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公开(公告)号：US20100247572A1
公开(公告)日：2010-09-30
申请号：US12467492
申请日：2009-05-18
申请人： Yoshihiro Kawaoka
发明人： Yoshihiro Kawaoka
IPC分类号： A61K39/145 , A61P37/04 , C12N7/01
CPC分类号： C12N7/00 , A61K39/00 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C12N2760/16043 , C12N2760/16062 , C12N2760/16121 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134 , C12N2760/16222 , C12N2760/16322
摘要： A method to prepare viruses with a mutant membrane protein gene, and viruses obtained by the method, are provided.
摘要翻译： 提供了制备具有突变膜蛋白基因的病毒的方法和通过该方法获得的病毒。
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公开(公告)号：US09220769B2
公开(公告)日：2015-12-29
申请号：US14346669
申请日：2012-09-21
发明人： Alain Townsend
IPC分类号： A61K39/145 , C12N7/00 , A61K39/12 , C07K14/005 , A61K39/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5254 , A61K2039/58 , C07K14/005 , C12N7/00 , C12N2760/16022 , C12N2760/16062 , C12N2760/16122 , C12N2760/16134 , C12N2760/16162
摘要： The present invention provides a modified influenza virus wherein the RNA of the haemagglutinin gene has been modified such that the haemagglutinin signal sequence is not expressed and the virus produces a haemagglutinin protein that lacks a functional signal sequence. The invention further provides composition comprising the modified virus and uses of the modified virus.
摘要翻译： 本发明提供了修饰的流感病毒，其中已经修饰了血凝素基因的RNA，使得血凝素信号序列不被表达，并且病毒产生缺乏功能信号序列的血凝素蛋白。 本发明还提供了包含经修饰的病毒和经修饰的病毒的用途的组合物。
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公开(公告)号：US20090297552A1
公开(公告)日：2009-12-03
申请号：US12429971
申请日：2009-04-24
CPC分类号： C12N7/00 , A61K39/39 , A61K2039/523 , A61K2039/5256 , A61K2039/55516 , A61K2039/60 , A61K2039/6068 , A61K2039/6075 , C07K14/005 , C07K2319/40 , C12N2760/16022 , C12N2760/16062 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396 , Y02A50/397 , Y02A50/412 , Y02A50/423 , Y02A50/47 , Y02A50/484 , Y02A50/487
摘要： Vaccines that comprise or generate immunomodulatory flagellin polypeptides able to stimulate an innate immune response intracellularly and extracellularly employ viruses, bacteria or parasitic cells that contain expression systems for such polypeptides, as well as fusion proteins that contain antigens and/or cell penetrating peptides along with the immunomodulatory peptide.
摘要翻译： 包含或产生免疫调节鞭毛蛋白多肽的疫苗，其能够在细胞内和细胞外刺激先天免疫应答，并且使用含有这种多肽的表达系统的病毒，细菌或寄生细胞，以及含有抗原和/或细胞穿透肽以及 免疫调节肽。
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公开(公告)号：US20170080079A1
公开(公告)日：2017-03-23
申请号：US15274491
申请日：2016-09-23
发明人： Ryan Andrew Langlois
IPC分类号： A61K39/145 , C12N5/00 , C12N7/00
CPC分类号： A61K39/145 , A61K2039/5254 , C12N5/00 , C12N7/00 , C12N15/111 , C12N2310/113 , C12N2330/50 , C12N2501/65 , C12N2760/16034 , C12N2760/16051 , C12N2760/16062
摘要： This disclosure provides a platform for making live, attenuated viruses. This disclosure also provides methods of using the live, attenuated viruses.
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公开(公告)号：US20160076006A1
公开(公告)日：2016-03-17
申请号：US14784827
申请日：2014-04-18
发明人： Bernard DELMAS
IPC分类号： C12N7/00 , A61K39/145
CPC分类号： C12N7/00 , A61K39/12 , A61K39/145 , A61K2039/525 , A61K2039/5254 , C07K14/005 , C12N7/04 , C12N2760/16034 , C12N2760/16062 , C12N2760/16121 , C12N2760/16134 , C12N2760/16151 , C12N2760/16162 , C12N2760/16262 , C12N2760/16321 , C12N2760/16362
摘要： The invention relates to thermosensitive mutants of influenza viruses, containing at least one mutation localised in a flexible region of a protein of said virus, such as especially the region of the sub-unit PA of the viral polymerase corresponding to the region 197-225 of the sub-unit PA of influenza A. These viruses can be especially used for preparing attenuated living vaccines.
摘要翻译： 本发明涉及流感病毒的热敏突变体，其含有位于所述病毒蛋白质的柔性区域中的至少一个突变体，特别是病毒聚合酶的亚单位PA区域对应于区域197-225的区域 流感A的亚单位PA。这些病毒可以特别用于制备减毒活疫苗。
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公开(公告)号：US20040219170A1
公开(公告)日：2004-11-04
申请号：US10827995
申请日：2004-04-20
发明人： Yoshihiro Kawaoka
IPC分类号： A61K039/145 , C12N007/00
CPC分类号： C12N7/00 , A61K39/00 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C12N2760/16043 , C12N2760/16062 , C12N2760/16121 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134 , C12N2760/16222 , C12N2760/16322
摘要： A method to prepare viruses with a mutant membrane protein gene, and viruses obtained by the method, are provided.
