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1.发明授权公开(公告)号：US08243742B2
公开(公告)日：2012-08-14
申请号：US12202622
申请日：2008-09-02
IPC分类号： H04L12/56
CPC分类号： H04L47/20 , H04L41/5003 , H04L41/5019 , H04L47/70 , H04L47/786
摘要： A service access gateway is described that provides enforcement of service level agreements across geographically remote domains. Each domain can comprise an access tier and a network tier that can be scaled by adding or removing server nodes. At the network tier level, a master node can be selected in each domain in order to maintain budget state information for the domain. Additionally, a global master can be elected in order to maintain the state information across multiple domains such that the service level agreements can be enforced in a synchronized manner. A geographical configuration service can also be implemented to generate alarms in cases where service level agreements across the multiple sites are not identical.
摘要翻译： 描述了一种服务访问网关，其提供跨地域远程域的服务级别协议的实施。 每个域可以包括可以通过添加或删除服务器节点进行扩展的访问层和网络层。 在网络层级，可以在每个域中选择主节点，以维护域的预算状态信息。 此外，可以选择全局主机以便在多个域中维护状态信息，以便可以以同步的方式实施服务级别协议。 在多个站点的服务级别协议不相同的情况下，还可以实施地理配置服务来生成警报。
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2.发明申请CONJUGATES BETWEEN A VARIANT STAPHYLOCOCCAL ENTEROTOXIN E SUPERANTIGEN AND A TARGETING ANTIBODY THAT BINDS TO A CANCER-ASSOCIATED CELL SURFACE STRUCTURE 审中-公开一个变化的血清肠毒素E特异性和与癌症相关细胞表面结构相结合的靶向抗体之间的结合公开(公告)号：US20100111978A1
公开(公告)日：2010-05-06
申请号：US12568579
申请日：2009-09-28
申请人： GORAN FORSBERG , EVA ERLANDSSON , PER ANTONSSON , BJORN WALSE
发明人： GORAN FORSBERG , EVA ERLANDSSON , PER ANTONSSON , BJORN WALSE
IPC分类号： A61K39/395 , C07K16/00 , A61P35/00
CPC分类号： C07K14/31 , A61K39/00 , A61K47/6851 , A61K2039/505 , C07K14/315 , C07K16/30 , C07K2319/00 , H04L51/063 , H04L51/38
摘要： The present invention relates to compositions and methods of use, wherein the composition comprises a conjugate of a bacterial superantigen and an antibody moiety. More particularly, the bacterial superantigen has been modified to decrease seroreactivity with retained superantigen activity.
摘要翻译： 本发明涉及组合物和使用方法，其中组合物包含细菌超抗原和抗体部分的缀合物。 更具体地，细菌超抗原已被修饰以降低具有保留的超抗原活性的血清反应性。
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3.发明申请公开(公告)号：US20090225763A1
公开(公告)日：2009-09-10
申请号：US12202622
申请日：2008-09-02
IPC分类号： H04L12/56
CPC分类号： H04L47/20 , H04L41/5003 , H04L41/5019 , H04L47/70 , H04L47/786
摘要： A service access gateway is described that provides enforcement of service level agreements across geographically remote domains. Each domain can comprise an access tier and a network tier that can be scaled by adding or removing server nodes. At the network tier level, a master node can be selected in each domain in order to maintain budget state information for the domain. Additionally, a global master can be elected in order to maintain the state information across multiple domains such that the service level agreements can be enforced in a synchronized manner. A geographical configuration service can also be implemented to generate alarms in cases where service level agreements across the multiple sites are not identical.
