公开(公告)号：US06897207B2

公开(公告)日：2005-05-24

申请号：US10177804

申请日：2002-06-21

Applicant: Paul J. Cox ,  Tahir N. Majid ,  Justine Yeun Quai Lai ,  Andrew D. Morley ,  Shelley Amendola ,  Stephanie D. Deprets ,  Christopher Edlin ,  Charles J. Gardner ,  Dorothea Kominos ,  Brian L. Pedgrift ,  Frank Halley ,  Timothy A. Gillespy ,  Michael Edwards ,  Francois F. Clerc ,  Conception Nemecek ,  Olivier Houille ,  Dominique Damour ,  Herve Bouchard ,  Daniel N. A. Bezard ,  Chantal Carrez

Inventor： Paul J. Cox ,  Tahir N. Majid ,  Justine Yeun Quai Lai ,  Andrew D. Morley ,  Shelley Amendola ,  Stephanie D. Deprets ,  Christopher Edlin ,  Charles J. Gardner ,  Dorothea Kominos ,  Brian L. Pedgrift ,  Frank Halley ,  Timothy A. Gillespy ,  Michael Edwards ,  Francois F. Clerc ,  Conception Nemecek ,  Olivier Houille ,  Dominique Damour ,  Herve Bouchard ,  Daniel N. A. Bezard ,  Chantal Carrez

IPC: A61K20060101 ,  A61K31/437 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/5355 ,  A61K31/5377 ,  A61K31/541 ,  A61P20060101 ,  A61P9/00 ,  A61P11/00 ,  A61P11/02 ,  A61P11/06 ,  A61P13/08 ,  A61P17/00 ,  A61P17/02 ,  A61P17/06 ,  A61P19/02 ,  A61P27/14 ,  A61P29/00 ,  A61P35/00 ,  A61P37/08 ,  A61P43/00 ,  C07D20060101 ,  C07D209/00 ,  C07D221/00 ,  C07D241/00 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00 ,  A61K31/33 ,  A61K31/66 ,  C07D417/02

CPC classification number: C07D519/00 ,  C07D471/04 ,  C07D487/04

Abstract: The invention is directed to physiologically active compounds of general formula (I): and compositions containing such compounds; and their prodrugs, and pharmaceutically acceptable salts and solvates of such compounds and their prodrugs, as well as to novel compounds within the scope of formula (I). Such compounds and compositions have valuable pharmaceutical properties, in particular the ability to inhibit kinases.

Abstract translation: 本发明涉及通式（I）的生理活性化合物：和含有这些化合物的组合物; 及其前药，以及这些化合物及其前药的药学上可接受的盐和溶剂合物，以及式（I）范围内的新化合物。 这些化合物和组合物具有有价值的药物特性，特别是抑制激酶的能力。

公开(公告)号：US07943616B2

公开(公告)日：2011-05-17

申请号：US10995103

申请日：2004-11-23

Applicant: Paul J. Cox ,  Tahir N. Majid ,  Justine Yeun Quai Lai ,  Andrew D. Morley ,  Shelley Amendola ,  Stephanie D. Deprets ,  Christopher Edlin ,  Charles J. Gardner ,  Dorothea Kominos ,  Brian L. Pedgrift ,  Frank Halley ,  Timothy A. Gillespy ,  Michael Edwards ,  Francois F. Clerc ,  Conception Nemecek ,  Olivier Houille ,  Dominique Damour ,  Herve Bouchard ,  Daniel N. A. Bezard ,  Chantal Carrez

Inventor： Paul J. Cox ,  Tahir N. Majid ,  Justine Yeun Quai Lai ,  Andrew D. Morley ,  Shelley Amendola ,  Stephanie D. Deprets ,  Christopher Edlin ,  Charles J. Gardner ,  Dorothea Kominos ,  Brian L. Pedgrift ,  Frank Halley ,  Timothy A. Gillespy ,  Michael Edwards ,  Francois F. Clerc ,  Conception Nemecek ,  Olivier Houille ,  Dominique Damour ,  Herve Bouchard ,  Daniel N. A. Bezard ,  Chantal Carrez

IPC: C07D487/04 ,  A61K31/5025 ,  A61P29/00 ,  A61P35/00 ,  A61P19/02

CPC classification number: C07D519/00 ,  C07D471/04 ,  C07D487/04

Abstract: The invention is directed to physiologically active compounds of general formula (I):— and compositions containing such compounds; and their prodrugs, and pharmaceutically acceptable salts and solvates of such compounds and their prodrugs, as well as to novel compounds within the scope of formula (I). Such compounds and compositions have valuable pharmaceutical properties, in particular the ability to inhibit kinases.

Abstract translation: 本发明涉及通式（I）的生理活性化合物： - 含有这些化合物的组合物; 及其前药，以及这些化合物及其前药的药学上可接受的盐和溶剂合物，以及式（I）范围内的新化合物。 这些化合物和组合物具有有价值的药物特性，特别是抑制激酶的能力。