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公开(公告)号：US20070173451A1
公开(公告)日：2007-07-26
申请号：US11690915
申请日：2007-03-26
Applicant: Yasmin Chandrasekher , Julia Novak , Donald Foster , Wenfeng Xu , Stephen Jaspers
Inventor： Yasmin Chandrasekher , Julia Novak , Donald Foster , Wenfeng Xu , Stephen Jaspers
IPC: A61K38/17
CPC classification number: C07K14/7155 , A61K38/00 , C07K2319/00
Abstract: A soluble receptor that binds to IL-20 having two polypeptide subunits, IL-22R and IL-20RB. The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
Abstract translation: 结合具有两个多肽亚基IL-22R和IL-20RB的IL-20的可溶性受体。 两个亚基优选连接在一起。 在一个实施方案中，一个亚基与免疫球蛋白的轻链的恒定区融合，另一个亚基与免疫球蛋白的重链的恒定区融合。 轻链和重链通过二硫键连接。
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公开(公告)号：US20070065403A1
公开(公告)日：2007-03-22
申请号：US11548810
申请日：2006-10-12
Applicant: Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
Inventor： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
IPC: A61K38/20
CPC classification number: G01N33/6893 , A61K38/1709 , C07K14/47 , C07K14/4702 , G01N2800/06 , G01N2800/065
Abstract: The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.
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3.发明申请Soluble ZcytoR21, anti-ZcytoR21 antibodies and binding partners and methods of using in inflammation 审中-公开可溶性ZcytoR21，抗ZcytoR21抗体和结合配偶体以及在炎症中使用的方法公开(公告)号：US20060142192A1
公开(公告)日：2006-06-29
申请号：US11253200
申请日：2005-10-18
Applicant: Zeren Gao , Rolf Kuestner , Mark Appleby , Katherine Lewis , Patricia McKernan , Shannon Okada , David Taft , Joseph Kuijper , Stephen Jaspers , Steven Levin
Inventor： Zeren Gao , Rolf Kuestner , Mark Appleby , Katherine Lewis , Patricia McKernan , Shannon Okada , David Taft , Joseph Kuijper , Stephen Jaspers , Steven Levin
IPC: A61K38/17 , C07K14/715
CPC classification number: C07K14/7155 , A61K38/00 , A61K39/395 , A61K47/50 , A61K47/60 , C07K14/54 , C07K16/00
Abstract: The present invention relates ZcytoR21 antagonists, such as soluble receptors and anti-ZcytoR21 antibodies, that are useful in blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17C. IL-17C is a cytokine that is involved in inflammatory processes and human disease. ZcytoR21 is a receptor for IL-17C. The present invention includes soluble ZcytoR21, anti-ZcytoR21 antibodies and binding partners, as well as methods for antagonizing IL-17C using such soluble receptors, antibodies and binding partners.
Abstract translation: 本发明涉及可用于阻断，抑制，降低，拮抗或中和IL-17C活性的ZcytoR21拮抗剂，例如可溶性受体和抗ZcytoR21抗体。 IL-17C是涉及炎症过程和人类疾病的细胞因子。 ZcytoR21是IL-17C的受体。 本发明包括可溶性ZcytoR21，抗ZcytoR21抗体和结合配偶体，以及使用这种可溶性受体，抗体和结合配偶体拮抗IL-17C的方法。
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公开(公告)号：US20050208626A1
公开(公告)日：2005-09-22
申请号：US11133912
申请日：2005-05-19
Applicant: Paul Sheppard , Stephen Jaspers , Theresa Deisher , Paul Bishop
Inventor： Paul Sheppard , Stephen Jaspers , Theresa Deisher , Paul Bishop
CPC classification number: C07K7/06 , A61K38/00 , C07K14/47 , C07K14/575 , C07K14/63
Abstract: The present invention is directed to polynucleotides, polypeptides, peptides, variants and uses thereof for novel peptide fragments which have homology to motilin. Tissue distribution of the mRNA for the novel polypeptide fragment is specific to the stomach, small intestine and pancreas. Binding of the peptide fragment has been shown in kidney and small intestine. The present invention further includes agonists, antagonists, variants, antibodies and host cells expressing the cDNA encoding the novel SGIP peptide.
Abstract translation: 本发明涉及与胃动素同源的新型肽片段的多核苷酸，多肽，肽，变体和用途。 新型多肽片段的mRNA的组织分布特异于胃，小肠和胰腺。 肽片段的结合已显示在肾脏和小肠中。 本发明还包括表达编码新型SGIP肽的cDNA的激动剂，拮抗剂，变体，抗体和宿主细胞。
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公开(公告)号：US20070087414A1
公开(公告)日：2007-04-19
申请号：US11548826
申请日：2006-10-12
Applicant: Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
Inventor： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
CPC classification number: G01N33/6893 , A61K38/1709 , C07K14/47 , C07K14/4702 , G01N2800/06 , G01N2800/065
Abstract: The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.
