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公开(公告)号：US08124026B2
公开(公告)日：2012-02-28
申请号：US12718139
申请日：2010-03-05
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01L2200/0673 , B01L2200/10 , B01L2300/0816 , B01L2400/0406 , B01L2400/0418 , F04B19/006 , Y10T436/2575
摘要： Devices with lateral flow elements and integral fluidics are disclosed. The integral fluidics consist of injector pumps comprised of fluidic elements under instrument control. The fluidic element of an injector pump is fluidically connected to lateral flow elements and can be used to control fluid entry into containment chambers referred to as micro-reactors. The lateral flow elements comprise conductor elements that can be used for sample application and transport of analyte contained in the sample to the micro-reactor. Fluidic transport through the fluidic element of the injector pump is under instrument-control. Both the lateral flow element and the fluidic element may contain chemical entities incorporated along their length. The chemical reactions that can be used for analyte detection using the devices are described. Also described are methods of manufacture of these devices.
摘要翻译： 公开了具有侧向流动元件和整体流体的装置。 积分流体由在仪器控制下由流体元素组成的喷射泵组成。 注射器泵的流体元件流体连接到侧向流动元件，并且可以用于控制流体进入称为微反应器的容纳室中。 横向流动元件包括导体元件，其可以用于将样品中包含的分析物的样品应用和运送到微反应器。 通过注射泵的流体元件的流体传输是在仪器控制下。 侧流元件和流体元件都可以包含沿其长度并入的化学物质。 描述了可用于使用装置进行分析物检测的化学反应。 还描述了这些装置的制造方法。
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公开(公告)号：US06458165B1
公开(公告)日：2002-10-01
申请号：US10042343
申请日：2002-01-11
申请人： Daniel A. Foucher , Raj D. Patel , Naveen Chopra , Peter M. Kazmaier , James Wojtyk , Erwin Buncel
发明人： Daniel A. Foucher , Raj D. Patel , Naveen Chopra , Peter M. Kazmaier , James Wojtyk , Erwin Buncel
IPC分类号： G09F932
CPC分类号： G03G9/0906 , G03G9/0912 , G03G9/0914
摘要： Disclosed are marking particles comprising a first polymer a second polymer, a chelating agent, and a spiropyran material of the formula wherein n is an integer representing the number of repeat —CH2— units and R is —H or —CH═CH2. The marking particles comprise a core containing the first polymer in which is dispersed the chelating agent and the spiropyran and encapsulated within a shell of the second polymer formulated by an interfacial polymerization.
摘要翻译： 公开了包含第一聚合物的标记颗粒，第二聚合物，螯合剂和糠醛的螺吡喃材料，n是表示重复-CH 2 - 单元的数目并且R为-H或-CH = CH 2的整数。 标记颗粒包含含有第一聚合物的核心，其中分散有螯合剂和螺吡喃并包封在通过界面聚合配制的第二聚合物的壳体内。
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公开(公告)号：US20100202926A1
公开(公告)日：2010-08-12
申请号：US12718139
申请日：2010-03-05
CPC分类号： B01L3/50273 , B01L2200/0673 , B01L2200/10 , B01L2300/0816 , B01L2400/0406 , B01L2400/0418 , F04B19/006 , Y10T436/2575
摘要： Devices with lateral flow elements and integral fluidics are disclosed. The integral fluidics consist of injector pumps comprised of fluidic elements under instrument control. The fluidic element of an injector pump is fluidically connected to lateral flow elements and can be used to control fluid entry into containment chambers referred to as micro-reactors. The lateral flow elements comprise conductor elements that can be used for sample application and transport of analyte contained in the sample to the micro-reactor. Fluidic transport through the fluidic element of the injector pump is under instrument-control. Both the lateral flow element and the fluidic element may contain chemical entities incorporated along their length. The chemical reactions that can be used for analyte detection using the devices are described. Also described are methods of manufacture of these devices.
摘要翻译： 公开了具有侧向流动元件和整体流体的装置。 积分流体由在仪器控制下由流体元素组成的喷射泵组成。 注射器泵的流体元件流体连接到侧向流动元件，并且可以用于控制流体进入称为微反应器的容纳室中。 横向流动元件包括导体元件，其可以用于将样品中包含的分析物的样品应用和运送到微反应器。 通过注射泵的流体元件的流体传输是在仪器控制下。 侧流元件和流体元件都可以包含沿其长度并入的化学物质。 描述了可用于使用装置进行分析物检测的化学反应。 还描述了这些装置的制造方法。
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公开(公告)号：US06365312B1
公开(公告)日：2002-04-02
申请号：US09864475
申请日：2001-05-24
申请人： Daniel A. Foucher , Raj D. Patel , Naveen Chopra , Peter M. Kazmaier , James Wojtyk , Erwin Buncel
发明人： Daniel A. Foucher , Raj D. Patel , Naveen Chopra , Peter M. Kazmaier , James Wojtyk , Erwin Buncel
IPC分类号： G03G909
CPC分类号： G03G9/0906 , G03G9/0912 , G03G9/0914
摘要： Disclosed are marking particles comprising a first polymer, a second polymer, a chelating agent, and a spiropyran material of the formula wherein n is an integer representing the number of repeat —CH2— units and R is —H or —CH═CH2. The marking particles comprise a core containing the first polymer in which is dispersed the chelating agent and the spiropyran and encapsulated within a shell of the second polymer formulated by an interfacial polymerization.
