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    Chlorins processing fused ring systems useful as photoselective compounds for photodynamic therapy
    3.
    发明申请
    Chlorins processing fused ring systems useful as photoselective compounds for photodynamic therapy 有权
    用于光动力学治疗的紫杉烷加工稠环系统可用作光选择性化合物

    公开(公告)号：US20050020560A1

    公开(公告)日：2005-01-27

    申请号：US10922974

    申请日：2004-08-23

    申请人： Byron Robinson ,  Dipanjan Sengupta ,  Avinash Phadke

    发明人： Byron Robinson ,  Dipanjan Sengupta ,  Avinash Phadke

    IPC分类号： A61K41/00 ,  C07D487/22 ,  A61K31/555

    CPC分类号： C07D487/22 ,  A61K41/0057 ,  A61K41/0071

    摘要： The present invention provides a process of preparation of naphthochlorins and other chlorins with annelated ring systems useful for photodynamic therapy and the compounds themselves. The method for producing naphthochlorin compounds include contacting compounds such as meso-(2′-hydroxymethyl)phenyl porphyrin or meso-(2′-N,N,N-trialkylaminomethyl)phenyl porphyrin precursors with at least one acid catalyst at sufficient temperature for a sufficient time to yield the desired conversion. In a similar manner chlorins possessing annelated ring systems may be made from compounds such as meso-(2′-hydroxymethyl)aryl porphyrins or meso-(2′-N,N,N-trialkylaminomethyl)phenyl porphyrin. The procedures described herein provide new routes for synthesizing naphthochlorins and chlorins with annelated ring systems.

    摘要翻译： 本发明提供了用于光动力学治疗和化合物本身的具有环状环系的萘并氯和其他二氢卟酚的制备方法。 制造萘并二氢黄汞化合物的方法包括将内消旋 - （2'-羟甲基）苯基卟啉或中 - （2-N，N，N-三烷基氨基甲基）苯基卟啉前体的化合物与足够温度的至少一种酸催化剂接触， 足够的时间产生所需的转化。 类似地，具有环状环系的二氢卟酚可以由诸如中 - （2'-羟甲基）芳基卟啉或中 - （2-N，N，N-三烷基氨基甲基）苯基卟啉的化合物制备。 本文所述的方法提供用于合成具有环状环系的萘并氯和二氢卟酚的新途径。

    Chlorins possessing fused ring systems useful as photoselective compounds for photodynamic therapy
    4.
    发明授权
    Chlorins possessing fused ring systems useful as photoselective compounds for photodynamic therapy 有权
    具有可用作光动力治疗的光选择性化合物的稠环体系的二氢卟酚

    公开(公告)号：US06794505B1

    公开(公告)日：2004-09-21

    申请号：US09538980

    申请日：2000-03-30

    申请人： Byron C. Robinson ,  Dipanjan Sengupta ,  Avinash Phadke

    发明人： Byron C. Robinson ,  Dipanjan Sengupta ,  Avinash Phadke

    IPC分类号： C07D48722

    CPC分类号： C07D487/22 ,  A61K41/0057 ,  A61K41/0071

    摘要： The present invention provides a process of preparation of naphthochlorins and other chlorins with annelated ring systems useful for photodynamic therapy and the compounds themselves. The method for producing naphthochlorin compounds include contacting compounds such as meso-(2′-hydroxymethyl)phenyl porphyrin or meso-(2′-N,N,N-trialkylaminomethyl)phenyl porphyrin precursors with at least one acid catalyst at sufficient temperature for a sufficient time to yield the desired conversion. In a similar manner chlorins possessing annelated ring systems may be made from compounds such as meso-(2′-hydroxymethyl)aryl porphyrins or meso-(2′-N,N,N-trialkylaminomethyl)phenyl porphyrin. The procedures described herein provide new routes for synthesizing naphthochlorins and chlorins with annelated ring systems.

