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37 条记录 (耗时 0.02 秒)

    Electrochemical sensors
    1.
    发明授权
    Electrochemical sensors 有权

    公开(公告)号：US10233084B2

    公开(公告)日：2019-03-19

    申请号：US14599595

    申请日：2015-01-19

    申请人： ISIS Innovation LTD.

    发明人： Sean P. McCormack ,  Richard G. Compton ,  Gregory George Wildgoose ,  Nathan Scott Lawrence

    IPC分类号： C01B32/174 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00 ,  G01N27/30 ,  C01B32/05 ,  C01B32/20

    摘要： An electrode for use in a electrochemical sensor comprises carbon modified with a chemically sensitive redox-active compound, excluding an electrode based on carbon having derivatized thereon two redox-active species wherein at least one of said species is selected from anthraquinone, phenanthrenequinone and N,N′-diphenyl-p-phenylenediamine (DPPD). The invention further provides a pH sensor comprising: a working electrode comprising carbon modified with a chemically sensitive redox active material; and a counter electrode, wherein the ratio of the surface area of the working electrode to the surface area of the counter electrode is from 1:10 to 10:1. Also provided is a pH sensor comprising: a working electrode comprising carbon modified with a chemically sensitive redox active material, and a counter electrode, wherein the area of the working electrode is from 500 μm2 to 0.1 m2. The uses of these electrodes and sensors are also described.

    Fast analysis method for non-invasive imaging of blood flow using vessel-encoded arterial spin labelling
    2.
    发明授权
    Fast analysis method for non-invasive imaging of blood flow using vessel-encoded arterial spin labelling 有权

    公开(公告)号：US09757047B2

    公开(公告)日：2017-09-12

    申请号：US13815815

    申请日：2013-03-14

    申请人： Isis Innovation Ltd.

    发明人： Michael Chappell ,  Mark Woolrich ,  Thomas Okell

    IPC分类号： G01V3/00 ,  A61B5/026 ,  G01R33/563

    CPC分类号： A61B5/0263 ,  G01R33/56333 ,  G01R33/56366 ,  G06F19/00

    摘要： Arterial spin labelling (ASL) MRI offers a non-invasive means to create blood-borne contrast in vivo for dynamic angiographic imaging. By spatial modulation of the ASL process it is possible to uniquely label individual arteries over a series of measurements, allowing each to be separately identified in the resulting images. This separation requires appropriate analysis for which a general framework has previously been proposed. Here the general framework is modified for fast analysis of non-invasive imaging of blood flow using vessel encoded arterial spin labelling (VE-ASL). This specifically addresses the issues of computational speed of the analysis and the robustness required to deal with real patient data. The modification applies various approaches for estimation of one or more parameters that change the way a vessel, for example an artery, is encoded to provide the fast analysis.

    Electric machine—evaporative cooling
    4.
    发明授权
    Electric machine—evaporative cooling 有权
    电机 - 蒸发冷却

    公开(公告)号：US09054566B2

    公开(公告)日：2015-06-09

    申请号：US14049322

    申请日：2013-10-09

    申请人： Isis Innovation Ltd.

    发明人： Tim Woolmer

    IPC分类号： H02K9/18 ,  H02K9/20 ,  H02K21/12 ,  B60K1/00 ,  H02K5/18 ,  H02K7/14 ,  H02K21/24 ,  B60K7/00 ,  H02K49/04

    CPC分类号： H02K9/20 ,  B60K7/0007 ,  H02K5/18 ,  H02K7/14 ,  H02K21/24 ,  H02K49/04

    摘要： An electric machine comprises a rotor, preferably having permanent magnets, although other field generation means are available, and a stator. The stator has coils wound on stator bars for interaction with the magnetic field of the rotor across an air gap defined between them. The rotor comprises a housing of a chamber containing refrigerant. The rotor housing has heat dissipating fins accessible by the open environment whereby air movement relative to the housing caused at least by rotation of the rotor absorbs heat from the fins. The machine may be an axial flux machine, the coils being wound on bars that are disposed circumferentially spaced around a fixed axle of the machine forming a rotational axis of the rotor. The machine may be a wheel motor for a vehicle, wherein the wheel is mounted directly on the rotor housing.

