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公开(公告)号:US20110124028A1
公开(公告)日:2011-05-26
申请号:US12780126
申请日:2010-05-14
申请人: RONNIE J. ROBINSON , MARK JOSEPH FANNING , STANLEY MICHAEL PHILIPAK , RICHARD SCOTT REMES , JAMES CLEMENT BISHOP , GARY W. SOMMER , LAWRENCE E. GUERRA , MICHAEL A. HERRON
发明人: RONNIE J. ROBINSON , MARK JOSEPH FANNING , STANLEY MICHAEL PHILIPAK , RICHARD SCOTT REMES , JAMES CLEMENT BISHOP , GARY W. SOMMER , LAWRENCE E. GUERRA , MICHAEL A. HERRON
CPC分类号: C12Q1/04 , C12M41/36 , C12Q1/02 , G01N35/00603 , G01N35/0099 , G01N35/026 , G01N2035/00148 , G01N2035/0406 , G01N2035/0453 , G01N2035/0465
摘要: A method and automated apparatus for rapid non-invasive detection of a microbial agent in a test sample is described herein. The apparatus may include one or more means for automated loading, automated transfer and/or automated unloading of a specimen container. The apparatus also includes a detection system for receiving a detection container, e.g., container or vial, containing a biological sample and culture media. The detection system may also include one or more heated sources, holding structures or racks, and/or a detection unit for monitoring and/or interrogating the specimen container to detect whether the container is positive for the presence of a microbial agent therein. In other embodiment, the automated instrument may include one or more, bar code readers, scanners, cameras, and/or weighing stations to aid in scanning, reading, imaging and weighing of specimen containers within the system.
摘要翻译: 本文描述了用于在测试样品中快速非侵入性检测微生物剂的方法和自动化装置。 该装置可以包括用于自动装载,自动转移和/或自动卸载标本容器的一种或多种装置。 该装置还包括用于接收包含生物样品和培养基的检测容器(例如容器或小瓶)的检测系统。 检测系统还可以包括一个或多个加热源,保持结构或架,和/或检测单元,用于监测和/或询问标本容器,以检测容器对于其中是否存在微生物剂是正的。 在另一个实施例中,自动化仪器可以包括一个或多个条形码阅读器,扫描器,照相机和/或称重站,以帮助对系统内的标本容器进行扫描,读取,成像和称重。
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公开(公告)号:US07578978B2
公开(公告)日:2009-08-25
申请号:US10695038
申请日:2003-10-28
IPC分类号: B01L9/00
CPC分类号: B01L9/527 , G01N35/00029 , G01N2035/00148 , G01N2035/0465 , Y10T436/113332 , Y10T436/2575
摘要: A carrier for holding up to N test sample devices as they are moved through a sample testing instrument. Each of the test sample devices are held in a receiving structure such as a slot in the carrier. The carrier also includes N optical interrupt positioning features, each placed in registry with one of the receiving structures (and thereby in registry with the test sample device). The instrument includes fixed optical interrupt sensors for detecting the position of the positioning feature as the carrier is moved through the instrument. In the illustrated embodiment, the position features comprise voids formed in a rib on the lower surface of the carrier. The optical interrupt sensors are positioned below the path the carrier travels over, whereby as the carrier moves past the sensor the voids, and hence position of the test sample devices, are detected.
摘要翻译: 用于在通过样品测试仪器移动时最多可容纳N个测试样品装置的载体。 每个测试样本装置保持在诸如载体中的槽的接收结构中。 载波还包括N个光学中断定位功能,每个功能都放置在其中一个接收结构的注册中(从而与测试样本设备注册)。 仪器包括固定光学中断传感器,用于在载体移动通过仪器时检测定位特征的位置。 在所示实施例中,位置特征包括形成在载体的下表面上的肋中的空隙。 光学中断传感器定位在载体行进路径的下方,由此当载体移动通过传感器时,检测到空隙,从而检测测试样品装置的位置。
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公开(公告)号:US20080156114A1
公开(公告)日:2008-07-03
申请号:US12074997
申请日:2008-03-06
CPC分类号: G01N21/13 , G01N35/00029 , G01N2035/00148 , G01N2035/0465 , G01N2035/0491 , Y10T436/11 , Y10T436/113332
摘要: A transport system is provided for a sample testing machine. The transport system includes a carrier holding a set of test sample devices and a drive subsystem for moving the carrier through the sample testing machine. The drive subsystem includes a reciprocating motor-driven block engaging the carrier and moving the carrier back and forth in a predetermined longitudinal path extending along a longitudinal axis from an entrance station to a plurality of processing stations in the sample testing machine. The processing stations are accessed as the carrier is moved along the path. The carrier includes features in the form of slots or voids that are detected by strategically placed optical interrupt sensors. As the carrier moves, the slots are detected by the sensors to thereby continuously track the position of the carrier and the test devices as they are moved through the instrument.
