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    Highly Concentrated Pourable Aqueous Solutions Of Potassium Ibuprofen, Their Preparation And Their Use
    4.
    发明申请
    Highly Concentrated Pourable Aqueous Solutions Of Potassium Ibuprofen, Their Preparation And Their Use 审中-公开
    高浓度易挥发的布洛芬钾水溶液及其制备及其应用

    公开(公告)号：US20080269334A1

    公开(公告)日：2008-10-30

    申请号：US12066371

    申请日：2006-09-15

    申请人： Partick C. Hu ,  Gregory H. Lambeth ,  Arcelio J. Malcolm

    发明人： Partick C. Hu ,  Gregory H. Lambeth ,  Arcelio J. Malcolm

    IPC分类号： A61K31/192 ,  A61P29/00

    CPC分类号： A61K9/4858 ,  A61K31/19 ,  A61K47/10

    摘要： Concentrated pourable potassium ibuprofen liquid compositions, and preparation and uses thereof are described. They are composed of (i) at least 60 wt % of potassium ibuprofen in dissolved form; (ii) water; (iii) one or more polyethylene glycols, (iv) optionally up to 5 wt % of at least one C2-3 alkanol; and (v) optionally, ibuprofen in free acid form. The weight ratio of (ii):(iii) is at least 0.9:1. Compositions containing as much as 85.2 wt % of potassium ibuprofen in dissolved form have been successfully made. The highest level of potassium ibuprofen in dissolved form achieved in experiments reported in the presently-known prior art is but 24.2 wt %. The present compositions are suitable for use in the preparation of pharmaceutical products and various pharmaceutical dosage forms such as liquid-filled soft gelatin capsules, syrups, elixirs, suspensions; solid dosage forms such as tablets or caplets; and topically-applied products. such as lotions, creams or ointments.

    摘要翻译： 浓缩的可倾倒的布洛芬钾液体组合物及其制备和用途进行了描述。 它们由以下组成：（i）至少60重量％的溶解形式的布洛芬钾; （ii）水; （iii）一种或多种聚乙二醇，（iv）任选至多5重量％的至少一种C 2至3-3链烷醇; 和（v）任选地，游离酸形式的布洛芬。 （ii）：（iii）的重量比至少为0.9:1。 含有多达85.2重量％溶解形式的布洛芬钾的组合物已经成功地制成。 目前已知的现有技术报道的实验中获得的溶解形式的最高水平的布洛芬钾仅为24.2重量％。 本发明的组合物适用于制备药物产品和各种药物剂型，例如液体填充的软明胶胶囊，糖浆，酏剂，悬浮液; 固体剂型如片剂或片剂; 和局部应用产品。 如乳液，霜剂或软膏。