Abstract:
The present invention relates to a microarray device for the screening or the finding of protein inhibitors, to a method for the production thereof, and to a corresponding method for screening or finding protein inhibitors. The microarray device according to the invention comprises a solid supporting element having a support material, at least one protein immobilized thereon for which inhibitors are to be screened or found, and at least one known inhibitor of the at least one protein, the inhibitor being bound to the at least one protein and comprising a detectable label.
Abstract:
A drilling tool for machine tools includes a drill shank provided with a radially outwardly projecting feed helix. The drilling tool also includes a drilling head disposed at the end of the drill shank and having two segment sections which are delimited radially outwardly by partially cylindrical peripheral surfaces and separated from each other by axially parallel chip grooves which are adjacent in the peripheral direction. The drilling head also includes at least two cutting plates disposed at different radial spacings from a drilling tool axis and each having a cutting edge projecting beyond the drilling head. The chip grooves are delimited on the side of the cutting plates by at least one axially parallel radial chip-deflection surface and by a chip-guide surface disposed on the adjacent segment section. The chip-deflection surfaces terminate at an axial spacing from the cutting edges at a substantially radial rear free edge and merge there into a chip-feed surface which delimits the relevant segment section at the rear in the direction of the drill shank, rising helically to the following chip channel. The annular space between the chip-feed surface and the end of the feed helix at the drilling head end forms a chip-stowing space from which the chips produced during drilling are carried away by the helix.
Abstract:
The invention relates to a cutting tool setting system comprising a tool head for the settable holding of a cutting tool, said head comprising an adjustment device for the cutting tool. The cutting tool setting system comprises a setting tool which can be mechanically removably engaged in the tool head at an interface for adjusting the adjustment device in the tool head. The setting tool comprises a shaft body having a key part. A key engagement for actuating the adjustment device is designed on the tool head. The key part can be displaced relative to the shaft body in the direction of the longitudinal axis of said body in order to selectively couple and release the key part of the setting tool and the key part at the interface of the tool head.
Abstract:
The tensioning mechanism (18) comprises a clamp bolt (28), arranged in a displaceable manner in a transverse bore (26) in the fitting plug (12) and two diametrically opposed retainers (34, 36) in the second component (14) which engage with an axially facing internal or external cone against a complementary internal or external cone on the clamp bolt (28) and, during tensioning, are tensioned with the same in a wedge fashion. According to the invention, the clamp bolt (28) comprises a frustum-shaped external cone (40), the base diameter of which is smaller than the diameter of the guide surface (62) thereof in the transverse bore (26).
Abstract:
A cutting tool setting system contains a tool head for the settable holding of a cutting tool, the head having an adjustment device for the cutting tool. The cutting tool setting system has a setting tool which can be mechanically removably engaged in the tool head at an interface for adjusting the adjustment device in the tool head. The setting tool contains a shaft body having a key part. A key engagement for actuating the adjustment device is designed on the tool head. The key part can be displaced relative to the shaft body in the direction of the longitudinal axis of the body in order to selectively couple and release the key part of the setting tool and the key part at the interface of the tool head.
Abstract:
The present invention relates to a microarray device for the screening or the finding of protein inhibitors, to a method for the production thereof, and to a corresponding method for screening or finding protein inhibitors. The microarray device according to the invention comprises a solid supporting element having a support material, at least one protein immobilized thereon for which inhibitors are to be screened or found, and at least one known inhibitor of the at least one protein, the inhibitor being bound to the at least one protein and comprising a detectable label.
Abstract:
The invention relates to a process and device for detecting and/or compensating for static jointing and wear errors in the fine drilling of workpieces by means of an adjusting tool (18) bearing an adjustable cutting insert (28) and capable of being clamped to a machine shaft (14). According to the invention, before a drilling or a series thereof is made, the diameter of the circle of travel of a radially outer cutting edge (44) of the cutting insert (28) is measured on the clamped adjusting tool with the machine shaft (14) rotating and evaluated within the adjusting tool (18) for adjustment purposes.