公开(公告)号：US5993972A

公开(公告)日：1999-11-30

申请号：US40692

申请日：1998-03-18

Applicant: Murray H. Reich ,  John Teffenhart ,  Jirina Kuzma

Inventor： Murray H. Reich ,  John Teffenhart ,  Jirina Kuzma

IPC: A61K8/87 ,  A61K9/22 ,  A61K47/34 ,  A61L27/18 ,  A61L29/06 ,  A61L31/06 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q19/00 ,  B32B27/40 ,  C08G18/40 ,  C08G18/44 ,  C08G18/48 ,  C08G18/50 ,  C08G18/61 ,  C08G18/66 ,  C08G18/75

CPC classification number: C08G18/758 ,  A61K47/34 ,  A61K8/87 ,  A61L27/18 ,  A61L29/06 ,  A61L31/06 ,  A61Q19/00 ,  B32B27/40 ,  C08G18/4018 ,  C08G18/44 ,  C08G18/4808 ,  C08G18/4858 ,  C08G18/5096 ,  C08G18/61 ,  C08G18/6607 ,  C08G18/667 ,  C08G18/6674 ,  C08G18/6681 ,  A61Q17/04 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q5/12 ,  A61Q9/02 ,  Y10T428/2933 ,  Y10T428/31551 ,  Y10T428/31565 ,  Y10T428/31587

Abstract: An improved amphiphilic diol is prepared with a controlled type and amount of alkylene glycol, catalyst, hydrophobic and hydrophilic diol with diisocyanate and water. Critical selection of the type, molecular weight and ratios of hydrophilic to hydrophobic diol, isocyanate to hydroxyl groups, average molecular weight of the diol component, the amount of water in the reaction mixture produces a polyuretheane having high slip, Shore A Hardness values, wet tensile strength and tear strength. This invention also includes uses of the polyurethane in catheters, shaving products, synthetic valves, veins and arteries, stents, ports, shunts and coatings. Preferably, the polyurethane is used in combination with a filler for application to rubber gloves. In addition, dispersions, lotions, gels and solutions can be formed of the polyurethane.

Abstract translation: 用受控类型和量的亚烷基二醇，催化剂，疏水和亲水二醇与二异氰酸酯和水制备改进的两亲二醇。 关键选择亲水至疏水二醇，异氰酸酯与羟基的类型，分子量和比例，二醇组分的平均分子量，反应混合物中的水量产生具有高滑移，肖氏A硬度值，湿润 拉伸强度和撕裂强度。 本发明还包括聚氨酯在导管，剃须产品，合成瓣膜，静脉和动脉，支架，端口，分流器和涂层中的用途。 优选地，聚氨酯与用于橡胶手套的填料结合使用。 此外，分散体，洗剂，凝胶和溶液可以由聚氨酯形成。

公开(公告)号：US5728762A

公开(公告)日：1998-03-17

申请号：US696467

申请日：1996-08-14

Applicant: Murray H. Reich ,  Ken Nelson ,  Jirina Kuzma

Inventor： Murray H. Reich ,  Ken Nelson ,  Jirina Kuzma

IPC: A61K8/87 ,  A61L26/00 ,  A61L27/18 ,  A61Q15/00 ,  A61Q19/00 ,  C08G18/08 ,  C08G18/30 ,  C08G18/66 ,  C08G18/75

CPC classification number: A61K8/042 ,  A61K8/87 ,  A61L26/0019 ,  A61L27/18 ,  A61Q19/00 ,  C08G18/0857 ,  C08G18/302 ,  C08G18/6674 ,  C08G18/75 ,  C08G18/758 ,  A61Q15/00 ,  A61Q17/04 ,  C08G2210/00 ,  C08G2220/00 ,  Y10S424/13 ,  Y10T428/31551

Abstract: An improved polyurethane is prepared by reacting a diol component and an organic diisocyanate with critical selection of the amount of water in the reaction mixture and the diol component. The diol component is a long chain polyoxyethylene glycol optionally mixed with a low molecular weight polyoxyethylene glycol. A tough gel can be formed by mixing the polyurethane in a diol or triol and water solution. The tough gel can be used in burn and wound dressings, electroconductive pads, high slip materials and surgical implants. An optically clear gel can also be formed. Solutions and emulsions can be formed of the polymer and can be combined with fillers to form face creams and antiperspirants. A film can cover one side of the gel for burn and wound applications. The gel can be used in squeeze tubes and in spray cans in burn wound care dressings and industrial applications and in bags and containers for use in plastic surgery implants.

