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1.发明申请Treatment of Hyperproliferative Diseases with Vinca Alkaloid N-Oxide Analogs 有权用长春花碱生物碱N-氧化物类似物治疗过度增生性疾病公开(公告)号：US20120107230A1
公开(公告)日：2012-05-03
申请号：US13280974
申请日：2011-10-25
Applicant: JOHN G. CURD , JOHN F.W. KEANA , ALSHAD S. LALANI , PAUL B. WESTBERG , BRADFORD GOODWIN , W. DAVID HENNER
Inventor： JOHN G. CURD , JOHN F.W. KEANA , ALSHAD S. LALANI , PAUL B. WESTBERG , BRADFORD GOODWIN , W. DAVID HENNER
IPC: A61K31/475 , A61P35/02 , A61P29/00 , A61P17/00 , A61P27/02 , A61P1/00 , A61P1/16 , A61P37/06 , A61P37/02 , A61P17/06 , A61P9/14 , A61K51/00 , A61K39/395 , A61K35/74 , A61K31/704 , A61K38/21 , A61K38/44 , A61K31/513 , A61K31/713 , A61K38/20 , A61K31/664 , A61K38/46 , A61P35/00
CPC classification number: C07D519/04
Abstract: The present invention relates to vinca alkaloid and analog N-oxides having activity for treating hyperproliferative disorders. Further, the invention relates to pharmaceutical compositions and methods of using vinca alkaloid and analog N-oxides, alone or in combination with one or more other active agents or treatments, to treat hyperproliferative disorders.
Abstract translation: 本发明涉及具有用于治疗过度增殖性疾病的活性的长春花生物碱和类似物N-氧化物。 此外，本发明涉及使用长春花生物碱和类似物N-氧化物的药物组合物和方法，其单独或与一种或多种其它活性剂或治疗剂组合以治疗过度增殖性疾病。
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公开(公告)号：US20110008338A1
公开(公告)日：2011-01-13
申请号：US12886185
申请日：2010-09-20
Applicant: John G. Curd , Lori A. Kunkel , Antonio J. Grillo-Lopez
Inventor： John G. Curd , Lori A. Kunkel , Antonio J. Grillo-Lopez
IPC: A61K39/395 , A61P37/00
CPC classification number: A61K39/3955 , A61K31/365 , A61K31/56 , A61K45/06 , A61K47/6849 , A61K51/1027 , A61K2039/505 , A61K2039/54 , C07K16/2803 , C07K16/2887 , C07K2317/24 , Y10S424/801 , Y10S424/81
Abstract: The present invention concerns treatment of autoimmune diseases with antagonists which bind to B cell surface markers, such as CD19 or CD20.
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3.发明申请Prevention and Treatment of Gastrointestinal and Bladder Disorders Associated with Chemotherapy or Radiation Therapy Using Active Vitamin D Compounds 审中-公开使用活性维生素D化合物预防和治疗与化疗或放射治疗相关的胃肠道和膀胱疾病公开(公告)号：US20090163453A1
公开(公告)日：2009-06-25
申请号：US11992300
申请日：2006-09-26
Applicant: John G. Curd , Bradford S. Goodwin , Jeffrey L. Cleland
Inventor： John G. Curd , Bradford S. Goodwin , Jeffrey L. Cleland
IPC: A61K31/593 , A61K31/59 , A61P35/00 , A61P35/02
CPC classification number: A61K31/59 , A61K9/1075 , A61K45/06 , A61K2300/00
Abstract: The present invention relates to a method for preventing, treating, or ameliorating gastrointestinal and bladder disorders in a patient receiving a chemotherapy or radiation therapy comprising administering to the patient a therapeutically effective amount of active vitamin D compound or a mimic thereof. According to the invention, the active vitamin D compound or a mimic thereof may be administered by high dose pulse administration so that high doses of the active vitamin D compound or a mimic thereof can be administered to an animal without inducing severe symptomatic hypercalcemia.
