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    Process for the preparation of isochroman-3-ones
    3.
    发明授权
    Process for the preparation of isochroman-3-ones 失效
    异苯并二氢吡喃-3-酮的制备方法

    公开(公告)号：US06348603B1

    公开(公告)日：2002-02-19

    申请号：US09668915

    申请日：2000-09-25

    申请人： Holger Geissler ,  Ralf Pfirmann

    发明人： Holger Geissler ,  Ralf Pfirmann

    IPC分类号： C07D40700

    CPC分类号： C07D311/76

    摘要： The present invention relates to a process for the preparation of an isochroman-3-one of the formula (I) by reaction of a 1,2-bishalomethylbenzene of the formula (II) in which X is chlorine, bromine or iodine, with carbon monoxide and a compound of the formula (III) R5R6R7C—OH  (III) at a CO pressure of 0.1 to 50 MPa and a temperature of 20 to 200° C. in the presence or absence of an ionic halide, in the presence of a palladium catalyst and of a dipolar aprotic solvent, with addition of water or without addition of water, where in the formulae (I) and (II) the radicals R1, R2, R3 and R4 independently of one another are: a hydrogen or fluorine atom; an NC or F3C group; an alkyl, alkoxy or acyloxy radical, in each case having 1 to 18 carbon atoms; or a C6-C18-aryloxy, aryl or heteroaryl radical, where 1 to 3 atoms from the group consisting of O, N and/or S are present as heteroatoms; or in which at least two of the radicals R1, R2, R3 and R4 are linked to one another and form at least one aliphatic or aromatic ring having 5 to 18 carbon atoms, and in formula (III) the radicals R5, R6 and R7 are identical or different and are a C1-C18-alkyl, an HOC(═O)—, H3CC(═O)CH2— or (C6-C18-aryl)-CH2— radical or at least two of the radicals R5, R6 and R7 are linked to one another and form at least one aliphatic or aromatic ring having 5 to 18 carbon atoms.

    摘要翻译： 本发明涉及一种制备式（I）的异苯并二氢吡喃-3-酮的方法，其中X为氯，溴或碘的式（Ⅱ）的1,2-二沙甲基苯与碳 一氧化碳和式（III）化合物在CO 2压力为0.1〜50MPa，温度为20〜200℃的条件下，在钯催化剂存在或不存在下，在钯催化剂和偶极 非质子溶剂，加入水或不加入水，其中在式（I）和（II）中，基团R 1，R 2，R 3和R 4彼此独立地为：氢或氟原子; NC或F3C组; 烷基，烷氧基或酰氧基，每种情况具有1至18个碳原子; 或C 6 -C 18芳氧基，芳基或杂芳基，其中以O，N和/或S为基的1至3个原子作为杂原子存在;或其中至少两个基团R 1，R 2，R 3和 R4彼此连接并形成至少一个具有5至18个碳原子的脂族或芳族环，并且在式（III）中，基团R 5，R 6和R 7相同或不同，为C 1 -C 18烷基，HOC （= O） - ，H 3 C（= O）CH 2 - 或（C 6 -C 18 - 芳基）-CH 2 - 基或基团R 5，R 6和R 7中的至少两个彼此连接并形成至少一个脂族或芳族 具有5至18个碳原子的环。

    Process for recovering cobalt carbonyl catalysts used to produced N-acyl-alpha-amino acid derivatives by amidocarbonylation
    4.
    发明授权
    Process for recovering cobalt carbonyl catalysts used to produced N-acyl-alpha-amino acid derivatives by amidocarbonylation 失效
    用于回收用于通过酰胺基羰基化产生N-酰基-α-氨基酸衍生物的羰基钴催化剂的方法

    公开(公告)号：US6162753A

    公开(公告)日：2000-12-19

    申请号：US319303

    申请日：1999-07-28

    申请人： Holger Geissler ,  Peter Gross ,  Sandra Bogdanovic

    发明人： Holger Geissler ,  Peter Gross ,  Sandra Bogdanovic

    IPC分类号： B01J38/00 ,  B01J31/40 ,  B01J20/34 ,  B01J38/64 ,  B01J38/68

    CPC分类号： B01J31/20 ,  B01J31/04 ,  B01J31/403 ,  B01J2231/34 ,  B01J2531/845

    摘要： The present invention relates to a process for recovering cobalt carbonyl catalysts used in the preparation of N-acyl-alpha-amino acid derivatives by amidocarbonylation comprising the process steps:adding aqueous hydrogen peroxide solution to the reaction solution present after the preparation of the N-acyl-.alpha.-amino acid derivative,then separating the aqueous phase containing water-soluble cobalt(II) salt from the nonaqueous product-containing phase,subsequently adding an alkali metal salt of the N-acyl-alpha-amino acid derivative to the aqueous phase from the previous process step,then separating off the precipitated cobalt salt of the N-acyl-alpha-amino acid derivative, andfinally converting the resulting cobalt salt of the N-acyl-alpha-amino acid derivative into the cobalt carbonyl catalyst in the presence of a mixture of carbon monoxide and hydrogen.

