公开(公告)号：US20090024040A1

公开(公告)日：2009-01-22

申请号：US12137227

申请日：2008-06-11

Applicant: Eduardo Ignacio Cespedes

Inventor： Eduardo Ignacio Cespedes

IPC: A61B8/12

CPC classification number: A61B8/12 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084

Abstract: The present invention provides intravascular diagnostic catheters that include one or more wall-contacting/wall-approaching probes including IVUS probe elements and diagnostic systems including such catheters, for the evaluation and diagnosis of blood vessels. Also provided are intravascular catheters in which the wall-contacting/wall-approaching probes further include an optical probe element and systems including such catheters, for combined IVUS and optical analysis of a blood vessel wall.

Abstract translation: 本发明提供血管内诊断导管，其包括用于评估和诊断血管的一个或多个壁接触/壁接近探针，包括IVUS探针元件和包括这种导管的诊断系统。 还提供了血管内导管，其中壁接触/壁接近探针还包括光学探针元件和包括这种导管的系统，用于组合的IVUS和血管壁的光学分析。

公开(公告)号：US06726629B1

公开(公告)日：2004-04-27

申请号：US09600219

申请日：2001-10-25

Applicant: Peter J. A. Frinking ,  E. Ignacio Cespedes ,  Nico de Jong

Inventor： Peter J. A. Frinking ,  E. Ignacio Cespedes ,  Nico de Jong

IPC: A61B814

CPC classification number: A61B8/481 ,  G01S7/52041 ,  G01S15/8952

Abstract: An ultrasound image is obtained by subjecting an object containing an ultrasound contrast enhancement agent to a first imaging pulse burst and then to a second release pulse and then to a second imaging pulse to obtain two images and then comparing the two images to obtain an enhanced image.

Abstract translation: 通过使包含超声对比度增强剂的物体经受第一成像脉冲脉冲​​串然后再到第二释放脉冲然后再到第二成像脉冲以获得两个图像，然后比较两个图像以获得增强图像来获得超声图像 。

公开(公告)号：US20050131400A1

公开(公告)日：2005-06-16

申请号：US10982504

申请日：2004-11-04

Applicant: David Hennings ,  Mitchel Goldman ,  Robert Weiss ,  Eric Taylor ,  Don Johnson ,  Ignacio Cespedes

Inventor： David Hennings ,  Mitchel Goldman ,  Robert Weiss ,  Eric Taylor ,  Don Johnson ,  Ignacio Cespedes

IPC: A61B17/00 ,  A61B18/00 ,  A61B18/22 ,  A61B18/24 ,  A61B19/00 ,  A61B18/20

CPC classification number: A61B18/24 ,  A61B2017/00084 ,  A61B2018/00005 ,  A61B2018/00196 ,  A61B2018/2261 ,  A61B2090/036

Abstract: This invention is an improved method and device for treating varicose veins 200 or the greater saphenous vein 202. The method comprises the use of infrared laser radiation in the region of 1.2 to 2.2 um in a manner from inside the vessel 200 or 202 such that the endothelial cells of the vessel wall 704 are damaged and collagen fibers in the vessel wall 704 are heated to the point where they permanently contract, the vessel 200 or 202 is occluded and ultimately resorbed. The device includes a laser 102 delivered via a fiber optic catheter 300 that may have frosted or diffusing fiber tips 308, or that may be provided with a protective spacer. A motorized pull back device 104 may be used, and a thermal sensor 600 may be used to help control the power required to maintain the proper treatment temperature.

Abstract translation: 本发明是用于治疗静脉曲张200或较大隐静脉202的改进方法和装置。该方法包括以1.2至2.2μm的范围使用红外激光辐射，从容器200或202内部的方式使得 血管壁704的内皮细胞被破坏，血管壁704中的胶原纤维被加热到它们永久收缩的位置，血管200或202被封闭并最终吸收。 该装置包括通过可以具有磨砂或漫射纤维尖端308的光纤导管300传送的激光器102，或者可以设置有保护隔离物的激光器102。 可以使用电动拉回装置104，并且可以使用热传感器600来帮助控制维持适当处理温度所需的功率。

公开(公告)号：US06213950B1

公开(公告)日：2001-04-10

申请号：US09297538

申请日：1999-07-02

Applicant: Eduardo Ignacio Cespedes ,  Charles Theodoor Lanceé ,  Antonius Franciscus Wilhelmus Van Der Steen ,  Wenguang Li ,  Nicolaas Bom