Abstract translation: 本发明涉及一种在接受化疗或放射治疗的患者中预防，治疗或改善胃肠和膀胱疾病的方法，包括向患者施用治疗有效量的活性维生素D化合物或其模拟物。 根据本发明，活性维生素D化合物或其模拟物可以通过高剂量脉冲施用来施用，使得可以向动物施用高剂量的活性维生素D化合物或其模拟物，而不引起严重的症状性高钙血症。
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4.发明申请Treatment of Hyperproliferative Diseases with Vinca Alkaloid N-Oxide and Analogs 有权用长春花碱生物碱N-氧化物和类似物治疗过度增殖性疾病公开(公告)号：US20080305075A1
公开(公告)日：2008-12-11
申请号：US12111672
申请日：2008-04-29
Applicant: John G. Curd , John F.W. Keana , Alshad S. Lalani , Paul B. Westberg , Bradford Goodwin , W. David Henner
Inventor： John G. Curd , John F.W. Keana , Alshad S. Lalani , Paul B. Westberg , Bradford Goodwin , W. David Henner
IPC: A61K31/475 , C07D471/04 , A61P35/00 , A61K39/395 , A61K38/20 , A61K38/21 , A61K31/4375 , A61K31/55
CPC classification number: C07D519/04
Abstract: The present invention relates to vinca alkaloid and analog N-oxides having activity for treating hyperproliferative disorders. Further, the invention relates to pharmaceutical compositions and methods of using vinca alkaloid and analog N-oxides, alone or in combination with one or more other active agents or treatments, to treat hyperproliferative disorders.
Abstract translation: 本发明涉及具有用于治疗过度增殖性疾病的活性的长春花生物碱和类似物N-氧化物。 此外，本发明涉及使用长春花生物碱和类似物N-氧化物的药物组合物和方法，其单独或与一种或多种其它活性剂或治疗剂组合以治疗过度增殖性疾病。
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公开(公告)号：US08545843B2
公开(公告)日：2013-10-01
申请号：US12886171
申请日：2010-09-20
Applicant: John G. Curd , Antonio J. Grillo-Lopez
Inventor： John G. Curd , Antonio J. Grillo-Lopez
IPC: A61K39/395 , C07K16/28
CPC classification number: A61K39/3955 , A61K31/365 , A61K31/56 , A61K45/06 , A61K47/6849 , A61K51/1027 , A61K2039/505 , A61K2039/54 , C07K16/2803 , C07K16/2887 , C07K2317/24 , Y10S424/801 , Y10S424/81
Abstract: The present invention concerns treatment of autoimmune diseases with antagonists which bind to B cell surface markers, such as CD19 or CD20.
Abstract translation: 本发明涉及用与B细胞表面标志物如CD19或CD20结合的拮抗剂治疗自身免疫性疾病。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20100080769A1
公开(公告)日：2010-04-01
申请号：US12629472
申请日：2009-12-02
Applicant: Antonio J. Grillo-Lopez , Christine A. White , John G. Curd , Susan Desmond-Hellmann
Inventor： Antonio J. Grillo-Lopez , Christine A. White , John G. Curd , Susan Desmond-Hellmann
IPC: A61K38/19 , A61K39/395 , A61P35/00 , A61P37/04
CPC classification number: C07K16/2887 , A61K31/196 , A61K31/573 , A61K31/675 , A61K31/7076 , A61K38/191 , A61K38/193 , A61K38/2026 , A61K38/212 , A61K39/395 , A61K39/3955 , A61K2039/505 , C23C2/02 , C23C2/06 , C23C2/30 , A61K2300/00
Abstract: Chronic Lymphocytic Leukemia (CLL) may be treated with antibodies directed against the CD20 antigen.
