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公开(公告)号：US08956602B2
公开(公告)日：2015-02-17
申请号：US11999415
申请日：2007-12-04
Applicant: David Taft , Steven Bitler , Qiang Zheng , Adam Bell , Stelios Tzannis
Inventor： David Taft , Steven Bitler , Qiang Zheng , Adam Bell , Stelios Tzannis
CPC classification number: A61K9/0024 , A61K9/0019 , A61K9/146
Abstract: Formulations of drugs and crystalline side chain polymers to provide controlled and/or sustained release drug formulations.
Abstract translation: 制备药物和结晶侧链聚合物以提供受控和/或缓释药物制剂。
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公开(公告)号：US08529922B2
公开(公告)日：2013-09-10
申请号：US13372510
申请日：2012-02-14
Applicant: David Taft , Stelios Tzannis , Wei-Guo Dai , Sandra Ottensmann , Steven Bitler , Qiang Zheng , Adam Bell
Inventor： David Taft , Stelios Tzannis , Wei-Guo Dai , Sandra Ottensmann , Steven Bitler , Qiang Zheng , Adam Bell
IPC: A61K38/02 , A61K31/195 , A61K31/519 , A61K47/34 , C08G63/06 , C08G63/91
CPC classification number: A61K9/146 , A61K9/1647 , A61K31/136 , A61K31/196 , A61K31/519 , A61K31/5513 , A61K47/34
Abstract: PLGA, PLA and PGA polymers which have crystallinity resulting from the presence of long chain alkyl groups in terminal units. The polymers are particularly useful for drug delivery.
Abstract translation: PLGA，PLA和PGA聚合物，其具有由末端单元中长链烷基的存在产生的结晶度。 聚合物特别适用于药物递送。
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公开(公告)号：US20090252777A1
公开(公告)日：2009-10-08
申请号：US12284755
申请日：2008-09-25
Applicant: David Taft , Stelios Tzannis , Wei-Guo Dai , Sandra Ottensmann , Steven Bitler , Qiang Zheng , Adam Bell
Inventor： David Taft , Stelios Tzannis , Wei-Guo Dai , Sandra Ottensmann , Steven Bitler , Qiang Zheng , Adam Bell
CPC classification number: A61K9/146 , A61K9/0019 , A61K9/0024
Abstract: Methods for making formulations of drugs and crystalline side chain polymers which formulations provide controlled and/or sustained release drug formulations.
Abstract translation: 制备药物和结晶侧链聚合物制剂的方法，其制剂提供受控和/或缓释药物制剂。
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公开(公告)号：US20080269105A1
公开(公告)日：2008-10-30
申请号：US11999415
申请日：2007-12-04
Applicant: David Taft , Steven Bitler , Qiang Zheng , Adam Bell , Stelios Tzannis
Inventor： David Taft , Steven Bitler , Qiang Zheng , Adam Bell , Stelios Tzannis
IPC: A61K47/32 , A61K38/02 , A61K31/136 , A61K31/519 , A61K31/5513
CPC classification number: A61K9/0024 , A61K9/0019 , A61K9/146
Abstract: Formulations of drugs and crystalline side chain polymers to provide controlled and/or sustained release drug formulations.
Abstract translation: 制备药物和结晶侧链聚合物以提供受控和/或缓释药物制剂。
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公开(公告)号：US20070280942A1
公开(公告)日：2007-12-06
申请号：US11748370
申请日：2007-05-14
Applicant: Steven Levin , Frederick Ramsdell , Zeren Gao , Edward Howard , David Taft , Janet Johnston , Mark Rixon , LuAnne Hebb
Inventor： Steven Levin , Frederick Ramsdell , Zeren Gao , Edward Howard , David Taft , Janet Johnston , Mark Rixon , LuAnne Hebb
IPC: A61K39/395
CPC classification number: C07K16/2818 , A61K38/00 , C07K14/70503 , C07K2317/73 , C07K2317/76 , C07K2319/30
Abstract: The present invention provides a newly identified CD28 family member that functions as lymphocyte inhibitory receptor termed pG6b, which is expressed on T cells. Methods and compositions for modulating pG6b-mediated negative signaling and interfering with the interaction of its counter-receptor for therapeutic, diagnostic, and research purposes are also provided.