    摘要翻译： 电机包括转子，优选地具有永磁体，尽管其它现场产生装置可用，也包括定子。 定子具有缠绕在定子棒上的线圈，用于与转子的磁场横跨跨它们之间限定的气隙相互作用。 转子包括容纳制冷剂的室的壳体。 转子壳体具有可通过开放环境访问的散热翅片，从而至少通过转子的旋转而相对于壳体的空气移动从散热片吸收热量。 机器可以是轴向通量机器，线圈缠绕在杆上，所述杆围绕形成转子的旋转轴线的机器的固定轴线周向隔开设置。 机器可以是用于车辆的车轮马达，其中车轮直接安装在转子壳体上。

    Quantification of blood volume flow rates from dynamic angiography data
    7.
    发明授权
    Quantification of blood volume flow rates from dynamic angiography data 有权

    公开(公告)号：US09501620B2

    公开(公告)日：2016-11-22

    申请号：US13815854

    申请日：2013-03-14

    申请人： Isis Innovation Ltd.

    发明人： Thomas Okell ,  Michael Chappell ,  Peter Jezzard

    IPC分类号： G06F19/00 ,  A61B6/00

    CPC分类号： G16H50/50 ,  A61B6/504 ,  A61B6/507 ,  A61B6/5217

    摘要： Systems and methods are disclosed for quantifying absolute blood volume flow rates by fitting a kinetic model incorporating blood volume, bolus dispersion and signal attenuation to dynamic angiographic data. A self-calibration method is described for both 2D and 3D data sets to convert the relative blood volume parameter into absolute units. The parameter values are then used to simulate the signal arising from a very short bolus, in the absence of signal attenuation, which can be readily encompassed within a vessel mask of interest. The volume flow rate can then be determined by calculating the blood volume within the vessel mask and dividing by the simulated bolus duration. This method is exemplified using non-contrast magnetic resonance imaging data from a flow phantom and the cerebral arteries of healthy volunteers and a patient with Moya-Moya disease acquired using a 2D vessel-encoded pseudo-continuous arterial spin labeling pulse sequence. This allows flow quantification in downstream vessels from each brain-feeding artery separately. The systems and methods can be of use in patients with a variety of cerebrovascular diseases, such as the assessment of collateral flow in patients with steno-occlusive disease or the evaluation of arteriovenous malformations.

    Compact Microscope
    8.
    发明申请
    Compact Microscope 审中-公开
    紧凑型显微镜

    公开(公告)号：US20160266362A1

    公开(公告)日：2016-09-15

    申请号：US15031807

    申请日：2014-10-27

    申请人： ISIS INNOVATION LTD.

    发明人： Achillefs KAPANIDIS ,  Bo JING ,  Robert CRAWFORD

    IPC分类号： G02B21/00 ,  G02B21/36 ,  G02B21/24 ,  G02B21/26 ,  G02B21/06

    CPC分类号： G02B21/0008 ,  G02B21/0088 ,  G02B21/06 ,  G02B21/244 ,  G02B21/26 ,  G02B21/36

    摘要： A compact microscope including an enclosure, a support element, a primary optical support element located within the enclosure and supported by the support element, at least one vibration isolating mount between the support element and the primary optical support element, an illumination section, an objective lens system, a sample stage mounted on the primary optical support element, an illumination optical system to direct an illumination light beam from the illumination section to the sample stage, and a return optical system to receive returned light from sample stage and transmit returned light to a detection apparatus, wherein the illumination optical system and return optical system are mounted on the primary optical support element.