Abstract translation: 可以用针对CD20抗原的抗体治疗慢性淋巴细胞白血病（CLL）。
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7.发明授权Treatment of hematologic malignancies associated with circulating tumor cells using chimeric anti-CD20 antibody 有权使用嵌合抗CD20抗体治疗与循环肿瘤细胞相关的血液恶性肿瘤公开(公告)号：US07682612B1
公开(公告)日：2010-03-23
申请号：US09436347
申请日：1999-11-09
Applicant: Christine A. White , Antonio J. Grillo-López , John G. Curd , Susan Desmond-Hellmann
Inventor： Christine A. White , Antonio J. Grillo-López , John G. Curd , Susan Desmond-Hellmann
IPC: A61K39/395 , A61K51/00
CPC classification number: C07K16/2887 , A61K31/196 , A61K31/573 , A61K31/675 , A61K31/7076 , A61K38/191 , A61K38/193 , A61K38/2026 , A61K38/212 , A61K39/395 , A61K39/3955 , A61K2039/505 , C23C2/02 , C23C2/06 , C23C2/30 , A61K2300/00
Abstract: Chronic Lymphocytic Leukemia (CLL) may be treated with antibodies directed against the CD20 antigen.
Abstract translation: 可以用针对CD20抗原的抗体治疗慢性淋巴细胞白血病（CLL）。
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公开(公告)号：US20120201818A1
公开(公告)日：2012-08-09
申请号：US13450377
申请日：2012-04-18
Applicant: John G. Curd , Lori A. Kunkel , Antonio J. Grillo-Lopez
Inventor： John G. Curd , Lori A. Kunkel , Antonio J. Grillo-Lopez
IPC: A61K39/395 , A61P25/00
CPC classification number: A61K39/3955 , A61K31/365 , A61K31/56 , A61K45/06 , A61K47/6849 , A61K51/1027 , A61K2039/505 , A61K2039/54 , C07K16/2803 , C07K16/2887 , C07K2317/24 , Y10S424/801 , Y10S424/81
Abstract: The present invention concerns treatment of autoimmune diseases with antagonists which bind to B cell surface markers, such as CD19 or CD20.
Abstract translation: 本发明涉及用与B细胞表面标志物如CD19或CD20结合的拮抗剂治疗自身免疫性疾病。
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公开(公告)号：US20110008337A1
公开(公告)日：2011-01-13
申请号：US12886171
申请日：2010-09-20
Applicant: John G. Curd , Lori A. Kunkel , Antonio J. Grillo-Lopez
Inventor： John G. Curd , Lori A. Kunkel , Antonio J. Grillo-Lopez
IPC: A61K39/395 , A61P29/00 , A61P9/00
CPC classification number: A61K39/3955 , A61K31/365 , A61K31/56 , A61K45/06 , A61K47/6849 , A61K51/1027 , A61K2039/505 , A61K2039/54 , C07K16/2803 , C07K16/2887 , C07K2317/24 , Y10S424/801 , Y10S424/81
Abstract: The present invention concerns treatment of autoimmune diseases with antagonists which bind to B cell surface markers, such as CD19 or CD20.
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10.发明申请Treatment, prevention and amelioration of pulmonary disorders associated with chemotherapy or radiotherapy with active vitamin D compounds or mimics thereof 审中-公开用活性维生素D化合物或其模拟物治疗，预防和改善与化疗或放疗有关的肺部疾病公开(公告)号：US20090069276A1
公开(公告)日：2009-03-12
申请号：US11918962
申请日：2006-04-24
Applicant: John G. Curd , Bradford S. Goodwin , Jeffrey L. Cleland
Inventor： John G. Curd , Bradford S. Goodwin , Jeffrey L. Cleland
CPC classification number: A61K31/59 , A61K9/1075 , A61K9/4858
Abstract: The present invention relates to a method for preventing, treating or ameliorating pulmonary disorders in a patient receiving a chemotherapeutic or radiotherapeutic agent or treatment comprising administering to the patient a pharmaceutical composition comprising an effective amount of active vitamin D compound or a mimic thereof. According to the invention, the active vitamin D compound, or the mimic thereof, may be administered by HDPA so that high doses of the active vitamin D compound can be administered to an animal without inducing severe symptomatic hypercalcemia.
Abstract translation: 本发明涉及在接受化学治疗剂或放射治疗剂或治疗的患者中预防，治疗或改善肺部疾病的方法，包括向患者施用包含有效量的活性维生素D化合物或其模拟物的药物组合物。 根据本发明，活性维生素D化合物或其模拟物可以通过HDPA施用，使得高剂量的活性维生素D化合物可以施用于动物而不引起严重的症状性高钙血症。
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