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    Methods of blood-based therapies having a microfluidic membraneless exchange device
    3.
    发明授权
    Methods of blood-based therapies having a microfluidic membraneless exchange device 有权
    具有微流体无膜交换装置的血液疗法的方法

    公开(公告)号：US08021318B2

    公开(公告)日：2011-09-20

    申请号：US12942519

    申请日：2010-11-09

    申请人： Edward F. Leonard ,  Alan C. West ,  Nina C. Shapley ,  Zhongliang Tang

    发明人： Edward F. Leonard ,  Alan C. West ,  Nina C. Shapley ,  Zhongliang Tang

    IPC分类号： A61M1/34 ,  B01D61/24 ,  B01D61/14 ,  B01D61/38

    CPC分类号： A61M1/14 ,  A61M1/1696 ,  A61M1/32 ,  A61M1/3482 ,  A61M1/3621 ,  A61M2206/11 ,  B01D11/04 ,  B01D11/0496 ,  B01D61/243 ,  B01D61/28 ,  B01L3/5027 ,  G01N2001/4016 ,  Y10T436/255

    摘要： The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of ‘small’ molecules, ‘middle’ molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.

    摘要翻译： 本发明涉及通过与第二流体接触从样品流体中除去不需要的材料的装置，系统和方法。 样品流体作为与第二流体的同时流动的层相邻或相邻的薄层流动，而没有中间膜。 在各种实施方案中，使用次级分离器来限制所需物质的去除并且实现从血液中除去不需要的物质。 本发明可用于各种情况，其中样品液体经由针对抽提流体的扩散机制进行纯化。 此外，本发明可用于从尺寸变化的样品流体中除去组分。 当血液是样品液体时，例如，这可能包括从血液样品到提取液中去除“小”分子，“中”分子，大分子，大分子聚集体和细胞。

    FLUID SEPARATION DEVICES, SYSTEMS AND METHODS
    4.
    发明申请
    FLUID SEPARATION DEVICES, SYSTEMS AND METHODS 有权
    流体分离装置，系统和方法

    公开(公告)号：US20110105982A1

    公开(公告)日：2011-05-05

    申请号：US12866017

    申请日：2009-02-04

    申请人： Edward F. Leonard ,  Ilan K. Reich ,  Stanley Cortell

    发明人： Edward F. Leonard ,  Ilan K. Reich ,  Stanley Cortell

    IPC分类号： A61M5/00

    CPC分类号： A61M1/14 ,  A61M1/3482 ,  A61M2206/11

    摘要： A membraneless separation device can be applied to a variety of treatments, such as the ultrafiltration of blood for a patient with end stage renal disease. An ultrafiltration device can include a membraneless separation device, which separates an incoming blood flow into a substantially cytoplasmic body-free plasma flow and remaining fraction, and a dialysate-free second stage, which selectively removes excess fluid, toxins and other substances from the plasma flow and returns the processed plasma to the membraneless separation device. A treatment protocol can include ultrafiltering blood of a patient using the ultrafiltration device and performing a secondary treatment on the blood of the patient at a reduced frequency compared to the ultrafiltering. The membraneless separation device can also be applied to treatment, analysis, and/or exchange of plasma from blood, or combined with conventional dialyzers to perform dialysis on a cytoplasmic body-free plasma fraction.

    摘要翻译： 无膜分离装置可用于各种治疗，例如用于终末期肾病的患者的血液超滤。 超滤装置可以包括无膜分离装置，其将进入的血流分离成基本上不含细胞质的无体质血浆流和剩余部分，以及无透析液的第二阶段，其从血浆中选择性地除去多余的流体，毒素和其他物质 流动并将处理的等离子体返回到无膜分离装置。 治疗方案可以包括使用超滤装置对患者的超滤血液，并且与超滤相比以更低的频率对患者的血液进行二次治疗。 无膜分离装置也可以应用于来自血液的血浆的治疗，分析和/或交换，或与常规透析器组合以在不含细胞质的体外血浆级分上进行透析。

    Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
    7.
    发明授权
    Systems and methods of blood-based therapies having a microfluidic membraneless exchange device 失效
    具有微流体无膜交换装置的血液疗法的系统和方法

    公开(公告)号：US07588550B2

    公开(公告)日：2009-09-15

    申请号：US11776360

    申请日：2007-07-11

    申请人： Edward F. Leonard ,  Alan C. West ,  Nina C. Shaplely ,  Zhongliang Tang

    发明人： Edward F. Leonard ,  Alan C. West ,  Nina C. Shaplely ,  Zhongliang Tang

    IPC分类号： A61M37/00 ,  B32B27/04 ,  B32B27/12

    CPC分类号： A61M1/14 ,  A61M2206/11 ,  B01D11/0288 ,  B01D11/0492 ,  B01D11/0496 ,  B01L3/5027

    摘要： The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of ‘small’ molecules, ‘middle’ molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.

    摘要翻译： 本发明涉及通过与第二流体接触从样品流体中除去不需要的材料的装置，系统和方法。 样品流体作为与第二流体的同时流动的层相邻或相邻的薄层流动，而没有中间膜。 在各种实施方案中，使用次级分离器来限制所需物质的去除并且实现从血液中除去不需要的物质。 本发明可用于各种情况，其中样品液体经由针对抽提流体的扩散机制进行纯化。 此外，本发明可用于从尺寸变化的样品流体中除去组分。 当血液是样品液体时，例如，这可能包括从血液样品到提取液中去除“小”分子，“中”分子，大分子，大分子聚集体和细胞。

    Articulated fabric formed by self-assembling fibers
    8.
    发明授权
    Articulated fabric formed by self-assembling fibers 失效
    通过自组装纤维形成的铰接织物

    公开(公告)号：US4441947A

    公开(公告)日：1984-04-10

    申请号：US533172

    申请日：1983-09-19

    申请人： Edward F. Leonard

    发明人： Edward F. Leonard

    IPC分类号： D04H1/06 ,  B32B31/00 ,  D04H3/16

    CPC分类号： D04H1/06 ,  Y10T428/169

    摘要： A patterned, nonwoven, articulated fabric exhibiting a substantially uniform texture and comprised of a multiplicity of synthetic fiber elements, the opposing free ends of each of said synthetic fiber elements being joined to one another to form substantially continuous loops, said loops being interconnected to one another in a predetermined pattern. Method for producing said nonwoven fabric using specially prepared fiber elements which curl in a predetermined configuration in response to an external stimulus is also disclosed.

    摘要翻译： 一种图案化的，非织造的，铰接的织物，其表现出基本上均匀的质地并且由多个合成纤维元件组成，每个所述合成纤维元件的相对的自由端彼此连接以形成基本上连续的环，所述环与一个 另一个以预定的模式。 还公开了使用特别制备的纤维元件来生产所述无纺织物的方法，所述纤维元件响应于外部刺激以预定构型卷曲。