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公开(公告)号：US09662327B2
公开(公告)日：2017-05-30
申请号：US14126791
申请日：2012-06-18
申请人： Sheldon Cao , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Xuefei Tan , Jeremy Travins , Shunqi Yan , Zhixiong Ye
发明人： Sheldon Cao , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Xuefei Tan , Jeremy Travins , Shunqi Yan , Zhixiong Ye
IPC分类号： C07D491/052 , C07D401/04 , C07D519/00 , C07D217/22 , C07D471/04 , C07D405/12 , A61K31/496 , A61K31/519 , C07D217/26 , C07D413/04 , A61K31/551
CPC分类号： C07D491/052 , A61K31/496 , A61K31/519 , A61K31/551 , C07D217/22 , C07D217/26 , C07D401/04 , C07D405/12 , C07D413/04 , C07D471/04 , C07D519/00
摘要： Provided are compounds of formula (I), wherein X, Y, Z, W, V, R2, R3 and m are defined as in the description. Their pharmaceutical compositions and their uses for treating cancers are also provided.
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公开(公告)号：US08178553B2
公开(公告)日：2012-05-15
申请号：US12690633
申请日：2010-01-20
申请人： Brian J. Lavey , Joseph A. Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael K. C. Wong , Shankar B. Bandarpalle , Neng-Yang Shih , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Aneta Maria Kosinski , Seong-Heon Kim , De-Yi Yang , Razia K. Rizvi
发明人： Brian J. Lavey , Joseph A. Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael K. C. Wong , Shankar B. Bandarpalle , Neng-Yang Shih , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Aneta Maria Kosinski , Seong-Heon Kim , De-Yi Yang , Razia K. Rizvi
IPC分类号： A61K31/4178 , A61K31/437 , A61K31/4439 , A61P3/00 , A61P29/00 , A61P11/00 , C07D491/048 , C07D471/04 , C07D401/14 , C07D403/06
CPC分类号： C07D403/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-α or combinations thereof.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖蛋白酶，TNF-α或其组合介导的疾病或病症 。
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公开(公告)号：US20120010181A1
公开(公告)日：2012-01-12
申请号：US13127952
申请日：2009-11-09
申请人： Joseph A. Kozlowski , Wensheng Yu , Michael K.C. Wong , Seong Heon Kim , Ling Tong , Brian J. Lavey , Bandarpalle B. Shankar , De-Yi Yang , Robert Feltz , Aneta Maria Kosinski , Guowei Zhou , Razia K. Rizvi , Chaoyang Dai , Luke Fire , Vinay Girijavallabhan , Dansu Li , Janeta Popovici-Muller , Judson E. Richard , Kristen E. Rosner , M. Arshad Siddiqui , Liping Yang
发明人： Joseph A. Kozlowski , Wensheng Yu , Michael K.C. Wong , Seong Heon Kim , Ling Tong , Brian J. Lavey , Bandarpalle B. Shankar , De-Yi Yang , Robert Feltz , Aneta Maria Kosinski , Guowei Zhou , Razia K. Rizvi , Chaoyang Dai , Luke Fire , Vinay Girijavallabhan , Dansu Li , Janeta Popovici-Muller , Judson E. Richard , Kristen E. Rosner , M. Arshad Siddiqui , Liping Yang
IPC分类号： A61K31/4178 , C07D401/14 , C07D491/052 , C07D413/14 , C07D417/14 , C07D403/14 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/436 , A61K31/5377 , A61K31/541 , A61K31/551 , A61P29/00 , A61P19/02 , A61P1/02 , A61P35/00 , A61P35/04 , A61P25/00 , A61P27/06 , A61P1/00 , A61P17/06 , A61P9/00 , A61P31/18 , A61P31/04 , C07D403/06
CPC分类号： C07D403/14
摘要： This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF—or combinations thereof.
