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    Stem cells of the islets of langerhans and their use in treating diabetes mellitus
    2.
    发明申请
    Stem cells of the islets of langerhans and their use in treating diabetes mellitus 有权
    朗格汉斯胰岛的干细胞及其在治疗糖尿病中的应用

    公开(公告)号：US20070071730A1

    公开(公告)日：2007-03-29

    申请号：US11410412

    申请日：2006-04-24

    Applicant: Joel Habener ,  Henryk Zulewski ,  Elizabeth Abraham ,  Melissa Thomas ,  Mario Vallejo

    Inventor： Joel Habener ,  Henryk Zulewski ,  Elizabeth Abraham ,  Melissa Thomas ,  Mario Vallejo

    IPC: C12N5/08 ,  C12N5/06 ,  A61K35/407

    CPC classification number: C12N5/0676 ,  A01K67/0271 ,  A61K35/12 ,  A61K2035/122 ,  C12N5/0677 ,  C12N5/0678 ,  C12N2500/34 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/335 ,  C12N2510/02

    Abstract: Methods and compositions are described for the treatment of type I insulin-dependent diabetes mellitus and other conditions using newly identified stem cells that are capable of differentiation into a variety of pancreatic islet cells, including insulin-producing beta cells, as well as hepatocytes. Nestin has been identified as a molecular marker for pancreatic stem cells, while cytokeratin-19 serves as a marker for a distinct class of islet ductal cells. Methods are described whereby nestin-positive stem cells can be isolated from pancreatic islets and cultured to obtain further stem cells or pseudo-islet like structures. Methods for ex vivo differentiation of the pancreatic stem cells are disclosed. Methods are described whereby pancreatic stem cells can be isolated, expanded, and transplanted into a patient in need thereof, either allogeneically, isogeneically or xenogenically, to provide replacement for lost or damaged insulin-secreting cells or other cells.

    Abstract translation: 描述了用于治疗I型胰岛素依赖性糖尿病和其它条件的方法和组合物，其使用能够分化成多种胰岛细胞（包括产生胰岛素的β细胞）以及肝细胞的新鉴定的干细胞。 巢蛋白已被鉴定为胰腺干细胞的分子标记，而细胞角蛋白-19可作为不同类别的胰岛导管细胞的标记物。 描述了方法，其中可以从胰岛中分离巢蛋白阳性干细胞并培养以获得进一步的干细胞或假胰岛样结构。 公开了胰腺干细胞离体分化方法。 描述了方法，其中胰腺干细胞可以被分离，扩增和移植到有需要的患者中，同种异体地，异质性或异质性的，以提供丢失或损伤的胰岛素分泌细胞或其他细胞的替代。

    ANCHOR FOR BEACH UMBRELLA
    5.
    发明申请
    ANCHOR FOR BEACH UMBRELLA 审中-公开
    海滩UMBRELLA锚

    公开(公告)号：US20130051707A1

    公开(公告)日：2013-02-28

    申请号：US13221854

    申请日：2011-08-30

    Applicant: Kathleen Pisano ,  Elizabeth Abraham

    Inventor： Kathleen Pisano ,  Elizabeth Abraham

    IPC: B65D33/28

    CPC classification number: A45B23/00 ,  A45B3/00 ,  A45B25/22 ,  A45B2023/0012 ,  A45C3/10 ,  A45C13/1046 ,  A45C13/30 ,  A45C15/00

    Abstract: A lightweight, flexible, portable bag which can be filled with beach sand, rocks, dirt or other loose material is connected to the upper part of the pole of a beach umbrella by a long flexible cord. The lower portion of the cord is secured to the open end of the nylon bag. The upper end of the cord is connected to the upper end of the pole of the umbrella by a hook-and-loop type fastener strap which wraps around the umbrella pole. The lower end of the cord is fitted within a hem in the opening of the bag to form a drawstring for closure of the bag to retain the sand or loose material in the bag during use. One end of the cord is formed into a loop with the long end of the cord passing through the loop and connected to the umbrella pole. Tension on the cord during use will cinch the drawstring closed thus retaining the material within the bag. The weight of the bag connected to the upper part of the pole will stabilize the umbrella in light to moderate winds. Prior to filling, the bag has minimal weight so as to be easily transported.

