公开(公告)号：US20060031023A1

公开(公告)日：2006-02-09

申请号：US11246325

申请日：2005-10-06

申请人： Frank Aguilera ,  Denis Faubert ,  Marguerite Boulos ,  John Tsang ,  Michael Hu ,  Joachim Ostermann ,  Paul Kearney ,  Pierre Thibault

发明人： Frank Aguilera ,  Denis Faubert ,  Marguerite Boulos ,  John Tsang ,  Michael Hu ,  Joachim Ostermann ,  Paul Kearney ,  Pierre Thibault

IPC分类号： G06F19/00 ,  G01N33/48 ,  G01N33/50

CPC分类号： G01N33/6848 ,  Y10T436/24

摘要： The present invention is directed to computer automated methods and systems for identifying and characterizing biomolecules in a biological sample. Mass spectrometry measurements are obtained on biomolecules in a sample. These measurements are analyzed to determine the abundance of the biomolecules in the sample, and the abundance measurements are coupled with one or more distinguishing characteristics of biomolecules they are associated with, thereby permitting computer-mediated comparison of abundances of biomolecules from multiple biological samples.

公开(公告)号：US20060269944A1

公开(公告)日：2006-11-30

申请号：US11429113

申请日：2006-05-04

申请人： Frank Aguilera ,  Denis Faubert ,  Marguerite Boulos ,  John Tsang ,  Michael Hu ,  Joachim Ostermann ,  Paul Kearney ,  Pierre Thibault

发明人： Frank Aguilera ,  Denis Faubert ,  Marguerite Boulos ,  John Tsang ,  Michael Hu ,  Joachim Ostermann ,  Paul Kearney ,  Pierre Thibault

IPC分类号： C12Q1/68 ,  G06F19/00 ,  G01N33/48

CPC分类号： G01N33/6848 ,  Y10T436/24

摘要： The present invention is directed to computer automated methods and systems for identifying and characterizing biomolecules in a biological sample. Mass spectrometry measurements are obtained on biomolecules in a sample. These measurements are analyzed to determine the abundance of the biomolecules in the sample, and the abundance measurements are coupled with one or more distinguishing characteristics of biomolecules they are associated with, thereby permitting computer-mediated comparison of abundances of biomolecules from multiple biological samples.

摘要翻译： 本发明涉及用于识别和表征生物样品中生物分子的计算机自动化方法和系统。 在样品中的生物分子上获得质谱测量。 分析这些测量以确定样品中生物分子的丰度，并且丰度测量与其相关联的生物分子的一个或多个区别特征相结合，从而允许计算机介导的来自多个生物样品的生物分子丰度的比较。

公开(公告)号：US20060003385A1

公开(公告)日：2006-01-05

申请号：US11188954

申请日：2005-07-25

申请人： Frank Aguilera ,  Denis Faubert ,  Marguerite Boulos ,  John Tsang ,  Michael Hu ,  Joachim Ostermann ,  Paul Kearney ,  Pierre Thibault

发明人： Frank Aguilera ,  Denis Faubert ,  Marguerite Boulos ,  John Tsang ,  Michael Hu ,  Joachim Ostermann ,  Paul Kearney ,  Pierre Thibault

IPC分类号： C12Q1/68 ,  G01N33/53 ,  G06F19/00

CPC分类号： G01N33/6848 ,  Y10T436/24

摘要： The present invention is directed to computer automated methods and systems for identifying and characterizing biomolecules in a biological sample. Mass spectrometry measurements are obtained on biomolecules in a sample. These measurements are analyzed to determine the abundance of the biomolecules in the sample, and the abundance measurements are coupled with one or more distinguishing characteristics of biomolecules they are associated with, thereby permitting computer-mediated comparison of abundances of biomolecules from multiple biological samples.

公开(公告)号：US20070292410A1

公开(公告)日：2007-12-20

申请号：US11682217

申请日：2007-03-05

申请人： Neil Cashman ,  Avijit Chakrabartty ,  Rishi Rakhit ,  Joachim Ostermann

发明人： Neil Cashman ,  Avijit Chakrabartty ,  Rishi Rakhit ,  Joachim Ostermann

IPC分类号： A61K31/70 ,  A61K38/16 ,  A61K39/395 ,  A61P25/28 ,  C07H21/04 ,  C07K14/00 ,  C07K16/00 ,  C12M3/00 ,  C12N5/08 ,  G01N33/53

CPC分类号： C07K16/40 ,  A01K2267/0312 ,  A01K2267/0318 ,  A61K31/7088 ,  A61K31/713 ,  A61K39/0005 ,  A61K39/0007 ,  A61K48/005 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/575 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/92 ,  C12N9/0089 ,  G01N33/573 ,  G01N33/6896 ,  G01N2333/90283 ,  G01N2800/2828

