专利检索 ap:"Elizabeth Mieuli" 第 1 页

1.

发明授权
Substituted imidazole derivatives 有权
标题翻译：取代的咪唑衍生物

公开(公告)号：US08318791B2

公开(公告)日：2012-11-27

申请号：US12455798

申请日：2009-06-05

申请人： Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le

发明人： Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le

IPC分类号： A61K39/395 , A61K31/4178 , A61K31/427 , A61K31/5386 , A61K31/4174

CPC分类号： C07D233/54 , C07D233/24 , C07D233/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/10

摘要： The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:

摘要翻译： 本发明涉及新的取代的咪唑化合物及其药学上可接受的盐，酯或前药，新化合物的组合物和药学上可接受的载体，以及新化合物的用途。本发明的化合物具有以下通式：

2.

发明申请
Substituted imidazole derivatives 有权
标题翻译：取代的咪唑衍生物

公开(公告)号：US20090258016A1

公开(公告)日：2009-10-15

申请号：US12455798

申请日：2009-06-05

申请人： Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le

发明人： Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le

IPC分类号： A61K39/395 , A61K31/4178 , A61K31/427 , A61K31/5386 , A61K31/4174 , A61P35/00

CPC分类号： C07D233/54 , C07D233/24 , C07D233/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/10

摘要： The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:

摘要翻译： 本发明涉及新的取代的咪唑化合物及其药学上可接受的盐，酯或前药，新化合物的组合物和药学上可接受的载体，以及新化合物的用途。本发明的化合物具有以下通式：

3.

发明申请
SUBSTITUTED IMIDAZOLE DERIVATIVES 有权
标题翻译：取代的咪唑衍生物

公开(公告)号：US20130017196A1

公开(公告)日：2013-01-17

申请号：US13613977

申请日：2012-09-13

申请人： Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagnition , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le

发明人： Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagnition , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le

IPC分类号： A61K31/4174 , C07D401/12 , A61K31/454 , C07D403/12 , A61K31/496 , A61K31/4439 , C07D405/12 , A61K31/4178 , C07D417/12 , A61K31/427 , C07D413/12 , A61K31/422 , A61K31/5377 , C07D498/10 , A61P35/00 , A61K31/4745 , A61K31/7068 , A61K39/395 , A61K33/24 , A61K31/664 , A61P35/02 , C07D233/64

CPC分类号： C07D233/54 , C07D233/24 , C07D233/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/10

摘要： The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:

摘要翻译： 本发明涉及新的取代的咪唑化合物及其药学上可接受的盐，酯或前药，新化合物的组合物和药学上可接受的载体，以及新化合物的用途。本发明的化合物具有以下通式：

4.

发明授权
Prostratin analogs, bryostatin analogs, prodrugs, synthetic methods, and methods of use 有权
标题翻译：前体类似物，苔藓抑制素类似物，前药，合成方法和使用方法

公开(公告)号：US08816122B2

公开(公告)日：2014-08-26

申请号：US12839808

申请日：2010-07-20

申请人： Paul A. Wender , Lars V. Heumann , Rainer Kramer , Carolyn Gauntlett , Elizabeth Mieuli , Dennis Fournogerakis , Pierre-Luc Boudreault , Adam Schrier , Brian DeChristopher

发明人： Paul A. Wender , Lars V. Heumann , Rainer Kramer , Carolyn Gauntlett , Elizabeth Mieuli , Dennis Fournogerakis , Pierre-Luc Boudreault , Adam Schrier , Brian DeChristopher

IPC分类号： C07C69/76

CPC分类号： C07C67/08 , C07C69/18 , C07C69/21 , C07C69/614 , C07C69/616 , C07C323/60 , C07C2603/30 , C07C2603/40

摘要： Embodiments of the present disclosure provide for prostratin analogs, bryostatin analogs, prodrugs of prostratin and prostratin analogs, methods of making prostratin analogs, and methods of making prodrugs of prostratin and prostratin analogs, methods of use of prostratin analogs, bryostatin analogs, and prodrugs thereof, and the like.

摘要翻译： 本公开的实施方案提供前体类似物，苔藓抑制素类似物，前列腺素和前驱素类似物的前药，制备前体蛋白类似物的方法，以及制备前列腺素和前列腺素类似物的前药的方法，前列腺素类似物的使用方法，苔藓抑制素类似物及其前药，等等。

5.

发明授权
Substituted imidazole derivates 有权
标题翻译：取代的咪唑衍生物

公开(公告)号：US08735599B2

公开(公告)日：2014-05-27

申请号：US13613977

申请日：2012-09-13

申请人： Weibo Wang , Paul A. Barsanti , Xia Yia , Rustum S. Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagnition , Ryan N. Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le

发明人： Weibo Wang , Paul A. Barsanti , Xia Yia , Rustum S. Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagnition , Ryan N. Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le

IPC分类号： A61K31/4174 , C07D233/00 , C07D233/54

CPC分类号： C07D233/54 , C07D233/24 , C07D233/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/10

摘要： The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:

摘要翻译： 本发明涉及新的取代的咪唑化合物及其药学上可接受的盐，酯或前药，新化合物的组合物和药学上可接受的载体，以及新化合物的用途。本发明的化合物具有以下通式：

6.