摘要翻译： 公开了包含第一聚合物，第二聚合物，螯合剂和糠醛的螺吡喃材料的标记颗粒，n是表示重复-CH 2 - 单元的数目的整数，R是-H或-CH = CH 2。 标记颗粒包含含有第一聚合物的核心，其中分散有螯合剂和螺吡喃并包封在通过界面聚合配制的第二聚合物的壳体内。
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公开(公告)号：US07201833B2
公开(公告)日：2007-04-10
申请号：US10307468
申请日：2002-12-02
IPC分类号： G01N33/487
CPC分类号： B01L3/5023 , B01J2219/00286 , B01J2219/00358 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00722 , B01J2219/00725 , B01J2219/00783 , B01J2219/00831 , B01J2219/00853 , B01J2219/0086 , B01L3/502707 , B01L3/50273 , B01L3/502753 , B01L2200/12 , B01L2200/16 , B01L2300/0645 , B01L2300/0825 , B01L2300/10 , B01L2400/0415 , B01L2400/0418 , G01N33/6845 , G01N2035/00158
摘要： The invention is directed to analytical devices and micro-arrays with integral fluidic inputs and outputs. The devices are constructed from planar solid-phase hydrophilic matrix circuits containing dry chemical reagents overlaying integral electro-kinetic pumping electrodes. The hydrophilic matrix circuits are enclosed within a gas permeable electrical insulator. The devices are for use in micro-scale bio-analysis, mixture separation and reaction.
摘要翻译： 本发明涉及具有积分流体输入和输出的分析装置和微阵列。 这些器件由平面固相亲水基质电路构成，其包含覆盖整体电动泵浦电极的干化学试剂。 亲水基质电路封闭在透气电绝缘体内。 该装置用于微量生物分析，混合物分离和反应。
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公开(公告)号：US06677163B1
公开(公告)日：2004-01-13
申请号：US09713300
申请日：2000-11-16
IPC分类号： G01N33552
CPC分类号： C07H15/26 , G01N33/54353 , G01N33/552 , Y10S436/823
摘要： Provided is a method for modifying silicon with an organic molecule, under mild conditions. If the attached molecule is bi-functional, it may be subsequently reacted with a bio-molecule, to form a covalently attached layer of bio-molecule on the silicon surface.
摘要翻译： 提供了在温和条件下用有机分子改性硅的方法。 如果连接的分子是双功能的，则其可以随后与生物分子反应，以在硅表面上形成共价连接的生物分子层。
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公开(公告)号：US06549327B2
公开(公告)日：2003-04-15
申请号：US09864386
申请日：2001-05-24
申请人： Daniel A. Foucher , Raj D. Patel , Naveen Chopra , Peter M. Kazmaier , Erwin Buncel , James Wojtyk
发明人： Daniel A. Foucher , Raj D. Patel , Naveen Chopra , Peter M. Kazmaier , Erwin Buncel , James Wojtyk
IPC分类号： G09G308
CPC分类号： G02B26/026 , C07D491/10
摘要： Disclosed is a display comprising an arrangement of a plurality of optically anisotropic rotatable elements, each of the rotatable elements having a surface in contact with an enabling fluid, the rotatable elements being electrically dipolar in the presence of the enabling fluid and thus being subject to rotation upon application of an electric field, the rotatable elements being free to rotate in place but not free to translate substantially so as to disrupt the arrangement of rotatable elements, wherein a first portion of the surface contains a mixture of a chelating agent and a spiropyran material of the formula wherein n is an integer representing the number of repeat —CH2— units and R is —H or —CH═CH2, and wherein a second portion of the surface contains substantially no spiropyran.
