公开(公告)号：US07749758B2

公开(公告)日：2010-07-06

申请号：US11840884

申请日：2007-08-17

申请人： Tasuku Honjo ,  Kei Tashiro ,  Jun Takahashi ,  Hiroki Toda

发明人： Tasuku Honjo ,  Kei Tashiro ,  Jun Takahashi ,  Hiroki Toda

IPC分类号： C12N5/02 ,  C12N5/06 ,  C12N5/08

CPC分类号： C07K16/18 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/47 ,  G01N33/6896 ,  G01N2333/47 ,  G01N2500/00 ,  G01N2500/04

摘要： The present invention relates to human, rat and mouse stem cell-derived neuron survival factor polypeptides (SDNSF), a process for producing them, cDNA encoding SDNSF, a vector comprising the cDNA, host cells transformed by the vector, an antibody against SDNSF, pharmaceutical compositions containing SDNSF or the antibody, a method of assaying SDNSF, a reagent for assaying SDNSF, and a screening method using SDNSF. The polypeptides are effective in the survival of nerve cells and, therefore, efficacious in treating injury to the central nerve system caused by brain infarction, brain hemorrhage, spinal cord injury, etc.

摘要翻译： 本发明涉及人，大鼠和小鼠干细胞来源的神经元存活因子多肽（SDNSF），其制备方法，编码SDNSF的cDNA，包含cDNA的载体，载体转化的宿主细胞，针对SDNSF的抗体， 含有SDNSF或抗体的药物组合物，测定SDNSF的方法，用于测定SDNSF的试剂和使用SDNSF的筛选方法。 这些多肽在神经细胞的存活中是有效的，因此对于脑梗塞，脑出血，脊髓损伤等引起的中枢神经系统的损伤是有效的。

公开(公告)号：US07662620B2

公开(公告)日：2010-02-16

申请号：US10833108

申请日：2004-04-28

申请人： Tasuku Honjo ,  Kei Tashiro ,  Jun Takahashi ,  Hiroki Toda

发明人： Tasuku Honjo ,  Kei Tashiro ,  Jun Takahashi ,  Hiroki Toda

IPC分类号： C12N5/10 ,  C12N15/63 ,  C07H21/00

CPC分类号： C07K16/18 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/47 ,  G01N33/6896 ,  G01N2333/47 ,  G01N2500/00 ,  G01N2500/04

摘要： The present invention relates to human, rat and mouse stem cell-derived neuron survival factor polypeptides (SDNSF), a process for producing them, cDNA encoding SDNSF, a vector comprising the cDNA, host cells transformed by the vector, an antibody against SDNSF, pharmaceutical compositions containing SDNSF or the antibody, a method of assaying SDNSF, a reagent for assaying SDNSF, and a screening method using SDNSF. The polypeptides are effective in the survival of nerve cells and neuronal stem cells, therefore, efficacious in treating injury to the central nerve system and cancer.

摘要翻译： 本发明涉及人，大鼠和小鼠干细胞来源的神经元存活因子多肽（SDNSF），其制备方法，编码SDNSF的cDNA，包含cDNA的载体，载体转化的宿主细胞，针对SDNSF的抗体， 含有SDNSF或抗体的药物组合物，测定SDNSF的方法，用于测定SDNSF的试剂和使用SDNSF的筛选方法。 这些多肽在神经细胞和神经元干细胞的存活中是有效的，因此在治疗中枢神经系统和癌症的损伤方面是有效的。

公开(公告)号：US07633769B2

公开(公告)日：2009-12-15

申请号：US11772602

申请日：2007-07-02

申请人： Hiroki Toda ,  Kenichi Fukumoto ,  Yosuke Aoyagi ,  Hiroyuki Fujita

发明人： Hiroki Toda ,  Kenichi Fukumoto ,  Yosuke Aoyagi ,  Hiroyuki Fujita

IPC分类号： H02M3/335 ,  H02H7/122 ,  H02M7/538

CPC分类号： H02M7/5381 ,  H02M3/3372 ,  H02M2001/0048 ,  H05B41/2824 ,  H05B41/3927 ,  Y02B70/1491

摘要： First and second semiconductor switches which are activated alternately are provided between ends of a primary winding and a common potential point, wherein a DC power supply voltage is supplied to a center tap. An electric current flowing into a load is fed back to thereby subject the semiconductor switches to PWM control. Series circuits consisting of capacitors and semiconductor switches are connected between the center tap of the primary winding and the ends of the same. The semiconductor switches are activated in synchronism with the first and second semiconductor switches, thereby preventing occurrence of an anomalous high voltage, which would otherwise be caused at the time of switching operation.