    摘要翻译： PCT No.PCT / EP97 / 06707 Sec。 371日期1999年7月28日第 102（e）日期1999年7月28日PCT 1997年12月1日PCT PCT。 第WO98 / 24547号公报 日期：1998年6月11日本发明涉及一种用于回收用于通过酰胺基羰基化制备N-酰基-α-氨基酸衍生物的羰基钴催化剂的方法，其包括以下步骤：向过后的反应溶液中加入过氧化氢水溶液 制备N-酰基-α-氨基酸衍生物，然后从含非水产物的相分离含水溶性钴（II）盐的水相，随后加入N-酰基-α-氨基的碱金属盐 酸衍生物与前述工艺步骤的水相反应，然后分离N-酰基-α-氨基酸衍生物的沉淀的钴盐，最后将所得N-酰基-α-氨基酸衍生物的钴盐转化为 在一氧化碳和氢气的混合物存在下的羰基钴催化剂。

    Process for preparing phenylacetic acid derivatives
    5.
    发明授权
    Process for preparing phenylacetic acid derivatives 失效
    制备苯乙酸衍生物的方法

    公开(公告)号：US06653502B2

    公开(公告)日：2003-11-25

    申请号：US10037078

    申请日：2001-11-09

    申请人： Holger Geissler

    发明人： Holger Geissler

    IPC分类号： C07C6736

    CPC分类号： C07C51/10 ,  C07C67/36 ,  C07C57/32 ,  C07C57/58 ,  C07C69/612

    摘要： A process for preparing phenylacetic acid derivatives of the formula (I) by reacting benzyl chlorides of the formula (II) with a compound of the formula R6OH and with carbon monoxide in a dipolar aprotic solvent in the presence of a catalyst which comprises at least one compound of a transition metal of subgroup VIII of the Periodic Table of the Elements, where R1, R2, R3, R4, and R5 independently of one another are the following radicals: a hydrogen or fluorine atom; a CH2Cl radical; a HO2CCH═CH—, NC— or CF3— group; an alkyl, alkoxy or acyloxy radical having in each case 1 to 18 carbon atoms; or a C6-C18-aryloxy, aryl or heteroaryl radical.

    摘要翻译： 一种制备式（I）的苯乙酸衍生物的方法，其通过式（II）的苄基氯与式R 6 OH的化合物和一氧化碳在偶极非质子传递溶剂中在催化剂存在下反应， 包括至少一种元素周期表第VIII族过渡金属的化合物，其中R 1，R 2，R 3，R 4和R 5彼此独立地是 是以下基团：氢或氟原子; CH 2 Cl基; HO 2 CCH = CH-，NC-或CF 3 - 基团;在每种情况下具有1至18个碳原子的烷基，烷氧基或酰氧基; 或C 6 -C 18芳氧基，芳基或杂芳基。

    Method for the catalytic production of substituted bipyridyl derivatives
    6.
    发明授权
    Method for the catalytic production of substituted bipyridyl derivatives 失效
    催化生产取代联吡啶衍生物的方法