摘要翻译： 描述了一种服务访问网关，其提供跨地域远程域的服务级别协议的实施。 每个域可以包括可以通过添加或删除服务器节点进行扩展的访问层和网络层。 在网络层级，可以在每个域中选择主节点，以维护域的预算状态信息。 此外，可以选择全局主机以便在多个域中维护状态信息，以便可以以同步的方式实施服务级别协议。 在多个站点的服务级别协议不相同的情况下，还可以实施地理配置服务来生成警报。
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公开(公告)号：US20070082001A1
公开(公告)日：2007-04-12
申请号：US11526437
申请日：2006-11-21
申请人： Goran Forsberg , Eva Erlandsson , Per Antonsson , Bjorn Walse
发明人： Goran Forsberg , Eva Erlandsson , Per Antonsson , Bjorn Walse
IPC分类号： A61K39/395 , C07K16/30 , C07K16/46
CPC分类号： C07K14/31 , A61K39/00 , A61K47/6851 , A61K2039/505 , C07K14/315 , C07K16/30 , C07K2319/00 , H04L51/063 , H04L51/38
摘要： The present invention relates to compositions and methods of use, wherein the composition comprises a conjugate of a bacterial superantigen and an antibody moiety. More particularly, the bacterial superantigen has been modified to decrease seroreactivity with retained superantigen activity.
摘要翻译： 本发明涉及组合物和使用方法，其中组合物包含细菌超抗原和抗体部分的缀合物。 更具体地，细菌超抗原已被修饰以降低具有保留的超抗原活性的血清反应性。
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公开(公告)号：US07125554B2
公开(公告)日：2006-10-24
申请号：US09900766
申请日：2001-07-06
申请人： Goran Forsberg , Eva Erlandsson , Per Antonsson , Bjorn Walse
发明人： Goran Forsberg , Eva Erlandsson , Per Antonsson , Bjorn Walse
IPC分类号： A61K39/395 , A61K39/40 , A61K39/42 , C07K16/00
CPC分类号： C07K14/31 , A61K39/00 , A61K47/6851 , A61K2039/505 , C07K14/315 , C07K16/30 , C07K2319/00 , H04L51/063 , H04L51/38
摘要： The present invention relates to compositions and methods of use, wherein the composition comprises a conjugate of a bacterial superantigen and an antibody moiety. More particularly, the bacterial superantigen has been modified to decrease seroreactivity with retained superantigen activity.
摘要翻译： 本发明涉及组合物和使用方法，其中组合物包含细菌超抗原和抗体部分的缀合物。 更具体地，细菌超抗原已被修饰以降低具有保留的超抗原活性的血清反应性。
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6.发明授权Application server platform for telecom-based applications using an actor container 有权应用服务器平台，用于使用actor容器的基于电信的应用公开(公告)号：US09553944B2
公开(公告)日：2017-01-24
申请号：US13339252
申请日：2011-12-28
CPC分类号： H04L67/2809
摘要： In accordance with various embodiments, a set of features are described for enabling an application server platform for telecom based applications. A system for providing an application server for telecom-based applications can include a computer, including a computer readable medium and processor. The system can also include an application server, executing on the computer. The application server can include an actor container that manages and provides lifecycle and runtime properties for application classes that are executed as actors in the application server. The actor container can manages a set of event transactions, wherein all storage operations are performed as part of the event transaction that spans each event handler invocation.
摘要翻译： 根据各种实施例，描述了一组功能，用于启用用于基于电信的应用的应用服务器平台。 用于为基于电信的应用提供应用服务器的系统可以包括计算机，包括计算机可读介质和处理器。 系统还可以包括在计算机上执行的应用程序服务器。 应用程序服务器可以包括一个actor容器，用于管理并提供作为应用程序服务器中的actor执行的应用程序类的生命周期和运行时属性。 actor容器可以管理一组事件事务，其中所有存储操作都作为跨越每个事件处理程序调用的事件事务的一部分执行。
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7.发明授权System and method for providing a pluggable architecture for state management in a telecommunication service access gateway 有权在电信业务接入网关中为状态管理提供可插拔架构的系统和方法公开(公告)号：US07953100B2
公开(公告)日：2011-05-31
申请号：US12248729
申请日：2008-10-09
IPC分类号： H04L12/56
CPC分类号： H04L67/101 , H04L67/1002 , H04L67/2823
摘要： A network service access gateway is described that provides a pluggable state management architecture for storing state information. The gateway typically processes requests between entities such as external applications and subscriber mobile devices. In processing data, the gateway can implement multiple storage providers which are selected according to the data access requirements of the specific request. Each storage provider can implement a different caching or data management technique in order to provide access to the required information. Examples of the storage providers include in-memory only caches, write-through disk based storage provider, write-behind disk based storage provider and non-cached disk-based storage provider. The particular storage provider can be selected based on a configuration file and according to the traffic path associated with the request.
