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公开(公告)号：US10154972B2
公开(公告)日：2018-12-18
申请号：US15339346
申请日：2016-10-31
IPC分类号： A61P3/10 , C07C279/26 , A61K9/22 , A61K31/155 , A61K45/06 , A61K31/341 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/53 , A61K31/4196 , A61K31/4453 , A61K31/454 , A61K31/55 , A61K9/20 , A61K9/48 , A61K9/28 , A61K31/137 , A61K31/35 , A61K31/485
摘要： Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.
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公开(公告)号：US20130177604A1
公开(公告)日：2013-07-11
申请号：US13734966
申请日：2013-01-05
IPC分类号： A61K9/28 , A61K45/06 , A61K31/155
CPC分类号： A61K31/155 , A61K9/0053 , A61K9/2054 , A61K9/2813 , A61K9/282 , A61K9/2846 , A61K9/2866 , A61K31/36 , A61K31/4196 , A61K31/53 , A61K31/55 , A61K45/06 , C07D249/14 , C07D251/10 , C07D251/18 , C07D255/02 , C07D307/52 , C07D317/58 , C07D405/12 , A61K2300/00
摘要： Methods for improving the gastrointestinal tolerability of biguanide compounds and for treating metabolic disorders and/or inducing weight loss in patients in need thereof, particularly in individuals having a contraindication for treatment with biguanide compounds, are provided comprising administering delayed release formulations of such biguanide compounds, including metformin, targeted to the small intestine.
摘要翻译： 提供了改善双胍类化合物的胃肠耐受性和用于治疗有需要的患者，特别是在用双胍类化合物治疗禁忌症的个体中的代谢紊乱和/或诱导体重减轻的方法，包括施用这种双胍化合物的延迟释放制剂， 包括二甲双胍，针对小肠。
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公开(公告)号：US10201511B2
公开(公告)日：2019-02-12
申请号：US14370450
申请日：2013-01-05
IPC分类号： A61K9/20 , A61K9/24 , A61K9/28 , A61K9/48 , A61P3/10 , C07C279/26 , A61K31/155 , C07D317/58 , A61K31/357 , C07D307/52 , A61K31/341 , A61K9/00 , A61K31/19 , A61K31/198 , A61K31/7016 , A61K31/704 , A61K45/06
摘要： Methods for improving the gastrointestinal tolerability of biguanide compounds and for treating metabolic disorders and/or inducing weight loss in patients in need thereof, particularly in individuals having a contraindication for treatment with biguanide compounds, are provided comprising administering delayed release formulations of such biguanide compounds, including metformin, targeted to the small intestine.
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公开(公告)号：US09211263B2
公开(公告)日：2015-12-15
申请号：US13734966
申请日：2013-01-05
IPC分类号： A61K31/155 , A61K9/28 , A61P3/10 , A61K45/06 , A61K9/20 , A61K31/4196 , A61K31/53 , A61K31/55 , C07D317/58 , C07D405/12 , C07D249/14 , C07D251/10 , C07D251/18 , C07D255/02 , C07D307/52 , A61K31/36
CPC分类号： A61K31/155 , A61K9/0053 , A61K9/2054 , A61K9/2813 , A61K9/282 , A61K9/2846 , A61K9/2866 , A61K31/36 , A61K31/4196 , A61K31/53 , A61K31/55 , A61K45/06 , C07D249/14 , C07D251/10 , C07D251/18 , C07D255/02 , C07D307/52 , C07D317/58 , C07D405/12 , A61K2300/00
摘要： Methods for improving the gastrointestinal tolerability of biguanide compounds and for treating metabolic disorders and/or inducing weight loss in patients in need thereof, particularly in individuals having a contraindication for treatment with biguanide compounds, are provided comprising administering delayed release formulations of such biguanide compounds, including metformin, targeted to the small intestine.