公开(公告)号：US5932200A

公开(公告)日：1999-08-03

申请号：US039694

申请日：1998-03-16

Applicant: Murray H. Reich ,  Ken Nelson ,  Jirina Kuzma

Inventor： Murray H. Reich ,  Ken Nelson ,  Jirina Kuzma

IPC: A61K8/87 ,  A61Q15/00 ,  A61Q19/00 ,  C08G18/66 ,  C08G18/75 ,  A61K7/32 ,  A61K7/00 ,  A61K31/74 ,  C08G18/30

CPC classification number: A61K8/042 ,  A61K8/87 ,  A61Q15/00 ,  A61Q19/00 ,  C08G18/6674 ,  C08G18/75 ,  C08G2220/00

Abstract: An improved polyurethane is prepared by reacting a diol component and an organic diisocyanate with critical selection of the amount of water in the reaction mixture and the diol component. The diol component is a long chain polyoxyethylene glycol optionally mixed with a low molecular weight polyoxyethylene glycol. A tough gel can be formed by mixing the polyurethane in a diol or triol and water solution. The tough gel can be used in burn and wound dressings, electroconductive pads, high slip materials and surgical implants. An optically clear gel can also be formed. Solutions and emulsions can be formed of the polymer and can be combined with fillers to form face creams and antiperspirants. A film can cover one side of the gel for burn and wound applications. The gel can be used in squeeze tubes and in spray cans in burn wound care dressings and industrial applications and in bags and containers for use in plastic surgery implants.

Abstract translation: 改进的聚氨酯通过使二醇组分和有机二异氰酸酯与反应混合物和二醇组分中的水量的临界选择反应来制备。 二醇组分是任选与低分子量聚氧乙烯二醇混合的长链聚氧乙二醇。 可以通过将聚氨酯混合在二醇或三醇和水溶液中来形成坚韧的凝胶。 坚韧的凝胶可用于烧伤和伤口敷料，导电垫，高滑动材料和外科植入物。 还可以形成光学透明的凝胶。 溶液和乳液可以由聚合物形成并且可与填料组合以形成面霜和止汗剂。 胶片可以覆盖凝胶的一面，用于烧伤和伤口应用。 该凝胶可用于挤压管和喷涂罐中，用于烧伤伤口护理敷料和工业应用以及用于整形手术植入物的袋子和容器中。

公开(公告)号：US5962620A

公开(公告)日：1999-10-05

申请号：US915583

申请日：1997-08-26

Applicant: Murray H. Reich ,  Ken Nelson ,  Jirina Kuzma

Inventor： Murray H. Reich ,  Ken Nelson ,  Jirina Kuzma

IPC: A61K8/87 ,  A61K47/34 ,  A61L26/00 ,  A61L27/18 ,  A61L27/34 ,  A61L29/06 ,  A61L29/08 ,  A61L31/06 ,  A61L31/10 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q19/00 ,  B32B27/40 ,  C08G18/30 ,  C08G18/40 ,  C08G18/44 ,  C08G18/48 ,  C08G18/50 ,  C08G18/61 ,  C08G18/65 ,  C08G18/66 ,  C08G18/75

CPC classification number: C08G18/667 ,  A61K47/34 ,  A61K8/87 ,  A61L26/0019 ,  A61L27/18 ,  A61L27/34 ,  A61L29/06 ,  A61L29/085 ,  A61L31/06 ,  A61L31/10 ,  A61Q19/00 ,  B32B27/40 ,  C08G18/302 ,  C08G18/4018 ,  C08G18/44 ,  C08G18/4808 ,  C08G18/4858 ,  C08G18/5096 ,  C08G18/61 ,  C08G18/6511 ,  C08G18/6607 ,  C08G18/6674 ,  C08G18/6681 ,  C08G18/758 ,  A61Q5/02 ,  A61Q5/12