摘要翻译： 提供了制备具有突变膜蛋白基因的病毒的方法和通过该方法获得的病毒。
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公开(公告)号：US12037364B2
公开(公告)日：2024-07-16
申请号：US17718056
申请日：2022-04-11
申请人： SANOFI PASTEUR INC.
发明人： Tod Strugnell , Eliud Oloo , Raymond Oomen
IPC分类号： A61K39/145 , A61K9/00 , A61K39/12 , A61K39/39 , C07K14/005 , C07K14/11 , C07K16/10 , C12N9/24 , A61K39/00
CPC分类号： C07K14/005 , A61K9/0019 , A61K9/0053 , A61K39/145 , A61K39/39 , C12N9/2402 , C12Y302/01018 , A61K2039/5258 , A61K2039/54 , C07K2319/00 , C12N2760/16022 , C12N2760/16023 , C12N2760/16034 , C12N2760/16052 , C12N2760/16062 , C12N2760/16071 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134 , C12N2760/16152 , C12N2760/16162 , C12N2760/16171 , C12N2760/16222 , C12N2760/16223 , C12N2760/16234 , C12N2760/16252 , C12N2760/16262 , C12N2760/16271
摘要： The present invention provides, among other things, a novel and improved method for generating “mosaic” influenza antigenic polypeptides including hemagglutinin (HA) and neuraminidase (NA) polypeptides based on unique combination of epitope patterns that maximize exposure to epitopes present across multiple HA or NA sequences and therefore improved influenza strain coverage. In particular, the present invention provides engineered H1N1 influenza hemagglutinin (HA) polypeptides that are comprised of novel combinations of protective epitopes and antigenic regions from multiple H1N1 viral strains. Such engineered HA polypeptides have improved properties over HA polypeptides developed through conventional approaches that rely on consensus alignments of viral sequences.
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公开(公告)号：US20180298063A1
公开(公告)日：2018-10-18
申请号：US15578880
申请日：2016-06-02
申请人： SANOFI PASTEUR INC.
发明人： Tod STRUGNELL , Eliud OLOO , Raymond OOMEN
IPC分类号： C07K14/005 , A61K39/145 , A61K39/39 , A61K9/00 , C12N9/24
CPC分类号： C07K14/005 , A61K9/0019 , A61K9/0053 , A61K39/145 , A61K39/39 , A61K2039/5258 , A61K2039/54 , C07K2319/00 , C12N9/2402 , C12N2760/16022 , C12N2760/16023 , C12N2760/16034 , C12N2760/16052 , C12N2760/16062 , C12N2760/16071 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134 , C12N2760/16152 , C12N2760/16162 , C12N2760/16171 , C12N2760/16222 , C12N2760/16223 , C12N2760/16234 , C12N2760/16252 , C12N2760/16262 , C12N2760/16271 , C12Y302/01018
摘要： The present invention provides, among other things, a novel and improved method for generating “mosaic” influenza antigenic polypeptides including hemagglutinin (HA) and neuraminidase (NA) polypeptides based on unique combination of epitope patterns that maximize exposure to epitopes present across multiple HA or NA sequences and therefore improved influenza strain coverage. In particular, the present invention provides engineered H1N1 influenza hemagglutinin (HA) polypeptides that are comprised of novel combinations of protective epitopes and antigenic regions from multiple H1N1 viral strains. Such engineered HA polypeptides have improved properties over HA polypeptides developed through conventional approaches that rely on consensus alignments of viral sequences.
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公开(公告)号：US20140242103A1
公开(公告)日：2014-08-28
申请号：US14346669
申请日：2012-09-21
发明人： Alain Townsend
IPC分类号： A61K39/145
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5254 , A61K2039/58 , C07K14/005 , C12N7/00 , C12N2760/16022 , C12N2760/16062 , C12N2760/16122 , C12N2760/16134 , C12N2760/16162
摘要： The present invention provides a modified influenza virus wherein the RNA of the haemagglutinin gene has been modified such that the haemagglutinin signal sequence is not expressed and the virus produces a haemagglutinin protein that lacks a functional signal sequence. The invention further provides composition comprising the modified virus and uses of the modified virus.
摘要翻译： 本发明提供了修饰的流感病毒，其中已经修饰了血凝素基因的RNA，使得血凝素信号序列不被表达，并且病毒产生缺乏功能信号序列的血凝素蛋白。 本发明还提供了包含经修饰的病毒和经修饰的病毒的用途的组合物。
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公开(公告)号：US07588769B2
公开(公告)日：2009-09-15
申请号：US10827995
申请日：2004-04-20
申请人： Yoshihiro Kawaoka
发明人： Yoshihiro Kawaoka
IPC分类号： A61K39/145 , C12N7/00 , C12N7/01 , C12N15/44 , C12N15/86 , C12N5/10 , C12N7/04 , A61K39/295
CPC分类号： C12N7/00 , A61K39/00 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C12N2760/16043 , C12N2760/16062 , C12N2760/16121 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134 , C12N2760/16222 , C12N2760/16322
摘要： A method to prepare viruses with a mutant membrane protein gene, and viruses obtained by the method, are provided.
摘要翻译： 提供了制备具有突变膜蛋白基因的病毒的方法和通过该方法获得的病毒。
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