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    Asymmetrically branched polymer conjugates and microarray assays
    3.
    发明授权
    Asymmetrically branched polymer conjugates and microarray assays 有权
    不对称支化的聚合物共轭物和微阵列测定

    公开(公告)号：US08591904B2

    公开(公告)日：2013-11-26

    申请号：US12833991

    申请日：2010-07-11

    申请人： Ray Yin ,  Dujie Qin ,  Jing Pan

    发明人： Ray Yin ,  Dujie Qin ,  Jing Pan

    IPC分类号： A61K47/00

    CPC分类号： G01N33/5308 ,  A61K47/6949 ,  A61K49/0002 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y30/00 ,  Y10S435/975 ,  Y10T436/11

    摘要： A conjugate of a modified randomly branched asymmetric polymer without a core and a member of a binding pair is described. The modified randomly branched asymmetric polymer can contain chain branches, terminal branches or both. The modified randomly branched asymmetric polymer can contain random asymmetric branches or random asymmetric junctions. The binding pair can be an antibody, antigen or a ligand. The conjugate includes a drug.

    摘要翻译： 描述了不具有核心和结合对成员的改性的随机支化的不对称聚合物的缀合物。 改性的无规支化不对称聚合物可以含有支链，末端分枝或两者。 改性的无规支化不对称聚合物可以包含随机不对称分支或随机不对称连接。 结合对可以是抗体，抗原或配体。 缀合物包括药物。

    Enhancing protein activity through nanoencapsulation
    5.
    发明授权
    Enhancing protein activity through nanoencapsulation 有权
    通过纳米胶囊增强蛋白质活性

    公开(公告)号：US06716450B1

    公开(公告)日：2004-04-06

    申请号：US09859260

    申请日：2001-05-17

    申请人： Ray Yin ,  Tu-Chen Cheng ,  H. Dupont Durst ,  Dujie Qin

    发明人： Ray Yin ,  Tu-Chen Cheng ,  H. Dupont Durst ,  Dujie Qin

    IPC分类号： A61K948

    CPC分类号： A61K9/5146 ,  A61K31/74 ,  A61K31/765

    摘要： Nanocapsules useful for encapsulating bioactive molecules such as proteins are disclosed. These nanocapsules are comprised of branched or hyperbranched polymers and copolymers and have a core-shell structure forming a pocket volume appropriate for complexing and retaining enzymes and other bioactive molecules. The nanoencapsulated bioactive molecule is stable in extreme temperatures and pH, soluble in aqueous or organic solvents, and can be lyophilized to a dry powder for long-term storage without loss of enzyme activity.

    摘要翻译： 公开了可用于包封生物活性分子如蛋白质的纳米胶囊。 这些纳米胶囊由支链或超支化聚合物和共聚物组成，并且具有形成适于络合和保留酶和其它生物活性分子的口袋体积的核 - 壳结构。 纳米封装的生物活性分子在极端温度和pH下是稳定的，可溶于水溶液或有机溶剂，并且可以冻干至干燥粉末以进行长期保存而不损失酶活性。

    Convergent self-branching polymerization
    6.
    发明授权
    Convergent self-branching polymerization 失效
    会聚自分支聚合

    公开(公告)号：US06632889B1

    公开(公告)日：2003-10-14

    申请号：US09365609

    申请日：1999-08-02

    申请人： Rui Yin ,  Donald A. Tomalia ,  Dujie Qin ,  Jamie Dunham

    发明人： Rui Yin ,  Donald A. Tomalia ,  Dujie Qin ,  Jamie Dunham

    IPC分类号： C08J27102

    CPC分类号： C08G83/005 ,  C08F8/30 ,  C08F293/00 ,  C08F293/005 ,  C08F297/00 ,  C08G81/00

    摘要： A method of forming a branched polymer includes forming a plurality of growing linear polymer chains by polymerizing a monomer which is protected against branching and which forms a reactive end group which is in a first condition which is one of electrophilic or nucleophilic, exposing the growing linear polymer chains to a chain transfer agent to cause the reactive end group of at least a first growing linear polymer chain to reverse its electrophilic or nucleophilic character, whereby a non-reversed reactive end group on a second growing linear polymer chain reacts with the reversed reactive end group on the first growing linear polymer chain to create a branched polymer and reverses the electrophilic or nucleophilic character of the reversed reactive end group back to its first condition, whereby it may continue adding monomer in a linear fashion; and quenching the polymerization by adding a compound having multiple reactive sites capable of reacting with the reactive end groups of the polymer chains when they are in the first condition. The method allows the preparation of ultra-high molecular weight dendritic polymers in which the branching junctures are assembled in situ (i.e., are self-branching) in a convergent manner during polymerization of the monomers.

    摘要翻译： 形成支化聚合物的方法包括通过聚合保护不支化的单体形成多个生长的线性聚合物链，并形成作为亲电子或亲核之一的第一条件的反应性端基，暴露生长线 聚合物链与链转移剂反应以使至少第一生长的线性聚合物链的反应性端基反向其亲电或亲核性质，由此第二生长线性聚合物链上的非反相端基与反应的反应性 在第一次生长的线性聚合物链上产生支链聚合物并将反向反应端基的亲电或亲核特性反转回其第一条件，由此其可以以线性方式继续添加单体; 并且当它们处于第一状态时，通过添加具有能够与聚合物链的反应性端基反应的多个反应性位点的化合物来淬灭聚合。 该方法允许制备超高分子量树枝状聚合物，其中在聚合单体期间，分支接合点原位组装（即自支化）以收敛的方式组装。