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公开(公告)号：US20230380451A1
公开(公告)日：2023-11-30
申请号：US18029365
申请日：2021-09-30
Applicant: Erber Aktiengesellschaft
Inventor： Eva Maria BINDER , Elisabeth STREIT , Günter BRADER , Claudia BERNARD , Barbara WEBER , Lia MARTINEZ MONTERO , Jörg SCHRITTWIESER , Wolfgang KROUTIL , Milica PASTAR , Angela SESSITSCH , Jan DOLINSEK
CPC classification number: A23K20/147 , A23K10/14 , A23K10/30 , A23K50/30 , A23L5/25 , A23L7/107 , C12P17/181 , C12Y101/01002
Abstract: The present invention relates to polypeptides capable of modifying the C8-atom of deoxynivalenol and methods (e.g., for detoxifying mycotoxins) based thereon. The present invention further relates to compositions, kits, transgenic plants, transgenic seeds, transgenic pollen grains, foodstuff, intermediate foodstuff; fodder, intermediate fodder; feed, intermediate feed; additive (e.g., foodstuff-, fodder- or feed additive), intermediate additive (e.g., foodstuff-, fodder- or feed intermediate additive); detoxifying agent, intermediate detoxifying agent; nutritional supplement, intermediate nutritional supplement, prebiotic, intermediate prebiotic and/or mixture/s thereof comprising one or more of the polypeptides capable of modifying the C8-atom of deoxynivalenol.
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2.发明公开公开(公告)号：US20230235297A1
公开(公告)日：2023-07-27
申请号：US18008939
申请日：2021-06-08
Applicant: ERBER AKTIENGESELLSCHAFT
Inventor： Bernhard Neumayer , Elisabeth Streit , Barbara Weber , Gudrun Vogtentanz
IPC: C12N9/02 , A23K20/189 , A23L29/00
CPC classification number: C12N9/0008 , A23K20/189 , A23L29/06 , C12Y197/00
Abstract: The present invention relates to a method of converting 3-keto-DON into 3-epi-DON, reducing the content of DON in a composition comprising DON or of reducing the toxicity of a composition comprising DON as well as a method for converting a trichothecene comprising a 3-oxo group into a trichothecene comprising a 3-hydroxy group using one or more polypeptide(s) comprising or consisting of SEQ ID NO. 1 or a sequence having a sequence identity of at least 72.0% to SEQ ID NO. 1. Also envisioned are feed or food additives or feed or food as well as pharmaceutical compositions comprising one or more polypeptide(s) comprising or consisting of a sequence of SEQ ID NO. 1 or a sequence having a sequence identity of at least 72.0% to SEQ ID NO. 1 as well as the manufacture thereof. Encompassed are further polypeptide(s) comprising or consisting of a sequence of SEQ ID NO. 1 or a sequence having a sequence identity of at least 88.5% to SEQ ID NO. 1. Also envisioned are host cells or plants.
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公开(公告)号：US11324235B2
公开(公告)日：2022-05-10
申请号：US16934179
申请日：2020-07-21
Applicant: Erber Aktiengesellschaft
Inventor： Sebastian Fruhauf , Michaela Thamhesl , Martin Pfeffer , Dieter Moll , Gerd Schatzmayr , Eva Maria Binder
Abstract: The invention relates to a polypeptide for the hydrolytic cleavage of zearalenone and/or at least one zearalenone derivative, said polypeptide being a hydrolase having an amino acid sequence selected from the group consisting of SEQ ID NO: 1-15 or a functional variant thereof, wherein the sequence of the functional variant is at least 40% identical to at least one of the amino acid sequences. The invention also relates to: an additive containing the polypeptide; an isolated polynucleotide that encodes the polypeptide; and a method for the hydrolytic cleavage of zearalenone and/or of at least one zearalenone derivative using the polypeptide.
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4.发明授权公开(公告)号：US11096980B2
公开(公告)日：2021-08-24
申请号：US16473643
申请日：2017-12-14
Applicant: Erber Aktiengesellschaft
Inventor： Elisabeth Mayer , Barbara Novak , Christina Schwab-Andics , Ursula Hofstätter-Schaehs , Gerd Schatzmayr
IPC: A61K36/484 , A23K20/163 , A23K10/30 , A61K31/704 , A23K50/30 , A23K50/75 , A61K9/00
Abstract: A method of using at least one Glycyrrhiza plant preparation selected from the group of flour of a whole, dried Glycyrrhiza plant, flour of the leaves of the dried Glycyrrhiza plant, flour of roots of the dried Glycyrrhiza plant, aqueous dry extract of the Glycyrrhiza plant, aqueous/ethanolic dry extract of the Glycyrrhiza plant, aqueous extract of the Glycyrrhiza plant, optionally together with at least one excipient, for reducing the toxic effect of at least one polypeptide fungitoxin in agrarian products.