摘要翻译: 为样品测试机提供运输系统。 运输系统包括一个承载一组测试样品装置的托架和用于使载体移动通过样品测试机的驱动子系统。 驱动子系统包括一个往复运动的马达驱动的块,其与载体相接合,并以沿着纵向轴线从入口站到样品测试机中的多个处理站的预定纵向路径来回移动载体。 当载体沿着路径移动时,处理站被访问。 载体包括通过策略放置的光中断传感器检测到的槽或空隙形式的特征。 当载体移动时,通过传感器检测槽,从而在载体和测试装置移动通过仪器时连续跟踪载体和测试装置的位置。
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公开(公告)号:US5881781A
公开(公告)日:1999-03-16
申请号:US799475
申请日:1997-02-12
申请人: James Clement Bishop
发明人: James Clement Bishop
CPC分类号: G01N35/00029 , Y10T436/119163
摘要: A diluting station and a pipetting station for a machine such as a biological sample testing machine. The diluting station has a rotating shot tube that fills with diluent without the need for priming when the shot tube is in a vertically inclined orientation, and which dispenses the diluent into a receptacle when the shot tube is rotated to a downward orientation. A thimble valve is placed in the shot tube to control the flow of diluent into the valve.The pipetting station includes a cylindrical housing storing a plurality of straws and a concentric rotating drum that sweeps a straw into a straw withdrawal slot. A tubular tapered transfer pin is inserted into frictional engagement with the straw. The tubular transfer pin rotates the straw out of the slot and into a generally downward orientation towards a receptacle containing a fluid. The pin and straw are lowered so as to place the end of the straw into the fluid. The fluid is withdrawn into the straw by means of vacuum applied to the tubular tapered transfer pin. The pin and straw are then raised out of the fluid. The fluid can then be deposited into a second receptacle that is moved below the straw and transfer pin by lowering the straw into the second receptacle and releasing the vacuum.
摘要翻译: 用于机器的稀释站和移液站,例如生物样品测试机。 稀释站具有旋转喷射管,其在喷射管处于垂直倾斜的方向时填充稀释剂而不需要起泡,并且当喷射管旋转到向下的方向时,稀释站将稀释剂分配到容器中。 将喷射阀放置在喷射管中以控制稀释剂进入阀门的流量。 移液站包括一个储存多个吸管的圆柱形外壳和一个将吸管扫入吸管槽的同心旋转鼓。 管状锥形传递销插入与吸管摩擦接合。 管状传送销将吸管从狭槽中旋转并且朝向包含流体的容器大致向下的方向旋转。 销和秸秆被降下,以将秸秆的末端放入流体中。 通过施加到管状锥形传递销的真空将流体抽吸到吸管中。 然后将针和吸管从液体中升出。 然后可以将流体沉积到通过将吸管降低到第二容器中并释放真空而移动到吸管和传送销下方的第二容器中。
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公开(公告)号:US10006074B2
公开(公告)日:2018-06-26
申请号:US12780126
申请日:2010-05-14
申请人: Ronnie J. Robinson , Mark Joseph Fanning , Stanley Michael Philipak , Richard Scott Remes , James Clement Bishop , Gary W. Sommer , Lawrence E. Guerra , Michael A. Herron
发明人: Ronnie J. Robinson , Mark Joseph Fanning , Stanley Michael Philipak , Richard Scott Remes , James Clement Bishop , Gary W. Sommer , Lawrence E. Guerra , Michael A. Herron
CPC分类号: C12Q1/04 , C12M41/36 , C12Q1/02 , G01N35/00603 , G01N35/0099 , G01N35/026 , G01N2035/00148 , G01N2035/0406 , G01N2035/0453 , G01N2035/0465
摘要: A method and automated apparatus for rapid non-invasive detection of a microbial agent in a test sample is described herein. The apparatus may include one or more means for automated loading, automated transfer and/or automated unloading of a specimen container. The apparatus also includes a detection system for receiving a detection container, e.g., container or vial, containing a biological sample and culture media. The detection system may also include one or more heated sources, holding structures or racks, and/or a detection unit for monitoring and/or interrogating the specimen container to detect whether the container is positive for the presence of a microbial agent therein. In other embodiment, the automated instrument may include one or more, bar code readers, scanners, cameras, and/or weighing stations to aid in scanning, reading, imaging and weighing of specimen containers within the system.
