公开(公告)号：US08596064B2

公开(公告)日：2013-12-03

申请号：US12915592

申请日：2010-10-29

Applicant: Brien Lloyd Fulton ,  Gopal Krishna Chamarthi ,  Dean Pennala ,  David Curtis Ives ,  David Robert Nader ,  Paul Martin Niessen ,  Jason Ronald Smith

Inventor： Brien Lloyd Fulton ,  Gopal Krishna Chamarthi ,  Dean Pennala ,  David Curtis Ives ,  David Robert Nader ,  Paul Martin Niessen ,  Jason Ronald Smith

IPC: F02B33/44 ,  F01N3/00 ,  F01N3/02

CPC classification number: F02D23/00 ,  F01N9/002 ,  F01N2900/0416 ,  F01N2900/0421 ,  F01N2900/0422 ,  F01N2900/08 ,  F02D41/0007 ,  F02D41/029 ,  F02D2200/703 ,  F02D2250/26 ,  Y02T10/144 ,  Y02T10/47

Abstract: A method for operating a turbocharged engine is disclosed. In one example, an engine operation is adjusted in response to a turbocharger expansion ratio. Degradation of the engine may be reduced under some engine operating conditions by adjusting engine operation in response to the turbocharger expansion ratio.

Abstract translation: 公开了一种用于操作涡轮增压发动机的方法。 在一个示例中，响应于涡轮增压器膨胀比来调节发动机操作。 通过根据涡轮增压器膨胀比来调节发动机运转，可以在一些发动机运行条件下降低发动机的降级。

公开(公告)号：US20130187696A1

公开(公告)日：2013-07-25

申请号：US13356610

申请日：2012-01-23

Applicant: Siddhartha Gopal Krishna ,  Senthil Velan K

Inventor： Siddhartha Gopal Krishna ,  Senthil Velan K

IPC: H03K3/00

CPC classification number: H03K5/13

Abstract: A circuit for generating multi-phase, non-overlapping clock signals includes a shift register that generates first and second clock signals from an input clock signal. First and second circuit modules generate corresponding first and second interim signals using the first and second clock signals and first and second feedback signals, respectively. The first and second interim signals are non-overlapping by at least a predetermined minimum time difference. The first and second interim signals are multiplexed to generate an output signal. The output signal is delayed by a first predetermined time to generate a first delay signal. The first delay signal is delayed by a second predetermined time to generate a second delay signal. The second delay signal is de-multiplexed to generate the first and the second feedback signals, and the first delay signal is de-multiplexed to generate the set of multi-phase, non-overlapping clock signals.

Abstract translation: 用于产生多相不重叠时钟信号的电路包括从输入时钟信号产生第一和第二时钟信号的移位寄存器。 第一和第二电路模块分别使用第一和第二时钟信号以及第一和第二反馈信号产生对应的第一和第二中间信号。 第一和第二中间信号至少是预定的最小时间差不重叠。 第一和第二中间信号被多路复用以产生输出信号。 输出信号被延迟第一预定时间以产生第一延迟信号。 第一延迟信号被延迟第二预定时间以产生第二延迟信号。 第二延迟信号被解复用以产生第一和第二反馈信号，并且第一延迟信号被去多路复用以产生一组多相不重叠的时钟信号。

公开(公告)号：US20120322836A1

公开(公告)日：2012-12-20

申请号：US13600083

申请日：2012-08-30

Applicant: Gopal Krishna ,  Rajeshwar Motheram ,  Min Ding

Inventor： Gopal Krishna ,  Rajeshwar Motheram ,  Min Ding

IPC: A61K31/4418 ,  A61P9/12 ,  C07D213/80

CPC classification number: A61K31/519 ,  A61K9/0019 ,  A61K9/10 ,  A61K31/435 ,  A61K31/4418 ,  A61K2300/00

Abstract: Pharmaceutical compositions, and a method of stabilizing pharmaceutical compositions having clevidipine, or any pharmaceutically acceptable salt thereof, as the active ingredient is described. The method includes the slowing down or inhibiting of the oxidation pathway of clevidipine. This can be accomplished by reducing the amount the pharmaceutical composition is exposed to oxygen and/or light during the manufacturing and storing processes. According to this method, oxygen must be removed or replaced, or light must be sufficiently blocked such that light energy cannot reach the active ingredient of the composition, or is reduced to a level that the light-induced oxidation reaction converting clevidipine to H324/78 is minimized, such that the total detectable level of H324/78 in a given composition sample does not exceed about 0.2% on a weight-by-weight basis, or the ratio of clevidipine to H324/78 is equal to or greater than about 450 to 1 on a weight-to-weight basis.