摘要翻译： 提供了改善双胍类化合物的胃肠耐受性和用于治疗有需要的患者，特别是在用双胍类化合物治疗禁忌症的个体中的代谢紊乱和/或诱导体重减轻的方法，包括施用这种双胍化合物的延迟释放制剂， 包括二甲双胍，针对小肠。
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公开(公告)号：US20140341986A1
公开(公告)日：2014-11-20
申请号：US14451323
申请日：2014-08-04
IPC分类号： C07C279/26 , C07D251/18 , C07D255/02 , A61K31/155 , A61K9/28 , A61K9/20 , C07D317/58 , A61K31/343 , C07D307/52 , A61K31/341 , C07D207/06 , A61K31/40 , C07D211/14 , A61K31/4453 , C07D207/34 , C07D307/66 , A61K31/4196 , C07D401/04 , A61K31/454 , C07D405/12 , C07D409/12 , A61K31/53 , C07D251/10 , A61K31/55 , A61K45/06 , C07D249/14
CPC分类号： A61K31/155 , A61K9/00 , A61K9/0053 , A61K9/1623 , A61K9/20 , A61K9/2018 , A61K9/2054 , A61K9/2086 , A61K9/209 , A61K9/2846 , A61K9/2853 , A61K31/137 , A61K31/341 , A61K31/343 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/4196 , A61K31/4453 , A61K31/454 , A61K31/485 , A61K31/53 , A61K31/55 , A61K45/06 , C07C279/26 , C07D207/06 , C07D207/34 , C07D211/14 , C07D249/14 , C07D251/10 , C07D251/18 , C07D255/02 , C07D307/52 , C07D307/66 , C07D317/58 , C07D401/04 , C07D405/12 , C07D409/12
摘要： Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.
摘要翻译： 本文提供了通过施用包含双胍或相关杂环化合物（例如二甲双胍）的组合来治疗某些病症（包括糖尿病，肥胖症和其它代谢疾病，病症或病症）的方法。 本文还提供双胍类或相关杂环化合物组合物及其制备用于本发明方法的方法。 本文还提供包含二甲双胍及其盐及其使用方法的组合物。
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公开(公告)号：US10028923B2
公开(公告)日：2018-07-24
申请号：US15339378
申请日：2016-10-31
IPC分类号： A61P3/10 , C07C279/26 , A61K9/22 , A61K31/155 , A61K45/06 , A61K31/55 , A61K31/137 , A61K31/357 , A61K31/485 , A61K9/20 , A61K9/00
CPC分类号： A61K31/155 , A61K9/00 , A61K9/0053 , A61K9/1623 , A61K9/20 , A61K9/2018 , A61K9/2054 , A61K9/2086 , A61K9/209 , A61K9/2846 , A61K9/2853 , A61K31/137 , A61K31/341 , A61K31/343 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/4196 , A61K31/4453 , A61K31/454 , A61K31/485 , A61K31/53 , A61K31/55 , A61K45/06 , C07C279/26 , C07D207/06 , C07D207/34 , C07D211/14 , C07D249/14 , C07D251/10 , C07D251/18 , C07D255/02 , C07D307/52 , C07D307/66 , C07D317/58 , C07D401/04 , C07D405/12 , C07D409/12
摘要： Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.
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公开(公告)号：US09962344B2
公开(公告)日：2018-05-08
申请号：US15289713
申请日：2016-10-10
IPC分类号： A61K31/155 , A61K9/20 , A61K9/24 , A61K9/28 , A61K9/48 , A61K9/00 , A61K31/19 , A61K31/198 , A61K31/7016 , A61K31/704 , A61K45/06
CPC分类号： A61K31/155 , A61K9/0053 , A61K9/2054 , A61K9/209 , A61K9/2846 , A61K9/4808 , A61K31/19 , A61K31/198 , A61K31/7016 , A61K31/704 , A61K45/06
摘要： Provided herein are methods for treating conditions associated with a chemosensory receptor, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a chemosensory receptor ligand, such as a bitter receptor ligand. Also provided herein are chemosensory receptor ligand compositions, including bitter receptor ligand compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.