摘要翻译： 公开了一种显示器，其包括多个光学各向异性可旋转元件的布置，每个可旋转元件具有与启用流体接触的表面，可旋转元件在有效流体存在的情况下是电偶极性的，因此被旋转 在施加电场时，可旋转元件可自由旋转到位，但不能自由平移以便基本上平移以便破坏可旋转元件的布置，其中表面的第一部分包含螯合剂和螺吡喃材料的混合物 其中n是表示重复-CH 2 - 单元的数目的整数，并且R是-H或-CH = CH 2，并且其中该表面的第二部分基本上不含螺吡喃。
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公开(公告)号：US07722817B2
公开(公告)日：2010-05-25
申请号：US10649683
申请日：2003-08-28
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01L2200/0673 , B01L2200/10 , B01L2300/0816 , B01L2400/0406 , B01L2400/0418 , F04B19/006 , Y10T436/2575
摘要： Devices with lateral flow elements and integral fluidics are disclosed. The integral fluidics consist of injector pumps comprised of fluidic elements under instrument control. The fluidic element of an injector pump is fluidically connected to lateral flow elements and can be used to control fluid entry into containment chambers referred to as micro-reactors. The lateral flow elements comprise conductor elements that can be used for sample application and transport of analyte contained in the sample to the micro-reactor. Fluidic transport through the fluidic element of the injector pump is under instrument-control. Both the lateral flow element and the fluidic element may contain chemical entities incorporated along their length. The chemical reactions that can be used for analyte detection using the devices are described. Also described are methods of manufacture of these devices.
摘要翻译： 公开了具有侧向流动元件和整体流体的装置。 积分流体由在仪器控制下由流体元素组成的喷射泵组成。 注射器泵的流体元件流体连接到侧向流动元件，并且可以用于控制流体进入称为微反应器的容纳室中。 横向流动元件包括导体元件，其可以用于将样品中包含的分析物的样品应用和运送到微反应器。 通过注射泵的流体元件的流体传输是在仪器控制下。 侧流元件和流体元件都可以包含沿其长度并入的化学物质。 描述了可用于使用装置进行分析物检测的化学反应。 还描述了这些装置的制造方法。
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公开(公告)号：US20050047972A1
公开(公告)日：2005-03-03
申请号：US10649683
申请日：2003-08-28
申请人： Imants Lauks , Raymond Pierce , James Wojtyk , Benoit Bergevin
发明人： Imants Lauks , Raymond Pierce , James Wojtyk , Benoit Bergevin
CPC分类号： B01L3/50273 , B01L2200/0673 , B01L2200/10 , B01L2300/0816 , B01L2400/0406 , B01L2400/0418 , F04B19/006 , Y10T436/2575
摘要： Devices with lateral flow elements and integral fluidics are disclosed. The integral fluidics consist of injector pumps comprised of fluidic elements under instrument control. The fluidic element of an injector pump is fluidically connected to lateral flow elements and can be used to control fluid entry into containment chambers referred to as micro-reactors. The lateral flow elements comprise conductor elements that can be used for sample application and transport of analyte contained in the sample to the micro-reactor. Fluidic transport through the fluidic element of the injector pump is under instrument-control. Both the lateral flow element and the fluidic element may contain chemical entities incorporated along their length. The chemical reactions that can be used for analyte detection using the devices are described. Also described are methods of manufacture of these devices.
摘要翻译： 公开了具有侧向流动元件和整体流体的装置。 积分流体由在仪器控制下由流体元素组成的喷射泵组成。 注射器泵的流体元件流体连接到侧向流动元件，并且可以用于控制流体进入称为微反应器的容纳室中。 横向流动元件包括导体元件，其可以用于将样品中包含的分析物的样品应用和运送到微反应器。 通过注射泵的流体元件的流体传输是在仪器控制下。 侧流元件和流体元件都可以包含沿其长度并入的化学物质。 描述了可用于使用装置进行分析物检测的化学反应。 还描述了这些装置的制造方法。
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公开(公告)号：US06517618B2
公开(公告)日：2003-02-11
申请号：US09864902
申请日：2001-05-24
申请人： Daniel A. Foucher , Raj D. Patel , Naveen Chopra , Peter M. Kazmaier , James Wojtyk , Erwin Buncel
发明人： Daniel A. Foucher , Raj D. Patel , Naveen Chopra , Peter M. Kazmaier , James Wojtyk , Erwin Buncel
IPC分类号： C09D1100
CPC分类号： C09D11/50 , G02F2001/1678
摘要： Disclosed is an electrophoretic ink comprising a suspending fluid and, suspended in the suspending fluid, a plurality of particles comprising a mixture of a chelating agent and a spiropyran material of the formula wherein n is an integer representing the number of repeat —CH2— units and R is —H or —CH═CH2, the particles being free to migrate within the suspending fluid under the influence of an electric field.
摘要翻译： 公开了一种包含悬浮液并且悬浮在悬浮液中的多个包含螯合剂和糠醛的螺吡喃物质的混合物的颗粒的电泳墨水，n是表示重复-CH 2 - 单元数目的整数，并且R 是-H或-CH = CH 2，颗粒在电场的影响下在悬浮液中自由迁移。
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