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公开(公告)号:US09150900B2
公开(公告)日:2015-10-06
申请号:US12780322
申请日:2010-05-14
CPC分类号: C12Q1/04 , C12M41/36 , C12Q1/02 , G01N35/00603 , G01N35/0099 , G01N35/026 , G01N2035/00148 , G01N2035/0406 , G01N2035/0453 , G01N2035/0465
摘要: The present invention is directed to a method and automated transfer means for transferring a container within an apparatus. The apparatus of the present invention may include a means for automated loading, a means for automated transfer and/or a means for automated unloading of a container (e.g., a specimen container). In one embodiment, the apparatus can be an automated detection apparatus for rapid non-invasive detection of a microbial agent in a test sample. The detection system also including a heated enclosure, a holding means or rack, and/or a detection unit for monitoring and/or interrogating the specimen container to detect whether the container is positive for the presence of a microbial agent. In other embodiment, the automated instrument may include one or more, bar code readers, scanners, cameras, and/or weighing stations to aid in scanning, reading, imaging and weighing of specimen containers within the system.
摘要翻译: 本发明涉及一种用于在装置内转移容器的方法和自动转移装置。 本发明的装置可以包括用于自动装载的装置,用于自动转移的装置和/或用于容器(例如,样本容器)的自动卸载的装置。 在一个实施例中,该装置可以是用于在测试样品中快速非侵入式检测微生物剂的自动检测装置。 检测系统还包括加热的外壳,保持装置或搁架,和/或检测单元,用于监测和/或询问样本容器,以检测容器对微生物剂的存在是否为阳性。 在另一个实施例中,自动化仪器可以包括一个或多个条形码阅读器,扫描器,照相机和/或称重站,以帮助对系统内的标本容器进行扫描,读取,成像和称重。
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公开(公告)号:US5856193A
公开(公告)日:1999-01-05
申请号:US838983
申请日:1997-04-23
申请人: Mark Joseph Fanning , Jean-Pierre Bernard Gayral , Clifford W. Karl , Bernard Jean Marie Limon , Donald Meyer , Roger James Morris , Ron Robinson , William Ernest Seaton , David B. Shine , Paul Springer , James Clement Bishop , Craig Drager , Thomas Burchard , David Chastain , Stephen Guerrera , Andrew Moore , David Porat , Arthur Rousmaniere , Andrew Zeigler
发明人: Mark Joseph Fanning , Jean-Pierre Bernard Gayral , Clifford W. Karl , Bernard Jean Marie Limon , Donald Meyer , Roger James Morris , Ron Robinson , William Ernest Seaton , David B. Shine , Paul Springer , James Clement Bishop , Craig Drager , Thomas Burchard , David Chastain , Stephen Guerrera , Andrew Moore , David Porat , Arthur Rousmaniere , Andrew Zeigler
CPC分类号: B01L3/50 , G01N35/00029 , G01N1/38 , G01N2035/00089 , G01N2035/00138 , G01N2035/00148 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/115831 , Y10T436/119163 , Y10T436/25625 , Y10T436/2575
摘要: An automatic sample testing machine for testing samples stored in test cards. The machine has a test sample positioning system for moving a tray containing a plurality of test sample cards and fluid receptacles among various stations in the machine. The machine has a diluting station for adding a predetermined quantity of diluent to the receptacles as needed. A pipetting station transfers fluid from one receptacle to another. A vacuum station is provided having a vacuum chamber moveable relative to the tray between upper and lower positions. The chamber cooperates with the tray to make a sealing engagement with the top surface of the tray when it is lowered to the lower position. A vacuum generator supplies vacuum to the chamber. When the vacuum is released from the chamber, the fluid samples are loaded into the cards from the receptacles. The test sample positioning system moves the tray to a cutting and sealing station and then to an incubation station and loads the cards one at a time into a carousel within the incubation station. A test card transport station transports the test cards from the incubation station to an optical reading station, where optical measurements (e.g., transmittance and/or fluorescence optical testing) is conducted on the wells of the card. When the card has been read, it is either moved back to the incubation station for additional incubation and reading or transferred to a card disposal system when the reading is complete.
