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公开(公告)号:US20090264346A1
公开(公告)日:2009-10-22
申请号:US12493681
申请日:2009-06-29
申请人: Montse LLINAS-BRUNET , Murray BAILEY , Francois BILODEAU , Pasquale FORGIONE , Elise GHIRO , Nathalie GOUDREAU , Teddy HALMOS , Jean RANCOURT
发明人: Montse LLINAS-BRUNET , Murray BAILEY , Francois BILODEAU , Pasquale FORGIONE , Elise GHIRO , Nathalie GOUDREAU , Teddy HALMOS , Jean RANCOURT
CPC分类号: C07K5/0808 , A61K38/00 , C07K5/0812 , C07K5/0827
摘要: Compounds of formula (I): wherein R1, R2, X, R3, D, and the dotted line b are as defined herein; or a pharmaceutically acceptable salt or ester thereof, are useful as inhibitors of the HCV NS3 protease.
摘要翻译: 式(I)化合物:其中R1,R2,X,R3,D和虚线b如本文所定义; 或其药学上可接受的盐或酯可用作HCV NS3蛋白酶的抑制剂。
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公开(公告)号:US4900119A
公开(公告)日:1990-02-13
申请号:US176683
申请日:1988-04-01
CPC分类号: G02B6/29332 , G02B2006/12164 , G02B6/2934 , G02B6/29353
摘要: New types of narrowband wavelength selective optical devices are described. Various configurations are possible, according to the invention, that perform as narrowband wavelength selective transmission or reflection filters or as narrowband wavelength selective optical taps or combiners. The optical devices of the invention include a 3 dB optical directional coupler and wavelength selecting elements such as Bragg reflection gratings or Fabry-Perot resonators usually positioned in optical symmetry with respect to the directional coupler. Two or more wavelength selecting elements can be used to obtain desired filtering characteristics.
摘要翻译: 描述了新型窄带波长选择光学器件。 根据本发明,根据本发明的各种配置可以作为窄带波长选择性透射或反射滤波器或者作为窄带波长选择性光学抽头或组合器来执行。 本发明的光学器件包括3dB光学定向耦合器和诸如布拉格反射光栅或法布里 - 珀罗谐振器的波长选择元件,通常相对于定向耦合器定位成光学对称。 可以使用两个或更多个波长选择元件来获得期望的滤波特性。
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公开(公告)号:US09249158B2
公开(公告)日:2016-02-02
申请号:US14390246
申请日:2013-04-03
申请人: Lee Fader , Pierre Louis Beaulieu , Murray Bailey , Francois Bilodeau , Rebekah J. Carson , André Giroux , Cédrickx Godbout , Oliver Hucke , Marc-André Joly , Mélissa Leblanc , Olivier Lepage , Benoit Moreau , Julie Naud , Martin Poirier , Elisia Villemure
发明人: Lee Fader , Pierre Louis Beaulieu , Murray Bailey , Francois Bilodeau , Rebekah J. Carson , André Giroux , Cédrickx Godbout , Oliver Hucke , Marc-André Joly , Mélissa Leblanc , Olivier Lepage , Benoit Moreau , Julie Naud , Martin Poirier , Elisia Villemure
IPC分类号: C07D498/22 , C07D471/14 , A61K31/4375 , C07D471/22 , C07D491/147 , C07D498/14 , C07D519/00 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D491/107
CPC分类号: C07D498/22 , A61K31/4375 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D471/14 , C07D471/22 , C07D491/107 , C07D491/147 , C07D498/14 , C07D519/00
摘要: Compounds of Formula (I) wherein n, A, R1, R2, R3 and R5 are defined herein, are useful for the treatment of cytomegalovirus disease and/or infection.
