公开(公告)号：US4917885A

公开(公告)日：1990-04-17

申请号：US946119

申请日：1986-12-23

Applicant: Tohru Chiba ,  Hiroaki Muto ,  Soji Tanioka ,  Yuichi Nishiyama ,  Noboru Hoshi ,  Yoshiro Onda

Inventor： Tohru Chiba ,  Hiroaki Muto ,  Soji Tanioka ,  Yuichi Nishiyama ,  Noboru Hoshi ,  Yoshiro Onda

IPC: A61K9/48 ,  C08L1/28

CPC classification number: A61K9/4816 ,  C08L1/28

Abstract: In place of gelatin conventionally used as a material for shaping hard medicinal capsules, the invention proposes a hard capsule for medicinal use shaped of a polymer blend of a water-soluble cellulose ether, e.g., alkyl cellulose, hydroxyalkyl cellulose and alkyl hydroxyalkyl cellulose, and a polyvinyl alcohol in a weight ratio of 70:30 to 98:2. The inventive hard medicinal capsules have remarkably low permeability to oxygen and moisture with little influences on the medicament contained therein along with sufficiently high mechanical strengths and are much more stable than conventional gelatin-made capsules against the influences of the ambient conditions, such as, the crack formation unavoidable in a gelatin-made hard capsule when it is kept under an extremely low humidity.

Abstract translation: 本发明代替通常用作形成硬药胶囊的材料的明胶，而提出了一种用于医用的硬胶囊，其形式为水溶性纤维素醚，例如烷基纤维素，羟烷基纤维素和烷基羟烷基纤维素的聚合物共混物，以及 聚乙烯醇，重量比为70:30至98:2。 本发明的硬药物胶囊具有非常低的氧气和水分渗透性，对其中所含的药物几乎没有影响，同时具有足够高的机械强度，并且比常规明胶制成的胶囊比环境条件的影响更稳定，例如 当明胶制成的硬胶囊保持在极低的湿度下时，不可避免的裂缝形成。

公开(公告)号：US4322524A

公开(公告)日：1982-03-30

申请号：US168269

申请日：1980-07-10

Applicant: Yoshiro Onda ,  Hiroaki Muto ,  Hiroshi Suzuki

Inventor： Yoshiro Onda ,  Hiroaki Muto ,  Hiroshi Suzuki

IPC: C08B37/00

CPC classification number: C08B37/0018

Abstract: The present invention provides a novel compound cyanoethylpullulan which is a cyanoethylation product of pullulan. Pullulan is readily cyanoethylated by the reaction with acrylonitrile in the presence of an alkali catalyst such as sodium hydroxide.The cyanoethylpullulan having a degree of cyanoethylation of at least 50% has various unique properties in the heat resistance, solubility in organic solvents, film-forming property, adhesive bonding to metals and the like in comparison with related cyanoethylated products such as cyanoethylcellulose and cyanoethylated polyvinyl alcohol.

Abstract translation: 本发明提供了作为支链淀粉的氰乙基化产物的新型化合物氰乙基普兰兰。 在碱性催化剂如氢氧化钠的存在下，通过与丙烯腈的反应，将支链淀粉容易地氰乙基化。 具有至少50％氰基乙基化度的氰乙基普兰兰与相关的氰乙基纤维素和氰乙基化聚乙烯吡咯烷酮相关的氰乙基化产物相比具有各种独特的耐热性，在有机溶剂中的溶解性，成膜性，与金属的粘合性等 醇。

公开(公告)号：US4993137A

公开(公告)日：1991-02-19

申请号：US449354

申请日：1989-12-13

Applicant: Hiroaki Muto ,  Yuichi Nishiyama ,  Toru Chiba ,  Kiyoshi Araume

Inventor： Hiroaki Muto ,  Yuichi Nishiyama ,  Toru Chiba ,  Kiyoshi Araume

IPC: A61J3/07 ,  A61K9/48

CPC classification number: A61J3/077 ,  A61K9/4816 ,  Y10S264/37 ,  Y10S425/804 ,  Y10T29/49872

Abstract: A method for manufacturing capsules causes the solution of thermo-gelling material to gelatinize once, and then drys the gel. Therefore the process of manufacturing capsules is less affected by drying conditions, thus providing capsules of uniform wall thickness without wrinkle. In the apparatus, circulating capsule pins are dipped in the solution of thermo-gelling material, thus the solution adheres to the pins. The pins are rotated upside down, thus thickness of the solution adhering to the pins becoming uniform. Then the pins are retained in the vessel maintained at a higher temperature than the gelling temperature of the solution, and the solution adhering to the pins is gelatinized. The thus-formed gel is dried through a drying device, and the dried gel, i.e. capsules, is removed from capsule pins.