    摘要翻译： 一种紧凑型显微镜，包括外壳，支撑元件，位于外壳内并由支撑元件支撑的主要光学支撑元件，支撑元件和主光学支撑元件之间的至少一个防振安装件，照明部分，物镜 透镜系统，安装在主光学支撑元件上的样品台，将来自照明部分的照明光束引导到样品台的照明光学系统，以及返回光学系统，用于接收来自样品台的返回光并将返回的光传输到 检测装置，其中照明光学系统和返回光学系统安装在主光学支撑元件上。

    PHARMACEUTICAL COMPOUNDS
    9.
    发明申请
    PHARMACEUTICAL COMPOUNDS 审中-公开
    药物化合物

    公开(公告)号：US20160151347A1

    公开(公告)日：2016-06-02

    申请号：US14904005

    申请日：2014-07-10

    申请人： ISIS Innovation LTD

    发明人： Rebecca Burton

    IPC分类号： A61K31/4706 ,  A61K45/06

    CPC分类号： A61K31/4706 ,  A61K31/165 ,  A61K31/505 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention provides hydroxychloroquine or a pharmaceutically acceptable salt thereof for use in the prevention and/or treatment of systolic heart failure, sincus tachycardia, cardiac syndrome X and/or essential hypertension.

    摘要翻译： 本发明提供用于预防和/或治疗收缩期心力衰竭，心绞痛心动过速，心脏综合征X和/或原发性高血压的羟氯喹或其药学上可接受的盐。

    DIFFUSION-INSENSTIVE VELOCITY SELECTIVE LABELLING MODULE FOR MAGNETIC RESONANCE IMAGING
    10.
    发明申请
    DIFFUSION-INSENSTIVE VELOCITY SELECTIVE LABELLING MODULE FOR MAGNETIC RESONANCE IMAGING 审中-公开
    用于磁共振成像的扩散速度选择性标签模块

    公开(公告)号：US20150309134A1

    公开(公告)日：2015-10-29

    申请号：US14660576

    申请日：2015-03-17

    申请人： ISIS INNOVATION LTD

    发明人： James MEAKIN ,  Peter JEZZARD

    IPC分类号： G01R33/48 ,  A61B5/026

    CPC分类号： A61B5/0263 ,  A61B5/4058 ,  A61B2576/026 ,  G01R33/56366 ,  G01R33/56509

    摘要： A velocity selective preparation method, for Velocity Selective Magnetisation Transfer Insensitive labelling technique (VS-TILT), said VS-TILT method using non-selective RadioFrequency (RF) pulses and magnetic field gradients to modulate the longitudinal magnetization of moving spins in magnetic resonance imaging that is insensitive to diffusion effects, said method comprising the steps of: a) play out two velocity selective pulses: VS-A and VS-B, sequentially without any spoiling between said pulses; b) each individual pulse VS-A and VS-B having half the first gradient moment m1 of the original velocity selective pulse; c) assigning the VS-TILT tag condition gradients to have the same polarity, such that total m1 is perserved; and d) assigning the VS_TILT control condition, negating the n gradients in the first pulse such total m1=0, but the b-value remains unchanged.

    摘要翻译： 用于速度选择性磁化转移不敏感标记技术（VS-TILT）的速度选择性制备方法，所述VS-TILT方法使用非选择性射频（RF）脉冲和磁场梯度来调节磁共振成像中移动自旋的纵向磁化 对扩散效应不敏感，所述方法包括以下步骤：a）顺序地播放两个速度选择脉冲：VS-A和VS-B，而不会在所述脉冲之间发生任何破坏; b）每个独立脉冲VS-A和VS-B具有原始速度选择脉冲的第一梯度矩m1的一半; c）将VS-TILT标签条件梯度分配为具有相同的极性，使得总共m1被持续; 和d）分配VS_TILT控制条件，否定第一脉冲中的n个梯度，总共m1 = 0，但是b值保持不变。