Abstract translation: 描述了药物组合物和稳定具有氯维地平的药物组合物或其任何药学上可接受的盐作为活性成分的方法。 该方法包括减缓或抑制氯维地平的氧化途径。 这可以通过在制造和储存过程中减少药物组合物暴露于氧和/或光的量来实现。 根据该方法，必须除去或更换氧气，或者必须充分阻挡光，使得光能不能达到组合物的活性成分，或者降低到光诱导的氧化反应将氯维地平转化为H324 / 78 被最小化，使得给定组合物样品中H324 / 78的总可检测水平以重量计不超过约0.2％，或者氯维地平与H324 / 78的比例等于或大于约450 至1，以重量为基准。

公开(公告)号：US20120322835A1

公开(公告)日：2012-12-20

申请号：US13600056

申请日：2012-08-30

Applicant: Rajeshwar Motheram ,  Gopal Krishna ,  Min Ding ,  Keith Flood ,  Kornepati Ramakrishna

Inventor： Rajeshwar Motheram ,  Gopal Krishna ,  Min Ding ,  Keith Flood ,  Kornepati Ramakrishna

IPC: A61K31/4418 ,  C07D213/80 ,  G01N30/00 ,  A61P9/12

CPC classification number: A61K31/4422 ,  A61K31/519 ,  G01N30/02

Abstract: A composition having clevidipine as an active ingredient is described. The composition includes clevidipine as an active ingredient and an amount of the impurity H168/79 that is no greater than about 1.5%, or where the ratio between clevidipine and H168/79 is equal or above 60 to 1.

Abstract translation: 描述了具有氯维地平作为活性成分的组合物。 组合物包括氯维西肽作为活性成分，杂质H168 / 79的量不大于约1.5％，或者氯维地平与H168 / 79之间的比例等于或大于60比1。

公开(公告)号：US20110258150A1

公开(公告)日：2011-10-20

申请号：US13007430

申请日：2011-01-14

Applicant: Depankar NEOGI ,  Steven K. LADD ,  Girish WELLING ,  Arjun KUMAR ,  Vartika SINGH ,  Matthew DUGGAN ,  Tushar MAHATA ,  Xiaobin YANG ,  Jian-Wu XU ,  Janice O'NEIL ,  Nirupam SARKAR ,  Gopal KRISHNA

Inventor： Depankar NEOGI ,  Steven K. LADD ,  Girish WELLING ,  Arjun KUMAR ,  Vartika SINGH ,  Matthew DUGGAN ,  Tushar MAHATA ,  Xiaobin YANG ,  Jian-Wu XU ,  Janice O'NEIL ,  Nirupam SARKAR ,  Gopal KRISHNA

IPC: G06F15/18

CPC classification number: G06K9/00442 ,  G06K9/48 ,  G06K9/72 ,  G06K2209/01

Abstract: A method of training a document analysis system to extract data from documents is provided. The method includes: automatically analyzing images and text features extracted from a document to associate the document with a corresponding document category; comparing the extracted text features with a set of text features associated with corresponding category of the document, in which the set of text features includes a set of characters, words, and phrases; if the extracted features are found to consist of the characters, words, and phrases belonging to the set of text features associated with the corresponding document category, storing the extracted text features as the data contained in the corresponding document; and, if the extracted text features are found to include at least one text feature that does not belong to the set of text features associated with the corresponding document category, submitting the unrecognized text features to a training phase.

