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    Hemofiltration system and method
    2.
    发明授权
    Hemofiltration system and method 失效
    血液滤过系统及方法

    公开(公告)号：US5344568A

    公开(公告)日：1994-09-06

    申请号：US62928

    申请日：1993-05-17

    申请人： Yuli Kitaevich ,  Nat Hemasilpin ,  J. Gabriel Marchevsky ,  John J. Bissler ,  George Benzing, III ,  Paul T. McEnery

    发明人： Yuli Kitaevich ,  Nat Hemasilpin ,  J. Gabriel Marchevsky ,  John J. Bissler ,  George Benzing, III ,  Paul T. McEnery

    IPC分类号： A61M1/16 ,  A61M1/34 ,  B01D61/100

    CPC分类号： A61M1/16 ,  A61M1/1643 ,  A61M1/34 ,  A61M1/3427 ,  A61M1/3451 ,  A61M2205/3393 ,  Y10S210/929

    摘要： A multipurpose hemofiltration system and method are disclosed for the removal of fluid and/or soluble waste from the blood of a patient. The system and method are equally applicable to adult, pediatric and neonatal patients. The system continuously monitors the weight of infusate in a first reservoir and drained fluid in a second reservoir and compares those weights to corresponding predetermined computed weights. When necessary, the pumping rates of the infusate, drained fluid and blood are adjusted in order to achieve a preselected amount of fluid removal from the patient's blood in a preselected time period. Application of this system and method provide repeatable and highly precise results.

    摘要翻译： 公开了用于从患者的血液中去除流体和/或可溶性废物的多用途血液滤过系统和方法。 该系统和方法同样适用于成人，儿科和新生儿患者。 该系统连续地监测第一储存器中的输注物的重量和第二储存器中排出的流体，并将这些权重与相应的预定计算权重进行比较。 必要时调节输液，排出的液体和血液的泵送速率，以便在预选的时间段内实现从患者血液中预先选择的流体去除量。 该系统和方法的应用提供了可重复和高精度的结果。

    Hemofiltration system
    3.
    发明授权
    Hemofiltration system 失效
    血液滤过系统

    公开(公告)号：US06780322B1

    公开(公告)日：2004-08-24

    申请号：US10030011

    申请日：2002-06-11

    申请人： John J. Bissler ,  Marios M. Polycarpou ,  Nat Hemasilpin ,  Efrain O. Morales

    发明人： John J. Bissler ,  Marios M. Polycarpou ,  Nat Hemasilpin ,  Efrain O. Morales

    IPC分类号： B01D6122

    CPC分类号： G05B13/0275 ,  A61M1/16 ,  A61M1/1603 ,  A61M1/1605 ,  A61M1/1611 ,  A61M1/1615 ,  A61M1/1643 ,  A61M1/1647 ,  A61M1/34 ,  A61M1/341 ,  A61M1/3413 ,  A61M1/342 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/3451 ,  A61M1/3496 ,  A61M1/3607 ,  A61M1/3639 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3344 ,  A61M2205/3393 ,  A61M2205/50 ,  Y10S210/929

    摘要： A multipurpose hemofiltration system (10) and method are disclosed for the removal of fluid and/or soluble waste from the blood of a patient. The system (10) continuously monitors the flow rates of drained fluid, blood, and infusate. When necessary, the pumping rates of the infusate, drained fluid and blood are adjusted to remove a preselected amount of fluid from the blood in a preselected time period. A supervisory controller (160) can monitor patient parameters, such as heart rate (120) and blood pressure (130), and adjust the pumping rates accordingly. The supervisory controller (160) uses fuzzy logic to make expert decisions, based upon a set of supervisory rules, to control each pumping rate to achieve a desired flow rate and to respond to fault conditions. An adaptive controller (162) corrects temporal variations in the flow rate based upon an adaptive law and a control law.