摘要翻译： 本发明涉及式（I）的化合物：（化学式应该插在这里，它以纸的形式出现）（I）或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗 由MMP，ADAM，TACE，聚蛋白聚糖蛋白聚糖酶，TNF-或其组合介导的疾病或病症。
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公开(公告)号：US20090156586A1
公开(公告)日：2009-06-18
申请号：US12364845
申请日：2009-02-03
申请人： Brian J. Lavey , Joseph A. Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael K. C. Wong , Bandarpalle B. Shankar , Neng-Yang Shih , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Razia Rizvi , Lei Chen , De-Yi Yang , Robert Feltz , Seong Heon Kim
发明人： Brian J. Lavey , Joseph A. Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael K. C. Wong , Bandarpalle B. Shankar , Neng-Yang Shih , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Razia Rizvi , Lei Chen , De-Yi Yang , Robert Feltz , Seong Heon Kim
IPC分类号： A61K31/4178 , C07D403/06 , C07D401/14 , C07D403/14 , C07D409/14 , C07D417/14 , C07D413/14 , A61K31/427 , A61K31/517 , A61K31/54 , A61K31/5377 , A61K31/4725 , A61K31/4709 , A61K31/4439 , A61K31/506
CPC分类号： C07D403/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-α or combinations thereof.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖蛋白酶，TNF-α或其组合介导的疾病或病症 。
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公开(公告)号：US07524842B2
公开(公告)日：2009-04-28
申请号：US11653511
申请日：2007-01-16
申请人： Brian J. Lavey , Joseph A. Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael K. C. Wong , Bandarpalle B. Shankar , Neng-Yang Shih , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Razia Rizvi , Lei Chen , De-Yi Yang , Robert Feltz , Seong Heon Kim
发明人： Brian J. Lavey , Joseph A. Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael K. C. Wong , Bandarpalle B. Shankar , Neng-Yang Shih , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Razia Rizvi , Lei Chen , De-Yi Yang , Robert Feltz , Seong Heon Kim
IPC分类号： A61K31/428 , A61K31/4015 , A61K31/4166 , C07D209/04 , C07D233/24 , C07D277/34 , C07D417/06
CPC分类号： C07D403/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-α or combinations thereof.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖蛋白酶，TNF-α或其组合介导的疾病或病症 。
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公开(公告)号：US20160046579A1
公开(公告)日：2016-02-18
申请号：US14776635
申请日：2014-03-13
申请人： Giovanni CIANCHETTA , Janeta POPOVICI-MULLER , Robert ZAHLER , Sheldon CAO , Xiaolei WANG , Zhixiong YE , AGIOS PHARMACEUTICALS, INC.
发明人： Giovanni Cianchetta , Janeta Popovici-Muller , Robert Zahler , Sheldon Cao , Xiaolei Wang , Zhixiong Ye
IPC分类号： C07D211/48 , C07D405/12 , C07D417/12 , C07D401/14 , C07D417/14 , C07F9/6558 , C07D405/14 , C07D413/12 , C07D471/04 , C07D513/04 , C07D413/14 , C07D401/12 , C07D495/04
CPC分类号： C07D401/12 , C07D211/48 , C07D211/52 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04 , C07F9/65583
摘要： Compounds of general formula (I) and compositions comprising compounds of general formula (I) that modulate pyruvate kinase are described herein. Also described herein are methods of using the compounds that modulate pyruvate kinase in the treatment of diseases.
摘要翻译： 本文描述了通式（I）的化合物和包含调节丙酮酸激酶的通式（I）化合物的组合物。 本文还描述了使用调节丙酮酸激酶的化合物治疗疾病的方法。
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公开(公告)号：US09108921B2
公开(公告)日：2015-08-18
申请号：US14210583
申请日：2014-03-14
申请人： Giovanni Cianchetta , Janeta Popovici-Muller , Robert Zahler , Sheldon Cao , Xiaolei Wang , Zhixiong Ye
发明人： Giovanni Cianchetta , Janeta Popovici-Muller , Robert Zahler , Sheldon Cao , Xiaolei Wang , Zhixiong Ye
IPC分类号： A61K31/4709 , C07D401/12 , C07D211/52 , C07D401/14 , C07D417/12 , C07D413/12 , C07D211/48 , C07D405/12 , C07D417/14
CPC分类号： C07D401/12 , C07D211/48 , C07D211/52 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04 , C07F9/65583
摘要： Compounds of general formula I: and compositions comprising compounds of general formula I that modulate pyruvate kinase are described herein. Also described herein are methods of using the compounds that modulate pyruvate kinase in the treatment of diseases.
摘要翻译： 本文描述了通式I的化合物和包含调节丙酮酸激酶的通式I化合物的组合物。 本文还描述了使用调节丙酮酸激酶的化合物治疗疾病的方法。
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公开(公告)号：US08569336B2
公开(公告)日：2013-10-29
申请号：US13127953
申请日：2009-11-09
申请人： Ling Tong , Brian J. Lavey , Bandarpalle B. Shankar , Seong Heon Kim , Wensheng Yu , Joseph A. Kozlowski , Michael K. C. Wong , Lei Chen , Guowei Zhou , Razia K. Rizvi , Robert Feltz , Aneta Maria Kosinski , De-Yi Yang , Chaoyang Dai , Luke Fire , Vinay Girijavallabhan , Dansu Li , Janeta Popovici-Muller , Judson E. Richard , Kristin E. Rosner , M. Arshad Siddiqui , Liping Yang
发明人： Ling Tong , Brian J. Lavey , Bandarpalle B. Shankar , Seong Heon Kim , Wensheng Yu , Joseph A. Kozlowski , Michael K. C. Wong , Lei Chen , Guowei Zhou , Razia K. Rizvi , Robert Feltz , Aneta Maria Kosinski , De-Yi Yang , Chaoyang Dai , Luke Fire , Vinay Girijavallabhan , Dansu Li , Janeta Popovici-Muller , Judson E. Richard , Kristin E. Rosner , M. Arshad Siddiqui , Liping Yang
IPC分类号： A61K31/4166 , A61K31/4178 , A61K31/4439 , A61K31/454 , A61K31/506 , C07D233/76 , C07D213/24
CPC分类号： C07D498/04 , C07D513/00 , C07D519/00
摘要： This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.