摘要翻译： 描述了提供用于存储状态信息的可插拔状态管理架构的网络服务访问网关。 网关通常处理诸如外部应用和用户移动设备的实体之间的请求。 在处理数据时，网关可以实现根据特定请求的数据访问要求选择的多个存储提供者。 每个存储提供商可以实现不同的缓存或数据管理技术，以便提供对所需信息的访问。 存储提供商的示例包括内存中缓存，基于直写磁盘的存储提供程序，基于后写盘的存储提供程序和非高速缓存的基于磁盘的存储提供程序。 可以基于配置文件并根据与请求相关联的业务路径来选择特定存储提供商。
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8.发明申请System and Method for Providing a Pluggable Architecture for State Management in a Telecommunication Service Access Gateway 有权在电信业务接入网关中为状态管理提供可插拔架构的系统和方法公开(公告)号：US20090279556A1
公开(公告)日：2009-11-12
申请号：US12248729
申请日：2008-10-09
IPC分类号： H04L12/66
CPC分类号： H04L67/101 , H04L67/1002 , H04L67/2823
摘要： A network service access gateway is described that provides a pluggable state management architecture for storing state information. The gateway typically processes requests between entities such as external applications and subscriber mobile devices. In processing data, the gateway can implement multiple storage providers which are selected according to the data access requirements of the specific request. Each storage provider can implement a different caching or data management technique in order to provide access to the required information. Examples of the storage providers include in-memory only caches, write-through disk based storage provider, write-behind disk based storage provider and non-cached disk-based storage provider. The particular storage provider can be selected based on a configuration file and according to the traffic path associated with the request.
摘要翻译： 描述了提供用于存储状态信息的可插拔状态管理架构的网络服务访问网关。 网关通常处理诸如外部应用和用户移动设备的实体之间的请求。 在处理数据时，网关可以实现根据特定请求的数据访问要求选择的多个存储提供者。 每个存储提供商可以实现不同的缓存或数据管理技术，以便提供对所需信息的访问。 存储提供商的示例包括内存中缓存，基于直写磁盘的存储提供程序，基于后写盘的存储提供程序和非高速缓存的基于磁盘的存储提供程序。 可以基于配置文件并根据与请求相关联的业务路径来选择特定存储提供商。
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9.发明申请Treatment of hyperproliferative disease with superantigens in combination with another anticancer agent 有权用超抗原与另一种抗癌剂联合治疗过度增殖性疾病公开(公告)号：US20060057111A1
公开(公告)日：2006-03-16
申请号：US11202507
申请日：2005-08-12
IPC分类号： A61K38/16 , A61K31/7072
CPC分类号： A61K39/00 , A61K31/7072 , A61K33/24 , A61K38/00 , A61K39/0005 , A61K39/0011 , A61K45/06 , A61K47/6811 , A61K47/6851 , C07K14/31 , C07K2319/30 , C07K2319/33 , A61K2300/00
摘要： The present invention relates to methods of treating mammals affected by, for example, a hyperproliferative disease such as cancer, by administering a tumor-targeted superantigen and a chemotherapeutic agent, whereby the administration of the tumor-targeted superantigen and chemotherapeutic agent reduce the antibody response and enhance the T cell response. The superantigen, wild-type or modified, is fused to a target-seeking moiety, such as an antibody or an antibody active fragment. The combined administration of a superantigen and a chemotherapeutic agent provides enhanced therapeutic effects in a treated animal.