    Abstract translation: 一个轻巧，灵活，便携的袋子，可以充满沙滩沙子，岩石，污垢或其他松散的材料通过长的柔性绳子连接到沙滩伞的杆的上部。 绳的下部固定在尼龙袋的开口端。 绳索的上端通过环绕伞杆的钩环型紧固带连接到伞的杆的上端。 绳索的下端安装在袋的开口内的下摆中，以形成用于封闭袋的束带，以在使用期间将沙子或松散材料保持在袋中。 绳的一端形成为环，绳的长端通过环并连接到伞杆。 在使用过程中，电线上的张力会束紧束带，从而将材料保持在袋子内。 连接到杆的上部的袋子的重量将使伞在轻微至适度的风中稳定。 在填充之前，该袋具有最小的重量以便容易地运输。

    Stem cells of the islets of langerhans and their use in treating diabetes mellitus
    7.
    发明申请
    Stem cells of the islets of langerhans and their use in treating diabetes mellitus 有权
    朗格汉斯胰岛的干细胞及其在治疗糖尿病中的应用

    公开(公告)号：US20070128176A1

    公开(公告)日：2007-06-07

    申请号：US11438790

    申请日：2006-05-22

    Applicant: Joel Habener ,  Henryk Zulewski ,  Melissa Thomas ,  Elizabeth Abraham ,  Mario Vallejo ,  Colin Leech ,  Anna Nolan ,  Andreas Lechner

    Inventor： Joel Habener ,  Henryk Zulewski ,  Melissa Thomas ,  Elizabeth Abraham ,  Mario Vallejo ,  Colin Leech ,  Anna Nolan ,  Andreas Lechner

    IPC: A61K48/00 ,  C12N5/08

    CPC classification number: A01K67/0271 ,  A61K35/12 ,  A61K2035/122 ,  C12N5/0678 ,  C12N2500/34 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/335 ,  C12N2510/02

    Abstract: Methods and compositions are described for the treatment of type I insulin-dependent diabetes mellitus and other conditions using newly identified stem cells that are capable of differentiation into a variety of pancreatic islet cells, including insulin-producing beta cells, as well as hepatocytes. Nestin and ABCG2 have been identified as molecular markers for pancreatic stem cells, while cytokeratin-19 serves as a marker for a distinct class of islet ductal cells. Methods are described whereby nestin and/or ABCG2-positive stem cells can be isolated from pancreatic islets and cultured to obtain further stem cells or pseudo-islet like structures. Methods for ex vivo differentiation of the pancreatic stem cells are disclosed. Methods are described whereby pancreatic stem cells can be isolated, expanded, and transplanted into a patient in need thereof, either allogeneically, isogeneically or xenogenically, to provide replacement for lost or damaged insulin-secreting cells or other cells.

    Abstract translation: 描述了用于治疗I型胰岛素依赖性糖尿病和其它条件的方法和组合物，其使用能够分化成多种胰岛细胞（包括产生胰岛素的β细胞）以及肝细胞的新鉴定的干细胞。 Nestin和ABCG2已被鉴定为胰干细胞的分子标记，而细胞角蛋白-19可作为不同类型的胰岛导管细胞的标记物。 描述了方法，其中可以从胰岛中分离巢蛋白和/或ABCG2-阳性干细胞并进行培养以获得进一步的干细胞或假胰岛样结构。 公开了胰腺干细胞离体分化方法。 描述了方法，其中胰腺干细胞可以被分离，扩增和移植到有需要的患者中，同种异体地，异质性或异质性的，以提供丢失或损伤的胰岛素分泌细胞或其他细胞的替代。

    METHOD OF PRE-INDUCING A STATE OF IMMUNE TOLERANCE BEFORE ORGAN TRANSPLANTATION
    8.
    发明申请
    METHOD OF PRE-INDUCING A STATE OF IMMUNE TOLERANCE BEFORE ORGAN TRANSPLANTATION 有权
    在组织移植之前预先诱导免疫耐受状态的方法

    公开(公告)号：US20060062769A1

    公开(公告)日：2006-03-23

    申请号：US11132687

    申请日：2005-05-19

    Applicant: Joel Habener ,  Hendrik Zulewski ,  Elizabeth Abraham ,  Mario Vallejo ,  Denise Faustman ,  Melissa Thomas

    Inventor： Joel Habener ,  Hendrik Zulewski ,  Elizabeth Abraham ,  Mario Vallejo ,  Denise Faustman ,  Melissa Thomas