摘要翻译： 交替激活的第一和第二半导体开关设置在初级绕组的端部和公共电位点之间，其中DC电源电压被提供给中心抽头。 流入负载的电流被反馈，从而使半导体开关进行PWM控制。 由电容器和半导体开关组成的串联电路连接在初级绕组的中心抽头和其一端之间。 半导体开关与第一和第二半导体开关同步地被激活，从而防止在切换操作时会引起异常高电压的发生。

公开(公告)号：US07273725B2

公开(公告)日：2007-09-25

申请号：US10493393

申请日：2002-10-22

申请人： Tasuku Honjo ,  Kei Tashiro ,  Jun Takahashi ,  Hiroki Toda

发明人： Tasuku Honjo ,  Kei Tashiro ,  Jun Takahashi ,  Hiroki Toda

IPC分类号： C12P21/06 ,  C07K14/00

CPC分类号： C07K16/18 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/47 ,  G01N33/6896 ,  G01N2333/47 ,  G01N2500/00 ,  G01N2500/04

摘要： The present invention relates to human, rat and mouse stem cell-derived neuron survival factor polypeptides (SDNSF), a process for producing them, cDNA encoding SDNSF, a vector comprising the cDNA, host cells transformed by the vector, an antibody against SDNSF, pharmaceutical compositions containing SDNSF or the antibody, a method of assaying SDNSF, a reagent for assaying SDNSF, and a screening method using SDNSF. The polypeptides are effective in the survival of nerve cells and, therefore, efficacious in treating injury to the central nerve system caused by brain infarction, brain hemorrhage, spinal cord injury, etc.

摘要翻译： 本发明涉及人，大鼠和小鼠干细胞来源的神经元存活因子多肽（SDNSF），其制备方法，编码SDNSF的cDNA，包含cDNA的载体，载体转化的宿主细胞，针对SDNSF的抗体， 含有SDNSF或抗体的药物组合物，测定SDNSF的方法，用于测定SDNSF的试剂和使用SDNSF的筛选方法。 这些多肽在神经细胞的存活中是有效的，因此对于脑梗塞，脑出血，脊髓损伤等引起的中枢神经系统的损伤是有效的。

公开(公告)号：US07126831B2

公开(公告)日：2006-10-24

申请号：US11340396

申请日：2006-01-26

申请人： Hiroki Toda ,  Kenichi Fukumoto ,  Yosuke Aoyagi ,  Hiroyuki Fujita

发明人： Hiroki Toda ,  Kenichi Fukumoto ,  Yosuke Aoyagi ,  Hiroyuki Fujita

IPC分类号： H02M3/335 ,  H02M7/538 ,  H02H7/122

CPC分类号： H02M7/5381 ,  H02M3/3372 ,  H02M2001/0048 ,  H05B41/2824 ,  H05B41/3927 ,  Y02B70/1491

摘要： First and second semiconductor switches which are activated alternately are provided between ends of a primary winding and a common potential point, wherein a DC power supply voltage is supplied to a center tap. An electric current flowing into a load is fed back to thereby subject the semiconductor switches to PWM control. Series circuits consisting of capacitors and semiconductor switches are connected between the center tap of the primary winding and the ends of the same. The semiconductor switches are activated in synchronism with the first and second semiconductor switches, thereby preventing occurrence of an anomalous high voltage, which would otherwise be caused at the time of switching operation.

公开(公告)号：US07046526B2

公开(公告)日：2006-05-16

申请号：US10806262

申请日：2004-03-22

申请人： Hiroki Toda ,  Kenichi Fukumoto ,  Yosuke Aoyagi ,  Hiroyuki Fujita

发明人： Hiroki Toda ,  Kenichi Fukumoto ,  Yosuke Aoyagi ,  Hiroyuki Fujita

IPC分类号： H02M3/335 ,  H02M3/315

CPC分类号： H02M7/5381 ,  H02M3/3372 ,  H02M2001/0048 ,  H05B41/2824 ,  H05B41/3927 ,  Y02B70/1491

摘要： First and second semiconductor switches which are activated alternately are provided between ends of a primary winding and a common potential point, wherein a DC power supply voltage is supplied to a center tap. An electric current flowing into a load is fed back to thereby subject the semiconductor switches to PWM control. Series circuits consisting of capacitors and semiconductor switches are connected between the center tap of the primary winding and the ends of the same. The semiconductor switches are activated in synchronism with the first and second semiconductor switches, thereby preventing occurrence of an anomalous high voltage, which would otherwise be caused at the time of switching operation.

公开(公告)号：US20080145365A1

公开(公告)日：2008-06-19

申请号：US10833108

申请日：2004-04-28

申请人： Tasuku Honjo ,  Kei Tashiro ,  Jun Takahashi ,  Hiroki Toda

发明人： Tasuku Honjo ,  Kei Tashiro ,  Jun Takahashi ,  Hiroki Toda

IPC分类号： A61K39/395 ,  C07K14/435 ,  C07H21/04 ,  C12N15/00 ,  A61K38/17 ,  A61P25/00 ,  G01N33/00 ,  A61P35/04 ,  A61K31/713 ,  C12N5/00 ,  C12P21/06 ,  C07K16/00

CPC分类号： C07K16/18 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/47 ,  G01N33/6896 ,  G01N2333/47 ,  G01N2500/00 ,  G01N2500/04

摘要： The present invention relates to human, rat and mouse stem cell-derived neuron survival factor polypeptides (SDNSF), a process for producing them, cDNA encoding SDNSF, a vector comprising the cDNA, host cells transformed by the vector, an antibody against SDNSF, pharmaceutical compositions containing SDNSF or the antibody, a method of assaying SDNSF, a reagent for assaying SDNSF, and a screening method using SDNSF. The polypeptides are effective in the survival of nerve cells and neuronal stem cells, therefore, efficacious in treating injury to the central nerve system and cancer.

