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公开(公告)号：US08461329B2
公开(公告)日：2013-06-11
申请号：US13142230
申请日：2009-12-25
申请人： Tetsuo Takayama , Hajime Asanuma , Daisuke Wakasugi , Rie Nishikawa , Yoshinori Sekiguchi , Madoka Kawamura , Naoya Ono , Tetsuya Yabuuchi , Takahiro Oi , Yusuke Oka , Shoichi Kuroda , Fumito Uneuchi , Takeshi Koami
发明人： Tetsuo Takayama , Hajime Asanuma , Daisuke Wakasugi , Rie Nishikawa , Yoshinori Sekiguchi , Madoka Kawamura , Naoya Ono , Tetsuya Yabuuchi , Takahiro Oi , Yusuke Oka , Shoichi Kuroda , Fumito Uneuchi , Takeshi Koami
IPC分类号： C07D413/12 , C07D401/12 , C07D405/12 , C07D217/24
CPC分类号： C07D217/16 , C07D217/18 , C07D217/20 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04
摘要： A compound represented by formula (I) or a pharmaceutically acceptable salt thereof has an effect of inhibiting CRTH2 and, therefore, is useful as a preventive or a remedy for allergic diseases such as asthma, atopic dermatitis and allergic rhinitis.
摘要翻译： 由式（I）表示的化合物或其药学上可接受的盐具有抑制CRTH2的作用，因此可用作哮喘，特应性皮炎和过敏性鼻炎等过敏性疾病的预防或治疗。
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公开(公告)号：US09073821B2
公开(公告)日：2015-07-07
申请号：US13642320
申请日：2011-04-20
申请人： Hajime Takashima , Risa Tsuruta , Tetsuya Yabuuchi , Yusuke Oka , Hiroki Urabe , Yoichiro Suga , Masato Takahashi , Fumito Uneuchi , Hironori Kotsubo , Muneo Shoji , Yasuko Kawaguchi
发明人： Hajime Takashima , Risa Tsuruta , Tetsuya Yabuuchi , Yusuke Oka , Hiroki Urabe , Yoichiro Suga , Masato Takahashi , Fumito Uneuchi , Hironori Kotsubo , Muneo Shoji , Yasuko Kawaguchi
IPC分类号： C07C259/06 , C07C323/62 , C07D305/06 , C07D307/14 , C07D317/30 , C07D319/18 , C07D295/08 , C07D285/12 , C07D271/12 , C07D265/30 , C07D263/14 , C07D261/08 , C07D241/04 , C07C271/22 , C07C271/28 , C07C311/08 , C07C317/28 , C07C317/44 , C07C323/41 , C07D205/12 , C07D207/12 , C07D207/27 , C07D207/327 , C07D209/12 , C07D209/14 , C07D209/44 , C07D209/52 , C07D211/18 , C07D211/38 , C07D211/46 , C07D211/56 , C07D211/70 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/74 , C07D213/81 , C07D215/14 , C07D217/12 , C07D231/56 , C07D257/04 , C07D263/32 , C07D263/56 , C07D265/38 , C07D267/10 , C07D277/20 , C07D277/30 , C07D277/62 , C07D277/66 , C07D295/12 , C07D295/14 , C07D295/16 , C07D305/08 , C07D307/18 , C07D307/52 , C07D307/54 , C07D307/78 , C07D307/82 , C07D307/87 , C07D309/04 , C07D309/14 , C07D317/60 , C07D319/20 , C07D333/24 , C07D405/06 , C07D413/06 , C07D471/04 , C07D471/10 , C07D487/08 , C07D491/20 , C07D498/08 , C07F9/09 , C07D239/26 , C07D235/04 , C07D233/61 , C07D231/12 , C07D217/04 , C07D211/14 , C07D209/08 , C07D207/10 , C07D205/04
CPC分类号： C07C233/83 , C07C235/84 , C07C237/36 , C07C259/06 , C07C271/22 , C07C271/28 , C07C309/30 , C07C311/08 , C07C317/28 , C07C317/44 , C07C323/41 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/08 , C07D205/04 , C07D205/12 , C07D207/10 , C07D207/12 , C07D207/27 , C07D207/327 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/44 , C07D209/52 , C07D211/14 , C07D211/18 , C07D211/38 , C07D211/46 , C07D211/56 , C07D211/70 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/74 , C07D213/81 , C07D215/14 , C07D217/04 , C07D217/12 , C07D231/12 , C07D231/56 , C07D233/61 , C07D235/04 , C07D257/04 , C07D261/08 , C07D263/14 , C07D263/32 , C07D263/56 , C07D265/30 , C07D265/36 , C07D265/38 , C07D267/10 , C07D271/12 , C07D277/20 , C07D277/30 , C07D277/62 , C07D277/66 , C07D285/12 , C07D295/08 , C07D295/12 , C07D295/14 , C07D295/16 , C07D305/06 , C07D305/08 , C07D307/14 , C07D307/18 , C07D307/52 , C07D307/54 , C07D307/78 , C07D307/81 , C07D307/82 , C07D307/87 , C07D309/04 , C07D309/14 , C07D317/30 , C07D317/60 , C07D319/18 , C07D319/20 , C07D333/24 , C07D405/06 , C07D413/06 , C07D471/04 , C07D471/10 , C07D487/08 , C07D491/20 , C07D498/04 , C07D498/08 , C07F9/091
