-
公开(公告)号：US07622131B2
公开(公告)日：2009-11-24
申请号：US11148552
申请日：2005-06-09
申请人： Anton Willem Bosman , Hendricus Marie Janssen , Gaby Maria Leonarda Van Gemert , Ronny Mathieu Versteegen , Egbert Willem Meijer , Rintje Pieter Sijbesma
发明人： Anton Willem Bosman , Hendricus Marie Janssen , Gaby Maria Leonarda Van Gemert , Ronny Mathieu Versteegen , Egbert Willem Meijer , Rintje Pieter Sijbesma
CPC分类号： A61K8/898 , A61K8/0229 , A61K8/042 , A61Q15/00 , C08G77/26 , C08G77/388 , C08G77/54 , C08G83/008
摘要： The invention relates to the synthesis of siloxane polymers containing self-complementary quadruple hydrogen bonding groups (4H-units). The resulting polymers show unique new characteristics that result from the reversible, physical interactions between the polysiloxane chains that are based on the (supramolecular) interactions between the 4H-units. The polysiloxanes in this invention show unprecedented bulk material properties and are used as gelling agents for silicone fluids. The resulting gels are clear and display good material properties, while having unparalleled high silicone fluid contents.
摘要翻译： 本发明涉及含有自互补四氢键合基团（4H-单元）的硅氧烷聚合物的合成。 所得到的聚合物显示由基于4H单元之间的（超分子）相互作用的聚硅氧烷链之间的可逆的物理相互作用产生的独特的新特征。 本发明中的聚硅氧烷显示出前所未有的散装材料性能，并且用作有机硅流体的胶凝剂。 所得凝胶是透明的并且显示出良好的材料性质，同时具有无与伦比的高硅液体含量。
-
公开(公告)号：US09421274B2
公开(公告)日：2016-08-23
申请号：US14117246
申请日：2012-05-16
IPC分类号： C07D257/08 , C07D237/26 , C07C13/263 , C07C33/16 , A61K31/435 , A61K31/502 , A61K31/045 , A61K47/48 , B82Y5/00
CPC分类号： A61K47/6803 , A61K31/435 , A61K31/444 , A61K31/704 , A61K38/05 , A61K39/3955 , A61K39/39558 , A61K47/22 , A61K47/545 , A61K47/555 , A61K47/558 , A61K47/6897 , B82Y5/00 , C07C33/16 , C07D237/26 , C07D257/08 , Y02A50/471
摘要： The invention relates to a Prodrug activation method, for therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention also relates to a Prodrug kit comprising at least one Prodrug and at least one Activator, wherein the Prodrug comprises a Drug and a first Bio-orthogonal Reactive Group (the Trigger), and wherein the Activator comprises a second Bio-orthogonal Reactive Group. The invention also relates to targeted therapeutics used in the above-mentioned method and kit. The invention particularly pertains to antibody-drug conjugates and to bi- and trispecific antibody derivatives.
摘要翻译： 本发明涉及用于治疗剂的前药活化方法，其中使用对彼此具有生物正交反应性的非生物活性化学基团。 本发明还涉及包含至少一种前药和至少一种活化剂的前药盒，其中所述前药包含药物和第一生物正交反应性组（所述触发剂），并且其中所述活化剂包含第二生物正交反应性组 。 本发明还涉及上述方法和试剂盒中使用的靶向治疗剂。 本发明特别涉及抗体 - 药物偶联物和双特异性和三特异性抗体衍生物。
-
公开(公告)号：US20140093522A1
公开(公告)日：2014-04-03
申请号：US14117655
申请日：2012-05-16
申请人： Marc Stefan Robillard , Hendricus Marie Janssen , Wolter Ten Hoeve , Ronny Mathieu Versteegen , Raffaella Rossin
发明人： Marc Stefan Robillard , Hendricus Marie Janssen , Wolter Ten Hoeve , Ronny Mathieu Versteegen , Raffaella Rossin
IPC分类号： A61K47/48
CPC分类号： A61K47/6803 , A61K31/435 , A61K31/444 , A61K31/704 , A61K38/05 , A61K39/3955 , A61K39/39558 , A61K47/22 , A61K47/545 , A61K47/555 , A61K47/558 , A61K47/6897 , B82Y5/00 , C07C33/16 , C07D237/26 , C07D257/08 , Y02A50/471
摘要： The invention relates to a Prodrug activation method, for therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention also relates to a Prodrug kit comprising at least one Prodrug and at least one Activator, wherein the Prodrug comprises a Drug and a first Bio-orthogonal Reactive Group (the Trigger), and wherein the Activator comprises a second Bio-orthogonal Reactive Group. The invention also relates to targeted therapeutics used in the above-mentioned method and kit. The invention particularly pertains to antibody-drug conjugates and to bi- and trispecific antibody derivatives.