摘要翻译: 用于测试存储在测试卡中的样品的自动样品测试机。 该机器具有测试样品定位系统,用于在机器中的各个站之间移动包含多个测试样品卡和流体容器的托盘。 该机器具有用于根据需要向容器添加预定量的稀释剂的稀释站。 移液站将流体从一个容器传送到另一个容器。 设置真空站,其具有可在上位置和下位置之间相对于托盘移动的真空室。 当室下降到较低位置时,室与托盘配合以与托盘的顶表面进行密封接合。 真空发生器为腔室提供真空。 当从室释放真空时,将流体样品从容器装载到卡中。 测试样品定位系统将托盘移动到切割和密封站,然后移动到孵化站,并将卡一次装载到孵育站内的转盘中。 测试卡传输站将测试卡从孵化站运送到光学读取站,其中在卡的孔上进行光学测量(例如,透射率和/或荧光光学测试)。 读卡完成后,将其移回孵化站进行额外的孵化和阅读,或者将其转移到卡片处理系统。
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公开(公告)号:US5762873A
公开(公告)日:1998-06-09
申请号:US604672
申请日:1996-02-21
申请人: Mark Joseph Fanning , Jean-Pierre Bernard Gayral , Clifford W. Karl , Bernard Jean Marie Limon , Donald Meyer , Roger James Morris , Ron Robinson , William Ernest Seaton , David B. Shine , Paul Springer , Daniel Ray Williams , James Clement Bishop , Craig Drager , Thomas Burchard , David Chastain , Stephen Guerrera , Andrew Moore , David Porat , Arthur Rousmaniere , Andrew Zeigler
发明人: Mark Joseph Fanning , Jean-Pierre Bernard Gayral , Clifford W. Karl , Bernard Jean Marie Limon , Donald Meyer , Roger James Morris , Ron Robinson , William Ernest Seaton , David B. Shine , Paul Springer , Daniel Ray Williams , James Clement Bishop , Craig Drager , Thomas Burchard , David Chastain , Stephen Guerrera , Andrew Moore , David Porat , Arthur Rousmaniere , Andrew Zeigler
CPC分类号: B01L3/50 , G01N35/00029 , G01N1/38 , G01N2035/00089 , G01N2035/00138 , G01N2035/00148 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/115831 , Y10T436/119163 , Y10T436/25625 , Y10T436/2575
摘要: An automatic sample testing machine for testing samples stored in test cards. The machine has a test sample positioning system for moving a tray containing a plurality of test sample cards and fluid receptacles among various stations in the machine. The machine has a diluting station for adding a predetermined quantity of diluent to the receptacles as needed. A pipetting station transfers fluid from one receptacle to another. A vacuum station is provided having a vacuum chamber moveable relative to the tray between upper and lower positions. The chamber cooperates with the tray to make a sealing engagement with the top surface of the tray when it is lowered to the lower position. A vacuum generator supplies vacuum to the chamber. When the vacuum is released from the chamber, the fluid samples are loaded into the cards from the receptacles. The test sample positioning system moves the tray to a cutting and sealing station and then to an incubation station and loads the cards one at a time into a carousel within the incubation station. A test card transport station transports the test cards from the incubation station to an optical reading station, where optical measurements (e.g., transmittance and/or fluorescence optical testing) is conducted on the wells of the card. When the card has been read, it is either moved back to the incubation station for additional incubation and reading or transferred to a card disposal system when the reading is complete.