    公开(公告)号：US06500956B1

    公开(公告)日：2002-12-31

    申请号：US09674063

    申请日：2000-11-30

    申请人： Holger Geissler ,  Peter Gross

    发明人： Holger Geissler ,  Peter Gross

    IPC分类号： C07D40102

    CPC分类号： C07B37/04 ,  C07D213/22 ,  C07D213/64 ,  C07D213/803

    摘要： The invention relates to a process for the preparation of bipyridyls by converting at least one pyridine of the formula (III) in which S′, S″, S′″, S″″ and S′″″, independently of one another, are identical or different and are hydrogen, (C1-C18)-alkyl, alkoxy-(C1-C18), acyloxy-(C1-C18), aryloxy-(C1-C18), perfluoroacyloxy-(C1-C8), NO2, (C1-C18)-aryl, (C1-C18)-heteroaryl, halogen, hydroxyl, nitro, nitroso, CN, COOH, CHO, PO3H2, SO3H, SO2R, SOR, NH2, NH-alkyl-(C1-C18), N-alkyl2-(C1-C18), protected amine, CF3, NHCO-alkyl-(C1-C4), N-alkyl-(C1-C4)-CO-alkyl-(C1-C4), COO-alkyl-(C1-C18), CONH2, CO-alkyl-(C1-C18), NHCOH, NHCOO-alkyl-(C1-C4), CO-(C1-C18)-aryl, COO-(C1-C18)-aryl, CHCH-CO2-alkyl-(C1-C18), CHCHCO2H, PO-phenyl2, PO-alkyl2-(C1-C4), (COO−)n(cation)n+, (PO32−)n(cation)2n+, (SO3−)n(cation)n+ and/or (O−)n(cation)n+, where optionally S′, S″, S′″, S″″ and/or S′″″ among one another together form one or more aliphatic and/or aromatic rings and/or in which optionally S′, S″, S′″, S″″and/or S′″″forms a bridge to at least one further pyridine of the formula (III) and/or in which optionally the radicals S′, S″, S′″, S″″, and/or S′″″ have the meanings given above and are substituted by at least one radical which has the meaning given above for S′, S″, S′″, S″″ and/or S′″″ in water in the presence of an alcohol, a base, a palladium catalyst and optionally one or more further solvents at a temperature of 0-200° C.

    摘要翻译： 本发明涉及通过将至少一种式（III）的吡啶独立地转化成其中S'，S“，S”'，S“”和“”“的吡啶来制备联吡啶的方法。 （C 1 -C 18），酰氧基 - （C 1 -C 18），芳氧基 - （C 1 -C 18），全氟酰氧基 - （C 1 -C 8）烷基， ），NO2，（C1-C18） - 芳基，（C1-C18） - 杂芳基，卤素，羟基，硝基，亚硝基，CN，COOH，CHO，PO3H2，SO3H，SO2R，SOR，NH2，NH-烷基 - （C1 （C1-C4）-CO-烷基 - （C1-C4），CO-烷基 - （C1-C4）-CO-烷基 - （C1-C4） （C 1 -C 18） - 烷基 - （C 1 -C 18），CONH 2，CO-烷基 - （C 1 -C 18），NHCOH，NHCOO-烷基 - （C 1 -C 4） 芳基，CHCH-CO 2 - 烷基 - （C 1 -C 18），CHCHCO 2 H，PO-苯基2，PO-烷基2-（C 1 -C 4），（COO-）n（阳离子）n +，（PO32-） ，（SO 3 - ）n（阳离子）n +和/或（O-）n（阳离子）n +，其中任选地有S'，S“，S”'，S“'和/或S” “彼此在一起形成一个或多个脂族和/或芳香环和/或其中任选的S'，S”，S“'，S” '和/或S''''与至少一种式（III）的另外的吡啶形成桥，和/或其中任选的基团S'，S“，S”'，S“ '和/或S'''具有上述含义，并被至少一个具有上述意义的基团代替S'，S“，S”，S“”和/ 在醇，碱，钯催化剂和任选的一种或多种其它溶剂的存在下，在0-200℃的温度下，在水中加入S“或”S“

    Process for preparing isochroman-3-ones
    7.
    发明授权
    Process for preparing isochroman-3-ones 失效
    异苯并二氢吡喃-3-酮的制备方法