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公开(公告)号：US09481642B2
公开(公告)日：2016-11-01
申请号：US14451323
申请日：2014-08-04
IPC分类号： A61P3/10 , C07C279/26 , A61K9/22 , A61K31/155 , C07D317/58 , A61K31/357 , C07D307/52 , A61K31/341 , C07D249/14 , A61K31/4196 , C07D405/12 , C07D251/18 , A61K31/53 , C07D251/10 , C07D255/02 , A61K31/55 , A61K45/06 , A61K9/00 , A61K9/20 , A61K9/24 , A61K9/28 , A61K9/16 , A61K31/36 , A61K31/381 , A61K31/4453 , A61K31/343 , A61K31/40 , A61K31/454 , C07D207/06 , C07D207/34 , C07D211/14 , C07D307/66 , C07D401/04 , C07D409/12
CPC分类号： A61K31/155 , A61K9/00 , A61K9/0053 , A61K9/1623 , A61K9/20 , A61K9/2018 , A61K9/2054 , A61K9/2086 , A61K9/209 , A61K9/2846 , A61K9/2853 , A61K31/137 , A61K31/341 , A61K31/343 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/4196 , A61K31/4453 , A61K31/454 , A61K31/485 , A61K31/53 , A61K31/55 , A61K45/06 , C07C279/26 , C07D207/06 , C07D207/34 , C07D211/14 , C07D249/14 , C07D251/10 , C07D251/18 , C07D255/02 , C07D307/52 , C07D307/66 , C07D317/58 , C07D401/04 , C07D405/12 , C07D409/12
摘要： Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.
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9.发明授权公开(公告)号：US10159658B2
公开(公告)日：2018-12-25
申请号：US15433987
申请日：2017-02-15
IPC分类号： A61K31/155 , A61K45/06 , A61K31/366 , A61K31/40 , A61K31/616 , A61K9/28 , A61K31/341 , A61K31/343 , A61K31/36 , A61K31/4196 , A61K31/53 , A61K31/55 , C07C279/26 , C07D317/58 , C07D401/04 , C07D405/12 , C07D409/12 , C07D249/14 , C07D251/10 , C07D251/18 , C07D255/02 , C07D207/06 , C07D207/34 , C07D211/14 , C07D307/52 , C07D307/66 , A61K9/00 , A61K31/41
摘要： Compositions and methods comprising at least one biguanide compound and at least one statin combined with at least one additional active agent in fixed dose combinations are provided for reducing cardiometabolic risk, and for the treatment of cardiovascular disease, wherein the biguanide compound is formulated for delayed release.
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公开(公告)号：US09770422B2
公开(公告)日：2017-09-26
申请号：US14968696
申请日：2015-12-14
IPC分类号： A61K9/20 , C07C279/02 , A61K31/155 , A61K45/06 , A61K9/28 , A61K31/4196 , A61K31/53 , A61K31/55 , C07D317/58 , C07D405/12 , C07D249/14 , C07D251/10 , C07D251/18 , C07D255/02 , C07D307/52 , A61K31/36 , A61K9/00
CPC分类号： A61K31/155 , A61K9/0053 , A61K9/2054 , A61K9/2813 , A61K9/282 , A61K9/2846 , A61K9/2866 , A61K31/36 , A61K31/4196 , A61K31/53 , A61K31/55 , A61K45/06 , C07D249/14 , C07D251/10 , C07D251/18 , C07D255/02 , C07D307/52 , C07D317/58 , C07D405/12 , A61K2300/00
摘要： Methods for improving the gastrointestinal tolerability of biguanide compounds and for treating metabolic disorders and/or inducing weight loss in patients in need thereof, particularly in individuals having a contraindication for treatment with biguanide compounds, are provided comprising administering delayed release formulations of such biguanide compounds, including metformin, targeted to the small intestine.
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