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公开(公告)号:US5697409A
公开(公告)日:1997-12-16
申请号:US604461
申请日:1996-02-21
CPC分类号: G01N35/00029 , Y10T436/119163
摘要: A diluting station and a pipetting station for a machine such as a biological sample testing machine. The diluting station has a rotating shot tube that fills with diluent without the need for priming when the shot tube is in a vertically inclined orientation, and which dispenses the diluent into a receptacle when the shot tube is rotated to a downward orientation. A thimble valve is placed in the shot tube to control the flow of diluent into the valve. The pipetting station includes a cylindrical housing storing a plurality of straws and a concentric rotating drum that sweeps a straw into a straw withdrawal slot. A tubular tapered transfer pin is inserted into the straw frictional into engagement with the straw. The tubular transfer pin rotates the straw out of the slot into a generally downward orientation towards a receptacle containing a fluid. The pin and straw are lowered so as to place the end of the straw into the fluid. The fluid is withdrawn into the straw by means of vacuum applied to the tubular tapered transfer pin. The pin and straw are then raised out of the fluid. The fluid can then be deposited into a second receptacle that is moved below the straw and transfer pin by lowering the straw into the second receptacle and releasing the vacuum.
摘要翻译: 用于机器的稀释站和移液站,例如生物样品测试机。 稀释站具有旋转喷射管,其在喷射管处于垂直倾斜的方向时填充稀释剂而不需要起泡,并且当喷射管旋转到向下的方向时,稀释站将稀释剂分配到容器中。 将喷射阀放置在喷射管中以控制稀释剂进入阀门的流量。 移液站包括一个储存多个吸管的圆柱形外壳和一个将吸管扫入吸管槽的同心旋转鼓。 管状锥形传递销插入秸秆摩擦中与吸管接合。 管状传送销将吸管从槽中旋转到朝向容纳流体的容器的大致向下的方位。 销和秸秆被降下,以将秸秆的末端放入流体中。 通过施加到管状锥形传递销的真空将流体抽吸到吸管中。 然后将针和吸管从液体中升出。 然后可以将流体沉积到通过将吸管降低到第二容器中并释放真空而移动到吸管和传送销下方的第二容器中。
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公开(公告)号:US08741655B2
公开(公告)日:2014-06-03
申请号:US12074997
申请日:2008-03-06
IPC分类号: G01N35/02
CPC分类号: G01N21/13 , G01N35/00029 , G01N2035/00148 , G01N2035/0465 , G01N2035/0491 , Y10T436/11 , Y10T436/113332
摘要: A transport system is provided for a sample testing machine. The transport system includes a carrier holding a set of test sample devices and a drive subsystem for moving the carrier through the sample testing machine. The drive subsystem includes a reciprocating motor-driven block engaging the carrier and moving the carrier back and forth in a predetermined longitudinal path extending along a longitudinal axis from an entrance station to a plurality of processing stations in the sample testing machine. The processing stations are accessed as the carrier is moved along the path. The carrier includes features in the form of slots or voids that are detected by strategically placed optical interrupt sensors. As the carrier moves, the slots are detected by the sensors to thereby continuously track the position of the carrier and the test devices as they are moved through the instrument.
摘要翻译: 为样品测试机提供运输系统。 运输系统包括一个承载一组测试样品装置的托架和用于使载体移动通过样品测试机的驱动子系统。 驱动子系统包括一个往复运动的马达驱动的块,其与载体相接合,并以沿着纵向轴线从入口站到样品测试机中的多个处理站的预定纵向路径来回移动载体。 当载体沿着路径移动时,处理站被访问。 载体包括通过策略放置的光中断传感器检测到的槽或空隙形式的特征。 当载体移动时,通过传感器检测槽,从而在载体和测试装置移动通过仪器时连续跟踪载体和测试装置的位置。
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