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    MICROFLUIDIC SYSTEMS AND METHODS FOR THERMAL CONTROL
    4.
    发明申请
    MICROFLUIDIC SYSTEMS AND METHODS FOR THERMAL CONTROL 有权
    微流体系统和热控制方法

    公开(公告)号：US20110048547A1

    公开(公告)日：2011-03-03

    申请号：US12825476

    申请日：2010-06-29

    申请人： Kenton C. Hasson ,  Johnathan S. Coursey ,  Gregory H. Owen ,  Hiroshi Inoue

    发明人： Kenton C. Hasson ,  Johnathan S. Coursey ,  Gregory H. Owen ,  Hiroshi Inoue

    IPC分类号： F15D1/00 ,  G01K7/16 ,  H05B1/00

    CPC分类号： B01L7/52 ,  B01L3/502715 ,  B01L7/525 ,  B01L2200/14 ,  B01L2200/147 ,  B01L2300/0645 ,  B01L2300/1805 ,  B01L2300/1827 ,  C12Q3/00 ,  H05B1/02 ,  Y10T137/6606

    摘要： The invention relates to methods and devices for control of an integrated thin-film device with a plurality of microfluidic channels. In one embodiment, a microfluidic device is provided that includes a microfluidic chip having a plurality of microfluidic channels and a plurality of multiplexed resistive thermal detectors (RTDs). Each of the RTDs is associated with one of the microfluidic channels. The RTDs are connected to a power supply through individual electrodes and pairs of common electrodes. Adjacent RTDs may be driven with alternating polarities, and the current in the common electrodes may be minimized using a virtual ground circuit. The compact microfluidic device is capable of fast heating and highly precise thermal control. The compact microfluidic device is also capable using the RTDs to sense temperature without their heating capability.

    摘要翻译： 本发明涉及用于控制具有多个微流体通道的集成薄膜器件的方法和装置。 在一个实施例中，提供了包括具有多个微流体通道的微流体芯片和多个多路复用电阻热检测器（RTD）的微流体装置。 每个RTD与微流体通道中的一个相关联。 RTD通过单独的电极和公共电极对连接到电源。 可以用交替极性驱动相邻的RTD，并且可以使用虚拟接地电路来使公共电极中的电流最小化。 紧凑的微流体装置能够快速加热和高度精确的热控制。 紧凑型微流体装置还能够使用RTD来感测温度而不加热能力。

    Microfluidic systems and methods for thermal control
    5.
    发明授权
    Microfluidic systems and methods for thermal control 有权
    微流控系统和热控制方法

    公开(公告)号：US09061278B2

    公开(公告)日：2015-06-23

    申请号：US12825476

    申请日：2010-06-29

    申请人： Kenton C. Hasson ,  Johnathan S. Coursey ,  Gregory H. Owen ,  Hiroshi Inoue

    发明人： Kenton C. Hasson ,  Johnathan S. Coursey ,  Gregory H. Owen ,  Hiroshi Inoue

    IPC分类号： G01K7/16 ,  G01N7/00 ,  B01L3/00 ,  B01L7/00 ,  H05B1/02

    CPC分类号： B01L7/52 ,  B01L3/502715 ,  B01L7/525 ,  B01L2200/14 ,  B01L2200/147 ,  B01L2300/0645 ,  B01L2300/1805 ,  B01L2300/1827 ,  C12Q3/00 ,  H05B1/02 ,  Y10T137/6606

    摘要： The invention relates to methods and devices for control of an integrated thin-film device with a plurality of microfluidic channels. In one embodiment, a microfluidic device is provided that includes a microfluidic chip having a plurality of microfluidic channels and a plurality of multiplexed resistive thermal detectors (RTDs). Each of the RTDs is associated with one of the microfluidic channels. The RTDs are connected to a power supply through individual electrodes and pairs of common electrodes. Adjacent RTDs may be driven with alternating polarities, and the current in the common electrodes may be minimized using a virtual ground circuit. The compact microfluidic device is capable of fast heating and highly precise thermal control. The compact microfluidic device is also capable using the RTDs to sense temperature without their heating capability.