Abstract translation: 提供了一种培训文档分析系统从文档中提取数据的方法。 该方法包括：自动分析从文档中提取的图像和文本特征，将文档与相应的文档类别相关联; 将所提取的文本特征与与文档的相应类别相关联的一组文本特征进行比较，其中该组文本特征包括一组字符，单词和短语; 如果发现所提取的特征由属于与相应文档类别相关联的文本特征集合的字符，单词和短语组成，则将所提取的文本特征存储为包含在相应文档中的数据; 并且如果所提取的文本特征被发现包括不属于与相应文档类别相关联的一组文本特征的至少一个文本特征，则将未被识别的文本特征提交到训练阶段。

公开(公告)号：US20110123627A1

公开(公告)日：2011-05-26

申请号：US12999547

申请日：2009-04-15

Applicant: Larry Yun Fang ,  David Harris ,  Gopal Krishna ,  Allen E. Moton, JR. ,  Russell C. Prestipino ,  Marc Steinman ,  Jiansheng Wan ,  Hetty Anne Waskin

Inventor： Larry Yun Fang ,  David Harris ,  Gopal Krishna ,  Allen E. Moton, JR. ,  Russell C. Prestipino ,  Marc Steinman ,  Jiansheng Wan ,  Hetty Anne Waskin

IPC: A61K31/496 ,  A61K9/14 ,  A61P31/10

CPC classification number: A61K47/38 ,  A61K9/14 ,  A61K9/1652 ,  A61K31/496

Abstract: The present application provides novel compositions comprising posaconazole and a polymer wherein the composition has a glass transition temperature (Tg) of less than about 1100 C. The application also describes compositions comprising posaconazole and a polymer having a bulk density of greater than about 0.4 mg/mL. The application also describes compositions comprising posaconazole and a polymer which provide an exposure (AUCtf) of at least about 10,000 ng·hr/mL when administered to a patient in a fasted state. The application also describes a novel process for preparing these compositions. The preff erred polymer is HPMCAS. Preferably the composition is an extruded material.

Abstract translation: 本申请提供了包含泊沙康唑和聚合物的新型组合物，其中组合物的玻璃化转变温度（Tg）小于约1100℃。本申请还描述了包含泊沙康唑和堆积密度大于约0.4mg / mL。 本申请还描述了当以禁食状态给予患者时，包含泊沙康唑和提供至少约10,000ng·hr / mL的暴露（AUCtf）的聚合物的组合物。 本申请还描述了一种制备这些组合物的新方法。 优先聚合物是HPMCAS。 优选地，组合物是挤出材料。

公开(公告)号：US20100217782A1

公开(公告)日：2010-08-26

申请号：US12774879

申请日：2010-05-06

Applicant: Andrew D. Milligan ,  Charles R. Reeves ,  Jeffrey B. Parham ,  Gopal Krishna R. Kakivaya ,  Lawrence A. Buerk ,  Angela Mills ,  Richard L. Hasha

Inventor： Andrew D. Milligan ,  Charles R. Reeves ,  Jeffrey B. Parham ,  Gopal Krishna R. Kakivaya ,  Lawrence A. Buerk ,  Angela Mills ,  Richard L. Hasha

IPC: G06F9/46 ,  G06F17/30

CPC classification number: H04L67/16 ,  G06F9/541 ,  H04L29/12113 ,  H04L61/1541

Abstract: A system and methods for service discovery and publication are disclosed. Application programs write requests for service discovery, publication, and subscription to a service discovery application programming interface. The service discovery application programming interface invokes one or more lower-level protocols to satisfy the discovery, publication and/or subscription request. Service information retrieved from lower-layer protocols is formatted into a consistent data model and returned to the client application. In addition, service information may be stored in a persistent data store managed by a discovery persistence service communicatively connected to the service discovery API.

Abstract translation: 公开了一种用于服务发现和发布的系统和方法。 应用程序将服务发现，发布和订阅的请求写入服务发现应用程序编程接口。 服务发现应用程序编程接口调用一个或多个低级协议以满足发现，发布和/或订阅请求。 从低层协议检索的服务信息被格式化为一致的数据模型并返回给客户端应用程序。 此外，服务信息可以存储在通过通信地连接到服务发现API的发现持久性服务管理的持久数据存储中。

公开(公告)号：US07716357B2

公开(公告)日：2010-05-11

申请号：US10693653

申请日：2003-10-24

Applicant: Andrew D. Milligan ,  Charles R. Reeves ,  Jeffrey B. Parham ,  Gopal Krishna R. Kakivaya ,  Lawrence A. Buerk ,  Angela Mills ,  Richard L. Hasha