Abstract translation: 制造胶囊的方法使得热凝胶材料的溶液凝胶化一次，然后干燥凝胶。 因此，制造胶囊的过程较少受干燥条件的影响，从而提供均匀的壁厚而没有皱纹的胶囊。 在该装置中，将循环的胶囊销浸渍在热凝胶材料的溶液中，从而使溶液粘附到销上。 销被倒置旋转，因此粘附在销上的溶液的厚度变得均匀。 然后将销保持在保持在比溶液的胶凝温度更高的温度的容器中，并且粘附到销的溶液凝胶化。 将如此形成的凝胶通过干燥装置干燥，并将干燥的凝胶，即胶囊从胶囊销中取出。

公开(公告)号：US4948622A

公开(公告)日：1990-08-14

申请号：US224772

申请日：1988-06-09

Applicant: Hiroyasu Kokubo ,  Hiroaki Muto ,  Tohru Chiba

Inventor： Hiroyasu Kokubo ,  Hiroaki Muto ,  Tohru Chiba

IPC: A61K47/44 ,  A61K9/28 ,  A61K9/34 ,  A61K9/50 ,  A61K9/52 ,  A61K9/60 ,  A61K47/00 ,  A61K47/38

CPC classification number: A61K9/5047 ,  A61K9/2866 ,  A61K9/2886 ,  A61K9/5073

Abstract: Solid medicament forms, such as granules, beads, tablets, are first coated with a hot aqueous dispersion of a cellulose ether, which is soluble in cold water but insoluble in hot water, and then subjected to a wax treatment with heating to form a masking layer of the wax. Different from the coating film of a cellulose ether formed by using an aqueous or organic solution of the cellulose ether, the coating film formed by using the aqueous dispersion of the cellulose ether has a porous structure so that the amount of the wax deposited in the wax treatment is much larger than in the prior art methods to exhibit a high effect of masking the bitterness of the ingredient contained in the medicament form.

Abstract translation: PCT No.PCT / JP88 / 00483 Sec。 371日期：1988年6月9日 102（e）日期1988年6月9日PCT提交1988年5月23日PCT公布。 出版物WO89 / 05635 日期：1989年6月29日。固体药物形式，例如颗粒剂，珠粒，片剂，首先用纤维素醚的热水分散体包衣，纤维素醚可溶于冷水但不溶于热水，然后经受蜡 加热处理以形成蜡的掩蔽层。 与通过使用纤维素醚的水溶液或有机溶液形成的纤维素醚的涂膜不同，通过使用纤维素醚的水分散体形成的涂膜具有多孔结构，使得沉积在蜡中的蜡的量 处理比现有技术方法中大得多，以显示掩蔽药物形式中所含成分的苦味的高效果。

公开(公告)号：US08423220B2

公开(公告)日：2013-04-16

申请号：US13052639

申请日：2011-03-21

Applicant: Hiroaki Muto

Inventor： Hiroaki Muto

IPC: B60W20/00

CPC classification number: B60K6/46 ,  B60W10/06 ,  B60W10/08 ,  B60W20/50 ,  B60W2510/244 ,  Y02T10/6217 ,  Y02T10/6286

Abstract: There are provided a hybrid control unit, an engine control unit that controls an engine based on command information received from the hybrid control unit and an operation status of the engine, and a communication abnormality detection means that detects an abnormality in communication between the hybrid control unit and the engine control unit. In the case where due to an abnormality in the communication between the hybrid control unit and the engine control unit, the engine control unit cannot receive command information from the hybrid control unit, each of the hybrid control unit and the engine control unit performs control in preliminarily set sequence.