    摘要翻译： 本发明涉及用于控制具有多个微流体通道的集成薄膜器件的方法和装置。 在一个实施例中，提供了包括具有多个微流体通道的微流体芯片和多个多路复用电阻热检测器（RTD）的微流体装置。 每个RTD与微流体通道中的一个相关联。 RTD通过单独的电极和公共电极对连接到电源。 可以用交替极性驱动相邻的RTD，并且可以使用虚拟接地电路来使公共电极中的电流最小化。 紧凑的微流体装置能够快速加热和高度精确的热控制。 紧凑型微流体装置还能够使用RTD来感测温度而不加热能力。

    SYSTEMS AND METHODS FOR AUTO-CALIBRATION OF RESISTIVE TEMPERATURE SENSORS
    7.
    发明申请
    SYSTEMS AND METHODS FOR AUTO-CALIBRATION OF RESISTIVE TEMPERATURE SENSORS 有权
    用于自动校准电阻温度传感器的系统和方法

    公开(公告)号：US20100285571A1

    公开(公告)日：2010-11-11

    申请号：US12437775

    申请日：2009-05-08

    申请人： Johnathan S. Coursey ,  Kenton C. Hasson ,  Gregory H. Owen

    发明人： Johnathan S. Coursey ,  Kenton C. Hasson ,  Gregory H. Owen

    IPC分类号： C12M1/36 ,  G01K7/16 ,  G01K15/00

    CPC分类号： G01K19/00 ,  B01L7/52 ,  G01K7/16 ,  G01K7/20 ,  G01K15/00 ,  G01K15/005

    摘要： The invention relates to systems and methods for calibrating and using resistance temperature detectors. In one embodiment, the system includes a calibration circuit comprising a resistance temperature detector in a bridge circuit with at least one potentiometer, and a programmable gain amplifier coupled to the bridge circuit. Embodiments of the invention further comprise methods for calibrating the bridge circuit and the programmable gain amplifier for use with the resistance temperature detector and methods for determining the self heating voltage of the bridge circuit.

    摘要翻译： 本发明涉及用于校准和使用电阻温度检测器的系统和方法。 在一个实施例中，该系统包括校准电路，该校准电路包括具有至少一个电位器的桥接电路中的电阻温度检测器和耦合到该桥接电路的可编程增益放大器。 本发明的实施例还包括用于校准桥接电路的方法和用于电阻温度检测器的可编程增益放大器以及用于确定桥接电路的自身发热电压的方法。

    Microfluidic devices with integrated resistive heater electrodes including systems and methods for controlling and measuring the temperatures of such heater electrodes
    8.
    发明授权
    Microfluidic devices with integrated resistive heater electrodes including systems and methods for controlling and measuring the temperatures of such heater electrodes 有权
    具有集成电阻加热器电极的微流体装置包括用于控制和测量这种加热器电极的温度的系统和方法

    公开(公告)号：US08306773B2

    公开(公告)日：2012-11-06

    申请号：US12872068

    申请日：2010-08-31

    申请人： Kenton C. Hasson ,  Johnathan S. Coursey ,  Gregory H. Owen

    发明人： Kenton C. Hasson ,  Johnathan S. Coursey ,  Gregory H. Owen

    IPC分类号： G06F19/00

    CPC分类号： G01K7/16 ,  B01L3/5027 ,  B01L7/525 ,  B01L2300/0816 ,  B01L2300/1827 ,  G01K3/10 ,  G06F17/12

    摘要： The invention relates to methods and devices for control of an integrated thin-film device with a plurality of microfluidic channels. In one embodiment, a microfluidic device is provided that includes a microfluidic chip having a plurality of microfluidic channels and a plurality of multiplexed heater electrodes, wherein the heater electrodes are part of a multiplex circuit including a common lead connecting the heater electrodes to a power supply, each of the heater electrodes being associated with one of the microfluidic channels. The microfluidic device also includes a control system configured to regulate power applied to each heater electrode by varying a duty cycle, the control system being further configured to determine the temperature of each heater electrode by determining the resistance of each heater electrode.

    摘要翻译： 本发明涉及用于控制具有多个微流体通道的集成薄膜器件的方法和装置。 在一个实施例中，提供了一种微流体装置，其包括具有多个微流体通道的微流体芯片和多个多路加热器电极，其中加热器电极是多路复用电路的一部分，其包括将加热器电极连接到电源 ，每个加热器电极与微流体通道中的一个相关联。 微流体装置还包括控制系统，其被配置为通过改变占空比来调节施加到每个加热器电极的功率，所述控制系统还被配置为通过确定每个加热器电极的电阻来确定每个加热器电极的温度。