    摘要翻译： 公开了用于从患者的血液中除去流体和/或可溶性废物的多用途血液滤过系统（10）和方法。 系统（10）连续监测排出的流体，血液和灌注液的流量。 必要时，调节输注液，排出的液体和血液的泵送速率，以在预选的时间段内从血液中除去预选量的流体。 监督控制器（160）可以监测诸如心率（120）和血压（130）的患者参数，并相应地调节泵送速率。 监督控制器（160）使用模糊逻辑基于一组监督规则来做出专家决定，以控制每个泵送速率以实现期望的流速并对故障状况做出响应。 自适应控制器（162）基于自适应规律和控制律来校正流量的时间变化。

    Hemofiltration system and method
    5.
    发明授权
    Hemofiltration system and method 失效
    HEMOFILTRATION系统和方法

    公开(公告)号：US5211849A

    公开(公告)日：1993-05-18

    申请号：US775183

    申请日：1991-10-11

    申请人： Yuli Kitaevich ,  Nat Hemasilpin ,  J. Gabriel Marchevsky ,  John J. Bissler ,  George Benzing, III ,  Paul T. McEnery

    发明人： Yuli Kitaevich ,  Nat Hemasilpin ,  J. Gabriel Marchevsky ,  John J. Bissler ,  George Benzing, III ,  Paul T. McEnery

    IPC分类号： A61M1/16 ,  A61M1/34

    CPC分类号： A61M1/16 ,  A61M1/1643 ,  A61M1/34 ,  A61M1/3427 ,  A61M1/3451 ,  A61M2205/3393 ,  Y10S210/929

    摘要： A multipurpose hemofiltration system and method are disclosed for the removal of fluid and/or soluble waste from the blood of a patient. The system and method are equally applicable to adult, pediatric and neonatal patients. The system continuously monitors the weight of infusate in a first reservoir and drained fluid in a second reservoir and compares those weights to corresponding predetermined computed weights. When necessary, the pumping rates of the infusate, drained fluid and blood are adjusted in order to achieve a preselected amount of fluid removal from the patient's blood in a preselected time period. Application of this system and method provide repeatable and highly precise results.

    摘要翻译： 公开了用于从患者的血液中去除流体和/或可溶性废物的多用途血液滤过系统和方法。 该系统和方法同样适用于成人，儿科和新生儿患者。 该系统连续地监测第一储存器中的输注物的重量和第二储存器中排出的流体，并将这些权重与相应的预定计算权重进行比较。 必要时调节输液，排出的液体和血液的泵送速率，以便在预选的时间段内实现从患者血液中预先选择的流体去除量。 该系统和方法的应用提供了可重复和高精度的结果。

    Hemofiltration system and method based on monitored patient parameters
    7.
    发明授权
    Hemofiltration system and method based on monitored patient parameters 失效
    基于监测患者参数的血液滤过系统及方法

    公开(公告)号：US06471872B2

    公开(公告)日：2002-10-29

    申请号：US08814160

    申请日：1997-03-10

    申请人： Yuli Kitaevich ,  Nat Hemasilpin ,  J. Gabriel Marchevsky ,  John J. Bissler ,  George Benzing, III ,  Paul T. McEnery

    发明人： Yuli Kitaevich ,  Nat Hemasilpin ,  J. Gabriel Marchevsky ,  John J. Bissler ,  George Benzing, III ,  Paul T. McEnery

    IPC分类号： A61M134

    CPC分类号： A61M1/34 ,  A61M1/16 ,  A61M1/1611 ,  A61M1/1643 ,  A61M1/341 ,  A61M1/3427 ,  A61M1/3451 ,  A61M1/3607 ,  A61M2205/15 ,  A61M2205/18 ,  A61M2205/3331 ,  A61M2205/3344 ,  A61M2205/3393 ,  A61M2205/50 ,  A61M2205/52 ,  A61M2230/205 ,  Y10S210/929

    摘要： A multipurpose hemofiltration system and method are disclosed for the removal of fluid and/or soluble waste from the blood of a patient. The system and method are equally applicable to adult, pediatric and neonatal patients. In one embodiment, the system continuously monitors the weight of infusate in a first reservoir and drained fluid in a second reservoir and compares those weights to corresponding predetermined computed weights. When necessary, the pumping rates of the infusate, drained fluid and blood are adjusted in order to achieve a preselected amount of fluid removal from the patient's blood in a preselected time period. Application of this system and method provide repeatable and highly precise results. Alternatively, predetermined patient parameters can be monitored and the adjustment of pumping rates may be responsive to these monitored parameters. Suitable patient parameters are arterial pressure, central venous pressure, pulmonary arterial pressure, mean arterial pressure, capillary wedge pressure, systemic vascular resistance, cardiac output, mixed venous O2 saturation, arterial O2 saturation, blood pressure, heart rate, patient weight, and hematocrit.