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Patent Agency Ranking
公开(公告)号：US20070078259A1
公开(公告)日：2007-04-05
申请号：US11548830
申请日：2006-10-12
Applicant: Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
Inventor： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
IPC: C07K14/715
CPC classification number: G01N33/6893 , A61K38/1709 , C07K14/47 , C07K14/4702 , G01N2800/06 , G01N2800/065
Abstract: The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.
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公开(公告)号：US20070065405A1
公开(公告)日：2007-03-22
申请号：US11548824
申请日：2006-10-12
Applicant: Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
Inventor： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
IPC: A61K38/54
CPC classification number: G01N33/6893 , A61K38/1709 , C07K14/47 , C07K14/4702 , G01N2800/06 , G01N2800/065
Abstract: The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.
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8.发明申请公开(公告)号：US20070049524A1
公开(公告)日：2007-03-01
申请号：US11538549
申请日：2006-10-04
Applicant: Zeren Gao , Rolf Kuestner , Mark Appleby , Katherine Lewis , Patricia McKernan , Shannon Okada , David Taft , Joseph Kuijper , Stephen Jaspers , Steven Levin
Inventor： Zeren Gao , Rolf Kuestner , Mark Appleby , Katherine Lewis , Patricia McKernan , Shannon Okada , David Taft , Joseph Kuijper , Stephen Jaspers , Steven Levin
IPC: A61K38/17
CPC classification number: C07K14/7155 , A61K38/00 , A61K39/395 , A61K47/50 , A61K47/60 , C07K14/54 , C07K16/00
Abstract: The present invention relates ZcytoR21 antagonists, such as soluble receptors and anti-ZcytoR21 antibodies, that are useful in blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17C. IL-17C is a cytokine that is involved in inflammatory processes and human disease. ZcytoR21 is a receptor for IL-17C. The present invention includes soluble ZcytoR21, anti-ZcytoR21 antibodies and binding partners, as well as methods for antagonizing IL-17C using such soluble receptors, antibodies and binding partners.
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9.发明申请SOLUBLE ZCYTOR14, ANTI-ZCYTOR14 ANTIBODIES AND BINDING PARTNERS AND METHODS OF USING IN INFLAMMATION 审中-公开可溶性ZCYTOR14抗体ZIYTOR14抗体和结合合作伙伴及其使用方法公开(公告)号：US20070048826A1
公开(公告)日：2007-03-01
申请号：US11538574
申请日：2006-10-04
Applicant: Scott Presnell , Steven Burkhead , Steven Levin , Rolf Kuestner , Zeren Gao , Stephen Jaspers , Janine Bilsborough
Inventor： Scott Presnell , Steven Burkhead , Steven Levin , Rolf Kuestner , Zeren Gao , Stephen Jaspers , Janine Bilsborough
IPC: A61K38/17 , C07K14/715 , C07H21/04 , C12P21/06
CPC classification number: C07K16/2866 , A61K2039/505 , C07K14/7155 , C07K2317/73 , C07K2317/76 , C07K2319/30
Abstract: The present invention relates to blocking, inhibiting, reduceing, antagonizing or neutralizing the activity of IL-17F, IL-17A, or both IL-17A and IL-17F polypeptide molecules. IL-17A and IL-17F are cytokines that are involved in inflammatory processes and human disease. ZcytoR14 is a common receptor for IL-17A and IL-17F. The present invention includes soluble ZcytoR14, anti-ZcytoR14 antibodies and binding partners, as well as methods for antagonizing IL-17F, IL-17A or both IL-17A and IL-17F using such soluble receptors, antibodies and binding partners.
Abstract translation: 本发明涉及阻断，抑制，减少，拮抗或中和IL-17F，IL-17A或IL-17A和IL-17F两者多肽分子的活性。 IL-17A和IL-17F是参与炎症过程和人类疾病的细胞因子。 ZcytoR14是IL-17A和IL-17F的常见受体。 本发明包括可溶性ZcytoR14，抗ZcytoR14抗体和结合配偶体，以及使用这种可溶性受体，抗体和结合配偶体拮抗IL-17F，IL-17A或IL-17A和IL-17F两者的方法。
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公开(公告)号：US20070049526A1
公开(公告)日：2007-03-01
申请号：US11548805
申请日：2006-10-12
Applicant: Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
Inventor： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
IPC: A61K38/17
CPC classification number: G01N33/6893 , A61K38/1709 , C07K14/47 , C07K14/4702 , G01N2800/06 , G01N2800/065
Abstract: The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.
Abstract translation: 本发明提供使用Zven1和Zven2多肽来增加趋化因子产生的方法。 本发明还提供了用Zven1和Zven2多肽治疗肠蠕动障碍和改善胃肠功能的方法。
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