Abstract: An improved amphiphilic diol is prepared with a controlled type and amount of alkylene glycol, hydrophobic and hydrophilic diol with diisocyanate and water. Critical selection of the type, molecular weight and ratios of hydrophilic to hydrophobic diol, isocyanate to hydroxyl groups, average molecular weight of the diol component, the amount of water in the reaction mixture produces a polyuretheane having high slip, Shore A Hardness values, wet tensile strength and tear strength. This invention also includes uses of the polyurethane in catheters, shaving products, synthetic valves, veins and arteries, stents, ports, shunts and coatings. Preferably, the polyurethane is used in combination with a filler for application to rubber gloves. In addition, dispersions, lotions, gels and solutions can be formed of the polyurethane.

Abstract translation: 用受控类型和量的亚烷基二醇，疏水和亲水的二醇与二异氰酸酯和水制备改进的两亲二醇。 关键选择亲水至疏水二醇，异氰酸酯与羟基的类型，分子量和比例，二醇组分的平均分子量，反应混合物中的水量产生具有高滑移，肖氏A硬度值，湿润 拉伸强度和撕裂强度。 本发明还包括聚氨酯在导管，剃须产品，合成瓣膜，静脉和动脉，支架，端口，分流器和涂层中的用途。 优选地，聚氨酯与用于橡胶手套的填料结合使用。 此外，分散体，洗剂，凝胶和溶液可以由聚氨酯形成。

公开(公告)号：US5563233A

公开(公告)日：1996-10-08

申请号：US340606

申请日：1994-11-16

Applicant: Murray H. Reich ,  Ken Nelson ,  Jirina Kuzma

Inventor： Murray H. Reich ,  Ken Nelson ,  Jirina Kuzma

IPC: A61K8/87 ,  A61L26/00 ,  A61L27/18 ,  A61Q15/00 ,  A61Q19/00 ,  C08G18/08 ,  C08G18/30 ,  C08G18/66 ,  C08G18/75 ,  C08L75/08

CPC classification number: A61K8/042 ,  A61K8/87 ,  A61L26/0019 ,  A61L27/18 ,  A61Q19/00 ,  C08G18/0857 ,  C08G18/302 ,  C08G18/6674 ,  C08G18/75 ,  C08G18/758 ,  A61Q15/00 ,  A61Q17/04 ,  C08G2210/00 ,  C08G2220/00 ,  Y10S424/13 ,  Y10T428/31551

Abstract: An improved polyurethane is prepared by reacting a diol component and an organic diisocyanate with critical selection of the amount of water in the reaction mixture and the diol component. The diol component is a long chain polyoxyethylene glycol optionally mixed with a low molecular weight polyoxyethylene glycol. A tough gel can be formed by mixing the polyurethane in a diol or triol and water solution. The tough gel can be used in burn and wound dressings, electroconductive pads, high slip materials and surgical implants. An optically clear gel can also be formed. Solutions and emulsions can be formed of the polymer and can be combined with fillers to form face creams and antiperspirants. A film can cover one side of the gel for burn and wound applications. The gel can be used in squeeze tubes and in spray cans in burn wound care dressings and industrial applications and in bags and containers for use in plastic surgery implants.

Abstract translation: 改进的聚氨酯通过使二醇组分和有机二异氰酸酯与反应混合物和二醇组分中的水量的临界选择反应来制备。 二醇组分是任选与低分子量聚氧乙烯二醇混合的长链聚氧乙二醇。 可以通过将聚氨酯混合在二醇或三醇和水溶液中来形成坚韧的凝胶。 坚韧的凝胶可用于烧伤和伤口敷料，导电垫，高滑动材料和外科植入物。 还可以形成光学透明的凝胶。 溶液和乳液可以由聚合物形成并且可与填料组合以形成面霜和止汗剂。 胶片可以覆盖凝胶的一面，用于烧伤和伤口应用。 该凝胶可用于挤压管和喷涂罐中，用于烧伤伤口护理敷料和工业应用以及用于整形手术植入物的袋子和容器中。