    摘要翻译： 本发明提供了用于光动力学治疗和化合物本身的具有环状环系的萘并氯和其他二氢卟酚的制备方法。 制造萘并二氢黄汞化合物的方法包括将内消旋 - （2'-羟甲基）苯基卟啉或中 - （2-N，N，N-三烷基氨基甲基）苯基卟啉前体的化合物与足够温度的至少一种酸催化剂接触， 足够的时间产生所需的转化。 类似地，具有环状环系的二氢卟酚可以由诸如中 - （2'-羟甲基）芳基卟啉或中 - （2-N，N，N-三烷基氨基甲基）苯基卟啉的化合物制备。 本文所述的方法提供用于合成具有环状环系的萘并氯和二氢卟酚的新途径。

    CHLORINS POSSESSING FUSED RING SYSTEMS USEFUL AS PHOTOSELECTIVE COMPOUNDS FOR PHOTODYNAMIC THERAPY
    8.
    发明申请
    CHLORINS POSSESSING FUSED RING SYSTEMS USEFUL AS PHOTOSELECTIVE COMPOUNDS FOR PHOTODYNAMIC THERAPY 审中-公开
    适用于光化学治疗的化合物的氯林定点熔化系统

    公开(公告)号：US20080275232A1

    公开(公告)日：2008-11-06

    申请号：US12147208

    申请日：2008-06-26

    申请人： Byron C. Robinson ,  Dipanjan Sengupta ,  Avinash Phadke

    发明人： Byron C. Robinson ,  Dipanjan Sengupta ,  Avinash Phadke

    IPC分类号： C07D487/22

    CPC分类号： C07D487/22 ,  A61K41/0057 ,  A61K41/0071

    摘要： The present invention provides a process of preparation of naphthochlorins and other chlorins with annelated ring systems useful for photodynamic therapy and the compounds themselves. The method for producing naphthochlorin compounds include contacting compounds such as meso-(2′-hydroxymethyl)phenyl porphyrin or meso-(2′-N,N,N-trialkylaminomethyl)phenyl porphyrin precursors with at least one acid catalyst at sufficient temperature for a sufficient time to yield the desired conversion. In a similar manner chlorins possessing annelated ring systems may be made from compounds such as meso-(2′-hydroxymethyl)aryl porphyrins or meso-(2′-N,N,N-trialkylaminomethyl)phenyl porphyrin. The procedures described herein provide new routes for synthesizing naphthochlorins and chlorins with annelated ring systems.

    摘要翻译： 本发明提供了用于光动力学治疗和化合物本身的具有环状环系的萘并氯和其他二氢卟酚的制备方法。 制造萘并二氢黄汞化合物的方法包括将内消旋 - （2'-羟甲基）苯基卟啉或中 - （2-N，N，N-三烷基氨基甲基）苯基卟啉前体的化合物与足够温度的至少一种酸催化剂接触， 足够的时间产生所需的转化。 类似地，具有环状环系的二氢卟酚可以由诸如中 - （2'-羟甲基）芳基卟啉或中 - （2-N，N，N-三烷基氨基甲基）苯基卟啉的化合物制备。 本文所述的方法提供用于合成具有环状环系的萘并氯和二氢卟酚的新途径。

    Method and apparatus for an improved workflow for digital image editing
    10.
    发明授权
    Method and apparatus for an improved workflow for digital image editing 有权
    用于数字图像编辑的改进工作流程的方法和装置

    公开(公告)号：US08655112B2

    公开(公告)日：2014-02-18

    申请号：US13492367

    申请日：2012-06-08

    申请人： Swarnima Bansal ,  Dipanjan Sengupta

    发明人： Swarnima Bansal ,  Dipanjan Sengupta

    IPC分类号： G06K9/03

    CPC分类号： G06T11/60

    摘要： A method and apparatus for an improved workflow for digital image editing is disclosed. The method comprises accessing a file containing a plurality of effects to apply to an image; merging a plurality of visible layers of the image to create a merged layer; applying the plurality of effects to the merged layer; installing a layer mask on the merged layer; and applying a plurality of user strokes made during an image editing process to the installed layer mask.

    摘要翻译： 公开了一种用于数字图像编辑的改进工作流程的方法和装置。 该方法包括访问包含多个效果的文件以应用于图像; 合并图像的多个可见层以创建合并图层; 将多个效果应用于合并层; 在合并图层上安装图层蒙版; 以及将在图像编辑处理期间产生的多个用户笔画应用于所安装的图层蒙版。