摘要翻译： 本发明涉及用于治疗剂的前药活化方法，其中使用对彼此具有生物正交反应性的非生物活性化学基团。 本发明还涉及包含至少一种前药和至少一种活化剂的前药盒，其中所述前药包含药物和第一生物正交反应性组（所述触发剂），并且其中所述活化剂包含第二生物正交反应性组 。 本发明还涉及上述方法和试剂盒中使用的靶向治疗剂。 本发明特别涉及抗体 - 药物偶联物和双特异性和三特异性抗体衍生物。
-
4.发明授权Preparation of supramolecular polymers containing quadruple hydrogen bonding units in the polymer backbone 有权在聚合物主链中制备含有四氢键合单元的超分子聚合物公开(公告)号：US08247524B2
公开(公告)日：2012-08-21
申请号：US12907737
申请日：2010-10-19
申请人： Hendricus Marie Janssen , Gaby Maria Leonarda Van Gemert , Egbert Willem Meijer , Anton Willem Bosman
发明人： Hendricus Marie Janssen , Gaby Maria Leonarda Van Gemert , Egbert Willem Meijer , Anton Willem Bosman
CPC分类号： C08G83/008 , A61K8/87 , A61Q19/00 , B33Y70/00 , C08G18/3293 , C08G18/4202 , C08G18/4277 , C08G18/4837 , C08G18/714
摘要： The present invention relates to a supramolecular polymer comprising quadruple hydrogen bonding units within the polymer backbone, wherein at least a monomer comprising a 4H-unit is incorporated in the polymer backbone via at least two reactive groups up to four reactive groups, provided that the 4H-units are not covalently incorporated in the polymer backbone through one or more silicon-carbon bonds. The invention also relates to processes for preparing such supramolecular polymers and their use in personal care applications, surface coatings, imaging technologies, biomedical applications, (themo)reversible coatings, adhesive and sealing compositions and as thickening agents, gelling agents and binders.
摘要翻译： 本发明涉及在聚合物骨架内包含四氢氢键单元的超分子聚合物，其中至少包含4H单元的单体通过至多两个最多四个反应性基团的反应性基团引入到聚合物主链中，条件是4H 单元不能通过一个或多个硅 - 碳键共价掺入聚合物主链。 本发明还涉及制备这种超分子聚合物的方法及其在个人护理应用，表面涂层，成像技术，生物医学应用，（其）可逆涂层，粘合剂和密封组合物以及增稠剂，胶凝剂和粘合剂中的用途。
-
5.发明申请PREPARATION OF SUPRAMOLECULAR POLYMERS CONTAINING QUADRUPLE HYDROGEN BONDING UNITS IN THE POLYMER BACKBONE 有权在聚合物底胶中含有四氢化氢键合单体的分子聚合物的制备公开(公告)号：US20110034641A1
公开(公告)日：2011-02-10
申请号：US12907737
申请日：2010-10-19
申请人： HENDRICUS MARIE JANSSEN , GABY MARIA LEONARDA VAN GEMERT , EGBERT WILLEM MEIJER , ANTON WILLEM BOSMAN
发明人： HENDRICUS MARIE JANSSEN , GABY MARIA LEONARDA VAN GEMERT , EGBERT WILLEM MEIJER , ANTON WILLEM BOSMAN
IPC分类号： C08G73/06
CPC分类号： C08G83/008 , A61K8/87 , A61Q19/00 , B33Y70/00 , C08G18/3293 , C08G18/4202 , C08G18/4277 , C08G18/4837 , C08G18/714
摘要： The present invention relates to a supramolecular polymer comprising quadruple hydrogen bonding units within the polymer backbone, wherein at least a monomer comprising a 4H-unit is incorporated in the polymer backbone via at least two reactive groups up to four reactive groups, provided that the 4H-units are not covalently incorporated in the polymer backbone through one or more silicon-carbon bonds. The invention also relates to processes for preparing such supramolecular polymers and their use in personal care applications, surface coatings, imaging technologies, biomedical applications, (themo)reversible coatings, adhesive and sealing compositions and as thickening agents, gelling agents and binders.