摘要： The invention provides a method for treating a medical condition, disease, or disorder mediated by a misfolded form of superoxide dismutase (SOD) in a subject in need of treatment. The method optionally comprises administering to the subject a composition comprising a pharmaceutically acceptable vehicle and an agent selected from (1) an exogenous antibody or fragment thereof that binds selectively to the misfolded form of SOD, and/or (2) an immunogen that elicits production of an endogenous antibody that binds selectively to the misfolded form of SOD, and/or (3) a nucleic acid sequence encoding (1) or (2). In certain embodiments, the invention provides methods of treating diseases such as Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis using amyotrophic disease-specific epitopes, and compositions including these epitopes. The invention also provides antibodies that bind to monomeric or misfolded SOD1, and not on the molecular surface of native homodimeric SOD1. In addition, the invention includes methods of diagnosing Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis in a subject. Also, the invention provides methods of identifying substances for the treatment or prevention of Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis and kits using the binding proteins of the invention.

摘要翻译： 本发明提供了在需要治疗的受试者中治疗由错误折叠形式的超氧化物歧化酶（SOD）介导的医学病症，疾病或病症的方法。 所述方法任选包括向受试者施用包含药学上可接受的载体和选自（1）选择性结合SOD的错误折叠形式的外源性抗体或其片段的组合物，和/或（2）引起生产的免疫原 选择性结合SOD的错误折叠形式的内源性抗体，和/或（3）编码（1）或（2）的核酸序列。 在某些实施方案中，本发明提供了使用肌萎缩性疾病特异性表位治疗疾病如阿尔茨海默病，帕金森病或肌萎缩性侧索硬化的方法，以及包括这些表位的组合物。 本发明还提供结合单体或错折叠的SOD1，而不是在天然同二聚体SOD1的分子表面上的抗体。 此外，本发明包括在受试者中诊断阿尔茨海默病，帕金森病或肌萎缩性侧索硬化的方法。 此外，本发明提供了鉴定用于治疗或预防阿尔茨海默病，帕金森病或肌萎缩性侧索硬化的物质的方法以及使用本发明的结合蛋白的试剂盒。

公开(公告)号：US20070106065A1

公开(公告)日：2007-05-10

申请号：US11344933

申请日：2006-01-31

申请人： Paul Kearney ,  Heather Butler ,  Navdeep Jaitly ,  Sajani Swamy ,  Lyes Hamaidi ,  Marcelo Filgueira ,  Pierre Thibault ,  Denis Faubert ,  Daniel Chelsky ,  Joel Lanoix ,  Sylvain Brunet ,  Kevin Eng ,  Frank Aguilera ,  John Tsang ,  Michael Hu ,  Joachim Ostermann ,  Marguerite Boulos

发明人： Paul Kearney ,  Heather Butler ,  Navdeep Jaitly ,  Sajani Swamy ,  Lyes Hamaidi ,  Marcelo Filgueira ,  Pierre Thibault ,  Denis Faubert ,  Daniel Chelsky ,  Joel Lanoix ,  Sylvain Brunet ,  Kevin Eng ,  Frank Aguilera ,  John Tsang ,  Michael Hu ,  Joachim Ostermann ,  Marguerite Boulos

IPC分类号： C07K14/82 ,  C07K16/30 ,  C12P21/06 ,  A61K39/395 ,  A61K39/00 ,  C12P21/08 ,  C12P21/04

CPC分类号： C07K14/82 ,  C07K14/4748 ,  C07K16/3046

摘要： Surprisingly, the present inventors have discovered that expression of TAT-001 protein in human patients is associated with cancer, and that the overexpressed protein is present in plasma membrane fractions. Thus, the present inventors have discovered that TAT-001 is associated with abnormal development and growth, and may be useful as a target for the identification of anti-cancer compounds, including antibodies for use in immunotherapy. Accordingly, the present invention provides methods for the identification of compounds that inhibit TAT-001 expression or activity, comprising: contacting a candidate compound with a TAT-001 and detecting the presence or absence of binding between said compound and said TAT-001, or detecting a change in TAT-001 expression or activity. Methods are also included for the identification of anti-cancer compounds and compounds that modulate TAT-001 expression or activity, comprising: administering a compound to a cell or cell population, and detecting a change in TAT-001 expression or activity.

摘要翻译： 令人惊奇的是，本发明人已经发现，人类患者中TAT-001蛋白的表达与癌症有关，并且过表达的蛋白质存在于质膜组分中。 因此，本发明人已经发现，TAT-001与异常发育和生长有关，可用作鉴定抗癌化合物的靶标，包括用于免疫治疗的抗体。 因此，本发明提供了用于鉴定抑制TAT-001表达或活性的化合物的方法，包括：使候选化合物与TAT-001接触并检测所述化合物与所述TAT-001之间是否存在结合，或 检测TAT-001表达或活性的变化。 还包括用于鉴定调节TAT-001表达或活性的抗癌化合物和化合物的方法，包括：向细胞或细胞群施用化合物，并检测TAT-001表达或活性的变化。