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公开(公告)号：US08669098B2
公开(公告)日：2014-03-11
申请号：US12899007
申请日：2010-10-06
申请人： Hideshi Hattori
发明人： Hideshi Hattori
IPC分类号： C12M1/34
CPC分类号： B01J19/0046 , B01J2219/00527 , B01J2219/0054 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , C40B70/00
摘要： For the purpose of improving the accuracy of a variety analyses using a bio-microarray, it is a main object of the invention to provide a bio-microarray capable of producing relatively high signal intensity from a fluorescent molecule and capable of having improved quantification performance and to provide a substrate for bio-microarray.In order to achieve the object, the invention provides a substrate for bio-microarray characterized by having a reflection-suppressing function.
摘要翻译： 为了提高使用生物微阵列的多样性分析的准确性，本发明的主要目的是提供能够从荧光分子产生相对高的信号强度且能够提高定量性能的生物微阵列， 以提供用于生物微阵列的底物。 为了达到上述目的，本发明提供一种生物微阵列用基板，其特征在于具有反射抑制功能。
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公开(公告)号：US08153548B2
公开(公告)日：2012-04-10
申请号：US12662468
申请日：2010-04-19
CPC分类号： B01J23/002 , B01J21/066 , B01J23/58 , B01J23/6527 , B01J2523/00 , C10G35/085 , C10G45/62 , C10G2300/305 , C10G2300/70 , B01J2523/48 , B01J2523/69 , B01J2523/828 , B01J2523/12
摘要： The isomerization catalyst is a solid acid catalyst formed with a base of tungstated zirconium mixed oxides loaded with at least one hydrogenation/dehydrogenation metal catalyst from Groups 8-10 (IUPAC, 2006) and impregnated with at least one alkali metal from Group 1 (IUPAC, 2006). The metal from Groups 8-10 is preferably selected from platinum, palladium, ruthenium, rhodium, iridium, osmium and mixtures thereof, and most preferably is platinum. The Group I alkali metal is selected from lithium, sodium, potassium rubidium and cesium and mixtures thereof, and is preferably lithium, sodium, or potassium. Preferable, the catalyst forms, by weight, a base having between about 80-90% zirconium mixed oxides and between about 10-20% tungstate; between about 0.1-3.00% Group 8-10 metal; and between about 0.01-1.00% Group 1 alkali metal.
摘要翻译： 异构化催化剂是固体酸催化剂，其形成有装载有来自组8-10（IUPAC，2006）的至少一种氢化/脱氢金属催化剂的钨酸锆混合氧化物的基底，并用至少一种来自组1的碱金属（IUPAC） ，2006）。 来自组8-10的金属优选选自铂，钯，钌，铑，铱，锇及其混合物，最优选为铂。 I族碱金属选自锂，钠，钾铷和铯及其混合物，优选锂，钠或钾。 优选的是，催化剂重量含有约80-90％的锆混合氧化物和约10-20％的钨酸盐之间的碱; 介于约0.1-3.00％之间的第8-10族金属; 和约0.01-1.00％的第1族碱金属。
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3.发明申请公开(公告)号：US20070218554A1
公开(公告)日：2007-09-20
申请号：US11587363
申请日：2005-04-25
IPC分类号： C12N5/02
CPC分类号： C12N5/0068 , C12M23/20 , C12M25/06 , C12M33/00 , C12N2535/10 , C12N2539/10
摘要： A main object of the present invention is to provide a cell culture patterning substrate and a method for manufacturing the same, which can be used to culture the cells on the substrate in an intended shape. To achieve the object, the present invention provides a cell culture patterning substrate comprising: a base material provided with a convex portion; and a cell culture region, which is a region for culturing a cell, formed on a surface of the base material, wherein the cell culture region is partitioned with the convex portion of the base material provided with the convex portion.