摘要翻译: 其中n,A,R 1,R 2,R 3和R 5在本文中定义的式(I)化合物可用于治疗巨细胞病毒疾病和/或感染。
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公开(公告)号:US20150080366A1
公开(公告)日:2015-03-19
申请号:US14390246
申请日:2013-04-03
申请人: Lee Fader , Pierre Louis Beaulieu , Murray Bailey , Francois Bilodeau , Rebekah J. Carson , André Giroux , Cédrickx Godbout , Oliver Hucke , Marc-André Joly , Mélissa Leblanc , Olivier Lepage , Benoit Moreau , Julie Naud , Martin Poirier , Elisia Villemure
发明人: Lee Fader , Pierre Louis Beaulieu , Murray Bailey , Francois Bilodeau , Rebekah J. Carson , André Giroux , Cédrickx Godbout , Oliver Hucke , Marc-André Joly , Mélissa Leblanc , Olivier Lepage , Benoit Moreau , Julie Naud , Martin Poirier , Elisia Villemure
IPC分类号: C07D498/22 , A61K31/5377 , A61K31/506 , A61K31/5383 , C07D491/107 , C07D471/22 , C07D471/14 , A61K45/06 , A61K31/4375 , A61K31/496
CPC分类号: C07D498/22 , A61K31/4375 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D471/14 , C07D471/22 , C07D491/107 , C07D491/147 , C07D498/14 , C07D519/00
摘要: Compounds of Formula (I) wherein n, A, R1, R2, R3 and R5 are defined herein, are useful for the treatment of cytomegalovirus disease and/or infection.
摘要翻译: 其中n,A,R 1,R 2,R 3和R 5在本文中定义的式(I)化合物可用于治疗巨细胞病毒疾病和/或感染。
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公开(公告)号:US20090060417A1
公开(公告)日:2009-03-05
申请号:US12190861
申请日:2008-08-13
CPC分类号: G02B6/14 , G02B6/2551 , G02B6/2552
摘要: A device for providing an expanded mode field from a single mode optical waveguide is formed by fusing a length of single mode optical fiber with a length of fiber rod absent a cladding and adiabatically tapering the fused region. The length of single mode fiber has a core having a refractive index nco and a cladding having a refractive index ncl, wherein ncl
摘要翻译: 通过将单模光纤的长度与没有包层的纤维棒的长度融合,并绝热地使熔融区域逐渐变细来形成用于从单模光波导提供扩展模场的装置。 单模光纤的长度具有折射率nco的核和具有折射率ncl的包层,其中ncl
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公开(公告)号:US20080053275A1
公开(公告)日:2008-03-06
申请号:US10590472
申请日:2005-02-23
CPC分类号: B22D43/004 , B22D11/119
摘要: A method is described for priming an in-line molten metal filtration unit having a porous ceramic or refractory filter mounted substantially horizontally in a filter box. This filter box has an inlet for molten metal and an outlet for molten metal, the outlet being a closeable outlet in an exit well connecting to the downstream side of the filter. The method of the invention comprises the steps of adding a molten metal to the filter box sufficient to entirely cover the upstream side of the filter with a depth of molten metal and temporarily sealing the outlet in the exit well. A steadily increasing vacuum is then applied to the closed exit well at a rate between 0.1 and 10 kPa per second by withdrawing a stream of air from the exit well by means of a fan or air venturi until molten metal begins to flow through the filter At that point the vacuum is quickly released and the molten metal outlet is opened. Once the filter has been primed in this manner, flow of metal through the filter continues while requiring only a relatively low head of molten metal on the inlet side of the filter.
摘要翻译: 描述了一种用于启动具有基本水平地安装在过滤箱中的多孔陶瓷或耐火过滤器的在线熔融金属过滤单元的方法。 该过滤箱具有用于熔融金属的入口和用于熔融金属的出口,该出口是连接到过滤器下游侧的出口孔中的可关闭的出口。 本发明的方法包括以下步骤:将熔融金属添加到过滤箱中,足以使熔融金属的深度完全覆盖过滤器的上游侧并临时将出口密封在出口孔中。 然后通过风扇或空气文氏管抽出出口孔中的空气流,以0.1至10kPa /秒的速率将稳定增加的真空施加到封闭的出口孔,直到熔融金属开始流过过滤器。 这样就可以快速地释放真空并且打开熔融金属出口。 一旦过滤器以这种方式被喷涂,金属通过过滤器的流动继续进行,同时仅需要在过滤器的入口侧上较低的熔融金属头。
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公开(公告)号:US20050192212A1
公开(公告)日:2005-09-01
申请号:US11039698
申请日:2005-01-19
申请人: Montse Llinas-Brunet , Murray Bailey , Punit Bhardwaj , Francois Bilodeau , Pasquale Forgione , Elise Ghiro , Nathalie Goudreau , Teddy Halmos , Jean Rancourt
发明人: Montse Llinas-Brunet , Murray Bailey , Punit Bhardwaj , Francois Bilodeau , Pasquale Forgione , Elise Ghiro , Nathalie Goudreau , Teddy Halmos , Jean Rancourt
CPC分类号: C07K5/0808 , A61K38/00 , C07K5/0812 , C07K5/0827
摘要: Compounds of formula (I): wherein R1, R2, X, R3, D, and the dotted line b are as defined herein; or a pharmaceutically acceptable salt or ester thereof, are useful as inhibitors of the HCV NS3 protease.
