公开(公告)号：US08481009B2

公开(公告)日：2013-07-09

申请号：US13309259

申请日：2011-12-01

申请人： Dennis L. Gierhart ,  Joseph A. Fox

发明人： Dennis L. Gierhart ,  Joseph A. Fox

IPC分类号： A61K7/42

CPC分类号： A61K8/345 ,  A23L33/175 ,  A23V2002/00 ,  A61K8/27 ,  A61K8/31 ,  A61K8/922 ,  A61K8/97 ,  A61K31/015 ,  A61K31/047 ,  A61K31/05 ,  A61K45/06 ,  A61K2800/81 ,  A61K2800/92 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/04 ,  A23V2200/308 ,  A23V2250/0632 ,  A23V2250/065 ,  A23V2250/0626 ,  A23V2250/0628 ,  A23V2250/063 ,  A23V2250/0638 ,  A23V2250/0648 ,  A23V2250/0654 ,  A23V2250/0604 ,  A23V2250/0606 ,  A23V2250/0608 ,  A23V2250/0616 ,  A23V2250/0618 ,  A23V2250/0622 ,  A23V2250/064 ,  A23V2250/0642 ,  A23V2250/0652 ,  A23V2250/0624 ,  A61K2300/00

摘要： A carotenoid substance called zeaxanthin, when ingested orally at suitable dosages such as 30 to 100 mg/day for a span of 1 to 2 weeks, can provide effective protection against sunburns, and can give skin a darker tint that emulates a healthy suntan. In tests involving adults, it was found that zeaxanthin dosages of 30 to about 80 mg per day were sufficient to induce: (i) a mild but noticeable tinting, shading, or darkening of skin color, comparable to a mild suntan; (ii) a substantial increase in the person's ability to withstand elevated levels of sun or UV exposure; and, (iii) an increased ability of reddened and sunburned skin to convert into intact skin that looks browned and healthily tanned. Oral ingestion of dosages of zeaxanthin after a noticeable darkening of the skin has been achieved further enhances a tanned appearance and/or protects against sun damage.

摘要翻译： 称为玉米黄质的类胡萝卜素物质以适当剂量例如30至100mg /天以1至2周的间隔口服摄取可提供有效保护，防止晒伤，并可使皮肤更暗，模拟健康的防晒霜。 在涉及成年人的测试中，发现每天30至约80mg的玉米黄质剂量足以诱导：（i）与轻度晒黑相当的轻度但明显的着色，阴影或变暗的肤色， （ii）大幅增加人们抵御太阳或紫外线暴露水平的能力; 和（iii）增加的红色和日晒皮肤的能力转化成完整的皮肤，看起来变褐和健康鞣制。 在皮肤明显变暗之后口服摄入玉米黄质的剂量进一步增强了鞣制外观和/或防止晒伤。

公开(公告)号：US20100241450A1

公开(公告)日：2010-09-23

申请号：US12294827

申请日：2007-01-22

申请人： Dennis L. Gierhart ,  Terry B. Hatfield

发明人： Dennis L. Gierhart ,  Terry B. Hatfield

IPC分类号： G06Q50/00 ,  A61B3/10 ,  G06F15/16

CPC分类号： A61B3/0025 ,  A61B3/10 ,  A61B3/12 ,  A61B3/14 ,  A61B5/7275 ,  G06F19/00 ,  G06F19/325 ,  G06F19/3456 ,  G06Q50/22 ,  G06Q50/24 ,  G16H15/00 ,  G16H50/20

摘要： A macular health measurement and storage system comprises a plurality of macular-pigment measurement machine for measuring macular pigment density in humans, a plurality of computers each of which is associated with a corresponding one the macular-pigment measuring machines, and a central host. The plurality of macular-pigment measurement machines include a device for receiving macular pigment data from a patient, at least one data transfer port, and at least one processor that enables the transfer of the macular pigment data from the transfer port. The plurality of computers include a first port coupled to the data transfer port of the corresponding macular-pigment measurement machine for receiving the macular pigment data. Each of the computers includes a second port for transferring patient data. The central host is coupled to the second ports on each of the plurality of computers. The central host includes a storage device for storing the patient data.