    公开(公告)号：US6075152A

    公开(公告)日：2000-06-13

    申请号：US286566

    申请日：1999-04-05

    申请人： Holger Geissler ,  Ralf Pfirmann

    发明人： Holger Geissler ,  Ralf Pfirmann

    IPC分类号： B01J31/24 ,  C07B61/00 ,  C07D311/76 ,  C07D311/74

    CPC分类号： C07D311/76

    摘要： The present invention relates to a process for preparing an isochroman-3-one of the formula (I) by reacting a 1,2-bishalomethylbenzene of the formula (II) ##STR1## in which X is chlorine, bromine or iodine with carbon monoxide and water at a CO pressure of from 0.1 to 50 MPa and a temperature of from 20 to 200.degree. C. in the presence or absence of an ionic halide, in the presence of a palladium catalyst and a dipolar aprotic solvent, where in the formulae (I) and (II) the radicals R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently of one another denote:a hydrogen or fluorine atom;a HO.sub.2 CCH.dbd.CH--, NC-- or F.sub.3 C group;an alkyl, alkoxy or acyloxy radical having in each case 1 to 18 carbon atoms; or a C.sub.6 -C.sub.18 -aryloxy, aryl or heteroaryl radical, where the heteroatoms present are 1 to 3 atoms from the group O, N and/or S;a R.sup.5.sub.2 P(.dbd.O)--, R.sup.6 C(.dbd.O)--, R.sup.6 OC(.dbd.O)--, R.sup.6 OC(.dbd.O)CH.dbd.CH--, R.sup.7 C(.dbd.O)--, R.sup.7 OC(.dbd.O)CH.dbd.CH-- or R.sup.7.sub.2 P(.dbd.O) radical; in which R.sup.5 is a C.sub.1 -C.sub.4 -alkyl radical, R.sup.6 is a C.sub.1 -C.sub.18 -alkyl radical and R.sup.7 is a C.sub.6 -C.sub.18 -aryl radical; or in which at least one of the radicals R.sup.1, R.sup.2, R.sup.3 and R.sup.4 is substituted by a radical R.sup.8, where R.sup.8 has the same meaning as R.sup.1 ; or where at least two of the radicals R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are linked with one another and form at least one aliphatic or aromatic ring having 5 to 18 carbon atoms.

    摘要翻译： 本发明涉及通过使式（II）的1,2-二沙甲基苯（其中X为氯，溴或碘）与一氧化碳和水反应制备式（I）的异苯并二氢吡喃-3-酮的方法， 在钯催化剂和偶极非质子传递溶剂存在下，在离子型卤化物存在或不存在下，在0.1至50MPa的CO压力和20至200℃的温度下，其中式（I） 和（II）基团R 1，R 2，R 3和R 4彼此独立地表示：氢或氟原子; HO2CCH = CH-，NC-或F3C组; 在每种情况下具有1至18个碳原子的烷基，烷氧基或酰氧基; 或C 6 -C 18芳氧基，芳基或杂芳基，其中存在的杂原子是基团O，N和/或S 1至3个原子; （= O） - ，R6C（= O） - ，R6OC（= O） - ，R6OC（= O）CH = CH-，R7C（= O） - ，R7OC（= O）CH = CH-或R72P （= O）基团; 其中R 5是C 1 -C 4 - 烷基，R 6是C 1 -C 18烷基，R 7是C 6 -C 18芳基; 或其中基团R 1，R 2，R 3和R 4中的至少一个被基团R 8取代，其中R 8具有与R 1相同的含义; 或者其中基团R 1，R 2，R 3和R 4中的至少两个彼此连接并形成至少一个具有5至18个碳原子的脂族或芳族环。

    METHOD AND SYSTEM FOR INFORMATION TRANSMISSION
    10.
    发明申请
    METHOD AND SYSTEM FOR INFORMATION TRANSMISSION 有权

    公开(公告)号：US20220123942A1

    公开(公告)日：2022-04-21

    申请号：US17421254

    申请日：2020-01-04

    申请人： Holger Geissler

    发明人： Holger GEISSLER

    IPC分类号： H04L9/32 ,  H04L9/30

    摘要： The invention relates to a method and system for information transmission, wherein a piece of electronic information (2) is transmitted from a transmission terminal (3) of a transmitter (S) to a receiver terminal (31) of a receiver (E), comprising the following steps: a first transaction step (c), in which a first data record (22) is generated by the transmission terminal (3), said data record having at least one hash value (13, 14, 20), and the first data record (22) is transferred to a blockchain (16), a first verification step (d), in which the first data record (22) in the blockchain (16) is verified and stored as a first verified data record (6), a second transaction step (1), in which a second data record (7) is generated by the receiver terminal (31), said second data record having at least one public receiver key (17a) or a receiver identification (25), and the second data record (7) is transferred to the blockchain (16), a second verification step (m), in which the second data record (7) in the blockchain (16) is verified and stored as a second verified data record (8), a data encryption step (o, t, u), in which encrypted data (18, 19, 26) are generated by the transmission terminal (3) by means of the public receiver key (17a), a transmission step, in which the encrypted data (18, 19, 26) are transmitted to the receiver terminal (31), and—a data decryption step (v, w, y), in which the piece of electronic information (2) is made accessible to the receiver (E) by the encrypted data (18, 19, 26) being decrypted by the receiver terminal (31) by means of a private receiver key (17b).