公开(公告)号：US20240059690A1

公开(公告)日：2024-02-22

申请号：US17999421

申请日：2021-05-20

Applicant: ESTEVE PHARMACEUTICALS, S.A.

Inventor： Ariadna FERNANDEZ-DONIS ,  José-Luis DÍAZ-FERNÁNDEZ ,  Carmen ALMANSA-ROSALES ,  Mónica GARCIA-LOPEZ ,  Joan-Carles FERNANDEZ-COLLADO ,  Jordi GONZALEZ-GARCIA ,  Maria GARRIDO-MARTINEZ

IPC: C07D487/04 ,  A61P29/02

CPC classification number: C07D487/04 ,  A61P29/02

Abstract: The present invention relates to pyrazolopyrimidine derivatives having dual pharmacological activity towards both the α2δ subunit of the voltage-gated calcium channel and the sigma-1 (σ1) receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

公开(公告)号：US20210395249A1

公开(公告)日：2021-12-23

申请号：US17288934

申请日：2019-11-04

Applicant: ESTEVE PHARMACEUTICALS, S.A.

Inventor： Carmen ALMANSA-ROSALES ,  Félix CUEVAG-CORDOBÉS

IPC: C07D471/04

Abstract: The present invention relates to new compounds of formula (I) that show dual activity towards the subunit α2δ of voltage-gated calcium channels (VGCC), especially the α2δ-1 subunit of voltage-gated calcium channels, and the noradrenaline transporter (NET). The invention is also related to the process for the preparation of said compounds as well as to compositions comprising them, and to their use as medicaments.

公开(公告)号：US20210214695A1

公开(公告)日：2021-07-15

申请号：US17059723

申请日：2019-05-27

Applicant: ESTEVE PHARMACEUTICALS, S.A. ,  UNIVERSITAT AUTÓNOMA DE BARCELONA

Inventor： Maria Fàtima BOSCH TUBERT ,  Victor SANCHEZ CLARES ,  Albert RIBERA SANCHEZ ,  Virginia A. HAURIGOT

IPC: C12N9/16 ,  C12N15/86 ,  A61K9/00 ,  A61P43/00

Abstract: The present invention provides new polynucleotide sequences, adeno-associated virus-derived vectors and pharmaceutical compositions containing the same for the treatment of lysosomal storage disorders and specially, for the treatment of mucopolysaccharidosis type IVA or Morquio A syndrome.

公开(公告)号：US20200339597A1

公开(公告)日：2020-10-29

申请号：US16876522

申请日：2020-05-18

Applicant: Esteve Pharmaceuticals, S.A.

Inventor： Marina Virgili-Bernado ,  Monica Alonso-Xalma ,  Carlos Alegret-Molina ,  Carmen Almansa-Rosales ,  Monica Garcia Lopez

IPC: C07D498/10 ,  C07D519/00

Abstract: The present invention relates to compounds of general formula (I) having dual pharmacological activity towards both the sigma (σ) receptor, and the μ-opiod receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

公开(公告)号：US10807970B2

公开(公告)日：2020-10-20

申请号：US16301508

申请日：2017-05-19

Applicant: ESTEVE PHARMACEUTICALS, S.A.

Inventor： Monica Garcia-Lopez ,  Carmen Almansa-Rosales ,  Ana Virginia Llorente-Fernandez ,  Ute Christmann ,  Sergio Rodriguez Escrich

IPC: C07D405/04 ,  C07D405/14 ,  C07D487/04 ,  A61P29/00 ,  C07D307/04 ,  C07D407/14 ,  C07D407/06

Abstract: The present invention relates to tetrahydropyran and thiopyran derivatives having dual pharmacological activity towards both the sigma (σ) receptor, and the μ-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

公开(公告)号：US10428051B2

公开(公告)日：2019-10-01

申请号：US15746877

申请日：2016-07-28

Applicant: ESTEVE PHARMACEUTICALS, S.A.