Abstract translation: 本发明提供了新鉴定的CD28家族成员，其作为在T细胞上表达的称为pG6b的淋巴细胞抑制性受体起作用。 还提供了用于调节pG6b介导的负信号并干扰其用于治疗，诊断和研究目的的反向受体相互作用的方法和组合物。
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Patent Agency Ranking
公开(公告)号：US20070129302A1
公开(公告)日：2007-06-07
申请号：US11550609
申请日：2006-10-18
Applicant: Zeren Gao , Rolf Kuestner , Mark Appleby , Katherine Lewis , Patricia McKernan , Shannon Okada , David Taft , Joseph Kuijper , Stephen Jaspers , Steven Levin
Inventor： Zeren Gao , Rolf Kuestner , Mark Appleby , Katherine Lewis , Patricia McKernan , Shannon Okada , David Taft , Joseph Kuijper , Stephen Jaspers , Steven Levin
IPC: A61K38/17 , C07K14/715 , C07H21/04 , C12P21/06
CPC classification number: C07K14/7155 , A61K38/00 , C07K2319/20 , C07K2319/21 , C07K2319/30
Abstract: The present invention relates IL-17RE antagonists, such as soluble receptors and anti-IL-17RE antibodies, that are useful in blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17C. IL-17C is a cytokine that is involved in inflammatory processes and human disease. IL-17RE is a receptor for IL-17C. The present invention includes soluble IL-17RE, anti-IL-17RE antibodies and binding partners, as well as methods for antagonizing IL-17C using such soluble receptors, antibodies and binding partners.
Abstract translation: 本发明涉及可用于阻断，抑制，降低，拮抗或中和IL-17C活性的IL-17RE拮抗剂，例如可溶性受体和抗IL-17RE抗体。 IL-17C是涉及炎症过程和人类疾病的细胞因子。 IL-17RE是IL-17C的受体。 本发明包括可溶性IL-17RE，抗IL-17RE抗体和结合配偶体，以及使用这种可溶性受体，抗体和结合配偶体拮抗IL-17C的方法。
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公开(公告)号：US20070128158A1
公开(公告)日：2007-06-07
申请号：US11539068
申请日：2006-10-05
Applicant: Paul Sheppard , Brian Fox , Kevin Klucher , David Taft , Wayne Kindsvogel
Inventor： Paul Sheppard , Brian Fox , Kevin Klucher , David Taft , Wayne Kindsvogel
IPC: A61K38/19
CPC classification number: C07K14/715 , A61K38/20 , A61K38/21 , C07K14/56 , C07K16/24 , C07K16/2866 , C07K2317/76 , C12Q2600/158 , Y02A50/473
Abstract: The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
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公开(公告)号：US20060063233A1
公开(公告)日：2006-03-23
申请号：US11266626
申请日：2005-11-03
Applicant: Paul Sheppard , Brian Fox , Kevin Klucher , David Taft , Wayne Kindsvogel
Inventor： Paul Sheppard , Brian Fox , Kevin Klucher , David Taft , Wayne Kindsvogel
IPC: C07K14/705 , C12P21/06
CPC classification number: C07K14/715 , A61K38/20 , A61K38/21 , C07K14/56 , C07K16/24 , C07K16/2866 , C07K2317/76 , C12Q2600/158 , Y02A50/473
Abstract: The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
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公开(公告)号：US4796319A
公开(公告)日：1989-01-10
申请号：US60654
申请日：1987-06-11
Applicant: David Taft
Inventor： David Taft
CPC classification number: B25F3/00 , B25B21/007 , Y10T408/9065
Abstract: A drill accessory kit for mounting screw-type fasteners is comprised of several drill bit holders and a screwdriving attachment. The bit holder engages a common twist drill bit in the chuck of a drill and allows one to drill a pilot hole to a desired depth in a workpiece with a cutting action which provides a proper-shaped hole for clean flush mounting or countersinking of a screw. Subsequently, the screwdriver attachment slips over the drill bit and engages with the bit holder, allowing a quick change from drilling to powerdriving of a screw.
Abstract translation: 用于安装螺丝式紧固件的钻头附件套件包括多个钻头夹头和螺丝刀附件。 钻头保持器与钻头的卡盘中的公共麻将钻头接合，并且允许人们用切削动作将导向孔钻到工件的期望深度，该切削动作提供适当形状的孔，用于清洁冲洗安装或锪孔螺钉 。 随后，螺丝刀连接件滑过钻头并与钻头夹持器接合，允许从钻孔到螺杆动力驱动的快速更换。
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公开(公告)号：US20120142581A1
公开(公告)日：2012-06-07
申请号：US13372510
申请日：2012-02-14
Applicant: DAVID TAFT , STELIOS TZANNIS , WEI-GUO DAI , SANDRA OTTENSMANN , STEVEN BITLER , QIANG ZHENG , ADAM BELL
Inventor： DAVID TAFT , STELIOS TZANNIS , WEI-GUO DAI , SANDRA OTTENSMANN , STEVEN BITLER , QIANG ZHENG , ADAM BELL
IPC: A61K38/02 , A61K31/195 , A61K47/34 , A61K31/519 , C08G63/06 , C08G63/91
CPC classification number: A61K9/146 , A61K9/1647 , A61K31/136 , A61K31/196 , A61K31/519 , A61K31/5513 , A61K47/34
Abstract: PLGA, PLA and PGA polymers which have crystallinity resulting from the presence of long chain alkyl groups in terminal units. The polymers are particularly useful for drug delivery.
Abstract translation: PLGA，PLA和PGA聚合物，其具有由末端单元中长链烷基的存在产生的结晶度。 聚合物特别适用于药物递送。
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