发明申请
6-O-SUBSTITUTED BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AND METHODS OF INHIBITING CSF-1R SIGNALING 有权
标题翻译： 6-O-取代苯并噻唑和苯并噻唑化合物和抑制CSF-1R信号的方法

公开(公告)号：US20080045528A1

公开(公告)日：2008-02-21

申请号：US11737069

申请日：2007-04-18

申请人： James Sutton , Marion Wiesmann , Weibo Wang , Mika Lindvall , Jiong Lan , Savithri Ramurthy , Anu Sharma , Elizabeth Mieuli , Liana Klivansky , William Lenahan , Susan Kaufman , Hong Yang , Simon Ng , Keith Pfister , Allan Wagman , Victoria Sung , Martin Sendzik

发明人： James Sutton , Marion Wiesmann , Weibo Wang , Mika Lindvall , Jiong Lan , Savithri Ramurthy , Anu Sharma , Elizabeth Mieuli , Liana Klivansky , William Lenahan , Susan Kaufman , Hong Yang , Simon Ng , Keith Pfister , Allan Wagman , Victoria Sung , Martin Sendzik

IPC分类号： A61K31/535 , A61K31/44 , A61K31/445 , C07D211/00 , C07D413/00 , C07D417/00 , C07D401/00 , A61P43/00 , A61K31/497

CPC分类号： C07D413/12 , C07D417/12

摘要： Benzoxazole and benzothiazole compounds and the stereoisomers, tautomers, solvates, oxides, esters, and prodrugs thereof and pharmaceutically acceptable salts thereof are disclosed. Compositions of the compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier, and uses of the compounds, either alone or in combination with at least one additional therapeutic agent are also disclosed. The embodiments are useful for inhibiting cellular proliferation, inhibiting the growth and/or metathesis of tumors, treating or preventing cancer, treating or preventing degenerating bone diseases such as rheumatoid arthritis, and/or inhibiting molecules such as CSF-1R.

摘要翻译： 公开了苯并恶唑和苯并噻唑化合物及其立体异构体，互变异构体，溶剂合物，氧化物，酯和前药及其药学上可接受的盐。还公开了单独或与至少一种另外的治疗剂组合的化合物与药学上可接受的载体的组合，以及化合物单独或与至少一种另外的治疗剂组合的用途。这些实施方案可用于抑制细胞增殖，抑制肿瘤的生长和/或复分解，治疗或预防癌症，治疗或预防退行性骨疾病如类风湿性关节炎和/或抑制分子如CSF-1R。

7.

发明申请
PROSTRATIN ANALOGS, BRYOSTATIN ANALOGS, PRODRUGS, SYNTHETIC METHODS, AND METHODS OF USE 有权
标题翻译：前列腺素类似物，BRYOSTATIN ANALOGS，PRODRUGS，合成方法和使用方法

公开(公告)号：US20110014699A1

公开(公告)日：2011-01-20

申请号：US12839808

申请日：2010-07-20

申请人： Paul A. Wender , Lars V. Heumann , Rainer Kramer , Carolyn Gauntlett , Elizabeth Mieuli , Dennis Fournogerakis , Pierre-Luc Boudreault , Adam Schrier , Brian DeChristopher

发明人： Paul A. Wender , Lars V. Heumann , Rainer Kramer , Carolyn Gauntlett , Elizabeth Mieuli , Dennis Fournogerakis , Pierre-Luc Boudreault , Adam Schrier , Brian DeChristopher

IPC分类号： C12N5/0783 , C07C69/614 , C07C67/08 , C07C69/18 , C07C69/616 , C07C69/21 , C07C279/14 , C12N5/09

CPC分类号： C07C67/08 , C07C69/18 , C07C69/21 , C07C69/614 , C07C69/616 , C07C323/60 , C07C2603/30 , C07C2603/40

摘要： Embodiments of the present disclosure provide for prostratin analogs, bryostatin analogs, prodrugs of prostratin and prostratin analogs, methods of making prostratin analogs, and methods of making prodrugs of prostratin and prostratin analogs, methods of use of prostratin analogs, bryostatin analogs, and prodrugs thereof, and the like.

摘要翻译： 本公开的实施方案提供前体类似物，苔藓抑制素类似物，前列腺素和前驱素类似物的前药，制备前体蛋白类似物的方法，以及制备前列腺素和前列腺素类似物的前药的方法，前列腺素类似物的使用方法，苔藓抑制素类似物及其前药，等等。