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公开(公告)号：US10201511B2
公开(公告)日：2019-02-12
申请号：US14370450
申请日：2013-01-05
IPC分类号： A61K9/20 , A61K9/24 , A61K9/28 , A61K9/48 , A61P3/10 , C07C279/26 , A61K31/155 , C07D317/58 , A61K31/357 , C07D307/52 , A61K31/341 , A61K9/00 , A61K31/19 , A61K31/198 , A61K31/7016 , A61K31/704 , A61K45/06
摘要： Methods for improving the gastrointestinal tolerability of biguanide compounds and for treating metabolic disorders and/or inducing weight loss in patients in need thereof, particularly in individuals having a contraindication for treatment with biguanide compounds, are provided comprising administering delayed release formulations of such biguanide compounds, including metformin, targeted to the small intestine.
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公开(公告)号：US20170202790A1
公开(公告)日：2017-07-20
申请号：US15339378
申请日：2016-10-31
IPC分类号： A61K31/155 , A61K31/55 , A61K9/00 , A61K31/357 , A61K31/485 , A61K9/20 , A61K45/06 , A61K31/137
CPC分类号： A61K31/155 , A61K9/00 , A61K9/0053 , A61K9/1623 , A61K9/20 , A61K9/2018 , A61K9/2054 , A61K9/2086 , A61K9/209 , A61K9/2846 , A61K9/2853 , A61K31/137 , A61K31/341 , A61K31/343 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/4196 , A61K31/4453 , A61K31/454 , A61K31/485 , A61K31/53 , A61K31/55 , A61K45/06 , C07C279/26 , C07D207/06 , C07D207/34 , C07D211/14 , C07D249/14 , C07D251/10 , C07D251/18 , C07D255/02 , C07D307/52 , C07D307/66 , C07D317/58 , C07D401/04 , C07D405/12 , C07D409/12
摘要： Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.
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公开(公告)号：US20170020829A1
公开(公告)日：2017-01-26
申请号：US15289713
申请日：2016-10-10
IPC分类号： A61K31/155 , A61K45/06
CPC分类号： A61K31/155 , A61K9/0053 , A61K9/2054 , A61K9/209 , A61K9/2846 , A61K9/4808 , A61K31/19 , A61K31/198 , A61K31/7016 , A61K31/704 , A61K45/06
摘要： Provided herein are methods for treating conditions associated with a chemosensory receptor, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a chemosensory receptor ligand, such as a bitter receptor ligand. Also provided herein are chemosensory receptor ligand compositions, including bitter receptor ligand compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.
摘要翻译： 本文提供了通过施用包含化学感应受体配体如苦味受体配体的组合物来治疗与化学感觉受体相关的病症（包括糖尿病，肥胖症和其它代谢疾病，病症或病症）的方法。 本文还提供了化学感应受体配体组合物，包括苦味受体配体组合物及其制备用于本发明方法的方法。 本文还提供包含二甲双胍及其盐及其使用方法的组合物。
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公开(公告)号：US09211263B2
公开(公告)日：2015-12-15
申请号：US13734966
申请日：2013-01-05
IPC分类号： A61K31/155 , A61K9/28 , A61P3/10 , A61K45/06 , A61K9/20 , A61K31/4196 , A61K31/53 , A61K31/55 , C07D317/58 , C07D405/12 , C07D249/14 , C07D251/10 , C07D251/18 , C07D255/02 , C07D307/52 , A61K31/36
CPC分类号： A61K31/155 , A61K9/0053 , A61K9/2054 , A61K9/2813 , A61K9/282 , A61K9/2846 , A61K9/2866 , A61K31/36 , A61K31/4196 , A61K31/53 , A61K31/55 , A61K45/06 , C07D249/14 , C07D251/10 , C07D251/18 , C07D255/02 , C07D307/52 , C07D317/58 , C07D405/12 , A61K2300/00
摘要： Methods for improving the gastrointestinal tolerability of biguanide compounds and for treating metabolic disorders and/or inducing weight loss in patients in need thereof, particularly in individuals having a contraindication for treatment with biguanide compounds, are provided comprising administering delayed release formulations of such biguanide compounds, including metformin, targeted to the small intestine.
摘要翻译： 提供了改善双胍类化合物的胃肠耐受性和用于治疗有需要的患者，特别是在用双胍类化合物治疗禁忌症的个体中的代谢紊乱和/或诱导体重减轻的方法，包括施用这种双胍化合物的延迟释放制剂， 包括二甲双胍，针对小肠。
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公开(公告)号：US20140341986A1
公开(公告)日：2014-11-20
申请号：US14451323
申请日：2014-08-04
IPC分类号： C07C279/26 , C07D251/18 , C07D255/02 , A61K31/155 , A61K9/28 , A61K9/20 , C07D317/58 , A61K31/343 , C07D307/52 , A61K31/341 , C07D207/06 , A61K31/40 , C07D211/14 , A61K31/4453 , C07D207/34 , C07D307/66 , A61K31/4196 , C07D401/04 , A61K31/454 , C07D405/12 , C07D409/12 , A61K31/53 , C07D251/10 , A61K31/55 , A61K45/06 , C07D249/14
CPC分类号： A61K31/155 , A61K9/00 , A61K9/0053 , A61K9/1623 , A61K9/20 , A61K9/2018 , A61K9/2054 , A61K9/2086 , A61K9/209 , A61K9/2846 , A61K9/2853 , A61K31/137 , A61K31/341 , A61K31/343 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/4196 , A61K31/4453 , A61K31/454 , A61K31/485 , A61K31/53 , A61K31/55 , A61K45/06 , C07C279/26 , C07D207/06 , C07D207/34 , C07D211/14 , C07D249/14 , C07D251/10 , C07D251/18 , C07D255/02 , C07D307/52 , C07D307/66 , C07D317/58 , C07D401/04 , C07D405/12 , C07D409/12
摘要： Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.