    摘要翻译： 公开了用于从患者的血液中去除流体和/或可溶性废物的多用途血液滤过系统和方法。 该系统和方法同样适用于成人，儿科和新生儿患者。 在一个实施例中，系统连续监测第一储存器中的输注物的重量和第二储存器中的排出的流体，并将这些权重与相应的预定计算权重进行比较。 必要时调节输液，排出的液体和血液的泵送速率，以便在预选的时间段内实现从患者血液中预先选择的流体去除量。 该系统和方法的应用提供了可重复和高精度的结果。 或者，可以监测预定的患者参数，并且泵送速率的调整可以响应于这些监视的参数。 合适的患者参数是动脉压，中心静脉压，肺动脉压，平均动脉压，毛细血管楔压，全身血管阻力，心输出量，混合静脉血氧饱和度，动脉血氧饱和度，血压，心率，患者体重和血细胞比容 。

    Hemofiltration system and method
    8.
    发明授权
    Hemofiltration system and method 失效
    血液滤过系统及方法

    公开(公告)号：US06200485B1

    公开(公告)日：2001-03-13

    申请号：US09262437

    申请日：1999-03-04

    申请人： Yuli Kitaevich ,  Nat Hemasilpin ,  J. Gabriel Marchevsky ,  John J. Bissler ,  George Benzing, III ,  Paul T. McEnery

    发明人： Yuli Kitaevich ,  Nat Hemasilpin ,  J. Gabriel Marchevsky ,  John J. Bissler ,  George Benzing, III ,  Paul T. McEnery

    IPC分类号： A61M134

    CPC分类号： A61M1/34 ,  A61M1/16 ,  A61M1/1611 ,  A61M1/1643 ,  A61M1/341 ,  A61M1/3427 ,  A61M1/3451 ,  A61M1/3607 ,  A61M2205/15 ,  A61M2205/18 ,  A61M2205/3331 ,  A61M2205/3344 ,  A61M2205/3393 ,  A61M2205/50 ,  A61M2205/52 ,  A61M2230/205 ,  Y10S210/929

    摘要： A multipurpose hemofiltration system and method are disclosed for the removal of fluid and/or soluble waste from the blood of a patient. The system and method are equally applicable to adult, pediatric and neonatal patients. In one embodiment, the system continuously monitors the weight of infusate in a first reservoir and drained fluid in a second reservoir and compares those weights to corresponding predetermined computed weights. When necessary, the pumping rates of the infusate, drained fluid and blood are adjusted in order to achieve a preselected amount of fluid removal from the patient's blood in a preselected time period. Application of this system and method provide repeatable and highly precise results. Alternatively, predetermined patient parameters can be monitored and the adjustment of pumping rates may be responsive to these monitored parameters. Suitable patient parameters are arterial pressure, central venous pressure, pulmonary arterial pressure, mean arterial pressure, capillary wedge pressure, systemic vascular resistance, cardiac output, mixed venous O2 saturation, arterial O2 saturation, blood pressure, heart rate, patient weight, and hematocrit.

    摘要翻译： 公开了用于从患者的血液中去除流体和/或可溶性废物的多用途血液滤过系统和方法。 该系统和方法同样适用于成人，儿科和新生儿患者。 在一个实施例中，系统连续监测第一储存器中的输注物的重量和第二储存器中的排出的流体，并将这些权重与相应的预定计算权重进行比较。 必要时调节输液，排出的液体和血液的泵送速率，以便在预选的时间段内实现从患者血液中预先选择的流体去除量。 该系统和方法的应用提供了可重复和高精度的结果。 或者，可以监测预定的患者参数，并且泵送速率的调整可以响应于这些监视的参数。 合适的患者参数是动脉压，中心静脉压，肺动脉压，平均动脉压，毛细血管楔压，全身血管阻力，心输出量，混合静脉血氧饱和度，动脉血氧饱和度，血压，心率，患者体重和血细胞比容 。