摘要翻译： 本发明的主要目的在于提供一种细胞培养图案形成基板及其制造方法，其可以用于将基板上的细胞以期望的形状培养。 为了达到上述目的，本发明提供一种细胞培养图案形成基板，其特征在于，具备：设置有凸部的基材; 和形成在基材表面上的细胞培养区域的细胞培养区域，其中细胞培养区域与设置有凸部的基材的凸部分隔开。
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公开(公告)号：US20070190645A1
公开(公告)日：2007-08-16
申请号：US10592167
申请日：2005-03-10
CPC分类号： C12N5/069 , A61L27/3804 , A61L27/3895 , A61L27/507 , C12N2501/115 , C12N2533/90 , C12N2535/10
摘要： A vascular cell culture patterning substrate, which can efficiently form a plurality of blood vessels on one substrate. The vascular cell culture patterning substrate includes: a base material; a vascular cell adhesion portion formed in at least two substantially parallel lines on the base material, and having adhesive properties to a vascular cell which forms a blood vessel; and a vascular cell adhesion-inhibiting portion formed in between two adjacent vascular cell adhesion portions on the base material, and inhibiting adhesion to the vascular cell. The vascular cell adhesion-inhibiting portion contains a vascular cell adhesion-inhibiting material having vascular cell adhesion-inhibiting properties of inhibiting adhesion to the vascular cell.
摘要翻译： 一种血管细胞培养图案化衬底，其能够在一个衬底上有效地形成多个血管。 血管细胞培养图案形成基板包括：基材; 形成在所述基材上的至少两条基本上平行的线上的血管细胞粘附部分，并且对形成血管的血管细胞具有粘附性; 以及在基材上的两个相邻的血管细胞粘附部分之间形成的血管细胞粘附抑制部分，并且抑制对血管细胞的粘附。 血管细胞粘附抑制部分含有具有抑制对血管细胞粘附的血管细胞粘附抑制性质的血管细胞粘附抑制物质。
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公开(公告)号：US20070048292A1
公开(公告)日：2007-03-01
申请号：US11455112
申请日：2006-06-19
CPC分类号： A61F2/02 , A61F2210/0076 , A61F2240/001 , A61F2250/0067 , A61K35/12 , A61L27/3604 , A61L27/3804 , A61L27/3808 , A61L27/3843 , A61L27/58 , A61L2430/12 , A61L2430/34 , B82Y30/00 , C12N5/0068 , C12N5/069 , C12N2533/92 , C12N2535/10
摘要： In accordance with the present invention, an implant in which cells are arranged in a fine pattern that is available for immediate implantation and that does not need to be removed after implantation is provided. The present invention relates to a cell-containing sheet, which comprises cells and a support comprising a bioabsorbable material, in which the support has a cell adhesion protein-containing layer on the surface thereof and the cells form a pattern on the support.
摘要翻译： 根据本发明，提供了一种植入物，其中细胞被布置成可用于立即植入并且在植入后不需要移除的精细图案。 本发明涉及含细胞的片，其包含细胞和包含生物可吸收材料的载体，其中所述载体在其表面上具有含细胞粘附蛋白的层，并且所述细胞在载体上形成图案。
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公开(公告)号：US20070015277A1
公开(公告)日：2007-01-18
申请号：US11446913
申请日：2006-06-05
申请人： Hideshi Hattori , Masatoshi Kuroda
发明人： Hideshi Hattori , Masatoshi Kuroda
CPC分类号： C12N5/0068 , C12N2533/30
摘要： A main object of the present invention is to provide a cell transfer substrate capable of transplanting cells, maintaining a pattern as it is, on a living body tissue or the like, even when: the size of the cell sheet is extremely small; the cells are cultured sparsely; the cells are in a form of a small colony; or the cells are cultured in a pattern, for example, as a blood vessel, a vessel network such as a lymphatic vessel, or a nerve network, and to provide a substrate for cell transfer to be used for the cell transfer substrate. In order to achieve the above-mentioned object, the present invention provides a substrate for cell transfer comprising: a polymer base material; an intermediate layer formed on the polymer base material; and a cell transfer layer formed on the intermediate layer.
摘要翻译： 本发明的主要目的在于，提供一种能够将细胞移植到生物体组织等上的能够移动细胞的细胞转移基板，即使在细胞片的尺寸非常小的情况下， 细胞稀少培养; 细胞呈小菌落的形式; 或细胞以例如血管，血管网络例如淋巴管或神经网络的方式进行培养，并提供用于细胞转移基质的细胞转移用基板。 为了实现上述目的，本发明提供了一种用于电池转印的基板，包括：聚合物基材; 形成在聚合物基材上的中间层; 以及形成在中间层上的电池转印层。
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公开(公告)号：US20050266319A1
公开(公告)日：2005-12-01
申请号：US11044700
申请日：2005-01-27
CPC分类号： C12N5/0068 , C12N2533/30 , C12N2535/10
摘要： The present invention intends primarily to provide such as cells culture patterning substrate that is used to adhere a cell in a highly precise pattern on a base material to culture and a cell culture substrate on which cells are adhered in a high precision pattern. To attain the object, the invention provides a patterning substrate comprising: a base material; and a cell adhesive layer formed on the base material and comprising a cell adhesive material which has cell adhesive properties and is decomposed or denatured by action of a photocatalyst on the basis of irradiation with energy, and a binder.