摘要翻译： 黄斑健康测量和储存系统包括多个用于测量人体黄斑色素密度的黄斑 - 颜料测量机，多个计算机，每个计算机与相应的一个黄斑 - 颜料测量机和中心主机相关联。 多个黄斑 - 颜料测量机器包括用于从患者接收黄斑色素数据的装置，至少一个数据传送端口和至少一个处理器，其能够从传送端口传送黄斑色素数据。 多个计算机包括耦合到相应的黄斑 - 颜料测量机的数据传送端口的第一端口，用于接收黄斑色素数据。 每个计算机包括用于传送患者数据的第二端口。 中央主机耦合到多个计算机中的每一个上的第二端口。 中央主机包括用于存储患者数据的存储设备。

公开(公告)号：US07691406B2

公开(公告)日：2010-04-06

申请号：US10321921

申请日：2002-12-17

申请人： Kevin M. Garnett ,  Luis H. Guerra-Santos ,  Dennis L. Gierhart

发明人： Kevin M. Garnett ,  Luis H. Guerra-Santos ,  Dennis L. Gierhart

IPC分类号： A61K9/48

CPC分类号： A61K9/1075 ,  A23L33/105 ,  A61K9/4858 ,  A61K9/4866 ,  A61K31/045

摘要： A composition of matter comprising a capsule or tablet, sized and designed for oral ingestion by a human, containing the 3R-3′R stercoisorner of zeaxanthin. The 3R-3′R stereoisomer of zeaxanthin constitutes at least about 90 percent of all zeaxanthin, while S-S and S-R stereoisomers constitute less than about 10 percent of all zeaxanthin in the capsule or tablet. The capsule or tablet contains a sufficient quantity of the 3R-3′R stereoisomer of zeaxanthin to cause a detectable increase in zeaxanthin concentration in retinal tissue, or at least about 0.5 milligrams. It can be concentrated into an oily fluid or prepared in a microencapsulated granular formulation. The zeaxanthin can also be added to various types of foods, such as margarine, dairy products, syrup, cookie dough, and meat preparations. When consumed, the zeaxanthin can help treat and prevent eye diseases including macular degeneration, a leading cause of vision loss.

摘要翻译： 包含胶囊或片剂的物质组合物，其尺寸和设计用于人的口服摄取，其含有玉米黄质的3R-3'R灭菌剂。 玉米黄质的3R-3'R立体异构体占所有玉米黄质的至少约90％，而S-S和S-R立体异构体占胶囊或片剂中所有玉米黄质的少于约10％。 胶囊或片剂含有足量的玉米黄质的3R-3'R立体异构体，以引起视网膜组织中玉米黄质浓度的可检测的增加，或至少约0.5毫克。 它可以浓缩成油状液体或者在微胶囊化的颗粒制剂中制备。 玉米黄质也可以添加到各种类型的食物中，例如人造黄油，乳制品，糖浆，饼干面团和肉制品。 消耗时，玉米黄质可以帮助治疗和预防眼疾，包括黄斑变性，视力丧失的主要原因。

公开(公告)号：US4642236A

公开(公告)日：1987-02-10

申请号：US720110

申请日：1985-04-04

申请人： Beverly A. Friend ,  Dennis L. Gierhart ,  Judy K. O'Brien

发明人： Beverly A. Friend ,  Dennis L. Gierhart ,  Judy K. O'Brien

IPC分类号： A23J3/16 ,  A23J3/00 ,  A23L1/015 ,  A23L1/211

CPC分类号： A23J3/16

摘要： A process for the reduction of undesirable flavor components contained in a vegetable protein material such as a soy isolate, is described. An aqueous slurry of the vegetable protein material is formed and contacted with a mold of the genus Rhizopus or Aspergillus under conditions that are sufficient to reduce the level of undesirable flavor components in the protein material, yet insufficient to result in substantial replication or growth of the mold.