Inventor： Eduardo Ignacio Cespedes ,  Charles Theodoor Lanceé ,  Antonius Franciscus Wilhelmus Van Der Steen ,  Wenguang Li ,  Nicolaas Bom

IPC: A61B800

CPC classification number: A61B8/06 ,  A61B8/12

Abstract: A method to measure spatial fluid flow components and their velocity profiles in a number of locations in a cross-sectional area of a lumen or other body cavity by using ultrasound in which the cross-sectional area is interrogated by a plurality of ultrasonic beams; the estimation of the spatial flow components is obtained from a combination of estimations of axial, lateral and total flow; the estimation of one or more flow components is obtained through any combination of time-shift and decorrelation analysis of two or more beam-signals of the interrogating ultrasound transducer, and the estimation accuracy is further improved by the use of a reference decorrelation curve.

Abstract translation: 一种通过使用其中通过多个超声波束询问横截面积的超声波来在腔或其它体腔的横截面区域中的多个位置中测量空间流体流动分量及其速度分布的方法; 从轴向，横向和总流量的估计的组合获得空间流分量的估计; 通过询问超声换能器的两个或多个波束信号的时移和去相关分析的任意组合获得一个或多个流分量的估计，并且通过使用参考去相关曲线进一步提高估计精度。

公开(公告)号：US5474070A

公开(公告)日：1995-12-12

申请号：US212734

申请日：1994-03-11

Applicant: Jonathan Ophir ,  Ignacio Cespedes

Inventor： Jonathan Ophir ,  Ignacio Cespedes

IPC: G01N3/00 ,  G01N29/07 ,  G01N29/22 ,  G01N29/30 ,  G01N29/38 ,  G01N29/50 ,  G01S7/52 ,  G01S15/89 ,  A61B8/00

CPC classification number: G01S15/8945 ,  A61B5/0048 ,  G01N29/07 ,  G01N29/223 ,  G01N29/30 ,  G01N29/38 ,  G01N29/50 ,  G01S7/52036 ,  G01S7/52042 ,  G01N2203/0089 ,  G01N2291/02827 ,  G01N2291/101

Abstract: An improved ultrasonic pulse-echo method and apparatus that has particular application in making precision measurements of compressibility in any backscattering material, in particular organic tissue, is disclosed. The method employs a standard transducer or transducer containing device which is translated transaxially, thereby compressing or displacing a proximal region of a target body in small known increments. At each increment, a pulse is emitted and an echo sequence (A-line) is detected from regions within the target along the sonic travel path or beam of the transducer. Resulting time shifts in echo segments corresponding to features in the target, corrected for regions of varying sonic speed along the sonic path, provide relative and quantitative information concerning the strain caused by the compressions. The stress imparted by the transducer and containing device is also determined, corrected for depth along the sonic path. The appropriate values for stress are divided into the respective values for strain along each path to yield an elastogram, or array of compressibility values, of the target.

Abstract translation: 公开了一种改进的超声脉冲回波方法和装置，其特别适用于在任何后向散射材料，特别是有机组织中精确测量可压缩性。 该方法采用标准的换能器或换能器容纳装置，该装置被外延地平移，从而以小的已知增量压缩或移位靶体的近端区域。 在每个增量处，发射脉冲，并且沿着声波传播路径或传感器的波束从目标内的区域检测回波序列（A线）。 对应于目标中的特征的回波段产生的时间偏移，对于沿着声波路径的不同声速的区域进行校正，提供关于由压缩引起的应变的相关和定量信息。 由传感器和包含装置施加的应力也被确定，沿着声波路径的深度进行校正。 将适当的应力值分为沿着每个路径的应变的相应值，以产生目标的弹性图或压缩性值的阵列。

公开(公告)号：US5293870A

公开(公告)日：1994-03-15

申请号：US940182

申请日：1992-09-03

Applicant: Jonathan Ophir ,  Ignacio Cespedes ,  Hari Ponnekanti

Inventor： Jonathan Ophir ,  Ignacio Cespedes ,  Hari Ponnekanti

IPC: G01N3/00 ,  G01N29/07 ,  G01N29/22 ,  G01N29/38 ,  G01N29/50 ,  G01S7/52 ,  G01S15/89 ,  A61B8/00

CPC classification number: G01S7/52036 ,  A61B5/0051 ,  A61B8/485 ,  G01N29/07 ,  G01N29/223 ,  G01N29/38 ,  G01N29/50 ,  G01S15/8945 ,  G01S7/52042 ,  G01N2203/0089 ,  G01N2291/02827 ,  G01N2291/101