Abstract translation: 提供一种混合动力控制单元，根据从混合动力控制单元接收到的指令信息和发动机的运转状况来控制发动机的发动机控制单元，以及检测混合动力控制装置的通信异常的通信异常检测单元 单元和发动机控制单元。 在由于混合动力控制单元和发动机控制单元之间的通信异常的情况下，发动机控制单元不能从混合动力控制单元接收命令信息的情况下，混合动力控制单元和发动机控制单元中的每一个执行控制 初步设定顺序。

公开(公告)号：US5032074A

公开(公告)日：1991-07-16

申请号：US485835

申请日：1990-02-28

Applicant: Hiroaki Muto ,  Yuichi Nishiyama ,  Toru Chiba ,  Kiyoshi Araume

Inventor： Hiroaki Muto ,  Yuichi Nishiyama ,  Toru Chiba ,  Kiyoshi Araume

IPC: A61J3/07 ,  A61K9/48

CPC classification number: A61J3/077 ,  A61K9/4816 ,  Y10S264/37 ,  Y10S425/804 ,  Y10T29/49872

Abstract: An apparatus for manufacturing capsules which causes a solution of thermo-gelling material to gelatinize, and then drys the gel, whereby the process of manufacturing capsules is less affected by drying conditions, thus providing capsules of uniform wall thickness without wrinkles. In the apparatus of this invention, circulating capsule pins are dipped in the solution of thermo-gelling material, thus the solution adheres to the pins, and, the pins are rotated upside down, thus thickness of the solution adhering to the pins becomes uniform. Then, the pins are retained in the vessel maintained at a higher temperature than the gelling temperature of the solution, and the solution adhering to the pins is accelerated to gelatinization. The formed gel is dried in a drying device, and the dried gel bodies, i.e. capsules, are removed from the capsule pins.

公开(公告)号：US4385078A

公开(公告)日：1983-05-24

申请号：US71298

申请日：1979-08-30

Applicant: Yoshiro Onda ,  Hiroaki Muto ,  Hiroshi Suzuki ,  Kazumasa Maruyama ,  Atsushi Hatayama

Inventor： Yoshiro Onda ,  Hiroaki Muto ,  Hiroshi Suzuki ,  Kazumasa Maruyama ,  Atsushi Hatayama

IPC: A61K47/38 ,  A61K9/28 ,  C08L1/10 ,  C08L1/14

CPC classification number: A61K9/282 ,  A61K9/2866

Abstract: A novel aqueous coating composition is proposed for providing enteric coating on solid dosage forms such as tablets. The aqueous coating composition of the invention comprises a fine powder of an enterosoluble cellulose derivative such as hydroxypropylmethylcellulose phthalate and hydroxypropylmethylcellulose acetate succinate, which is insoluble in water but can be plasticized and solubilized with certain plasticizing agents, as dispersed in an aqueous dispersing medium and a plasticizing agent having compatibility with the enterosoluble cellulose derivative and dissolved in the aqueous dispersing medium. The particle size of the enterosoluble cellulose derivative and the boiling point of the plasticizing agent is the key parameters and should be finer than 100 .mu.m in an average particle diameter and not lower than 100.degree. C., respectively. Upon application of the aqueous coating composition to the solid dosage forms, water as the dispersing medium is first evaporated leaving the cellulose derivative and the plasticizing agent, which latter solubilizes the former to form a continuous coating layer on the solid dosage forms imparting good and satisfactory enterosolubility thereto.

Abstract translation: 提出了一种新颖的水性涂料组合物，用于在诸如片剂的固体剂型上提供肠溶衣。 本发明的水性涂料组合物包括不溶于水但可以用某些增塑剂增塑和溶解的分散在水分散介质中的肠溶性纤维素衍生物如羟丙基甲基纤维素邻苯二甲酸酯和羟丙基甲基纤维素乙酸酯琥珀酸盐的细粉末， 增塑剂与肠溶性纤维素衍生物具有相容性并溶于水分散介质中。 肠溶性纤维素衍生物的粒径和增塑剂的沸点是关键参数，平均粒径分别小于100μm，不低于100℃。 当将水性涂料组合物施用于固体剂型时，首先蒸发作为分散介质的水，留下纤维素衍生物和增塑剂，后者溶解前者，在固体剂型上形成连续涂层，赋予良好和令人满意的效果 肠溶性。