摘要翻译： 描述了用于减少包含在植物蛋白材料如大豆分离物中的不期望的风味成分的方法。 在足以降低蛋白质材料中不期望的风味成分的水平的条件下，形成植物蛋白材料的含水浆料并与根霉属或曲霉菌的霉菌接触，但不足以导致基本上复制或生长 模子。

公开(公告)号：US4485172A

公开(公告)日：1984-11-27

申请号：US416745

申请日：1982-09-10

申请人： Dennis L. Gierhart

发明人： Dennis L. Gierhart

IPC分类号： C12P7/64

CPC分类号： C12P7/6463 ,  Y10S435/921 ,  Y10S435/94 ,  Y10S435/944

摘要： A process for the production of fats and oils, and particularly fats and oils rich in triglycerides, comprising cultivating microorganisms capable of synthesizing the desired fats and oils to promote growth in a growth medium formulated to contain carbon and nitrogen nutrients and then cultivating the microorganisms in a lipid accumulation medium formulated to include at least one fatty acid containing 10 to 20 carbon atoms.

摘要翻译： 一种生产脂肪和油，特别是富含甘油三酸酯的脂肪和油的方法，包括培养能够合成所需脂肪和油的微生物，以促进配制成含有碳和氮营养物的生长培养基中的生长，然后培养微生物 配制成包含至少一种含有10-20个碳原子的脂肪酸的脂质蓄积培养基。

公开(公告)号：US09192586B2

公开(公告)日：2015-11-24

申请号：US10746403

申请日：2003-12-23

申请人： Dennis L. Gierhart

发明人： Dennis L. Gierhart

IPC分类号： A61K31/12 ,  A61K31/047 ,  A61K31/07

CPC分类号： A61K31/047 ,  A61K9/0048 ,  A61K31/07 ,  A61K2300/00

摘要： Oral formulations for promoting eye health, and in particular for preventing or treating macular degeneration, are disclosed, containing zeaxanthin, a carotenoid pigment, and at least two or more additional ocular-active nutrients selected from lipoic acid, omega-3 fatty acids, plant-derived compounds such as flavonoids, anthocyanins, or polyphenolics, taurine, carnitine, Coenzyme-Q10, carnosine, and nutrients that stimulate the production of glutathione. Processes are disclosed for identifying ocular-active nutrients that will interact in a synergistic and potentiating manner with zeaxanthin, to provide better and more effective protection, for eye health, than can be provided by zeaxanthin alone. Additional optional agents include zinc, vitamin E, and vitamin C.

摘要翻译： 公开了用于促进眼睛健康，特别是用于预防或治疗黄斑变性的口服制剂，其含有玉米黄质，类胡萝卜素色素和至少两种或多种另外的选自硫辛酸，ω-3脂肪酸，植物的眼睛活性营养物质 衍生的化合物如黄酮，花青素或多酚，牛磺酸，肉碱，辅酶Q10，肌肽以及刺激谷胱甘肽生成的营养物质。 公开了用于鉴定与玉米黄质以协同增效方式相互作用的眼部活性营养物的方法，以提供比仅由玉米黄质提供的更好和更有效的眼睛健康保护。 其他任选的试剂包括锌，维生素E和维生素C.

公开(公告)号：US08088363B2

公开(公告)日：2012-01-03

申请号：US10356134

申请日：2003-02-01

申请人： Dennis L. Gierhart ,  Joseph A. Fox

发明人： Dennis L. Gierhart ,  Joseph A. Fox

IPC分类号： A61K7/42 ,  A61K31/15

CPC分类号： A61K8/345 ,  A23L33/175 ,  A23V2002/00 ,  A61K8/27 ,  A61K8/31 ,  A61K8/922 ,  A61K8/97 ,  A61K31/015 ,  A61K31/047 ,  A61K31/05 ,  A61K45/06 ,  A61K2800/81 ,  A61K2800/92 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/04 ,  A23V2200/308 ,  A23V2250/0632 ,  A23V2250/065 ,  A23V2250/0626 ,  A23V2250/0628 ,  A23V2250/063 ,  A23V2250/0638 ,  A23V2250/0648 ,  A23V2250/0654 ,  A23V2250/0604 ,  A23V2250/0606 ,  A23V2250/0608 ,  A23V2250/0616 ,  A23V2250/0618 ,  A23V2250/0622 ,  A23V2250/064 ,  A23V2250/0642 ,  A23V2250/0652 ,  A23V2250/0624 ,  A61K2300/00