Abstract: An improved ultrasonic pulse-echo method and apparatus that has particular application in making precision measurements of compressibility in any backscattering material, in particular organic tissue, is disclosed. The method employs a standard transducer or transducer containing device which is translated transaxially, thereby compressing or displacing a proximal region of a target body in small known increments. At each increment, a pulse is emitted and an echo sequence (A-line) is detected from regions within the target along the sonic travel path or beam of the transducer. Resulting time shifts in echo segments corresponding to features in the target, corrected for regions of varying sonic speed along the sonic path, provide relative and quantitative information concerning the strain caused by the compressions. The stress imparted by the transducer and containing device is also determined, corrected for depth along the sonic path. The appropriate values for stress are divided into the respective values for strain along each path to yield an elastogram, or array of compressibility values, of the target.

Abstract translation: 公开了一种改进的超声脉冲回波方法和装置，其特别适用于在任何后向散射材料，特别是有机组织中精确测量可压缩性。 该方法采用标准的换能器或换能器容纳装置，该装置被外延地平移，从而以小的已知增量压缩或移位靶体的近端区域。 在每个增量处，发射脉冲，并且沿着声波传播路径或传感器的波束从目标内的区域检测回波序列（A线）。 对应于目标中的特征的回波段产生的时间偏移，对于沿着声波路径的不同声速的区域进行校正，提供关于由压缩引起的应变的相关和定量信息。 由传感器和包含装置施加的应力也被确定，沿着声波路径的深度进行校正。 将适当的应力值分为沿着每个路径的应变的相应值，以产生目标的弹性图或压缩性值的阵列。

公开(公告)号：US5178147A

公开(公告)日：1993-01-12

申请号：US699391

申请日：1991-05-10

Applicant: Jonathan Ophir ,  Ignacio Cespedes ,  Hari Ponnekanti

Inventor： Jonathan Ophir ,  Ignacio Cespedes ,  Hari Ponnekanti

IPC: A61B8/08 ,  A61B5/103 ,  G01N3/00 ,  G01N29/00 ,  G01N29/07 ,  G01N29/22 ,  G01N29/30 ,  G01N29/38 ,  G01N29/50 ,  G01S15/89

CPC classification number: G01S15/8945 ,  A61B5/0051 ,  A61B5/441 ,  G01N29/07 ,  G01N29/223 ,  G01N29/30 ,  G01N29/38 ,  G01N29/50 ,  G01S7/52042 ,  A61B8/4272 ,  G01N2203/0089 ,  G01N2291/02827 ,  G01N2291/101

Abstract: An improved ultrasonic pulse-echo method and apparatus that has particular application in making precision measurements of compressibility in any backscattering material, in particular organic tissue, is disclosed. The method employs a standard transducer or transducer containing device which is translated transaxially, thereby compressing or displacing a proximal region of a target body in small known increments. At each increment, a pulse is emitted and an echo sequence (A-line) is detected from regions within the target along the sonic travel path or beam of the transducer. Resulting time shifts in echo segments corresponding to features in the target, corrected for regions of varying sonic speed along the sonic path, provide relative and quantitative information concerning the strain caused by the compressions. The stress imparted by the transducer and containing device is also determined, corrected for depth along the sonic path. The appropriate values for stress are divided into the respective values for strain along each path to yield an elastogram, or array of compressibility values, of the target.

公开(公告)号：US07524316B2

公开(公告)日：2009-04-28

申请号：US10982504

申请日：2004-11-04

Applicant: David R. Hennings ,  Mitchel P. Goldman ,  Robert A. Weiss ,  Eric B. Taylor ,  Don Johnson ,  Ignacio Cespedes

Inventor： David R. Hennings ,  Mitchel P. Goldman ,  Robert A. Weiss ,  Eric B. Taylor ,  Don Johnson ,  Ignacio Cespedes

IPC: A61B18/18

CPC classification number: A61B18/24 ,  A61B2017/00084 ,  A61B2018/00005 ,  A61B2018/00196 ,  A61B2018/2261 ,  A61B2090/036

Abstract: This invention is an improved method and device for treating varicose veins 200 or the greater saphenous vein 202. The method comprises the use of infrared laser radiation in the region of 1.2 to 2.2 um in a manner from inside the vessel 200 or 202 such that the endothelial cells of the vessel wall 704 are damaged and collagen fibers in the vessel wall 704 are heated to the point where they permanently contract, the vessel 200 or 202 is occluded and ultimately resorbed. The device includes a laser 102 delivered via a fiber optic catheter 300 that may have frosted or diffusing fiber tips 308, or that may be provided with a protective spacer. A motorized pull back device 104 may be used, and a thermal sensor 600 may be used to help control the power required to maintain the proper treatment temperature.