摘要翻译: 式(I)化合物:其中R 1,R 2,X,R 3,D和虚线b如上所定义 在这里 或其药学上可接受的盐或酯可用作HCV NS3蛋白酶的抑制剂。
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公开(公告)号:US06256435B1
公开(公告)日:2001-07-03
申请号:US09421234
申请日:1999-10-20
IPC分类号: G02B634
CPC分类号: G02B6/124 , G02B6/02109 , G02B6/02147
摘要: A method is disclosed wherein optical structures such as Bragg gratings can be written into planar waveguides disposed on a substrate. By employing the method of this invention, a polarization insensitive device can be made. Such relatively thin planar waveguides disposed on a substrate are inherently polarization sensitive and the structure itself is birefringent. By writing structures in the waveguides or by simply writing a refractive index change in the waveguide by limiting the beam width at the waveguide layer to less than or equal to the thickness of the waveguiding layers on the substrate, in combination with conventional wider beam writing techniques, polarization sensitivity can be lessened or obviated.
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公开(公告)号:US4586784A
公开(公告)日:1986-05-06
申请号:US774851
申请日:1985-09-09
IPC分类号: G02B6/28
CPC分类号: G02B6/2835 , G02B6/2856
摘要: The modal-insensitive coupler consists of a number N of optical multimode fiber lengths, each fiber length having a core of initial predetermined cross-sectional area. The fiber lengths are fused together in a coupling section such that the cores of the fiber lengths have a reduced cross-sectional area in the coupling section which supports a minimum number of modes of optical energy at a predetermined wavelength, and such that the fiber lengths have different core cross-sectional areas to produce preselected coupling ratios.
摘要翻译: 模式不敏感耦合器由多个N个光纤多模光纤长度组成,每个光纤长度具有初始预定横截面积的核心。 纤维长度在耦合部分中熔合在一起,使得纤维长度的芯在耦合部分中具有减小的横截面面积,其支持在预定波长处的最小数量的光能量,并且使得光纤长度 具有不同的芯横截面积以产生预选的耦合比。
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公开(公告)号:US08354429B2
公开(公告)日:2013-01-15
申请号:US12742997
申请日:2008-09-11
申请人: Youla S. Tsantrizos , Murray D. Bailey , Francois Bilodeau , Rebekah J. Carson , Rene Coulombe , Lee Fader , Teddy Halmos , Stephen Kawai , Serge Landry , Steven LaPlante , Sebastien Morin , Mathieu Parisien , Marc-Andre Poupart , Bruno Simoneau
发明人: Youla S. Tsantrizos , Murray D. Bailey , Francois Bilodeau , Rebekah J. Carson , Rene Coulombe , Lee Fader , Teddy Halmos , Stephen Kawai , Serge Landry , Steven LaPlante , Sebastien Morin , Mathieu Parisien , Marc-Andre Poupart , Bruno Simoneau
IPC分类号: C07D215/14 , C07D401/04 , A61K31/47 , A61K31/4709
CPC分类号: C07D215/14 , A61K31/47 , A61K31/4709 , A61K31/473 , A61K31/4741 , A61K31/538 , A61K31/5383 , C07D215/18 , C07D221/16 , C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D491/06 , C07D498/06
摘要: Compounds of formula I: wherein R4, R6 and R7 are defined herein, are useful as inhibitors of HIV replication.
摘要翻译: 式I化合物(其中R 4,R 6和R 7在本文中定义)可用作HIV复制的抑制剂。
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