摘要翻译： 本发明主要提供用于将细胞以高精度图案附着在基材上进行培养的细胞培养图案形成基板和以高精度图案粘附细胞的细胞培养基板。 为了实现该目的，本发明提供了一种图案化衬底，包括：基材; 以及形成在基材上的电池粘合剂层，其包含具有电池粘合性的电池粘合剂材料，并且通过基于能量照射的光催化剂的作用而分解或变性。
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公开(公告)号：US06773801B2
公开(公告)日：2004-08-10
申请号：US10115790
申请日：2002-04-03
申请人： Hideshi Hattori
发明人： Hideshi Hattori
IPC分类号： B32B516
CPC分类号： B05D7/56 , B05D1/185 , C03C17/007 , C03C2217/42 , G02B1/00 , G02B1/11 , Y10T428/24802 , Y10T428/24893 , Y10T428/25 , Y10T428/251 , Y10T428/256 , Y10T428/257 , Y10T428/258 , Y10T428/259 , Y10T428/2998
摘要： The present invention discloses a fine particle layer laminated film configured in such a manner that a plurality of fine particle layers containing the fine particles, of which average particle diameters are in the range of 1 nm and 95 nm, are laminated; wherein the fine particles in the fine particle layer laminated film are accreted by polymer molecules; there are air spaces within a film of the fine particle layer laminated film; and a density of the fine particles in the fine particle layer laminated film is in the range of 40% and 80% in percentage by volume. According to the present invention, it is possible to obtain a laminated film sufficiently having a property of the fine particle, for example, a property such as a low index of refraction or the like. Therefore, the present invention has an effect such that the fine particle layer laminated film according to the present invention can be preferably used for an application such as an antirelection film or the like.
摘要翻译： 本发明公开了一种微粒层叠层膜，其中层叠有平均粒径为1nm〜95nm范围的包含微粒的多个微粒层， 其中微粒层层叠膜中的细颗粒由聚合物分子引起; 在微粒层层叠膜的膜内存在空气空间; 并且细颗粒层层叠膜中的细颗粒的密度在40体积％和80体积％的范围内。 根据本发明，可以获得充分具有微粒的性质的层叠膜，例如，诸如低折射率等的性质。 因此，本发明具有这样的效果，使得本发明的微粒层层叠膜可以优选用于抗反射膜等应用。
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公开(公告)号：US08592139B2
公开(公告)日：2013-11-26
申请号：US11936836
申请日：2007-11-08
CPC分类号： G01N33/5005
摘要： The present invention provides a method for performing a biological test under conditions in which an artificially prepared cell pattern with initial position coordinates that can be determined is three-dimensionally cultured within a gelled matrix. The present invention relates to a biological test method that comprises testing a biological indicator with reference to at least one selected from the group consisting of cell proliferation, cell movement, and cell differentiation in a cell pattern substantially embedded in gel. The present invention also relates to a kit for the biological test method.
摘要翻译： 本发明提供一种用于在可以测定初始位置坐标的人造制备的细胞图案在凝胶化基质内三维培养的条件下进行生物测试的方法。 本发明涉及一种生物测试方法，其包括参考选自基本上嵌入凝胶中的细胞图案中的细胞增殖，细胞运动和细胞分化中的至少一种来测试生物学指示剂。 本发明还涉及用于生物测试方法的试剂盒。
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公开(公告)号：US08500822B2
公开(公告)日：2013-08-06
申请号：US11628054
申请日：2005-05-31
IPC分类号： A61F2/02
CPC分类号： C12N5/0691 , A61L27/36 , A61L27/3886 , A61L2430/36 , C12N5/0697
摘要： An object of the present invention is to provide an artificial tissue construct that has means for transporting nutrients, oxygen, waste products, or the like and is viable in vivo. The present invention relates to a tissue construct formed in vitro, which comprises a vascular layer, a basal membrane layer, and a tissue-forming cell layer.
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