摘要翻译： 本发明涉及人，大鼠和小鼠干细胞来源的神经元存活因子多肽（SDNSF），其制备方法，编码SDNSF的cDNA，包含cDNA的载体，载体转化的宿主细胞，针对SDNSF的抗体， 含有SDNSF或抗体的药物组合物，测定SDNSF的方法，用于测定SDNSF的试剂和使用SDNSF的筛选方法。 这些多肽在神经细胞和神经元干细胞的存活中是有效的，因此在治疗中枢神经系统和癌症的损伤方面是有效的。

公开(公告)号：US20070008751A1

公开(公告)日：2007-01-11

申请号：US11521418

申请日：2006-09-13

申请人： Hiroki Toda ,  Kenichi Fukumoto ,  Yosuke Aoyagi ,  Hiroyuki Fujita

发明人： Hiroki Toda ,  Kenichi Fukumoto ,  Yosuke Aoyagi ,  Hiroyuki Fujita

IPC分类号： H02M3/335

CPC分类号： H02M7/5381 ,  H02M3/3372 ,  H02M2001/0048 ,  H05B41/2824 ,  H05B41/3927 ,  Y02B70/1491

摘要： First and second semiconductor switches which are activated alternately are provided between ends of a primary winding and a common potential point, wherein a DC power supply voltage is supplied to a center tap. An electric current flowing into a load is fed back to thereby subject the semiconductor switches to PWM control. Series circuits consisting of capacitors and semiconductor switches are connected between the center tap of the primary winding and the ends of the same. The semiconductor switches are activated in synchronism with the first and second semiconductor switches, thereby preventing occurrence of an anomalous high voltage, which would otherwise be caused at the time of switching operation.

公开(公告)号：US20060120117A1

公开(公告)日：2006-06-08

申请号：US11340396

申请日：2006-01-26

申请人： Hiroki Toda ,  Kenichi Fukumoto ,  Yosuke Aoyagi ,  Hiroyuki Fujita

发明人： Hiroki Toda ,  Kenichi Fukumoto ,  Yosuke Aoyagi ,  Hiroyuki Fujita

IPC分类号： H02M3/335

CPC分类号： H02M7/5381 ,  H02M3/3372 ,  H02M2001/0048 ,  H05B41/2824 ,  H05B41/3927 ,  Y02B70/1491

摘要： First and second semiconductor switches which are activated alternately are provided between ends of a primary winding and a common potential point, wherein a DC power supply voltage is supplied to a center tap. An electric current flowing into a load is fed back to thereby subject the semiconductor switches to PWM control. Series circuits consisting of capacitors and semiconductor switches are connected between the center tap of the primary winding and the ends of the same. The semiconductor switches are activated in synchronism with the first and second semiconductor switches, thereby preventing occurrence of an anomalous high voltage, which would otherwise be caused at the time of switching operation.

公开(公告)号：US20070279946A1

公开(公告)日：2007-12-06

申请号：US11772602

申请日：2007-07-02

申请人： Hiroki TODA ,  Kenichi Fukumoto ,  Yosuke Aoyagi ,  Hiroyuki Fujita

发明人： Hiroki TODA ,  Kenichi Fukumoto ,  Yosuke Aoyagi ,  Hiroyuki Fujita

IPC分类号： H02M3/335

CPC分类号： H02M7/5381 ,  H02M3/3372 ,  H02M2001/0048 ,  H05B41/2824 ,  H05B41/3927 ,  Y02B70/1491

摘要： First and second semiconductor switches which are activated alternately are provided between ends of a primary winding and a common potential point, wherein a DC power supply voltage is supplied to a center tap. An electric current flowing into a load is fed back to thereby subject the semiconductor switches to PWM control. Series circuits consisting of capacitors and semiconductor switches are connected between the center tap of the primary winding and the ends of the same. The semiconductor switches are activated in synchronism with the first and second semiconductor switches, thereby preventing occurrence of an anomalous high voltage, which would otherwise be caused at the time of switching operation.

摘要翻译： 交替激活的第一和第二半导体开关设置在初级绕组的端部和公共电位点之间，其中DC电源电压被提供给中心抽头。 流入负载的电流被反馈，从而使半导体开关进行PWM控制。 由电容器和半导体开关组成的串联电路连接在初级绕组的中心抽头和其一端之间。 半导体开关与第一和第二半导体开关同步地被激活，从而防止在切换操作时会引起异常高电压的发生。