摘要翻译： 本发明涉及式（I）的化合物：（化学式应该插在这里，它以纸的形式出现）（I）或其药学上可接受的盐，其可用于治疗疾病或病症介导 通过MMP，ADAM，TACE，聚蛋白聚糖蛋白聚糖酶，TNF-或其组合。
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公开(公告)号：US20130184222A1
公开(公告)日：2013-07-18
申请号：US13810410
申请日：2011-07-15
申请人： Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey Saunders , Jeremy Travins , Shunqi Yan
发明人： Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey Saunders , Jeremy Travins , Shunqi Yan
IPC分类号： C07C237/22 , C07D333/24 , C07D409/12 , C07D319/20 , C07C271/58 , C07D237/14 , C07D241/12 , C07D233/64 , C07C311/13 , C07K5/065 , C07D317/68
CPC分类号： C07K5/06078 , A61K38/00 , C07C237/22 , C07C271/22 , C07C271/44 , C07C271/58 , C07C311/06 , C07C311/13 , C07C311/19 , C07C317/36 , C07C335/32 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D207/10 , C07D207/16 , C07D209/08 , C07D209/14 , C07D209/26 , C07D209/42 , C07D209/44 , C07D211/14 , C07D211/38 , C07D211/54 , C07D211/60 , C07D213/30 , C07D213/38 , C07D213/56 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/74 , C07D217/04 , C07D221/18 , C07D231/12 , C07D231/42 , C07D231/56 , C07D233/61 , C07D233/64 , C07D233/70 , C07D233/88 , C07D235/04 , C07D237/14 , C07D239/26 , C07D241/12 , C07D249/04 , C07D249/18 , C07D253/06 , C07D257/04 , C07D261/18 , C07D265/36 , C07D271/06 , C07D271/10 , C07D277/28 , C07D277/30 , C07D277/56 , C07D295/04 , C07D295/205 , C07D305/08 , C07D307/20 , C07D307/22 , C07D309/12 , C07D309/14 , C07D317/68 , C07D319/20 , C07D333/24 , C07D333/38 , C07D409/12 , C07D471/04
摘要： Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1 comprising administering to a subject in need thereof a compound described here.
摘要翻译： 提供治疗以IDH1突变等位基因存在为特征的癌症的方法，其包括向有需要的受试者施用本文所述的化合物。
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公开(公告)号：US07652020B2
公开(公告)日：2010-01-26
申请号：US11142601
申请日：2005-06-01
申请人： Zhuyan Guo , Peter Orth , Zhaoning Zhu , Robert D. Mazzola , Tin-Yau Chan , Henry A. Vaccaro , Brian McKittrick , Joseph A. Kozlowski , Brian J. Lavey , Guowei Zhou , Sunil Paliwal , Shing-Chun Wong , Neng-Yang Shih , Pauline C. Ting , Kristin E. Rosner , Gerald W. Shipps, Jr. , M. Arshad Siddiqui , David B. Belanger , Chaoyang Dai , Dansu Li , Vinay M. Girijavallabhan , Janeta Popovici-Muller , Wensheng Yu , Lianyun Zhao
发明人： Zhuyan Guo , Peter Orth , Zhaoning Zhu , Robert D. Mazzola , Tin-Yau Chan , Henry A. Vaccaro , Brian McKittrick , Joseph A. Kozlowski , Brian J. Lavey , Guowei Zhou , Sunil Paliwal , Shing-Chun Wong , Neng-Yang Shih , Pauline C. Ting , Kristin E. Rosner , Gerald W. Shipps, Jr. , M. Arshad Siddiqui , David B. Belanger , Chaoyang Dai , Dansu Li , Vinay M. Girijavallabhan , Janeta Popovici-Muller , Wensheng Yu , Lianyun Zhao
IPC分类号： A61K31/519 , A61K31/506 , A61K31/4709 , A61K31/43 , A61K31/4245 , C07D413/00 , C07D241/36 , C07D471/00 , C07D295/00 , C07D471/02 , C07D401/00 , C07D513/00 , C07D277/22 , C07D277/62 , C07D263/30 , C07D261/06 , C07D235/00 , C07D209/04 , C07D207/00 , C07D205/00 , C07D409/00 , C07D307/00
CPC分类号： C07D409/14 , C07C235/06 , C07C235/08 , C07C235/10 , C07C2601/08 , C07D207/20 , C07D207/26 , C07D209/44 , C07D215/14 , C07D217/06 , C07D263/32 , C07D295/185 , C07D307/52 , C07D333/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D513/04
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF-α or combinations thereof.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗由MMP，ADAM，TACE，TNF-α或其组合介导的疾病或病症。
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