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公开(公告)号：US20100055734A1
公开(公告)日：2010-03-04
申请号：US12557916
申请日：2009-09-11
IPC分类号： C12Q1/02
CPC分类号： G01N33/49 , G01N33/497 , G01N33/5308 , G01N33/92 , G01N2800/08 , G01N2800/085
摘要： The disclosure provides a method for quantification of hepatic function in a subject comprising measuring the clearance of an orally administered isotopically labeled cholic acid in a subject with, or suspected of having or developing, a hepatic disorder, for example, chronic hepatitis C. The disclosure further provides methods and kits for assessment of hepatic function.
摘要翻译： 本公开提供了一种用于定量受试者中肝功能的方法，包括测量患有或疑似患有或发展为肝脏疾病例如慢性丙型肝炎的受试者的经口施用的同位素标记的胆酸的清除率。本公开 进一步提供评估肝功能的方法和试剂盒。
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公开(公告)号：US08778299B2
公开(公告)日：2014-07-15
申请号：US12557916
申请日：2009-09-11
IPC分类号： A61K51/00
CPC分类号： G01N33/49 , G01N33/497 , G01N33/5308 , G01N33/92 , G01N2800/08 , G01N2800/085
摘要： The disclosure provides a method for quantification of hepatic function in a subject comprising measuring the clearance of an orally administered isotopically labeled cholic acid in a subject with, or suspected of having or developing, a hepatic disorder, for example, chronic hepatitis C. The disclosure further provides methods and kits for assessment of hepatic function.
摘要翻译： 本公开提供了一种用于定量受试者中肝功能的方法，包括测量患有或疑似患有或发展为肝脏疾病例如慢性丙型肝炎的受试者的经口施用的同位素标记的胆酸的清除率。本公开 进一步提供评估肝功能的方法和试剂盒。
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公开(公告)号：US08613904B2
公开(公告)日：2013-12-24
申请号：US11814793
申请日：2006-01-26
IPC分类号： A61K51/00
CPC分类号： G06F19/34 , A61K51/1206 , G01N2800/085 , G06F19/00
摘要： The present disclosure concerns methods of administering and detecting a distinguishable agent in a sample from and assessing the condition of an organ in a subject. In a particular embodiment, the present invention concerns methods of detecting and comparing the cholate shunt, in a subject, preferably in a subject with chronic hepatitis C. In certain embodiments, the methods may comprise obtaining a sample from a subject such as a blood or saliva sample after administering an oral and intravenous dose of a distinguishable agent such as cholate and analyzing the sample clearance of the distinguishable agent from the subject and comparing the clearance levels in order to assess hepatic health. In another embodiment, the methods may comprise analyzing a sample from a subject for the presence of a distinguishable agent such as cholate and applying information obtained from analyzing the presence of the distinguishable agent to determine a treatment for a medical condition of the subject.
摘要翻译： 本公开涉及在样品中施用和检测可区分的试剂并评估受试者中器官的状况的方法。 在一个具体实施方案中，本发明涉及检测和比较受试者，优选在具有慢性丙型肝炎的受试者中的胆汁分流的方法。在某些实施方案中，所述方法可包括从受试者获得样品，例如血液或 在口服和静脉内剂量的可区分的药物如胆酸盐并且分析可辨别的药物与受试者的样品清除率并比较清除水平以评估肝脏健康状况后，进行唾液样品。 在另一个实施方案中，所述方法可以包括分析来自受试者的样品以存在可区分的试剂，例如胆酸盐，以及应用从分析可区分试剂的存在获得的信息，以确定受试者的医学状况的治疗。
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公开(公告)号：US20080279766A1
公开(公告)日：2008-11-13
申请号：US11814793
申请日：2006-01-26
IPC分类号： A61K51/04 , A61K31/575 , A61K31/437
CPC分类号： G06F19/34 , A61K51/1206 , G01N2800/085 , G06F19/00
摘要： The present disclosure concerns methods of administering and detecting a distinguishable agent in a sample from and assessing the condition of an organ in a subject. In a particular embodiment, the present invention concerns methods of detecting and comparing the cholate shunt, in a subject, preferably in a subject with chronic hepatitis C. In certain embodiments, the methods may comprise obtaining a sample from a subject such as a blood or saliva sample after administering an oral and intravenous dose of a distinguishable agent such as cholate and analyzing the sample clearance of the distinguishable agent from the subject and comparing the clearance levels in order to assess hepatic health. In another embodiment, the methods may comprise analyzing a sample from a subject for the presence of a distinguishable agent such as cholate and applying information obtained from analyzing the presence of the distinguishable agent to determine a treatment for a medical condition of the subject.
