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    Synthesis of cisapride
    6.
    发明授权
    Synthesis of cisapride 失效
    西沙必利的合成

    公开(公告)号：US06218542B1

    公开(公告)日：2001-04-17

    申请号：US09284513

    申请日：1999-04-14

    申请人： Alfons Gaston Maria De Knaep ,  Luc Jozef Raphael Moens ,  Max Rey

    发明人： Alfons Gaston Maria De Knaep ,  Luc Jozef Raphael Moens ,  Max Rey

    IPC分类号： C07D21158

    CPC分类号： C07D211/58

    摘要： A new Process of preparing cisapride, and the pharmaceutically acceptable acid addition salts thereof, by reductively aminating 1-[3-(4-fluorophenoxy)-propyl]-3-methoxy-4-piperidinone in the presence of benzylamine under hydrogen in a reaction-inert solvent, yielding 1-[3-(4-fluorophenoxy)-propyl]-3-methoxy-4-piperidinamine having a cis/trans ratio of about 93/7, which is enriched in the amount of cis-stereoisomer by converting it into its acid addition salt, by treatment with a suitable inorganic acid, in an appropriate solvent, subsequent crystallisation and conversion to its free base form by treatment with an appropriate base, yielding 1-[3-(4-fluorophenoxy)-propyl]-3-methoxy-4-piperidinamine having a cis/trans ratio of equal to or higher than 98/2.

    摘要翻译： 通过在苄基胺的存在下在氢气下在反应中还原性胺化1- [3-（4-氟苯氧基） - 丙基] -3-甲氧基-4-哌啶酮，制备西沙必利及其药学上可接受的酸加成盐的新方法 得到1-顺式/反式比为约93/7的1- [3-（4-氟苯氧基） - 丙基] -3-甲氧基-4-哌啶胺，其通过转化而得到顺式 - 立体异构体的量 通过用合适的无机酸处理，在合适的溶剂中将其加成其酸加成盐，随后结晶并用合适的碱处理转化成游离碱形式，得到1- [3-（4-氟苯氧基） - 丙基] -3-甲氧基-4-哌啶胺，其顺/反比等于或高于98/2。

    Composite label for fastening to an article
    7.
    发明授权
    Composite label for fastening to an article 失效
    用于固定到物品上的复合标签

    公开(公告)号：US4868027A

    公开(公告)日：1989-09-19

    申请号：US106251

    申请日：1987-10-07

    申请人： Franz Hunkeler ,  Max Rey ,  Renate Wunder

    发明人： Franz Hunkeler ,  Max Rey ,  Renate Wunder

    IPC分类号： G09F3/02 ,  G09F3/18

    CPC分类号： G09F3/0289 ,  Y10T428/1495 ,  Y10T428/15 ,  Y10T428/239

    摘要： A composite label affixable to a surface of an article comprising an adhesive-bearing base sheet for affixing the label to the article, a front sheet joined to the base sheet along its periphery and an enclosure placed in the pocket formed between the base and front sheets, wherein a tear line in the front sheet provides access to said pocket and to said enclosure; also, a carrier strip having such labels mounted thereon; also a labelled article having adhesively affixed thereto a composite label comprising a base sheet, a front sheet joined to the base sheet along its periphery and an enclosure placed in the pocket formed between the base and front sheets, wherein a tear line in the front sheet provides access to said pocket and to said enclosure.

    摘要翻译： 可贴合到制品表面的复合标签，其包括用于将标签固定到制品上的粘合剂承载基片，沿其周边连接到基片的前片和设置在基片和前片之间形成的口袋中的外壳 ，其中所述前片中的撕裂线提供对所述口袋和所述外壳的通路; 还具有安装在其上的这种标签的载体条; 还有一种粘贴在其上的标签制品，该复合标签包括基片，沿其周边接合到基片的前片和放置在形成在基片与前片之间的凹穴中的外壳，其中前片中的撕裂线 提供对所述口袋和所述外壳的访问。