Inventor： Monica Garcia-Lopez ,  Carmen Almansa-Rosales ,  Ana Virginia Llorente-Fernandez ,  Lourdes Garriga-Sanahuja ,  Ute Christmann

IPC: C07D405/04 ,  C07D309/06 ,  C07D305/06 ,  C07D311/96 ,  C07D295/13 ,  C07D213/75 ,  C07D211/26 ,  C07D409/14 ,  C07D405/12 ,  C07D417/14 ,  C07D409/12 ,  C07D307/54 ,  C07D333/38 ,  C07D277/46 ,  C07D213/38 ,  C07D295/192 ,  C07D487/04 ,  A61P25/04 ,  C07D405/14 ,  C07D401/04 ,  C07D401/12 ,  C07D295/12 ,  C07D295/125 ,  C07D295/135

Abstract: The present invention relates to substituted amide derivatives having dual pharmacological activity towards both the sigma (σ) receptor, and the μ-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

公开(公告)号：US20190284195A1

公开(公告)日：2019-09-19

申请号：US16464736

申请日：2017-11-30

Applicant: ESTEVE PHARMACEUTICALS, S.A.

Inventor： Marina VIRGILI-BERNADO ,  Monica ALONSO-XALMA ,  Carmen ALMANSA-ROSALES

IPC: C07D487/04

Abstract: The present invention relates to ortho substituted phenylpyrazolo- and pyrrolo-pyridazine derivatives having dual pharmacological activity towards both the α2δ subunit, in particular the α2δ-1 subunit, of the voltage-gated calcium channel and the μ-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

公开(公告)号：US20190142840A1

公开(公告)日：2019-05-16

申请号：US16306946

申请日：2017-06-05

Applicant: ESTEVE PHARMACEUTICALS, S.A.

Inventor： Daniel ZAMANILLO-CASTANEDO ,  José-Carlos PRADOS-SALAZAR ,  Sebastiá VIDELA-CÉS ,  José-Miguel VELA-HERNÁNDEZ ,  Carlos-Ramón PLATA-SALAMAN ,  Jordi BRUNA-ESCUER

IPC: A61K31/5377 ,  A61P35/00 ,  A61K31/337 ,  A61K31/555 ,  A61K33/243

Abstract: The invention relates to compounds of general formula (I) having pharmacological activity towards the sigma receptor, for use in decreasing cancer cells proliferation and improving chemotherapeutic drug efficacy.

公开(公告)号：US20190127357A1

公开(公告)日：2019-05-02

申请号：US16090403

申请日：2017-04-12

Applicant: ESTEVE PHARMACEUTICALS , S.A.

Inventor： Pilar GOYA ,  Antoni TORRENS-JOVER ,  Carmen ALMANSA-ROSALES ,  Joser-Luis DIAZ-FERNÁNDEZ ,  Ana-Maria CAAMAÑO-MOURE

IPC: C07D413/10 ,  C07D413/14 ,  C07D401/14 ,  C07D401/12 ,  C07D409/12 ,  C07D409/14 ,  C07D405/14 ,  C07D417/14

CPC classification number: C07D413/10 ,  A61P25/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention relates to arylamide derivatives having dual pharmacological activity towards both the α2δ subunit, in particular the α2δ-1 subunit, of the voltage-gated calcium channel and the μ-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

公开(公告)号：US11919926B2

公开(公告)日：2024-03-05

申请号：US17244042

申请日：2021-04-29

Applicant: ESTEVE PHARMACEUTICALS, S.A. ,  FUNDACIO PRIVADA INSTITUT DE RECERCA DE LA SIDA—CAIXA

Inventor： Christian Brander ,  Beatriz Mothe Pujadas ,  Anuska Llano

IPC: C07K14/005 ,  A61K39/12 ,  A61K39/21 ,  C12N7/00 ,  A61K39/00

CPC classification number: C07K14/005 ,  A61K39/12 ,  A61K39/21 ,  C12N7/00 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/57 ,  A61K2039/575 ,  C07K2319/00 ,  C07K2319/35 ,  C12N2740/16022 ,  C12N2740/16034 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16222 ,  C12N2740/16322

Abstract: The present invention relates to novel immunogens based on overlapping peptides (OLPs) and peptides derived therefrom useful for the prevention and treatment of AIDS and its related opportunistic diseases. The invention also relates to isolated nucleic acids, vectors and host cells expressing these immunogens as well as vaccines including said immunogens.