摘要翻译： 本文提供了通过施用包含双胍或相关杂环化合物（例如二甲双胍）的组合来治疗某些病症（包括糖尿病，肥胖症和其它代谢疾病，病症或病症）的方法。 本文还提供双胍类或相关杂环化合物组合物及其制备用于本发明方法的方法。 本文还提供包含二甲双胍及其盐及其使用方法的组合物。
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公开(公告)号：US10154972B2
公开(公告)日：2018-12-18
申请号：US15339346
申请日：2016-10-31
IPC分类号： A61P3/10 , C07C279/26 , A61K9/22 , A61K31/155 , A61K45/06 , A61K31/341 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/53 , A61K31/4196 , A61K31/4453 , A61K31/454 , A61K31/55 , A61K9/20 , A61K9/48 , A61K9/28 , A61K31/137 , A61K31/35 , A61K31/485
摘要： Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.
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公开(公告)号：US20180008561A1
公开(公告)日：2018-01-11
申请号：US15712026
申请日：2017-09-21
IPC分类号： A61K31/155 , A61K9/00 , C07D307/52 , C07D255/02 , C07D251/18 , C07D251/10 , C07D249/14 , A61K45/06 , A61K31/55 , A61K31/53 , A61K31/4196 , A61K31/36 , A61K9/28 , A61K9/20 , C07D317/58 , C07D405/12
CPC分类号： A61K31/155 , A61K9/0053 , A61K9/2054 , A61K9/2813 , A61K9/282 , A61K9/2846 , A61K9/2866 , A61K31/36 , A61K31/4196 , A61K31/53 , A61K31/55 , A61K45/06 , C07D249/14 , C07D251/10 , C07D251/18 , C07D255/02 , C07D307/52 , C07D317/58 , C07D405/12 , A61K2300/00
摘要： Methods for improving the gastrointestinal tolerability of biguanide compounds and for treating metabolic disorders and/or inducing weight loss in patients in need thereof, particularly in individuals having a contraindication for treatment with biguanide compounds, are provided comprising administering delayed release formulations of such biguanide compounds, including metformin, targeted to the small intestine.
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公开(公告)号：US20170209394A1
公开(公告)日：2017-07-27
申请号：US15339346
申请日：2016-10-31
IPC分类号： A61K31/155 , A61K31/485 , A61K31/137 , A61K31/35 , A61K45/06 , A61K31/55
CPC分类号： A61K31/155 , A61K9/2086 , A61K9/2806 , A61K9/4808 , A61K31/137 , A61K31/341 , A61K31/35 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/4196 , A61K31/4453 , A61K31/454 , A61K31/485 , A61K31/53 , A61K31/55 , A61K45/06 , A61K2300/00
摘要： Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.
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公开(公告)号：US20140193498A1
公开(公告)日：2014-07-10
申请号：US14147449
申请日：2014-01-03
IPC分类号： A61K9/28 , A61K31/155
CPC分类号： A61K9/2846 , A61K9/2886 , A61K31/155
摘要： Compositions and methods for improving the pharmacokinetics and reducing the risk of adverse events resulting from biguanide compound administration are provided, comprising administering delayed release formulations of such compounds having a lag phase release.
摘要翻译： 提供了用于改善药物动力学和降低由双胍化合物给药引起的不良事件的风险的组合物和方法，其包括施用具有滞后期释放的这种化合物的延迟释放制剂。
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公开(公告)号：US20130177604A1
公开(公告)日：2013-07-11
申请号：US13734966
申请日：2013-01-05
IPC分类号： A61K9/28 , A61K45/06 , A61K31/155
CPC分类号： A61K31/155 , A61K9/0053 , A61K9/2054 , A61K9/2813 , A61K9/282 , A61K9/2846 , A61K9/2866 , A61K31/36 , A61K31/4196 , A61K31/53 , A61K31/55 , A61K45/06 , C07D249/14 , C07D251/10 , C07D251/18 , C07D255/02 , C07D307/52 , C07D317/58 , C07D405/12 , A61K2300/00
摘要： Methods for improving the gastrointestinal tolerability of biguanide compounds and for treating metabolic disorders and/or inducing weight loss in patients in need thereof, particularly in individuals having a contraindication for treatment with biguanide compounds, are provided comprising administering delayed release formulations of such biguanide compounds, including metformin, targeted to the small intestine.
摘要翻译： 提供了改善双胍类化合物的胃肠耐受性和用于治疗有需要的患者，特别是在用双胍类化合物治疗禁忌症的个体中的代谢紊乱和/或诱导体重减轻的方法，包括施用这种双胍化合物的延迟释放制剂， 包括二甲双胍，针对小肠。
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