摘要： A carotenoid substance called zeaxanthin, when ingested orally at suitable dosages such as 30 to 100 mg/day for a span of 1 to 2 weeks, can provide effective protection against sunburns, and can give skin a darker tint that emulates a healthy suntan. In tests involving adults, it was found that zeaxanthin dosages of 30 to about 80 mg per day were sufficient to induce: (i) a mild but noticeable tinting, shading, or darkening of skin color, comparable to a mild suntan; (ii) a substantial increase in the person's ability to withstand elevated levels of sun or UV exposure without any subsequent pain or discomfort, and without the subsequent peeling and flaking that characterizes sunburns; and, (iii) an increased ability of reddened and sunburned skin to convert into intact skin that looks browned and healthily tanned. By reducing the amount of exposure to sunlight (or tanning lights) that are required to achieve a desired level of tanning, zeaxanthin can reduce the risks of skin cancer, premature aging or wrinkling, and similar skin problems. Since zeaxanthin also has retina-protecting properties and reduces the risk of a disease called macular degeneration, oral ingestion of these dosages of a zeaxanthin to enhance a tanned appearance and/or to protect against sun damage is believed to pose no health risks, and can offer several benefits due to the anti-oxidant and other activities of zeaxanthin.

摘要翻译： 称为玉米黄质的类胡萝卜素物质以适当剂量例如30至100mg /天以1至2周的间隔口服摄取可提供有效保护，防止晒伤，并可使皮肤更暗，模拟健康的防晒霜。 在涉及成年人的测试中，发现每天30至约80mg的玉米黄质剂量足以诱导：（i）与轻度晒黑相当的轻度但明显的着色，阴影或变暗的肤色， （ii）大幅度增加人体抵抗阳光或紫外线暴露水平的能力，无任何后续的疼痛或不适，并且没有随后的晒伤和剥落，表现为晒伤; 和（iii）增加的红色和日晒皮肤的能力转化成完整的皮肤，看起来变褐和健康鞣制。 通过减少实现所需鞣制水平所需的阳光（或晒黑灯）的量，玉米黄质可以减少皮肤癌，过早老化或皱纹的风险，以及类似的皮肤问题。 由于玉米黄质还具有视网膜保护性质，并且降低称为黄斑变性的疾病的风险，因此认为这些剂量的玉米黄质的口服摄取可以增强鞣制外观和/或防止日晒损伤，这不构成健康风险，并且可以 由于玉米黄质的抗氧化和其他活性，提供了几个好处。

公开(公告)号：US07942526B2

公开(公告)日：2011-05-17

申请号：US12294827

申请日：2007-01-22

申请人： Dennis L. Gierhart ,  Terry B. Hatfield

发明人： Dennis L. Gierhart ,  Terry B. Hatfield

IPC分类号： A61B3/10 ,  A61B3/14 ,  A61B3/00

CPC分类号： A61B3/0025 ,  A61B3/10 ,  A61B3/12 ,  A61B3/14 ,  A61B5/7275 ,  G06F19/00 ,  G06F19/325 ,  G06F19/3456 ,  G06Q50/22 ,  G06Q50/24 ,  G16H15/00 ,  G16H50/20

摘要： A macular health measurement and storage system comprises a plurality of macular-pigment measurement machine for measuring macular pigment density in humans, a plurality of computers each of which is associated with a corresponding one the macular-pigment measuring machines, and a central host. The plurality of macular-pigment measurement machines include a device for receiving macular pigment data from a patient, at least one data transfer port, and at least one processor that enables the transfer of the macular pigment data from the transfer port. The computers include a first port coupled to the data transfer port of the corresponding macular-pigment measurement machine for receiving the macular pigment data. Each of the computers includes a second port for transferring patient data. The central host is coupled to the second ports on each of the computers. The central host includes a storage device for storing the patient data.

摘要翻译： 黄斑健康测量和储存系统包括多个用于测量人体黄斑色素密度的黄斑 - 颜料测量机，多个计算机，每个计算机与相应的一个黄斑 - 颜料测量机和中心主机相关联。 多个黄斑 - 颜料测量机器包括用于从患者接收黄斑色素数据的装置，至少一个数据传送端口和至少一个处理器，其能够从传送端口传送黄斑色素数据。 计算机包括耦合到相应的黄斑 - 颜料测量机的数据传送端口的第一端口，用于接收黄斑色素数据。 每个计算机包括用于传送患者数据的第二端口。 中央主机耦合到每个计算机上的第二端口。 中央主机包括用于存储患者数据的存储设备。