摘要翻译： 本公开涉及在样品中施用和检测可区分的试剂并评估受试者中器官的状况的方法。 在一个具体实施方案中，本发明涉及检测和比较受试者，优选在具有慢性丙型肝炎的受试者中的胆汁分流的方法。在某些实施方案中，所述方法可包括从受试者获得样品，例如血液或 在口服和静脉内剂量的可区分的药物如胆酸盐并且分析可辨别的药物与受试者的样品清除率并比较清除水平以评估肝脏健康状况后，进行唾液样品。 在另一个实施方案中，所述方法可以包括分析来自受试者的样品以存在可区分的试剂，例如胆酸盐，以及应用从分析可区分试剂的存在获得的信息，以确定受试者的医学状况的治疗。
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公开(公告)号：US08961925B2
公开(公告)日：2015-02-24
申请号：US13484083
申请日：2012-05-30
CPC分类号： G01N33/49 , A61J1/05 , G01N33/92 , G01N2800/085 , Y02A90/26
摘要： A method for estimating portal blood flow and hepatic function in a subject is provided. In one example, the STAT test is an in vitro simplified, convenient test intended for screening purposes that can reasonably estimate the portal blood flow from a single blood sample taken 60 minutes after orally administered deuterated-cholate. The test can be administered to a patient having, or suspected of having, Chronic Hepatitis C, Primary Sclerosing Cholangitis (PSC), Non-Alcoholic Fatty Liver Disease (NAFLD), or any chronic liver disease.
摘要翻译： 提供了一种用于估计受试者门静脉血流量和肝功能的方法。 在一个实例中，STAT测试是用于筛选目的的体外简化的便利测试，其可以合理地估计口服施用氘代胆酸酯后60分钟摄取的单个血液样品的门静脉血流量。 可以对具有或疑似患有慢性丙型肝炎，原发性硬化性胆管炎（PSC），非酒精性脂肪性肝病（NAFLD）或任何慢性肝病）的患者施用该测试。
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公开(公告)号：US20120329161A1
公开(公告)日：2012-12-27
申请号：US13484083
申请日：2012-05-30
CPC分类号： G01N33/49 , A61J1/05 , G01N33/92 , G01N2800/085 , Y02A90/26
摘要： A method for estimating portal blood flow and hepatic function in a subject is provided. In one example, the STAT test is an in vitro simplified, convenient test intended for screening purposes that can reasonably estimate the portal blood flow from a single blood sample taken 60 minutes after orally administered deuterated-cholate. The test can be administered to a patient having, or suspected of having, Chronic Hepatitis C, Primary Sclerosing Cholangitis (PSC), Non-Alcoholic Fatty Liver Disease (NAFLD), or any chronic liver disease.
摘要翻译： 提供了一种用于估计受试者门静脉血流量和肝功能的方法。 在一个实例中，STAT测试是用于筛选目的的体外简化的便利测试，其可以合理地估计口服施用氘代胆酸酯后60分钟摄取的单个血液样品的门静脉血流量。 可以对具有或疑似患有慢性丙型肝炎，原发性硬化性胆管炎（PSC），非酒精性脂肪肝（NAFLD）或任何慢性肝病）的患者施用该测试。
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