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公开(公告)号：US20210147647A1
公开(公告)日：2021-05-20
申请号：US17097620
申请日：2020-11-13
IPC分类号： C08J7/04 , C09D7/40 , C09D7/62 , C08K3/36 , C08K5/54 , C08K9/06 , C08L33/12 , C08L69/00 , C08J7/056
摘要： Methods of preparing surfaces are disclosed relating to polymeric substrates that include the use of nano-scale silica particles, solvents and oligomers. Resulting surface preparations on those polymeric substrates may take the form of resilient superhydrophobic coatings having high optical transmittance.
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公开(公告)号：US09322047B2
公开(公告)日：2016-04-26
申请号：US13656295
申请日：2012-10-19
申请人： Taehyun Park , Daniel Sang-Won Park , Sudheer D Rani , Michael C Murphy , Dimitris E Nikitopoulos
发明人： Taehyun Park , Daniel Sang-Won Park , Sudheer D Rani , Michael C Murphy , Dimitris E Nikitopoulos
IPC分类号： B01L3/00 , C12Q1/24 , G01N33/569 , G01N33/574
CPC分类号： B01L3/502761 , B01L3/502753 , B01L2200/0668 , B01L2300/0816 , B01L2300/0858 , B01L2400/0487 , C12M47/04 , C12Q1/24 , G01N33/56966 , G01N33/574
摘要： A device and methods are provided for efficient and quick capture of target cells through a main microchannel having capture elements immobilized thereon and manipulating a velocity profile of a sample as it passes through the main microchannel. The cell capture device may have a main microchannel with a depth slightly larger than the diameter of the target cells and a plurality of side microchannels. The side microchannels may have a depth smaller than the diameter of the target cells. The device and methods may be used for early cancer detection.
摘要翻译： 提供了一种装置和方法，用于通过具有固定在其上的捕获元件的主微通道有效且快速地捕获靶细胞，并且当样品通过主微通道时操纵样品的速度分布。 细胞捕获装置可以具有深度略大于靶细胞的直径的主微通道和多个侧微通道。 侧面微通道的深度可以小于靶细胞的直径。 该装置和方法可用于早期癌症检测。
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公开(公告)号：US09670540B2
公开(公告)日：2017-06-06
申请号：US14234011
申请日：2012-07-23
申请人： Francis A. Barany , Steven A. Soper , George Grills , Yu-wei Cheng , Jianmin Huang , Hong Wang , Malgorzata A. Witek , Daniel Sang-won Park , Michael C. Murphy , Robin Lindsey McCarley , Mateusz L. Hupert
发明人： Francis A. Barany , Steven A. Soper , George Grills , Yu-wei Cheng , Jianmin Huang , Hong Wang , Malgorzata A. Witek , Daniel Sang-won Park , Michael C. Murphy , Robin Lindsey McCarley , Mateusz L. Hupert
CPC分类号： C12Q1/6874 , C12Q1/6806 , G01N33/585 , C12Q2525/197 , C12Q2525/313 , C12Q2535/122 , C12Q2563/131 , C12Q2565/543
摘要： The present invention is directed to methods for capturing, amplifying and identifying one or more of a plurality of target nucleotide sequences in a sample. The present invention is further directed to a device comprising a solid support having a plurality of wells or pillars and a plurality of oligonucleotides attached to the wells or pillars. Other aspects of the invention are directed to methods of making such devices.
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公开(公告)号：US20160193606A1
公开(公告)日：2016-07-07
申请号：US15066426
申请日：2016-03-10
申请人： Taehyun Park , Daniel Sang-Won Park , Sudheer D. Rani , Michael C. Murphy , Dimitris E. Nikitopoulos
发明人： Taehyun Park , Daniel Sang-Won Park , Sudheer D. Rani , Michael C. Murphy , Dimitris E. Nikitopoulos
IPC分类号： B01L3/00 , G01N33/569 , G01N33/574 , C12Q1/24
CPC分类号： B01L3/502761 , B01L3/502753 , B01L2200/0668 , B01L2300/0816 , B01L2300/0858 , B01L2400/0487 , C12M47/04 , C12Q1/24 , G01N33/56966 , G01N33/574
摘要： A device and methods are provided for efficient and quick capture of target cells through a main microchannel having capture elements immobilized thereon and manipulating a velocity profile of a sample as it passes through the main microchannel. The cell capture device may have a main microchannel with a depth slightly larger than the diameter of the target cells and a plurality of side microchannels. The side microchannels may have a depth smaller than the diameter of the target cells. The device and methods may be used for early cancer detection.
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