摘要： Provided is a novel compound which is useful as a pharmaceutical composition by inhibiting an LpxC activity, thereby exhibiting potent antimicrobial activity against gram-negative bacteria including Pseudomonas aeruginosa and its drug resistant bacteria. Provided is a hydroxamic acid derivative represented by the following general formula [1] or a pharmaceutically acceptable salt thereof:
摘要翻译： 提供了通过抑制LpxC活性可用作药物组合物的新型化合物，从而对包括绿脓假单胞菌及其耐药细菌在内的革兰氏阴性细菌表现出有效的抗微生物活性。 提供由以下通式[1]表示的异羟肟酸衍生物或其药学上可接受的盐：
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公开(公告)号：US20130072677A1
公开(公告)日：2013-03-21
申请号：US13642320
申请日：2011-04-20
申请人： Hajime Takashima , Risa Tsuruta , Tetsuya Yabuuchi , Yusuke Oka , Hiroki Urabe , Yoichiro Suga , Masato Takahashi , Fumito Uneuchi , Hironori Kotsubo , Muneo Shoji , Yasuko Kawaguchi
发明人： Hajime Takashima , Risa Tsuruta , Tetsuya Yabuuchi , Yusuke Oka , Hiroki Urabe , Yoichiro Suga , Masato Takahashi , Fumito Uneuchi , Hironori Kotsubo , Muneo Shoji , Yasuko Kawaguchi
IPC分类号： C07C259/06 , C07D267/10 , C07D261/08 , C07D205/04 , C07D211/46 , C07D498/04 , C07D305/08 , C07D491/107 , C07D307/52 , C07D295/155 , C07D413/06 , C07D265/36 , C07D295/088 , C07D305/06
CPC分类号： C07C233/83 , C07C235/84 , C07C237/36 , C07C259/06 , C07C271/22 , C07C271/28 , C07C309/30 , C07C311/08 , C07C317/28 , C07C317/44 , C07C323/41 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/08 , C07D205/04 , C07D205/12 , C07D207/10 , C07D207/12 , C07D207/27 , C07D207/327 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/44 , C07D209/52 , C07D211/14 , C07D211/18 , C07D211/38 , C07D211/46 , C07D211/56 , C07D211/70 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/74 , C07D213/81 , C07D215/14 , C07D217/04 , C07D217/12 , C07D231/12 , C07D231/56 , C07D233/61 , C07D235/04 , C07D257/04 , C07D261/08 , C07D263/14 , C07D263/32 , C07D263/56 , C07D265/30 , C07D265/36 , C07D265/38 , C07D267/10 , C07D271/12 , C07D277/20 , C07D277/30 , C07D277/62 , C07D277/66 , C07D285/12 , C07D295/08 , C07D295/12 , C07D295/14 , C07D295/16 , C07D305/06 , C07D305/08 , C07D307/14 , C07D307/18 , C07D307/52 , C07D307/54 , C07D307/78 , C07D307/81 , C07D307/82 , C07D307/87 , C07D309/04 , C07D309/14 , C07D317/30 , C07D317/60 , C07D319/18 , C07D319/20 , C07D333/24 , C07D405/06 , C07D413/06 , C07D471/04 , C07D471/10 , C07D487/08 , C07D491/20 , C07D498/04 , C07D498/08 , C07F9/091
摘要： Provided is a novel compound which is useful as a pharmaceutical composition by inhibiting an LpxC activity, thereby exhibiting potent antimicrobial activity against gram-negative bacteria including Pseudomonas aeruginosa and its drug resistant bacteria. Provided is a hydroxamic acid derivative represented by the following general formula [1] or a pharmaceutically acceptable salt thereof:
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公开(公告)号：US20110288293A1
公开(公告)日：2011-11-24
申请号：US13142230
申请日：2009-12-25
申请人： Tetsuo Takayama , Hajime Asanuma , Daisuke Wakasugi , Rie Nishikawa , Yoshinori Sekiguchi , Madoka Kawamura , Naoya Ono , Tetsuya Yabuuchi , Takahiro Oi , Yusuke Oka , Shoichi Kuroda , Fumito Uneuchi , Takeshi Koami
发明人： Tetsuo Takayama , Hajime Asanuma , Daisuke Wakasugi , Rie Nishikawa , Yoshinori Sekiguchi , Madoka Kawamura , Naoya Ono , Tetsuya Yabuuchi , Takahiro Oi , Yusuke Oka , Shoichi Kuroda , Fumito Uneuchi , Takeshi Koami
IPC分类号： C07D413/12 , C07D401/12 , C07D405/12 , C07D217/24 , C07D409/12 , C07D471/04 , C07D401/06 , C07D217/16 , C07D417/12
CPC分类号： C07D217/16 , C07D217/18 , C07D217/20 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04
摘要： A compound represented by formula (I) or a pharmaceutically acceptable salt thereof has an effect of inhibiting CRTH2 and, therefore, is useful as a preventive or a remedy for allergic diseases such as asthma, atopic dermatitis and allergic rhinitis.
摘要翻译： 由式（I）表示的化合物或其药学上可接受的盐具有抑制CRTH2的作用，因此可用作哮喘，特应性皮炎和过敏性鼻炎等过敏性疾病的预防或治疗。
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