Abstract translation: 本发明是用于治疗静脉曲张200或较大隐静脉202的改进方法和装置。该方法包括以1.2至2.2μm的范围使用红外激光辐射，从容器200或202内部的方式使得 血管壁704的内皮细胞被破坏，血管壁704中的胶原纤维被加热到它们永久收缩的位置，血管200或202被封闭并最终吸收。 该装置包括通过可以具有磨砂或漫射纤维尖端308的光纤导管300传送的激光器102，或者可以设置有保护隔离物的激光器102。 可以使用电动拉回装置104，并且可以使用热传感器600来帮助控制维持适当处理温度所需的功率。

公开(公告)号：US20090076395A1

公开(公告)日：2009-03-19

申请号：US11902170

申请日：2007-09-19

Applicant: E. Ignacio Cespedes

Inventor： E. Ignacio Cespedes

IPC: A61B8/12

CPC classification number: A61B8/4488 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B8/12 ,  A61B8/445

Abstract: The present invention provides intravascular diagnostic catheters that include a centrally disposed intravascular ultrasound (IVUS) imaging element and radially extendable, wall-contacting optical probe arms of a novel design for improving the IVUS imaging aspect of combined IVUS and optical analysis. In one embodiment, the dimension of the portion of the probe arm(s) that is in the field-of-view of the IVUS imaging element is minimized. In another embodiment, thin tethers are disposed in the field-of-view of the IVUS imaging element, rather than a continuation of the probe arm itself into the IVUS field. In still another embodiment, the probe arms at least substantially do not impinge on the field-of-view of the IVUS imaging element and tethers that are not within the field-of-view of the IVUS imaging element are used to control the probe arms, thereby providing a clear field-of-view for the IVUS imaging element.

Abstract translation: 本发明提供血管内诊断导管，其包括中心设置的血管内超声（IVUS）成像元件和用于改善组合IVUS和光学分析的IVUS成像方面的新颖设计的可径向延伸的壁接触光学探针臂。 在一个实施例中，位于IVUS成像元件的视野中的探针臂部分的尺寸最小化。 在另一个实施例中，薄系带设置在IVUS成像元件的视场中，而不是探针臂本身延伸到IVUS场中。 在另一个实施例中，探针臂至少基本上不会撞击到IVUS成像元件的视场上，并且不在IVUS成像元件的视野内的系绳用于控制探针臂 从而为IVUS成像元件提供清晰的视场。

公开(公告)号：US06685646B2

公开(公告)日：2004-02-03

申请号：US09748464

申请日：2000-12-26

Applicant: Eduardo Ignacio Cespedes ,  Charles Theodoor Lanceé ,  Antonius Franciscus Wilhemus Van Der Steen ,  Wenguang Li ,  Nicolaas Bom

Inventor： Eduardo Ignacio Cespedes ,  Charles Theodoor Lanceé ,  Antonius Franciscus Wilhemus Van Der Steen ,  Wenguang Li ,  Nicolaas Bom

IPC: A61B800

CPC classification number: A61B8/06 ,  A61B8/12

Abstract: A method to measure spatial fluid flow components and their velocity profiles in a number of locations in a cross-sectional area of a lumen or other body cavity by using ultrasound in which the cross-sectional area is interrogated by a plurality of ultrasonic beams; the estimation of the spatial flow components is obtained from a combination of estimations of axial, lateral and total flow; the estimation of one or more flow components is obtained through any combination of time-shift and decorrelation analysis of two or more beam-signals of the interrogating ultrasound transducer; and the estimation accuracy is further improved by the use of a reference decorrelation curve obtained from experiments or beam-theory or both.

Abstract translation: 一种通过使用其中通过多个超声波束询问横截面积的超声波来在腔或其它体腔的横截面区域中的多个位置中测量空间流体流动分量及其速度分布的方法; 从轴向，横向和总流量的估计的组合获得空间流分量的估计; 通过询问超声换能器的两个或多个波束信号的时移和去相关分析的任意组合来获得一个或多个流分量的估计; 并且通过使用从实验或束理论或两者获得的参考去相关曲线来进一步提高估计精度。