摘要翻译： 本发明涉及通过施用肿瘤靶向的超抗原和化学治疗剂来治疗受到例如癌症的过度增殖性疾病影响的哺乳动物的方法，由此施用肿瘤靶向的超抗原和化学治疗剂降低抗体应答 并增强T细胞反应。 将超抗原，野生型或修饰的融合到寻靶部位，例如抗体或抗体活性片段。 超抗原和化学治疗剂的组合给药在治疗的动物中提供增强的治疗效果。
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10.发明申请Cytolysis of target cells by superantigen conjugates inducing T-cell activation 审中-公开通过诱导T细胞活化的超抗原共轭物对靶细胞进行细胞溶解公开(公告)号：US20050226885A1
公开(公告)日：2005-10-13
申请号：US11023086
申请日：2004-12-27
申请人： Morten Soegaard , Lars Abrahmsen , Peter Lando , Goran Forsberg , Terje Kalland , Mikael Dohlsten
发明人： Morten Soegaard , Lars Abrahmsen , Peter Lando , Goran Forsberg , Terje Kalland , Mikael Dohlsten
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/085 , A61K39/385 , A61K39/395 , A61K45/00 , A61K47/48 , A61P35/00 , A61P37/00 , C07K14/31 , C07K14/47 , C07K14/715 , C07K16/00 , C07K19/00 , C12N5/10
CPC分类号： C07K14/47 , A61K47/642 , A61K47/6801 , A61K47/6813 , A61K47/6829 , A61K47/6863 , C07K2319/035
摘要： A method for inactivating target cells in the presence of T cells by bringing the two types of cells in contact with a superantigen (SAG) in the presence of an immune modulator, characterized in that at least one of the superantigen and the immune modulator is in the form of a conjugate between a “free” superantigen (Sag) and a moiety targeting the conjugate to the target cells. A superantigen conjugate complying with the formula (1): (T)x(Sag)y(IM)z; a) T is a targeting moiety, Sag corresponds to a free superantigen, IM is an immune modulator that is not a superantigen and T, Sag and IM are linked together via organic linkers B; b) x, y and z are integers that typically are selected among 0-10 and represent the number of moieties T, Sag and IM, respetively, in a given conjugate molecule, with the provision that y>0 and also one or both of x and z>0. The superantigen conjugate is preferably a triple fusion protein. A targeted immune modulator, characterized in that it is a conjugate between a targeting moiety (T′″) and a modified immune modulator (IM′″). The conjugate complies with a formula analogous to formula (I) except for the imperative presence of the modified immune modulator. A superantigen moiety may be present. A DNA molecule encoding a superantigen and an immune modulator.
摘要翻译： 一种通过在免疫调节剂存在下使两种类型的细胞与超抗原（SAG）接触而在T细胞存在下灭活靶细胞的方法，其特征在于，超抗原和免疫调节剂中的至少一种在 “自由”超抗原（Sag）与靶向靶细胞靶向缀合物的部分之间的缀合物的形式。 符合式（1）的超抗原共轭：（T）X（Sag）Y（IM）z a）T是靶向部分，Sag对应于游离超抗原，IM是不是超抗原的免疫调节剂，T，Sag和IM通过有机接头B连接在一起; b）x，y和z是通常在0-10中选择的整数，并且在给定的共轭分子中分别表示部分T，Sag和IM的数目，其规定y> 0，并且还包括一个或两个 x和z> 0。 超抗原缀合物优选为三重融合蛋白。 靶向免疫调节剂，其特征在于它是靶向部分（T“'”和修饰的免疫调节剂（IM“）之间的缀合物。 除了修饰的免疫调节剂的命令存在之外，缀合物符合类似于式（I）的式。 可能存在超抗原部分。 编码超抗原和免疫调节剂的DNA分子。
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