摘要翻译： 本发明涉及在聚合物骨架内包含四氢氢键单元的超分子聚合物，其中至少包含4H单元的单体通过至多两个最多四个反应性基团的反应性基团引入到聚合物主链中，条件是4H 单元不能通过一个或多个硅 - 碳键共价掺入聚合物主链。 本发明还涉及制备这种超分子聚合物的方法及其在个人护理应用，表面涂层，成像技术，生物医学应用，（其）可逆涂层，粘合剂和密封组合物以及增稠剂，胶凝剂和粘合剂中的用途。
-
公开(公告)号：US09931408B2
公开(公告)日：2018-04-03
申请号：US14117655
申请日：2012-05-16
申请人： Marc Stefan Robillard , Hendricus Marie Janssen , Wolter Ten Hoeve , Ronny Mathieu Versteegen , Raffaella Rossin
发明人： Marc Stefan Robillard , Hendricus Marie Janssen , Wolter Ten Hoeve , Ronny Mathieu Versteegen , Raffaella Rossin
IPC分类号： C07D257/08 , C07D237/26 , A61K31/435 , A61K31/502 , C07C13/263 , C07C33/16 , A61K31/045 , A61K47/48 , B82Y5/00 , A61K31/704 , A61K38/05 , A61K39/395 , A61K47/22
CPC分类号： A61K47/6803 , A61K31/435 , A61K31/444 , A61K31/704 , A61K38/05 , A61K39/3955 , A61K39/39558 , A61K47/22 , A61K47/545 , A61K47/555 , A61K47/558 , A61K47/6897 , B82Y5/00 , C07C33/16 , C07D237/26 , C07D257/08 , Y02A50/471
摘要： The invention relates to a Prodrug activation method, for therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention also relates to a Prodrug kit comprising at least one Prodrug and at least one Activator, wherein the Prodrug comprises a Drug and a first Bio-orthogonal Reactive Group (the Trigger), and wherein the Activator comprises a second Bio-orthogonal Reactive Group. The invention also relates to targeted therapeutics used in the above-mentioned method and kit. The invention particularly pertains to antibody-drug conjugates and to bi- and trispecific antibody derivatives.
-
公开(公告)号：US20140199331A1
公开(公告)日：2014-07-17
申请号：US14117246
申请日：2012-05-16
IPC分类号： A61K47/48
CPC分类号： A61K47/6803 , A61K31/435 , A61K31/444 , A61K31/704 , A61K38/05 , A61K39/3955 , A61K39/39558 , A61K47/22 , A61K47/545 , A61K47/555 , A61K47/558 , A61K47/6897 , B82Y5/00 , C07C33/16 , C07D237/26 , C07D257/08 , Y02A50/471
摘要： The invention relates to a Prodrug activation method, for therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention also relates to a Prodrug kit comprising at least one Prodrug and at least one Activator, wherein the Prodrug comprises a Drug and a first Bio-orthogonal Reactive Group (the Trigger), and wherein the Activator comprises a second Bio-orthogonal Reactive Group. The invention also relates to targeted therapeutics used in the above-mentioned method and kit. The invention particularly pertains to antibody-drug conjugates and to bi- and trispecific antibody derivatives.
-
8.发明授权Preparation of supramolecular polymer containing quadruple hydrogen bonding units in the polymer backbone 有权在聚合物骨架中制备含有四氢键合单元的超分子聚合物公开(公告)号：US07838621B2
公开(公告)日：2010-11-23
申请号：US10577946
申请日：2003-11-04
申请人： Hendricus Marie Janssen , Gaby Maria Leonarda Van Gemert , Egbert Willem Meijer , Anton Willem Bosman
发明人： Hendricus Marie Janssen , Gaby Maria Leonarda Van Gemert , Egbert Willem Meijer , Anton Willem Bosman
CPC分类号： C08G83/008 , A61K8/87 , A61Q19/00 , B33Y70/00 , C08G18/3293 , C08G18/4202 , C08G18/4277 , C08G18/4837 , C08G18/714
摘要： The present invention relates to a supramolecular polymer comprising quadruple hydrogen bonding units within the polymer backbone, wherein at least a monomer comprising a 4H-unit is incorporated in the polymer backbone via at least two reactive groups up to four reactive groups, provided that the 4H-units are not covalently incorporated in the polymer backbone through one or more silicon-carbon bonds. The invention also relates to processes for preparing such supramolecular polymers and their use in personal care applications, surface coatings, imaging technologies, biomedical applications, (thermo)reversible coatings, adhesive and sealing compositions and as thickening agents, gelling agents and binders.
摘要翻译： 本发明涉及在聚合物骨架内包含四氢氢键单元的超分子聚合物，其中至少包含4H单元的单体通过至多两个最多四个反应性基团的反应性基团引入到聚合物主链中，条件是4H 单元不能通过一个或多个硅 - 碳键共价掺入聚合物主链。 本发明还涉及制备这种超分子聚合物的方法及其在个人护理应用，表面涂层，成像技术，生物医学应用，（热）可逆涂层，粘合剂和密封组合物以及增稠剂，胶凝剂和粘合剂中的用途。
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.018 秒)