    IPC: C12N5/06

    CPC classification number: C12N5/0676 ,  A01K67/0271 ,  A61K35/12 ,  A61K2035/122 ,  C12N5/0677 ,  C12N5/0678 ,  C12N2500/34 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/335 ,  C12N2510/02

    Abstract: Methods and compositions are described for the treatment of type I insulin-dependent diabetes mellitus and other conditions using newly identified stem cells that are capable of differentiation into a variety of pancreatic islet cells, including insulin-producing beta cells, as well as hepatocytes. Nestin has been identified as a molecular marker for pancreatic stem cells, while cytokeratin-19 serves as a marker for a distinct class of islet ductal cells. Methods are described whereby nestin-positive stem cells can be isolated from pancreatic islets and cultured to obtain further stem cells or pseudo-islet like structures. Methods for ex vivo differentiation of the pancreatic stem cells are disclosed. Methods are described whereby pancreatic stem cells can be isolated, expanded, and transplanted into a patient in need thereof, either allogeneically, isogeneically or xenogenically, to provide replacement for lost or damaged insulin-secreting cells or other cells.

    Abstract translation: 描述了用于治疗I型胰岛素依赖性糖尿病和其它条件的方法和组合物，其使用能够分化成多种胰岛细胞（包括产生胰岛素的β细胞）以及肝细胞的新鉴定的干细胞。 巢蛋白已被鉴定为胰腺干细胞的分子标记，而细胞角蛋白-19可作为不同类别的胰岛导管细胞的标记物。 描述了方法，其中可以从胰岛中分离巢蛋白阳性干细胞并培养以获得进一步的干细胞或假胰岛样结构。 公开了胰腺干细胞离体分化方法。 描述了方法，其中胰腺干细胞可以被分离，扩增和移植到有需要的患者中，同种异体地，异质性或异质性的，以提供丢失或损伤的胰岛素分泌细胞或其他细胞的替代。

    Use of Loop and Addressing Mode Instruction Set Semantics to Direct Hardware Prefetching
    9.
    发明申请
    Use of Loop and Addressing Mode Instruction Set Semantics to Direct Hardware Prefetching 审中-公开
    使用循环和寻址模式指令集语义来直接硬件预取

    公开(公告)号：US20130185516A1

    公开(公告)日：2013-07-18

    申请号：US13350914

    申请日：2012-01-16

    Applicant: Peter G. Sassone ,  Suman Mamidi ,  Elizabeth Abraham ,  Suresh K. Venkumahanti ,  Lucian Codrescu

    Inventor： Peter G. Sassone ,  Suman Mamidi ,  Elizabeth Abraham ,  Suresh K. Venkumahanti ,  Lucian Codrescu

    IPC: G06F12/12

    CPC classification number: G06F9/30043 ,  G06F9/30047 ,  G06F9/3455 ,  G06F9/381 ,  G06F9/383 ,  G06F12/0862 ,  G06F2212/6026 ,  Y02D10/13

    Abstract: Systems and methods for prefetching cache lines into a cache coupled to a processor. A hardware prefetcher is configured to recognize a memory access instruction as an auto-increment-address (AIA) memory access instruction, infer a stride value from an increment field of the AIA instruction, and prefetch lines into the cache based on the stride value. Additionally or alternatively, the hardware prefetcher is configured to recognize that prefetched cache lines are part of a hardware loop, determine a maximum loop count of the hardware loop, and a remaining loop count as a difference between the maximum loop count and a number of loop iterations that have been completed, select a number of cache lines to prefetch, and truncate an actual number of cache lines to prefetch to be less than or equal to the remaining loop count, when the remaining loop count is less than the selected number of cache lines.

    Abstract translation: 将高速缓存线预取到耦合到处理器的高速缓存中的系统和方法。 硬件预取器被配置为将存储器访问指令识别为自动递增地址（AIA）存储器访问指令，从AIA指令的增量字段推断步幅值，并且基于步幅值将预取行预取到高速缓存中。 另外或替代地，硬件预取器被配置为识别预取的高速缓存行是硬件循环的一部分，确定硬件循环的最大循环计数，以及剩余循环计数作为最大循环计数和循环数之间的差 已经完成的迭代，当剩余循环数小于选定数量的缓存时，选择要预取的高速缓存行数，并将实际数量的缓存行预截取为小于或等于剩余循环计数 线条。

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