公开(公告)号：US08501163B2

公开(公告)日：2013-08-06

申请号：US13552461

申请日：2012-07-18

申请人： Dennis L. Gierhart ,  Joseph A. Fox

发明人： Dennis L. Gierhart ,  Joseph A. Fox

IPC分类号： A61K8/00

CPC分类号： A61K8/345 ,  A23L33/175 ,  A23V2002/00 ,  A61K8/27 ,  A61K8/31 ,  A61K8/922 ,  A61K8/97 ,  A61K31/015 ,  A61K31/047 ,  A61K31/05 ,  A61K45/06 ,  A61K2800/81 ,  A61K2800/92 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/04 ,  A23V2200/308 ,  A23V2250/0632 ,  A23V2250/065 ,  A23V2250/0626 ,  A23V2250/0628 ,  A23V2250/063 ,  A23V2250/0638 ,  A23V2250/0648 ,  A23V2250/0654 ,  A23V2250/0604 ,  A23V2250/0606 ,  A23V2250/0608 ,  A23V2250/0616 ,  A23V2250/0618 ,  A23V2250/0622 ,  A23V2250/064 ,  A23V2250/0642 ,  A23V2250/0652 ,  A23V2250/0624 ,  A61K2300/00

摘要： A carotenoid substance called zeaxanthin, when ingested orally at suitable dosages, can provide effective protection against sunburns and darken the skin to emulate a healthy suntan. Zeaxanthin may induce: (i) a mild but noticeable tinting, shading, or darkening of skin color, comparable to a mild suntan; (ii) a substantial increase in the person's ability to withstand elevated levels of sun or UV exposure; and, (iii) an increased ability of reddened and sunburned skin to convert into intact skin that looks browned and healthily tanned. Topical formulations containing zeaxanthin can be administered to the skin during the time period of ingesting the oral formulation to further protect the skin and provide an additional darkening of the skin.

摘要翻译： 称为玉米黄质的类胡萝卜素物质，以适当的剂量口服摄取时，可以有效防止晒伤，并使皮肤变暗，以效仿健康的晒黑。 玉米黄质可能诱发：（i）与轻度晒黑相当的皮肤颜色温和但明显的着色，阴影或变暗; （ii）大幅增加人们抵御太阳或紫外线暴露水平的能力; 和（iii）增加的红色和日晒皮肤的能力转化成完整的皮肤，看起来变褐和健康鞣制。 含有玉米黄质的局部制剂可以在摄取口服制剂的时间期间施用于皮肤，以进一步保护皮肤并提供皮肤的另外的变暗。

公开(公告)号：US07941211B2

公开(公告)日：2011-05-10

申请号：US10972699

申请日：2004-10-23

申请人： Dennis L. Gierhart

发明人： Dennis L. Gierhart

IPC分类号： A61N1/30 ,  A01N35/00 ,  A61K31/12

CPC分类号： A61N5/062 ,  A61F9/008 ,  A61F2009/00863 ,  A61K31/045

摘要： Pre-treatment using a xanthin carotenoid (preferably 3R,3′R-zeaxanthin) can improve the benefits and efficacy of photodynamic therapy (PDT), which uses a light-activated drug (such as verteporfin) in patients who suffer from unwanted retinal blood vessel growth, including the “wet” (exudative) form of macular degeneration. Before a PDT treatment, patients are given a regimen of orally-ingested zeaxanthin for a period of at least 1 and preferably at least 2 to 3 weeks, at dosages of at least 3 and preferably at least 10 milligrams per day. Since zeaxanthin imparts a yellowish color to the macula, a preferred dosage should increase a patient's macular pigment density before the PDT treatment is performed.

摘要翻译： 使用黄嘌呤类胡萝卜素（优选3R，3'R-玉米黄质）的预处理可以改善在患有不想要的视网膜血液的患者中使用光激活药物（例如维替泊芬）的光动力治疗（PDT）的益处和功效 血管生长，包括“湿”（渗出）形式的黄斑变性。 在PDT治疗之前，给予患者口服玉米黄质的方案至少1次，优选至少2至3周，剂量为至少3次，优选至少10mg /天。 由于玉米黄质对黄斑赋予淡黄色，所以优选的剂量应该在进行PDT治疗之前增加患者的黄斑色素密度。