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公开(公告)号：US20200375218A1
公开(公告)日：2020-12-03
申请号：US16934179
申请日：2020-07-21
Applicant: Erber Aktiengesellschaft
Inventor： Sebastian Fruhauf , Michaela Thamhesl , Martin Pfeffer , Dieter Moll , Gerd Schatzmayr , Eva Maria Binder
Abstract: The invention relates to a polypeptide for the hydrolytic cleavage of zearalenone and/or at least one zearalenone derivative, said polypeptide being a hydrolase having an amino acid sequence selected from the group consisting of SEQ ID NO: 1-15 or a functional variant thereof, wherein the sequence of the functional variant is at least 40% identical to at least one of the amino acid sequences. The invention also relates to: an additive containing the polypeptide; an isolated polynucleotide that encodes the polypeptide; and a method for the hydrolytic cleavage of zearalenone and/or of at least one zearalenone derivative using the polypeptide.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20200332269A1
公开(公告)日：2020-10-22
申请号：US16829204
申请日：2020-03-25
Applicant: Erber Aktiengesellschaft
Inventor： Juan Antonio TORRES ACOSTA , Gerhard ADAM , Elisavet KUNZ-VEKIRU , Wulf-Dieter MOLL , Rudolf MITTERBAUER , Clemens SCHMEITZL
Abstract: The invention relates to a polypeptide for the enzymatic detoxification of zearalenone, said polypeptide being a monooxygenase which converts the keto group in position 7 of zearalenone into an ester group, the monooxygenase in particular being an amino acid sequence selected from the group comprising sequence ID No. 1, 2 and 3 or a functional variant thereof. The functional variant and at least one of the amino acid sequences has a sequence identity of at least 60%, preferably at least 70%, more preferably at least 80% and most preferably 90%.
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7.发明申请公开(公告)号：US20180235255A1
公开(公告)日：2018-08-23
申请号：US15553218
申请日：2015-02-24
Applicant: ERBER AKTIENGESELLSCHAFT
Inventor： Markus ALESCHKO , Corinna KERN , Dieter MOLL , Eva Maria BINDER , Gerd SCHATZMAYR
IPC: A23K10/14 , A23K50/30 , A23K50/60 , A23K20/147 , C12N9/18
CPC classification number: A23K10/14 , A23K20/147 , A23K50/30 , A23K50/60 , C12N9/18
Abstract: The invention relates to fusarium toxin-cleaving polypeptide variants of a fusarium toxin carboxyl esterase with the SEQ ID NO:46. Each of the polypeptide variants has an amino acid sequence shortened by 47 amino acids at the N terminus, and the amino acid sequences have at least 70%, preferably 80%, in particular 100%, sequence identity, namely SEQ ID NO:1, to the amino acid sequence portion 48-540 of the SEQ ID NO:46. The invention also relates to isolated polynucleotides which code for the polypeptide variants, to a fusarium toxin-cleaving additive containing at least one polypeptide variant and optionally at least one auxiliary agent, to the use of the polypeptide variants or the additive, and to a method for hydrolytically cleaving at least one fusarium toxin.
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公开(公告)号：US20220322701A1
公开(公告)日：2022-10-13
申请号：US17829416
申请日：2022-06-01
Applicant: Erber Aktiengesellschaft
Inventor： Sebastian FRUHAUF , Michaela THAMHESL , Martin PFEFFER , Dieter MOLL , Gerd SCHATZMAYR , Eva Maria BINDER
Abstract: The invention relates to a polypeptide for the hydrolytic cleavage of zearalenone and/or at least one zearalenone derivative, said polypeptide being a hydrolase having an amino acid sequence selected from the group consisting of SEQ ID NO: 1-15 or a functional variant thereof, wherein the sequence of the functional variant is at least 40% identical to at least one of the amino acid sequences. The invention also relates to: an additive containing the polypeptide; an isolated polynucleotide that encodes the polypeptide; and a method for the hydrolytic cleavage of zearalenone and/or of at least one zearalenone derivative using the polypeptide.
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公开(公告)号：US11136561B2
公开(公告)日：2021-10-05
申请号：US16829204
申请日：2020-03-25
Applicant: Erber Aktiengesellschaft
Inventor： Juan Antonio Torres Acosta , Gerhard Adam , Elisavet Kunz-Vekiru , Wulf-Dieter Moll , Rudolf Mitterbauer , Clemens Schmeitzl
Abstract: The invention relates to a polypeptide for the enzymatic detoxification of zearalenone, said polypeptide being a monooxygenase which converts the keto group in position 7 of zearalenone into an ester group, the monooxygenase in particular being an amino acid sequence selected from the group comprising sequence ID No. 1, 2 and 3 or a functional variant thereof. The functional variant and at least one of the amino acid sequences has a sequence identity of at least 60%, preferably at least 70%, more preferably at least 80% and most preferably 90%.
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公开(公告)号：US09586990B2
公开(公告)日：2017-03-07
申请号：US14434219
申请日：2013-10-04
Applicant: Erber Aktiengesellschaft
Inventor： Gerd Schatzmayr , Eva-Maria Binder , Michaela Thamhesl , Dieter Moll
CPC classification number: C07K5/0806 , A23K10/14 , C12N9/14 , C12N9/52 , C12P17/183 , Y02P20/52
Abstract: Enzymes for transforming, in particular hydrolytically cleaving, ergopeptines, which ergopeptines are α/β-hydrolases hydrolytically cleaving ergopeptines in the cyclol ring, for the transformation of ergopeptines, and method for producing ergopeptine-metabolizing enzymes.
Abstract translation: 用于转化，特别是水解切割的麦角霉素，其中奥匹他霉素是环环中的α/β-水解酶水解切割蛋白多肽，用于转化ergopeptine，以及用于生产ergopeptine代谢酶的方法。
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