02-09

申请人： John P. Kane

发明人： John P. Kane

IPC分类号： B60C25/138 ,  B60C25/10

CPC分类号： B60C25/138

摘要： A horizontally disposed vehicle wheel having a tubeless tire resting upon the wheel in a forwardly offset inclined position is located beneath a work head which is then lowered to an operating position at a fixed distance above the wheel. A radially extensible arm is mounted for rotary oscillation below the head about an axis coaxial with that of the located wheel and carries at its outer end a set of rollers which, upon rotation of the arm in one direction will engage the lowermost bead of the tire where located above the upper rim of the wheel and progressively face the engaged bead radially outwardly beyond the rim and downwardly below the rim to mount the lower bead only on the wheel.The apparatus self adjusts itself to wheels of different diameters and axial widths.

摘要翻译： 具有在向前偏移倾斜位置处搁置在车轮上的无内胎轮胎的水平布置的车轮车轮位于工作头下方，然后下降到车轮上方固定距离的操作位置。 安装径向可伸缩的臂，用于围绕与定位的轮的轴线同轴的轴线旋转振动，并在其外端承载一组辊，当一个方向上的臂旋转时，该组辊将接合轮胎的最下部的胎圈 其位于车轮的上轮缘上方，并且逐渐地朝向轮毂的径向向外的接合胎圈并且在轮辋下方向下并且仅将下胎圈安装在车轮上。 该装置可以自身调整到不同直径和轴向宽度的轮子。

公开(公告)号：US20160259699A1

公开(公告)日：2016-09-08

申请号：US14636136

申请日：2015-03-02

申请人： Steven L. GREENSPAN ,  Debra J. DANIELSON ,  James D. RENO ,  John P. KANE ,  Prashant PARIKH

发明人： Steven L. GREENSPAN ,  Debra J. DANIELSON ,  James D. RENO ,  John P. KANE ,  Prashant PARIKH

IPC分类号： G06F11/26 ,  G06F11/263 ,  G06F9/455

CPC分类号： G06F11/261 ,  G06F8/65 ,  G06F11/0709 ,  G06F11/0739 ,  G06F11/079 ,  G06F11/263 ,  G06F11/30 ,  G06F11/3409

摘要： Systems and methods may include receiving real-time data from real components operating in a real-world environment. The systems and methods may further include generating a virtual representation of the real components based on the real-time data received from the real components and historical data associated with the real components. In addition, the systems and methods may include determining whether the real-time data from a component of the real components indicates an anomaly. The systems and methods also may include, in response to determining that the real-time data from the component indicates the anomaly, determining whether the anomaly indicated by the real-time data from the component is consistent with the virtual representation of the real components. Moreover, the systems and methods may include, in response to determining that the anomaly indicated by the real-time data from the component is not consistent with the virtual representation of the real components, determining that the component is a malfunctioning component.

摘要翻译： 系统和方法可以包括从在真实环境中操作的真实组件接收实时数据。 系统和方法还可以包括基于从真实组件接收到的实时数据和与实际组件相关联的历史数据来生成真实组件的虚拟表示。 此外，系统和方法可以包括确定来自真实组件的组件的实时数据是否指示异常。 响应于确定来自组件的实时数据指示异常，系统和方法还可以包括：确定来自组件的实时数据指示的异常是否与实际组件的虚拟表示一致。 此外，系统和方法可以响应于确定来自组件的实时数据指示的异常与实际组件的虚拟表示不一致，确定组件是故障组件。

公开(公告)号：US08713686B2

公开(公告)日：2014-04-29

申请号：US11339659

申请日：2006-01-25

申请人： John P. Kane

发明人： John P. Kane

IPC分类号： G06F21/00

CPC分类号： H04L1/0001 ,  G06F21/56 ,  H03M13/2789 ,  H03M13/353 ,  H03M13/6508 ,  H04L1/0015 ,  H04L1/0021 ,  H04L1/0026 ,  H04L1/0071 ,  H04L1/0075 ,  H04L1/20

摘要： A method for detecting a malicious program infection includes scanning data to determine whether the data exhibits one or more particular symptoms of being infected with a malicious program and, in response to determining that the scanned data exhibits the symptoms of being infected with a malicious program, comparing the scanned data to known-good data. The method also includes initiating remedial action in response to determining that the scanned data does not match the known-good data.

摘要翻译： 用于检测恶意程序感染的方法包括扫描数据以确定数据是否呈现出被恶意程序感染的一个或多个特定症状，并且响应于确定扫描的数据表现出被恶意程序感染的症状， 将扫描数据与已知数据进行比较。 该方法还包括响应于确定扫描数据与已知好的数据不匹配而启动补救动作。

公开(公告)号：US20110016467A1

公开(公告)日：2011-01-20

申请号：US12504297

申请日：2009-07-16

申请人： John P. Kane

发明人： John P. Kane

IPC分类号： G06F9/455

CPC分类号： G06F9/45558 ,  G06F2009/45575 ,  G06F2009/45587

摘要： In some embodiments, a method for virtual machine management includes receiving a request for a first virtual machine from a virtual host. The method also includes comparing the request for the first virtual machine to a policy. The policy includes rules that govern access to a plurality of virtual machines. In addition, the method includes providing the virtual host access to a second virtual machine in response to comparing the request for the first virtual machine to the policy.

摘要翻译： 在一些实施例中，用于虚拟机管理的方法包括从虚拟主机接收对第一虚拟机的请求。 该方法还包括将第一虚拟机的请求与策略进行比较。 该策略包括管理对多个虚拟机的访问的规则。 此外，该方法包括提供对第二虚拟机的虚拟主机访问以响应于将第一虚拟机的请求与策略进行比较。