Inventor： Andrew D. Milligan ,  Charles R. Reeves ,  Jeffrey B. Parham ,  Gopal Krishna R. Kakivaya ,  Lawrence A. Buerk ,  Angela Mills ,  Richard L. Hasha

IPC: G06F15/16

CPC classification number: H04L67/16 ,  G06F9/541 ,  H04L29/12113 ,  H04L61/1541

Abstract: A system and methods for service discovery and publication are disclosed. Application programs write requests for service discovery, publication, and subscription to a service discovery application programming interface. The service discovery application programming interface invokes one or more lower-level protocols to satisfy the discovery, publication and/or subscription request. Service information retrieved from lower-layer protocols is formatted into a consistent data model and returned to the client application. In addition, service information may be stored in a persistent data store managed by a discovery persistence service communicatively connected to the service discovery API.

Abstract translation: 公开了一种用于服务发现和发布的系统和方法。 应用程序将服务发现，发布和订阅的请求写入服务发现应用程序编程接口。 服务发现应用程序编程接口调用一个或多个低级协议以满足发现，发布和/或订阅请求。 从低层协议检索的服务信息被格式化为一致的数据模型并返回给客户端应用程序。 此外，服务信息可以存储在通过通信地连接到服务发现API的发现持久性服务管理的持久数据存储中。

公开(公告)号：US07281207B2

公开(公告)日：2007-10-09

申请号：US10892744

申请日：2004-07-16

Applicant: Andrew J. Layman ,  Gopal Krishna R. Kakivaya ,  Satish R. Thatte

Inventor： Andrew J. Layman ,  Gopal Krishna R. Kakivaya ,  Satish R. Thatte

IPC: G06F15/00

CPC classification number: G06F9/546 ,  G06F9/4493 ,  G06F9/465

Abstract: Herein is described an implementation of an object persister, which serializes an object to preserve the object's data structure and its current data. The serialized object is encoded using XML and inserted within a message. That message is transmitted to an entity over a network. Such a transmission is performed using standard Internet protocols, such as HTML. Upon receiving the serialized object, the receiving entity deserializes the object to use it. Rather than include copies of referenced objects within the serialized object, the object persister includes references to those objects. This avoids redundant inclusion of the same object and potentially infinite inclusion of the object itself that is being serialized.

Abstract translation: 这里描述了对象持久化的实现，其将对象序列化以保留对象的数据结构及其当前数据。 序列化对象使用XML编码并插入到消息中。 该消息通过网络发送到实体。 这样的传输是使用诸如HTML之类的标准因特网协议执行的。 在接收到序列化对象后，接收实体反序列化对象使用它。 对象持久化不是包含引用对象在序列化对象中的副本，而是包含对这些对象的引用。 这样可以避免同一个对象的冗余包含，并且可能无限地包含正在被序列化的对象本身。

公开(公告)号：US07149965B1

公开(公告)日：2006-12-12

申请号：US09635830

申请日：2000-08-09

Applicant: Andrew J. Layman ,  Gopal Krishna R. Kakivaya ,  Satish R. Thatte

Inventor： Andrew J. Layman ,  Gopal Krishna R. Kakivaya ,  Satish R. Thatte

IPC: G06F15/00

CPC classification number: G06F9/546 ,  G06F9/4493 ,  G06F9/465

Abstract: The object persister serializes an object to preserve the object's data structure and its current data. The serialized object is encoded using XML and inserted within a message. That message is transmitted to an entity over a network. Such a transmission is performed using standard Internet protocols, such as HTML. Upon receiving the serialized object, the receiving entity deserializes the object to use it. Rather than include copies of referenced objects within the serialized object, the object persister includes references to those objects. This avoids redundant inclusion of the same object and potentially infinite inclusion of the object itself that is being serialized.

Abstract translation: 对象持久化序列化对象以保留对象的数据结构及其当前数据。 序列化对象使用XML编码并插入到消息中。 该消息通过网络发送到实体。 这样的传输是使用诸如HTML之类的标准因特网协议执行的。 在接收到序列化对象后，接收实体反序列化对象使用它。 对象持久化不是包含引用对象在序列化对象中的副本，而是包含对这些对象的引用。 这样可以避免同一个对象的冗余包含，并且可能无限地包含被序列化的对象本身。