公开(公告)号：US4226981A

公开(公告)日：1980-10-07

申请号：US944177

申请日：1978-09-20

Applicant: Yoshiro Onda ,  Hiroaki Muto ,  Kazumasa Maruyama

Inventor： Yoshiro Onda ,  Hiroaki Muto ,  Kazumasa Maruyama

IPC: A61K9/28 ,  A61K9/36 ,  C08B13/00 ,  G03C1/835 ,  B44D1/50 ,  G03C1/92

CPC classification number: A61K9/2866 ,  C08B13/00 ,  G03C1/835

Abstract: A novel cellulose derivative provided in this invention is a mixed ester of an alkoxy or hydroxyalkoxy substituted cellulose ether, prepared by the esterification reaction of the ether with succinic anhydride and an anhydride of an aliphatic monocarboxylic acid. The cellulose derivatives are advantageous because of their capability of producing enteric coatings having sufficient flexibility without the use of a plasticizer as well as by their chemical and physical stability against moisture, and also by easy purification after completion of the esterification reaction. The coatings produced from the derivatives have a similar chemical and physical stability. The cellulose derivatives are useful for the enteric coating of pharmaceutical dosage forms and also for providing halation-preventing layers on photographic films.

Abstract translation: 本发明提供的新型纤维素衍生物是通过醚与琥珀酸酐的酯化反应和脂族一元羧酸的酸酐制备的烷氧基或羟基烷氧基取代的纤维素醚的混合酯。 纤维素衍生物是有利的，因为它们具有在不使用增塑剂的情况下具有足够柔韧性的肠溶衣的能力，以及它们对水分的化学和物理稳定性以及酯化反应完成后容易的纯化。 由衍生物生产的涂料具有相似的化学和物理稳定性。 纤维素衍生物可用于药物剂型的肠溶包衣以及用于在照相胶片上提供防晕层。

公开(公告)号：US4091205A

公开(公告)日：1978-05-23

申请号：US635286

申请日：1975-11-26

Applicant: Yoshiro Onda ,  Hiroaki Muto ,  Hiroshi Suzuki

Inventor： Yoshiro Onda ,  Hiroaki Muto ,  Hiroshi Suzuki

IPC: A61J3/06 ,  A61K9/20 ,  A61K47/38 ,  C08B11/00 ,  C08B11/20 ,  A61K31/72 ,  C08B11/02 ,  C08B11/08 ,  C08B11/12 ,  C08B11/193

CPC classification number: A61K9/2054 ,  C08B11/00 ,  C08B11/20 ,  Y10S514/951

Abstract: In the process for the preparation of low-substituted cellulose ethers comprising the successive steps of etherification of alkali cellulose, neutralization of the crude cellulose ether, washing, drying and pulverization, the neutralization step is carried out in two stages, i.e., by first employing 5 to 80% of an acid stoichiometrically required and then adding an additional amount of the acid to complete neutralization. The cellulose ethers thus prepared can readily be pulverized into fine powder having a very good flowing property and yet an excellent binding force, and work as a suitable disintegrator in tablets.

Abstract translation: 在制备低取代纤维素醚的方法中，包括碱纤维素醚化，中和粗纤维素醚，洗涤，干燥和粉碎的连续步骤，中和步骤分两个阶段进行，即首先采用 按化学计量要求的5至80％的酸，然后加入额外量的酸以完全中和。 如此制备的纤维素醚可以容易地粉碎成具有非常好的流动性能和优异的粘合力的细粉末，并且作为片剂中合适的崩解剂起作用。

公开(公告)号：US20120095630A1

公开(公告)日：2012-04-19

申请号：US13052639

申请日：2011-03-21

Applicant: Hiroaki MUTO

Inventor： Hiroaki MUTO

IPC: B60W10/04 ,  B60W20/00

CPC classification number: B60K6/46 ,  B60W10/06 ,  B60W10/08 ,  B60W20/50 ,  B60W2510/244 ,  Y02T10/6217 ,  Y02T10/6286

Abstract: There are provided a hybrid control unit, an engine control unit that controls an engine based on command information received from the hybrid control unit and an operation status of the engine, and a communication abnormality detection means that detects an abnormality in communication between the hybrid control unit and the engine control unit. In the case where due to an abnormality in the communication between the hybrid control unit and the engine control unit, the engine control unit cannot receive command information from the hybrid control unit, each of the hybrid control unit and the engine control unit performs control in preliminarily set sequence.

Abstract translation: 提供一种混合动力控制单元，根据从混合动力控制单元接收到的指令信息和发动机的运转状况来控制发动机的发动机控制单元，以及检测混合动力控制装置的通信异常的通信异常检测单元 单元和发动机控制单元。 在由于混合动力控制单元和发动机控制单元之间的通信异常的情况下，发动机控制单元不能从混合动力控制单元接收命令信息的情况下，混合动力控制单元和发动机控制单元中的每一个执行控制 初步设定顺序。